All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Neil Saigal, Rama Pichika, Balasubramaniam Easwaramoorthy, Daphne Collins, Bradley T Christian, Bingzhi Shi, Tanjore K Narayanan, Steven G Potkin, Jogeshwar Mukherje. Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 10. 2006-12-22. PMID:17015907. synthesis and biologic evaluation of a novel serotonin 5-ht1a receptor radioligand, 18f-labeled mefway, in rodents and imaging by pet in a nonhuman primate. 2006-12-22 2023-08-12 human
Neil Saigal, Rama Pichika, Balasubramaniam Easwaramoorthy, Daphne Collins, Bradley T Christian, Bingzhi Shi, Tanjore K Narayanan, Steven G Potkin, Jogeshwar Mukherje. Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 10. 2006-12-22. PMID:17015907. serotonin 5-ht1a receptors have been implicated in disorders of the central nervous system and, therefore, are being studied by pet. 2006-12-22 2023-08-12 human
Maria H Paluchowska, Sijka Charakchieva-Minol, Ewa Tatarczyńska, Aleksandra Kłodzińska, Katarzyna Stachowicz, Ewa Chojnacka-Wójci. New 4-[omega-(diarylmethylamino)alkyl]- and 4-[omega-(diarylmethoxy)alkyl]-1-arylpiperazines as selective 5-HT1A/5-HT2A receptor ligands with differentiated in vivo activity. Polish journal of pharmacology. vol 56. issue 6. 2006-12-21. PMID:15662087. they exhibited characteristics of partial agonists of postsynaptic 5-ht1a receptors (11a), of weak antagonists of pre- and postsynaptic sites (12a, 9b), of antagonists of presynaptic (5a) or of antagonists of postsynaptic 5-ht(1a) receptors (9a, 10a, 5b, 8b, 11b and 12b) while, 6a was devoid of functional activity at those receptors. 2006-12-21 2023-08-12 Not clear
Jerzy Kossakowski, Aldona Raszkiewicz, Ryszard Bugno, Andrzej J Bojarsk. Introduction of a new complex imide system into the structure of LCAPs. The synthesis and a 5-HT1A, 5-HT2A and D2 receptor binding study. Polish journal of pharmacology. vol 56. issue 6. 2006-12-21. PMID:15662099. a series of 17 long-chain arylpiperazines containing bulky, complex imide systems (5,8-dimethyl-3b,9-epoxy-(3a,4,5,6,7,8,9,9a)-octahydro-1h-benzo[e]isoindole-1,3(2h)-dione or 4,9-diphenyl-4,9-epoxy-3a,4,9,9a-tetra-hydro-1h-benzo[f]isoindole-1,3(2h)-dione) was synthesized and evaluated for their affinity for serotonin 5-ht1a, 5-ht2a and dopamine d2 receptors. 2006-12-21 2023-08-12 Not clear
Enza Palazzo, Vito de Novellis, Stefania Petrosino, Ida Marabese, Daniela Vita, Catia Giordano, Vincenzo Di Marzo, Giuseppe Salvatore Mangoni, Francesco Rossi, Sabatino Maion. Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system. The European journal of neuroscience. vol 24. issue 7. 2006-12-21. PMID:17040473. furthermore, as well as thermal and mechanical hyperalgesia, cci caused serotonergic hyperactivity (as shown by the increase of basal activity of serotonergic neurones, extracellular serotonin levels and expression of 5-ht1a receptor gene). 2006-12-21 2023-08-12 rat
Haruo Mizutani, Tetsuya Hori, Tomoyuki Takahash. 5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. The European journal of neuroscience. vol 24. issue 7. 2006-12-21. PMID:17067296. the 5-ht1b receptor agonist cp93129 mimicked the inhibitory effect of 5-ht, but the 5-ht1a agonist (r)-(+)-8-hydroxy-dpat (8-ohdpat) had no effect. 2006-12-21 2023-08-12 rat
