| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael S Spindle, Mark P Thoma. Activation of 5-HT2A receptors by TCB-2 induces recurrent oscillatory burst discharge in layer 5 pyramidal neurons of the mPFC in vitro. Physiological reports. vol 2. issue 5. 2014-05-21. PMID:24844635. |
the coexpression of both inhibitory serotonin 5-ht1a receptors on the axon initial segments, and excitatory 5-ht2a receptors throughout the somatodendritic compartments, by layer 5 pyramidal neurons allows serotonin to provide potent top-down regulation of input-output relationships within cortical microcircuits. |
2014-05-21 |
2023-08-13 |
mouse |
| C Gorini, H Jameson, A L Woerman, D C Perry, D Mendelowit. Prenatal nicotine exposure enhances the trigeminocardiac reflex via serotonin receptor facilitation in brainstem pathways. Journal of applied physiology (Bethesda, Md. : 1985). vol 115. issue 4. 2014-05-19. PMID:23766497. |
application of the 5-ht1a receptor antagonist way 100635 (100 μm) and 5-ht2a/c receptor antagonist ketanserin (10 μm)significantly decreased neurotransmission, indicating an increased facilitation of 5-ht function in prenatal nicotine-exposed animals. |
2014-05-19 |
2023-08-12 |
rat |
| Mei Huang, John J Panos, Sunoh Kwon, Yoshihiro Oyamada, Lakshmi Rajagopal, Herbert Y Meltze. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. Journal of neurochemistry. vol 128. issue 6. 2014-05-14. PMID:24164459. |
comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-ht)2a and da d2 antagonism and 5-ht1a partial agonism. |
2014-05-14 |
2023-08-12 |
rat |
| Mei Huang, John J Panos, Sunoh Kwon, Yoshihiro Oyamada, Lakshmi Rajagopal, Herbert Y Meltze. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. Journal of neurochemistry. vol 128. issue 6. 2014-05-14. PMID:24164459. |
more potent serotonin (5-ht)2a than dopamine (da) d2 receptors antagonism, and direct or indirect 5-ht1a agonism, characterize almost all aapds. |
2014-05-14 |
2023-08-12 |
rat |
| Edward C Lauterbach, Jeffrey L Cummings, Preetha Sharone Kuppuswam. Toward a more precise, clinically--informed pathophysiology of pathological laughing and crying. Neuroscience and biobehavioral reviews. vol 37. issue 8. 2014-05-08. PMID:23518269. |
pag activity is regulated by glutamatergic nmda, muscarinic m1-3, gaba-a, dopamine d2, norepinephrine alpha-1,2, serotonin 5ht1a, 5ht1b/d, and sigma-1 receptors, with an acetylcholine/gaba balance mediating volitional inhibition of the pag. |
2014-05-08 |
2023-08-12 |
Not clear |
| Ikuko Miyazaki, Masato Asanuma, Shinki Murakami, Mika Takeshima, Nao Torigoe, Yoshihisa Kitamura, Ko Miyosh. Targeting 5-HT(1A) receptors in astrocytes to protect dopaminergic neurons in Parkinsonian models. Neurobiology of disease. vol 59. 2014-05-05. PMID:23959140. |
serotonin 1a (5-ht1a) agonist 8-oh-dpat induced astrocyte proliferation and increased metallothionein-1/-2 (mt-1/-2), antioxidative molecules, in cultured astrocytes and the striatum of mice. |
2014-05-05 |
2023-08-12 |
mouse |
| Javier A Bravo, Timothy G Dinan, John F Crya. Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain. Frontiers in molecular neuroscience. vol 7. 2014-04-30. PMID:24782706. |
early-life stress induces persistent alterations in 5-ht1a receptor and serotonin transporter mrna expression in the adult rat brain. |
2014-04-30 |
2023-08-13 |
rat |
| Javier A Bravo, Timothy G Dinan, John F Crya. Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain. Frontiers in molecular neuroscience. vol 7. 2014-04-30. PMID:24782706. |
we hypothesize that this alteration may be caused by differences in 5-ht1a receptor and serotonin transporter (sert) mrna expression in brain areas involved in the control of emotions, memory, and fear as well as in regions controlling the central serotonergic tone. |
2014-04-30 |
2023-08-13 |
rat |
| Sawako Tabuchi, Tomomi Tsunematsu, Thomas S Kilduff, Shouta Sugio, Ming Xu, Kenji F Tanaka, Satoru Takahashi, Makoto Tominaga, Akihiro Yamanak. Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness. Sleep. vol 36. issue 9. 2014-04-25. PMID:23997373. |
serotonergic (5ht) neurons of the dorsal raphe nuclei receive excitatory input from hypothalamic orexin (hypocretin) neurons and reciprocally inhibit orexin neurons through the 5ht1a receptor. |
2014-04-25 |
2023-08-12 |
Not clear |
| Anita H Clayton, Sidney H Kennedy, John B Edwards, Susan Gallipoli, Carol R Ree. The effect of vilazodone on sexual function during the treatment of major depressive disorder. The journal of sexual medicine. vol 10. issue 10. 2014-04-24. PMID:23216998. |
vilazodone, a novel serotonin (5-ht) reuptake inhibitor and 5-ht1a partial agonist approved for mdd, exerts its effects at the 5-ht transporter and at both presynaptic and postsynaptic 5-ht1a receptors. |
2014-04-24 |
2023-08-12 |
Not clear |
| Per Stenkrona, Christer Halldin, Johan Lundber. 5-HTT and 5-HT(1A) receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23428337. |
