All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Satoshi Yamamura, Masao Abe, Masanori Nakagawa, Shinichiro Ochi, Shu-ichi Ueno, Motohiro Okad. Different actions for acute and chronic administration of mirtazapine on serotonergic transmission associated with raphe nuclei and their innervation cortical regions. Neuropharmacology. vol 60. issue 4. 2011-05-12. PMID:21195096. chronic administration of mirtazapine resulted in increased extracellular serotonin level via reduction of serotonin transporter with reduction of somatodendritic 5-ht1a autoreceptor function in raphe nuclei. 2011-05-12 2023-08-12 Not clear
Brent J Thompson, Tammy Jessen, L K Henry, Julie R Field, Karen L Gamble, Paul J Gresch, Ana M Carneiro, Rebecca E Horton, Peter J Chisnell, Yekaterina Belova, Douglas G McMahon, Lynette C Daws, Randy D Blakel. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 9. 2011-05-09. PMID:21282638. through a series of biochemical, electrophysiological, and behavioral assays, we demonstrate the unique properties of this model and establish directly that sert is the sole protein responsible for selective 5-ht reuptake inhibitor-mediated alterations in 5-ht clearance, in 5-ht1a autoreceptor modulation of raphe neuron firing, and in behaviors used to predict the utility of antidepressants. 2011-05-09 2023-08-12 mouse
L M Kozhevnikova, I F Sukhanova, P V Avdoni. [Activation of "silent" vasoconstrictive 5-HT1A receptors as a possible mechanism of synergism in angiotensin II and serotonin effect on vascular tone]. Izvestiia Akademii nauk. Seriia biologicheskaia. issue 1. 2011-05-04. PMID:21446059. [activation of "silent" vasoconstrictive 5-ht1a receptors as a possible mechanism of synergism in angiotensin ii and serotonin effect on vascular tone]. 2011-05-04 2023-08-12 rat
Albert Adel. Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety. IDrugs : the investigational drugs journal. vol 13. issue 12. 2011-05-02. PMID:21154150. lu-aa21004 belongs to a novel chemical class of antidepressant agents, the bisarylsulfanyl amines, and possesses a novel pharmacological profile, with activity at serotonergic receptors 5-ht3, 5-ht7 and 5-ht1a, and also at the 5-ht transporter. 2011-05-02 2023-08-12 rat
Kirsten X Jacobsen, Margaret Czesak, Mariam Deria, Brice Le François, Paul R Alber. Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21182526. serotonin (5-hydroxytryptamine, 5-ht) neurotransmission is negatively regulated by 5-ht1a autoreceptors on raphe neurons, and is implicated in mood disorders. 2011-04-15 2023-08-12 mouse
Kirsten X Jacobsen, Margaret Czesak, Mariam Deria, Brice Le François, Paul R Alber. Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21182526. these data indicate that, in addition to transcriptional regulation by pet-1 in raphe neurons, 5-ht1a receptor expression is regulated indirectly by alterations in 5-ht neurotransmission in a region-specific manner that together may contribute to the aggressive/anxiety phenotype observed in pet-1 null mice. 2011-04-15 2023-08-12 mouse
Robert H Howlan. Vilazodone: another novel atypical antidepressant drug. Journal of psychosocial nursing and mental health services. vol 49. issue 3. 2011-04-15. PMID:21323263. vilazodone is a dual-acting antidepressant drug, with a primary mechanism of action of blocking the serotonin reuptake transporter together with acting as a 5-ht1a receptor partial agonist. 2011-04-15 2023-08-12 Not clear
D G Kovalev, I A Zimin, L A Smirnova, A F Riabukh. [Neurochemical mechanisms of antidepressant action of new adenine derivative]. Eksperimental'naia i klinicheskaia farmakologiia. vol 73. issue 12. 2011-04-06. PMID:21395010. in addition, the effect of vma-99-82 on binding of 5-ht1a and 5-ht2a serotonin receptors and the system of 3h-serotonin reuptake in the brain synaptosomes has been studied in vitro. 2011-04-06 2023-08-12 rat
D G Kovalev, I A Zimin, L A Smirnova, A F Riabukh. [Neurochemical mechanisms of antidepressant action of new adenine derivative]. Eksperimental'naia i klinicheskaia farmakologiia. vol 73. issue 12. 2011-04-06. PMID:21395010. it is established that vma-99-82 at a dose of 10 mg/kg has no affinity to 5-ht1a and 5-ht2a serotonin receptors and produces no effect on the reuptake of [3h]-5-ht. 2011-04-06 2023-08-12 rat
Kristina Annerbrink, Marie Olsson, Jan Hedner, Elias Eriksso. Acute and chronic treatment with serotonin reuptake inhibitors exert opposite effects on respiration in rats: possible implications for panic disorder. Journal of psychopharmacology (Oxford, England). vol 24. issue 12. 2011-03-16. PMID:19825902. the effect on respiration after acute administration of compounds enhancing synaptic levels of serotonin, that is, the serotonin reuptake inhibitors paroxetine and fluoxetine, the serotonin-releasing agents m-chlorophenylpiperazine and d-fenfluramine, and the selective 5-ht1a antagonist way-100635, were investigated. 2011-03-16 2023-08-12 rat