Arata Watanabe, Akio Nakai, Yoshihiro Tohyama, Khnah Q Nguyen, Mirko Diksi. Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nuclear medicine and biology. vol 33. issue 3. 2006-12-18. PMID:16631081. these results suggest that it is likely that the terminal 5-ht1b receptors are involved in the regulation of 5-ht synthesis in the projection areas and that 5-ht synthesis, in the raphe, is likely influenced by anpirtoline's 5-ht1a and/or 5-ht1b agonistic properties. 2006-12-18 2023-08-12 rat
Shigeo Nakamura, Yukio Ago, Aiko Hayashi, Soichi Itoh, Michiya Kakuda, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsud. Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice. Synapse (New York, N.Y.). vol 60. issue 7. 2006-12-07. PMID:16952156. the present study examined in ddy-strain male mice the effects of the 5-ht1a receptor agonist osemozotan and the receptor antagonist way100635 on cocaine-induced locomotor stimulant effect and increases in extracellular levels of 5-ht and da in the prefrontal cortex. 2006-12-07 2023-08-12 mouse
Fumihiko Yasuno, Sami S Zoghbi, Julie A McCarron, Jinsoo Hong, Masanori Ichise, Amira K Brown, Robert L Gladding, John D Bacher, Victor W Pike, Robert B Inni. Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)-RWAY. Synapse (New York, N.Y.). vol 60. issue 7. 2006-12-07. PMID:16952161. quantification of serotonin 5-ht1a receptors in monkey brain with [11c](r)-(-)-rway. 2006-12-07 2023-08-12 monkey
José Brea, Marián Castro, M Isabel Loza, Christian F Masaguer, Enrique Raviña, Cristina Dezi, Manuel Pastor, Ferran Sanz, Araceli Cabrero-Castel, Beatriz Galán-Rodríguez, Emilio Fernández-Espejo, Rafael Maldonado, Patricia Robled. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine. Neuropharmacology. vol 51. issue 2. 2006-12-04. PMID:16697427. this compound showed a multi-receptor profile with affinities similar to those of clozapine for serotonin (5-ht2a, 5-ht1a, and 5-ht2c), dopamine (d1, d2, d3 and d4), alpha-adrenergic (alpha1, alpha2), muscarinic (m1, m2) and histamine h1 receptors. 2006-12-04 2023-08-12 Not clear
Juan A Mico, Esther Berrocoso, Antonio Ortega-Alvaro, Juan Gibert-Rahola, M Olga Rojas-Corrale. The role of 5-HT1A receptors in research strategy for extensive pain treatment. Current topics in medicinal chemistry. vol 6. issue 18. 2006-11-30. PMID:17017970. in these nuclei, 5-ht1a receptors function as somatodendritic autoreceptors controlling the release of serotonin in terminal areas. 2006-11-30 2023-08-12 Not clear
Kazuo Matsubara, Keiko Shimizu, Manabu Suno, Kento Ogawa, Toshio Awaya, Takehiro Yamada, Toshihiro Noda, Machiko Satomi, Ko-ichi Ohtaki, Kaoru Chiba, Yoshikazu Tasaki, Hiroshi Shion. Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions. Brain research. vol 1112. issue 1. 2006-11-28. PMID:16884702. serotonin 1a (5-ht1a) receptors are distributed throughout the brain with their highest concentrations in the frontal cortex, subthalamic nucleus and entopeduncular nucleus as well as the dorsal and median raphe nucleus. 2006-11-28 2023-08-12 rat
Teresa E Foley, Benjamin N Greenwood, Heidi E W Day, Lauren G Koch, Steven L Britton, Monika Fleshne. Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: implications for central fatigue. Behavioural brain research. vol 174. issue 1. 2006-11-28. PMID:16934883. using quantitative in situ hybridization, we measured messenger rna (mrna) levels of tryptophan hydroxylase (tph), 5-ht transporter (5-htt), 5-ht1a and 5-ht1b autoreceptors, dopamine receptor-d2 (dr-d2) autoreceptors and postsynaptic receptors, and dopamine receptor-d1 (dr-d1) postsynaptic receptors, in discrete brain regions of hcr and lcr. 2006-11-28 2023-08-12 rat
