All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Jillian H Broadbear, Ronan Y Depoortere, Kristina Vacy, David Ralph, Brendan J Tunstall, Adrian Newman-Tancred. Discriminative stimulus properties of the 5-HT1A receptor biased agonists NLX-101 and F13714, in rats trained to discriminate 8-OH-DPAT from saline. Behavioural pharmacology. vol 32. issue 8. 2021-11-17. PMID:34751175. nlx-101 and f13714 are selective, full efficacy, biased agonists of the serotonin (5-ht1a) receptor. 2021-11-17 2023-08-13 rat
Vincent Martin, Lionel Mathieu, Jorge Diaz, Haysam Salman, Jeanine Alterio, Caroline Chevarin, Laurence Lanfumey, Michel Hamon, Mark C Austin, Michèle Darmon, Craig A Stockmeier, Justine Masso. Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment. Journal of psychiatry & neuroscience : JPN. vol 45. issue 5. 2021-10-26. PMID:32459080. key role of the 5-ht1a receptor addressing protein yif1b in serotonin neurotransmission and ssri treatment. 2021-10-26 2023-08-13 Not clear
Giorgia Galiazzo, Claudio Tagliavia, Fiorella Giancola, Riccardo Rinnovati, Javad Sadeghinezhad, Cristiano Bombardi, Annamaria Grandis, Marco Pietra, Roberto Chiocchett. Localisation of Cannabinoid and Cannabinoid-Related Receptors in the Horse Ileum. Journal of equine veterinary science. vol 104. 2021-10-20. PMID:34416995. the tissues were fixed and processed to obtain cryosections which were used to investigate the immunoreactivity of canonical cannabinoid receptors 1 (cb1r) and 2 (cb2r), and three putative cannabinoid-related receptors: nuclear peroxisome proliferator-activated receptor-alpha (pparα), transient receptor potential ankyrin 1 and serotonin 5-ht1a receptor (5-ht1ar). 2021-10-20 2023-08-13 Not clear
Xiwen Geng, Hongyun Wu, Zifa Li, Chuanfen Li, Dan Chen, Jiancheng Zong, Zimin Liu, Sheng Wei, Wei Pen. Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway. Oxidative medicine and cellular longevity. vol 2021. 2021-10-15. PMID:34646421. in the hippocampus and prefrontal cortex, concentrations of 5-ht and its metabolite 5-hydroxyindoleacetic acid, as well as monoamine oxidase a, glucocorticoid receptor, and 5-ht1a receptor expression levels, were measured. 2021-10-15 2023-08-13 rat
Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. serotonin type 1a receptor (5ht1a) is primarily expressed on glutamatergic nerve terminals, and 5ht1b is expressed on gabaergic medium spiny neurons (msns). 2021-10-14 2023-08-13 rat
Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. continuously levodopa-infused rats or intermittently zns-injected rats did not develop aims, and no differences in the expression of brain-derived neurotrophic factor, 5-ht transporter, 5ht1a, and 5ht1b mrna between the lesioned striatum and normal side were observed. 2021-10-14 2023-08-13 rat
Jeon-Kyung Kim, Sang-Kap Han, Min-Kyung Joo, Dong-Hyun Ki. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33731795. buspirone, an agonist for serotonin 5-ht1a receptors, is used for the treatment of anxiety/depression. 2021-10-13 2023-08-13 mouse
Speranta Avram, Miruna Silvia Stan, Ana Maria Udrea, Cătălin Buiu, Anca Andreea Boboc, Maria Merne. 3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds. Pharmaceutics. vol 13. issue 9. 2021-10-01. PMID:34575524. their antidepressant and neuroleptic activities were predicted by 3d-almond-qsar models built by considering three important targets, namely serotonin transporter (sert), 5-hydroxytryptamine receptor 1a (5-ht1a), and dopamine d2 receptor. 2021-10-01 2023-08-13 Not clear
Nadine M Melhem, Yongqi Zhong, Jeffrey M Miller, Francesca Zanderigo, R Todd Ogden, M Elizabeth Sublette, Madison Newell, Ainsley Burke, John G Keilp, Mohammad Lesanpezeshki, Elizabeth Bartlett, David A Brent, J John Man. Brain 5-HT1A Receptor PET Binding, Cortisol Responses to Stress, and the Familial Transmission of Suicidal Behavior. The international journal of neuropsychopharmacology. 2021-09-23. PMID:34555145. the serotonin 1a (5-ht1a) receptor has been implicated in depression and suicidal behavior. 2021-09-23 2023-08-13 Not clear
Dan Domocos, Tudor Selescu, Laura Cristina Ceafalan, Mirela Iodi Carstens, Earl Carstens, Alexandru Babe. Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat. Journal of neuroscience research. vol 98. issue 10. 2021-09-17. PMID:32537854. using a combination of in vitro (calcium and voltage imaging and patch-clamp) and in vivo behavioral methods, we used both male and female wistar rats to provide evidence for the involvement of two 5-ht receptor subtypes, 5-ht1a and 5-ht3, in mediating the sustained and transient effects, respectively, of 5-ht on rat primary afferent neurons involved in pain and itch processing. 2021-09-17 2023-08-13 rat