it has high affinity for the 5-ht transporter (5-htt) and moderate affinity for the 5-ht1a receptor in vitro. |
2014-04-24 |
2023-08-12 |
human |
| Stal Saurav Shrestha, Eric E Nelson, Jeih-San Liow, Robert Gladding, Chul Hyoung Lyoo, Pam L Noble, Cheryl Morse, Ioline D Henter, Jeremy Kruger, Bo Zhang, Stephen J Suomi, Per Svenningsson, Victor W Pike, James T Winslow, Ellen Leibenluft, Daniel S Pine, Robert B Inni. Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior. The American journal of psychiatry. vol 171. issue 3. 2014-04-24. PMID:24480874. |
this study examined the long-term effects of fluoxetine administered to juvenile rhesus monkeys who, as young adults, were imaged with positron emission tomography for two serotonergic markers: serotonin transporter (sert) and serotonin 1a (5-ht1a) receptor. |
2014-04-24 |
2023-08-12 |
human |
| Alan L Pehrson, Thomas Cremers, Cecile Bétry, Marieke G C van der Hart, Laerke Jørgensen, Mathias Madsen, Nasser Haddjeri, Bjarke Ebert, Connie Sanche. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 2. 2014-04-21. PMID:22612991. |
preclinical research suggests that 5-ht receptor subtypes, including 5-ht1a, 5-ht1b, 5-ht3, and 5-ht7 receptors as well as the 5-ht transporter (sert), may have important roles in treating depression. |
2014-04-21 |
2023-08-12 |
rat |
| Colin P Leslie, Matteo Biagetti, Silvia Bison, Steven M Bromidge, Romano Di Fabio, Daniele Donati, Alessandro Falchi, Martine J Garnier, Albert Jaxa-Chamiec, Gary Manchee, Giancarlo Merlo, Domenica A Pizzi, Luigi P Stasi, Jessica Tibasco, Antonio Vong, Simon E Ward, Laura Zonzin. Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist. Journal of medicinal chemistry. vol 53. issue 23. 2014-04-15. PMID:21053897. |
a novel series of compounds was identified showing low intrinsic activities and potent affinities across the 5-ht1a, 5-ht1b, and 5-ht1d receptors as well as high selectivity against the serotonin transporter. |
2014-04-15 |
2023-08-12 |
Not clear |
| Marten P Smidt, Johannes A van Hoof. Subset specification of central serotonergic neurons. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24198761. |
in addition, more disperse refinement of these subsets is present as shown by the selective expression of the 5-ht1a autoreceptor, indicating functional diversity between 5-ht subsets. |
2014-03-25 |
2023-08-12 |
Not clear |
| Pau Celada, Analía Bortolozzi, Francesc Artiga. Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research. CNS drugs. vol 27. issue 9. 2014-03-19. PMID:23757185. |
serotonin 5-ht1a receptors as targets for agents to treat psychiatric disorders: rationale and current status of research. |
2014-03-19 |
2023-08-12 |
mouse |
| Yoko Shimoda, Joji Yui, Lin Xie, Masayuki Fujinaga, Tomoteru Yamasaki, Masanao Ogawa, Nobuki Nengaki, Katsushi Kumata, Akiko Hatori, Kazunori Kawamura, Ming-Rong Zhan. Synthesis and evaluation of 1-[2-(4-[(11)C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain. Bioorganic & medicinal chemistry. vol 21. issue 17. 2014-03-18. PMID:23830697. |
1-[2-(4-methoxyphenyl)phenyl]piperazine (4) is a potent serotonin 5-ht7 receptor antagonist (ki=2.6nm) with a low binding affinity for the 5-ht1a receptor (ki=476nm). |
2014-03-18 |
2023-08-12 |
rat |
| Zeyad Schwen, Yosuke Matsuta, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Ta. Inhibition of bladder overactivity by duloxetine in combination with foot stimulation or WAY-100635 treatment in cats. American journal of physiology. Renal physiology. vol 305. issue 12. 2014-03-18. PMID:24154699. |
the purpose of this study was to determine whether duloxetine [a serotonin (5-ht)-norepinephrine reuptake inhibitor] combined with transcutaneous foot stimulation or way-100635 (a 5-ht1a antagonist) can enhance inhibition of bladder overactivity in cats. |
2014-03-18 |
2023-08-12 |
Not clear |
| Hiroto Nakayama, Sumiyo Umeda, Masashi Nibuya, Takeshi Terao, Koichi Nisijima, Soichiro Nomur. Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation. Neuropsychiatric disease and treatment. vol 10. 2014-03-14. PMID:24627634. |
recently, the effectiveness of coadministrating 5-ht1a agonistic psychotropics with selective serotonin reuptake inhibitors (ssris) has been reported, and ssris with 5-ht1a agonistic activity have been newly approved in the treatment of depression. |
2014-03-14 |
2023-08-12 |
Not clear |
| Hiroto Nakayama, Sumiyo Umeda, Masashi Nibuya, Takeshi Terao, Koichi Nisijima, Soichiro Nomur. Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation. Neuropsychiatric disease and treatment. vol 10. 2014-03-14. PMID:24627634. |
animal studies have indicated that mild serotonin excess induces low body temperature through 5-ht1a, whereas severe serotonin excess induces high body temperature through 5-ht2a activation. |
2014-03-14 |
2023-08-12 |
Not clear |