Dnyanesh N Tipre, Sami S Zoghbi, Jeih-San Liow, Michael V Green, Jurgen Seidel, Masanori Ichise, Robert B Innis, Victor W Pik. PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 2. 2006-11-24. PMID:16455642. 18f-fcway (18f-trans-4-fluoro-n-(2-[4-(2-methoxyphenyl) piperazin-1-yl)ethyl]-n-(2-pyridyl)cyclohexanecarboxamide) is useful in clinical research with pet for measuring serotonin 1a (5-ht1a) receptor densities in brain regions of human subjects but has significant bone uptake of radioactivity due to defluorination. 2006-11-24 2023-08-12 human
Daniel J Birmingham, H N Nagaraja, Brad H Rovin, Lacramioara Spetie, Yanxing Zhao, Xiaobai Li, Kevin V Hackshaw, C Yung Yu, William B Malarkey, Lee A Heber. Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G allele. Arthritis and rheumatism. vol 54. issue 10. 2006-11-24. PMID:17009264. two serotonin-related gene polymorphisms, the serotonin receptor 1a (5-ht1a) polymorphism at -1019c>g and the serotonin transporter ls polymorphism, have been reported to affect stress-related behaviors. 2006-11-24 2023-08-12 Not clear
Shuji Iritani, Mizuho Tohgi, Tetsuaki Arai, Kenji Iked. Immunohistochemical study of the serotonergic neuronal system in an animal model of the mood disorder. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16677634. to elucidate these issues, we immunohistochemically examined vesicle monoamine transporter 2 (vmat2), serotonin receptor type 1a (5ht1a), and serotonin transporter (5htt) in the hippocampal region of reserpine-treated rats, an animal model of depression. 2006-11-14 2023-08-12 rat
Jolanta Obniska, Ewa Tatarczyńska, Agnieszka Nikiforuk, Sijka Charakchieva-Minol, Beata Duszyńsk. Synthesis and 5-HT1A/5-HT2A receptor activity of N-(4-arylpiperazin-1-yl)alkyl derivatives of 2-azaspiro([4.4]nonane and [4.5]decane-1,3-dione. Pharmacological reports : PR. vol 58. issue 1. 2006-11-09. PMID:16531637. two series of n-[(4-arylpiperazin-1-yl)-alkyl]-2-azaspiro[4.4]nonane (5-10) and [4.5]decane-1,3-dione (11-16) derivatives were synthesized and their serotonin 5-ht1a and 5-ht2a receptor affinities were determined. 2006-11-09 2023-08-12 Not clear
Anna M S Kindlundh-Högberg, Per Svenningsson, Helgi B Schiöt. Quantitative mapping shows that serotonin rather than dopamine receptor mRNA expressions are affected after repeated intermittent administration of MDMA in rat brain. Neuropharmacology. vol 51. issue 4. 2006-11-06. PMID:16820177. we used real-time rt-pcr to determine the gene expression of serotonin 5ht1a, 5ht1b, 5ht2a, 5ht2c, 5ht3, 5ht6 receptors and dopamine d1, d2, d3 receptors in seven brain nuclei. 2006-11-06 2023-08-12 rat
Yukio Ago, Shigeo Nakamura, Misato Uda, Yasushi Kajii, Michikazu Abe, Akemichi Baba, Toshio Matsud. Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice. Neuropharmacology. vol 51. issue 4. 2006-11-06. PMID:16863654. these results suggest that prefrontal 5-ht release is involved at least partly in the effects of osemozotan on single and repeated meth-induced behavioral effects in mice, and imply that the 5-ht1a receptors may have a potential therapeutic value in the remission of schizophrenia. 2006-11-06 2023-08-12 mouse
Jean-Philippe Guilloux, Denis J P David, Bruno P Guiard, Franck Chenu, Christelle Repérant, Miklos Toth, Michel Bourin, Alain M Gardie. Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16452992. blockade of 5-ht1a receptors by (+/-)-pindolol potentiates cortical 5-ht outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-ht1a receptor knockout mice. 2006-11-01 2023-08-12 mouse