Arianna Gentile Polese, Sunny Nigam, Laura M Hurle. 5-HT1A Receptors Alter Temporal Responses to Broadband Vocalizations in the Mouse Inferior Colliculus Through Response Suppression. Frontiers in neural circuits. vol 15. 2021-09-14. PMID:34512276. because serotonin in the ic is more likely to be elevated for mounting-associated bbvs than for rejection-associated bbvs, these effects of the 5-ht1a receptor could contribute to the differential auditory processing of bbvs in different behavioral subcontexts. 2021-09-14 2023-08-13 mouse
Daniela Adamo, Elena Calabria, Noemi Coppola, Giuseppe Pecoraro, Michele Davide Mignogn. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Therapeutic advances in psychopharmacology. vol 11. 2021-09-10. PMID:34497709. this drug inhibits the serotonin transporter with a high affinity, antagonises the 5-ht3, 5-ht1d and 5ht7 serotonin receptors, and activates the 5-ht1a and 5-ht1b receptors. 2021-09-10 2023-08-13 Not clear
Shasha Zhou, Yihang Shen, Shaolian Zang, Xiaoqin Yin, Pin L. The epigenetic role of HTR1A antagonist in facilitaing GnRH expression for pubertal initiation control. Molecular therapy. Nucleic acids. vol 25. 2021-08-31. PMID:34458005. serotonin (5-hydroxytryptamine [5-ht]), a metabolite of tryptophan, acts on the components of the hypothalamus-hypophysis-gonad axis and induces puberty delay in mammals via 5-ht receptor 1a (htr1a). 2021-08-31 2023-08-13 Not clear
Anoosha Attaran, Arash Salahinejad, Mohammad Naderi, Adam L Crane, Douglas P Chivers, Som Niyog. Transgenerational effects of selenomethionine on behaviour, social cognition, and the expression of genes in the serotonergic pathway in zebrafish. Environmental pollution (Barking, Essex : 1987). vol 286. 2021-08-25. PMID:33971468. maternal exposure to high levels of se-met also led to dysregulation of the serotonergic system via changes in mrna expression of serotonin receptors, including the 5-ht1a, 5-ht1b, and 5-ht1d subtypes, the serotonin transporter, and monoamine oxidase (mao). 2021-08-25 2023-08-13 human
Francesca Calabrese, Frank I Tarazi, Giorgio Racagni, Marco A Riv. The role of dopamine D CNS spectrums. vol 25. issue 3. 2021-08-24. PMID:31010452. specifically, cariprazine acts as a partial agonist at the dopamine (da) d2 and d3 receptors and serotonin 5-ht1a receptors, and as an antagonist at the 5-ht2b receptors. 2021-08-24 2023-08-13 Not clear
Jan Terock, Antoine Weihs, Alexander Teumer, Johanna Klinger-König, Deborah Janowitz, Hans J Grab. Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples. Psychiatry research. vol 298. 2021-08-19. PMID:33567384. specifically, genetic polymorphisms of the serotonin receptors 5-ht1a and 5-ht2a were found to be associated with alexithymia. 2021-08-19 2023-08-13 human
Preeti Jha, Shubhra Chaturvedi, Ruchika Bhat, Nidhi Jain, Anil K Mishr. Insights of ligand binding in modeled h5-HT Journal of biomolecular structure & dynamics. 2021-08-13. PMID:34387135. insights of ligand binding in modeled h5-ht the pharmacologically characterized receptor subtype of the serotonin family, the 5ht1a receptor is implicated in the pathophysiology and treatment of depression and anxiety-related disorders. 2021-08-13 2023-08-13 Not clear
Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. 2021-08-11 2023-08-13 mouse
Luana Olegário da Silva, Raquel da Silva Aragão, Manuella da Luz Duarte Barros, Kelli Nogueira Ferraz-Pereira, Isabeli Lins Pinheiro, Lígia Cristina Monteiro Galind. Maternal exposure to high-fat diet modifies anxiety-like/depression-like behaviors and compounds of Serotonergic System in offspring: A preclinical systematic review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-06. PMID:33788300. maternal consumption of hfd was found to be associated with an inconsistent pattern of the expression of tph2 as well as reduced the immunoreactivity of 5-ht in the prefrontal cortex and increased 5-ht1a receptor expression in the dorsal raphe of offspring. 2021-08-06 2023-08-13 Not clear
Nicholas Keks, Judith Hope, Darren Schwartz, Harold McLennan, David Copolov, Graham Meadow. Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia. CNS drugs. vol 34. issue 5. 2021-08-05. PMID:32246399. in contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine d2 activity and higher affinity for the serotonin 5-ht1a and 5-ht2a receptors, while cariprazine has the highest affinity for the dopamine d3 receptor, and the longest half-life. 2021-08-05 2023-08-13 Not clear