| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas Keks, Judith Hope, Darren Schwartz, Harold McLennan, David Copolov, Graham Meadow. Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia. CNS drugs. vol 34. issue 5. 2021-08-05. PMID:32246399. |
in contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine d2 activity and higher affinity for the serotonin 5-ht1a and 5-ht2a receptors, while cariprazine has the highest affinity for the dopamine d3 receptor, and the longest half-life. |
2021-08-05 |
2023-08-13 |
Not clear |
| Roger S Mcintyre, Eduard Vieta, Willie Earley, Mehul Pate. Effects of Cariprazine on Cognition in Patients With Bipolar Mania or Mixed States: Post Hoc Analysis From 3 Randomized, Controlled Phase III Studies. CNS spectrums. vol 26. issue 2. 2021-07-23. PMID:34127095. |
cariprazine, a dopamine d3-preferring d3/d2 and serotonin 5-ht1a receptor partial agonist, is approved for the treatment of schizophrenia and for depressive, manic, or mixed episodes associated with bipolar i disorder. |
2021-07-23 |
2023-08-13 |
Not clear |
| Hao Chen, Feng Wang, Xuan Ni, Yi Rigui, Yuxia Bai, Liang Xu, Jingfeng Yang, Xuefu Zhang, Jiang Deng, Jiawei Li, Xiaoyu Yin, Wuliji Ao, Kevin W H Kwok, Wu Don. Aconitine disrupts serotonin neurotransmission via 5-hydroxytryptamine receptor in zebrafish embryo. Journal of applied toxicology : JAT. vol 41. issue 3. 2021-07-12. PMID:33085127. |
experimental results showed that aconitine exposure (1, 10, and 100 μm) increased frequency of coiling behavior in zebrafish embryos in a dose-dependent manner and this effect can be triggered by either exposure to 5-hydroxytryptamine 1a (5-ht1a) receptor agonist (±)-8-hydroxy-2-(dipropylamino)tetralin (8-oh-dpat) or overexpression of serotonin receptor 5-htr1ab. |
2021-07-12 |
2023-08-13 |
zebrafish |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
the serotonin (5-ht) system is the target of multiple anxiolytics, including buspirone, which is a partial agonist of the serotonin 1a receptor (5-ht1a). |
2021-07-08 |
2023-08-13 |
mouse |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
as an initial step to define the function of 5-ht transmission in the insula, we quantified the proportion of specific neuronal populations of the insula expressing 5-ht1a or 5-ht2a. |
2021-07-08 |
2023-08-13 |
mouse |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
these observations suggest that most glutamatergic neurons can respond to 5-ht through 5-ht1a or 5-ht2a in the insula, and that 5-ht directly affects a limited number of gabaergic neurons. |
2021-07-08 |
2023-08-13 |
mouse |
| Erica Schlichting, Chris Welter, Tammi Schaeffer, Tania D Strou. Serotonin Syndrome Associated With Vilazodone Overdose in a 22-Month-Old Treated With Dexmedetomidine. The Journal of emergency medicine. vol 60. issue 2. 2021-07-08. PMID:33158691. |
vilazodone is a selective serotonin reuptake inhibitor and 5-ht1a agonist used in the treatment of depression in adults. |
2021-07-08 |
2023-08-13 |
Not clear |
| Erica Schlichting, Chris Welter, Tammi Schaeffer, Tania D Strou. Serotonin Syndrome Associated With Vilazodone Overdose in a 22-Month-Old Treated With Dexmedetomidine. The Journal of emergency medicine. vol 60. issue 2. 2021-07-08. PMID:33158691. |
vilazodone blocks the serotonin reuptake pump and desensitizes serotonin receptors (especially 5ht1a autoreceptors), therefore increasing serotonergic neurotransmission. |
2021-07-08 |
2023-08-13 |
Not clear |
| Shawn Zheng Kai Tan, Yasin Temel, Ariel Yovela Chan, Andrea Tsz Ching Mok, Jose Angelo Udal Perucho, Arjan Blokland, Luca Aquili, Wei Ling Lim, Lee Wei Li. Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation. Brain structure & function. vol 225. issue 7. 2021-07-06. PMID:32594260. |
in this study, we further analysed our previous data on the effects of escitalopram (a selective serotonin reuptake inhibitor, ssri) and buspirone (a 5-ht1a receptor partial agonist) on dlpag-induced anticipatory fear behaviour in a rat model using freezing as a measure. |
2021-07-06 |
2023-08-13 |
rat |
| Feras Altwal, Connor Moon, Anthony R West, Heinz Steine. The Multimodal Serotonergic Agent Vilazodone Inhibits L-DOPA-Induced Gene Regulation in Striatal Projection Neurons and Associated Dyskinesia in an Animal Model of Parkinson's Disease. Cells. vol 9. issue 10. 2021-07-02. PMID:33050305. |
previous work showed that modulating the striatal serotonin innervation with selective serotonin reuptake inhibitors (ssris) or 5-ht1a receptor agonists could attenuate l-dopa-induced dyskinesia. |
2021-07-02 |
2023-08-13 |