K Zavitsanou, H Wang, V S Dalton, V Nguye. Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20438810. in the present study, the effects of cannabinoid treatment on serotonin 5ht1a receptor density and mrna expression were investigated in two age groups: adolescent (postnatal day 35) and adult (postnatal day 70) rats were injected with the synthetic cannabinoid hu210 (25, 50 or 100 microg/kg) or vehicle for 1, 4 or 14 days and sacrificed 24 h after the last injection. 2011-03-04 2023-08-12 rat
K Zavitsanou, H Wang, V S Dalton, V Nguye. Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20438810. higher levels of both serotonin 5ht1a receptor binding and mrna expression were observed in limbic regions in adolescent control animals compared to adults. 2011-03-04 2023-08-12 rat
Maria S M Wai, Dietrich E Lorke, W H Kwong, Lihong Zhang, David T Ye. Profiles of serotonin receptors in the developing human thalamus. Psychiatry research. vol 185. issue 1-2. 2011-03-03. PMID:20538346. our observation that 5-ht1a, 5-ht2a, 5-ht2c and 5-ht4 receptors are present in the human thalamus prenatally indicates that 5-ht may play a role during fetal development. 2011-03-03 2023-08-12 human
Taro Kishi, Tomo Okochi, Tomoko Tsunoka, Takenori Okumura, Tsuyoshi Kitajima, Kunihiro Kawashima, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Naitoh, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Norio Ozaki, Nakao Iwat. Serotonin 1A receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis. Psychiatry research. vol 185. issue 1-2. 2011-03-03. PMID:20594600. several investigations have reported associations between serotonin 1a (5-ht1a) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (bp), making the 5-ht1a receptor gene (htr1a) a good candidate gene for the pathophysiology of schizophrenia and bp. 2011-03-03 2023-08-12 Not clear
Jayanthi Maniam, Margaret J Morri. Voluntary exercise and palatable high-fat diet both improve behavioural profile and stress responses in male rats exposed to early life stress: role of hippocampus. Psychoneuroendocrinology. vol 35. issue 10. 2011-02-17. PMID:20594764. glucocorticoid receptor (gr), brain-derived neurotrophic factor (bdnf) and 5-hydroxytryptamine receptor 1a (5ht1a) receptor mrna in the hippocampus were measured. 2011-02-17 2023-08-12 rat
Georgianna G Gould, Julie G Hensler, Teresa F Burke, Robert H Benno, Emmanuel S Onaivi, Lynette C Daw. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21070242. density and function of central serotonin (5-ht) transporters, 5-ht1a and 5-ht2a receptors, and effects of their targeting on btbr t+tf/j mouse social behavior. 2011-01-20 2023-08-12 mouse
Frederico G Graeff, Hélio Zangross. The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders. Central nervous system agents in medicinal chemistry. vol 10. issue 3. 2011-01-07. PMID:20528764. the reviewed results suggest that chronic, but not acute, administration of antidepressants suppress panic attacks by increasing the release of 5-ht and enhancing the responsivity of post-synaptic 5-ht1a and 5-ht2a receptors in the dpag. 2011-01-07 2023-08-12 human
Vincent Fournet, Marion Jany, Véronique Fabre, Farah Chali, Didier Orsal, Annie Schweitzer, Annie Andrieux, Fany Messanvi, Bruno Giros, Michel Hamon, Laurence Lanfumey, Jean-Christophe Deloulme, Marie-Pascale Martre. The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network. Journal of neurochemistry. vol 115. issue 6. 2011-01-04. PMID:20969568. in the brainstem, mutant mice displayed higher tissue 5-ht levels and in vivo synthesis rate, together with marked increases in 5-ht transporter densities and 5-ht1a autoreceptor levels and electrophysiological sensitivity, without modification of the serotonergic soma number. 2011-01-04 2023-08-12 mouse
P M Pitychoutis, A Zisaki, C Dalla, Z Papadopoulou-Daifot. Pharmacogenetic insights into depression and antidepressant response: does sex matter? Current pharmaceutical design. vol 16. issue 20. 2010-11-22. PMID:20459391. despite the fact that the contribution of the "genome" remains elusive when it comes to major depression, intriguing evidence has recently emerged pointing to sexually dimorphic influences of certain polymorphisms in genes related to the pathophysiology of major depression and antidepressant response, such as the serotonin transporter (5-htt), serotonin 1a (5ht1a) receptor, monoamine oxidase a (mao-a) and others. 2010-11-22 2023-08-12 Not clear
Mohammad Charkhpour, Ali Reza Mohajjel Nayebi, Yousef Doustar, Kambiz Hassanzade. 8-OH-DPAT prevents morphine-induced apoptosis in rat dorsal raphe nucleus: a possible mechanism for attenuating morphine tolerance. Anesthesia and analgesia. vol 111. issue 5. 2010-11-16. PMID:20736434. previously, we found that activation of serotonin 1a (5-ht1a) receptors in the dorsal raphe nucleus (drn) decreased the development of tolerance to the analgesic effect of morphine. 2010-11-16 2023-08-12 rat