rat |
| Z A Grieb, A P Ross, K E McCann, S Lee, M Welch, M G Gomez, A Norvelle, V Michopoulos, K L Huhman, H E Alber. Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus). Hormones and behavior. vol 127. 2021-06-25. PMID:33148500. |
dominance status in hamsters is driven by interactions between arginine-vasopressin v1a, oxytocin (ot), and serotonin 1a (5-ht1a) receptors. |
2021-06-25 |
2023-08-13 |
Not clear |
| Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinin. Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. Canadian journal of physiology and pharmacology. vol 99. issue 6. 2021-06-22. PMID:33186073. |
previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-ht1a receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress. |
2021-06-22 |
2023-08-13 |
rat |
| Michael W Lewis, Russell T Jones, Margaret T Davi. Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32678079. |
the serotonin 1-a receptor (5-ht1a) is an inhibitory g protein-coupled serotonin receptor encoded by the htr1a gene that plays a role in regulating serotonin release, physiological stress responding, and emotional behavior. |
2021-06-18 |
2023-08-13 |
human |
| Miguel A Núñez-Ochoa, Gustavo A Chiprés-Tinajero, Laura Medina-Cej. Evaluation of the hippocampal immunoreactivity of the serotonin 5-HT1A, 5-HT2 and 5-HT7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470771. |
evaluation of the hippocampal immunoreactivity of the serotonin 5-ht1a, 5-ht2 and 5-ht7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. |
2021-06-18 |
2023-08-13 |
rat |
| Miguel A Núñez-Ochoa, Gustavo A Chiprés-Tinajero, Laura Medina-Cej. Evaluation of the hippocampal immunoreactivity of the serotonin 5-HT1A, 5-HT2 and 5-HT7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470771. |
therefore, to gather more details about the state of the serotoninergic system in the hippocampus under an epileptogenic process, we studied the immunoreactivity of three 5-ht receptors (5-ht1a, 5-ht2 and 5-ht7) as well as the extracellular levels of 5-ht in the hippocampal tissue of epileptic rats with fr. |
2021-06-18 |
2023-08-13 |
rat |
| Hera Wu, DeVon Herr, Nancie J MacIver, Jeffrey C Rathmell, Valerie A Gerriet. CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism. International immunopharmacology. vol 88. 2021-05-25. PMID:32866787. |
we therefore examined the serotonergic-related machinery in teff and treg and found differential expression of the serotonin transporter sert and 5-ht1a and 5-ht2 receptors. |
2021-05-25 |
2023-08-13 |
Not clear |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Prevention of diet restriction induced hyperactivity but not body-weight reduction in rats co-treated with tryptophan: relationship with striatal serotonin and dopamine metabolism and serotonin-1A auto-receptor expression. Nutritional neuroscience. 2021-05-18. PMID:33722185. |
also, the release and availability of 5-ht are modulated by serotonin-1a (5-ht1a) auto-receptor. |
2021-05-18 |
2023-08-13 |
rat |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Prevention of diet restriction induced hyperactivity but not body-weight reduction in rats co-treated with tryptophan: relationship with striatal serotonin and dopamine metabolism and serotonin-1A auto-receptor expression. Nutritional neuroscience. 2021-05-18. PMID:33722185. |
the role of tryptophan (trp) in influencing the 5-ht metabolism and the mrna expression of 5-ht1a auto-receptor is also investigated. |
2021-05-18 |
2023-08-13 |
rat |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Prevention of diet restriction induced hyperactivity but not body-weight reduction in rats co-treated with tryptophan: relationship with striatal serotonin and dopamine metabolism and serotonin-1A auto-receptor expression. Nutritional neuroscience. 2021-05-18. PMID:33722185. |
the study suggests that the striatal metabolism of 5-ht and dopamine and mrna expression of 5-ht1a auto-receptor has an important role in the pathogenesis of an. |
2021-05-18 |
2023-08-13 |
rat |
| Rosaria Nardello, Fulvio Guccione, Claudia Gliubizzi, Antonio Marino, Mariarita Capizzi, Salvatore Mangan. Resolution of enuresis with aripiprazole in children with psychiatric disorders: two case reports. Journal of medical case reports. vol 15. issue 1. 2021-05-14. PMID:33883037. |
as partial agonist of the dopamine (d2) and serotonin (5-ht1a) receptors, it appears to be effective in reducing mania in patients with bipolar disorder, tics in tourette syndrome, aggression in schizophrenia and autism spectrum disorder. |
2021-05-14 |
2023-08-13 |
Not clear |