All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Dasiel O Borroto-Escuela, Patrizia Ambrogini, Barbara Chruścicka, Maria Lindskog, Minerva Crespo-Ramirez, Juan C Hernández-Mondragón, Miguel Perez de la Mora, Harriët Schellekens, Kjell Fux. The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects. International journal of molecular sciences. vol 22. issue 4. 2021-04-23. PMID:33672070. reduced 5-ht1a auto-receptor function, increased plasticity and trophic activity in the midbrain raphe 5-ht neurons can develop via agonist activation of allosteric receptor-receptor interactions in the 5-ht1a-fgfr1 heterocomplex. 2021-04-23 2023-08-13 Not clear
Ronan Depoortere, Laurent Bardin, Agnès L Auclair, Liesbeth A Bruins Slot, Adrian Newman-Tancred. Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT1A Receptor Biased Agonists. Pharmacology. vol 106. issue 1-2. 2021-03-22. PMID:32950991. the activity of ssris in this model is mediated through activation of 5-hydroxytryptamine (5-ht) 1a receptors, but the respective implication of pre- versus postsynaptic 5-ht1a receptors has not been elucidated. 2021-03-22 2023-08-13 mouse
Matheus Libarino-Santos, Ana Catherine Gomes de Santana Santos, Elisangela G Cata-Preta, Thaísa Barros-Santos, Nina Rosa Nunes Brandão, Aurea Lorena Nunes Borges, Renan Santos-Baldaia, André W Hollais, Marilia A Baldaia, Laís F Berro, Eduardo A V Marinho, Roberto Frussa-Filho, Alexandre J Oliveira-Lim. Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice. Drug and alcohol dependence. vol 208. 2021-01-18. PMID:31954952. evidence suggests that aripiprazole, a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist, show significant efficacy in reducing alcohol use. 2021-01-18 2023-08-13 mouse
Nami Isooka, Ikuko Miyazaki, Ryo Kikuoka, Kouichi Wada, Erika Nakayama, Kotaro Shin, Daichi Yamamoto, Yoshihisa Kitamura, Masato Asanum. Dopaminergic neuroprotective effects of rotigotine via 5-HT1A receptors: Possibly involvement of metallothionein expression in astrocytes. Neurochemistry international. vol 132. 2021-01-07. PMID:31765686. a recent study showed that stimulation of astrocyte serotonin 1a (5-ht1a) receptors promotes astrocyte proliferation and upregulation of the antioxidant molecules metallothionein (mt)-1,2, which protect dopaminergic neurons against oxidative stress. 2021-01-07 2023-08-13 mouse
Masato Asanuma, Ikuko Miyazak. [Anti-oxidants in astrocytes as target of neuroprotection for Parkinson's disease]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 156. issue 1. 2021-01-05. PMID:33390474. we previously revealed that several antiepileptic drugs, serotonin 5-ht1a receptor agonists, plant-derived chemicals (phytochemicals) increased xct expression, nrf2 activation, gsh or mt expression and release in/from astrocytes, and exerted a neuroprotective effect against dopaminergic neurodegeneration in parkinson's disease model. 2021-01-05 2023-08-13 Not clear
Yi-Fan Jiang, Jian Liu, Jie Yang, Yuan Guo, Wei Hu, Jin Zhang, Xue-Mei La, Wen Xie, Hui-Sheng Wang, Li Zhan. Involvement of the Dorsal Hippocampus 5-HT1A Receptors in the Regulation of Depressive-Like Behaviors in Hemiparkinsonian Rats. Neuropsychobiology. vol 79. issue 3. 2021-01-04. PMID:31940619. lines of evidence have indicated that the hippocampus and serotonin 1a (5-ht1a) receptors are related to the regulation of depression. 2021-01-04 2023-08-13 rat
Sophia Khom, Sarah A Wolfe, Reesha R Patel, Dean Kirson, David M Hedges, Florence P Varodayan, Michal Bajo, Marisa Robert. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 36. 2021-01-01. PMID:32769108. the cea receives dense innervation from the dorsal raphe nucleus, the major source of 5-ht, and expresses 5-ht receptor subtypes (e.g., 5-ht2c and 5-ht1a) critically linked to alcohol use disorder. 2021-01-01 2023-08-13 rat
Darakhshan Jabeen Halee. Glucocorticoids in the Physiological and Transcriptional Regulation of 5-HT1A Receptor and the Pathogenesis of Depression. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2020-11-27. PMID:33243080. substantial evidence supports a critical role of 5-ht1a receptors in these effects of 5-ht. 2020-11-27 2023-08-13 Not clear
Anderson Ribeiro-Carvalho, Carla S Lima, Ana C Dutra-Tavares, Fernanda Nunes, André L Nunes-Freitas, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaç. Mood-related behavioral and neurochemical alterations in mice exposed to low chlorpyrifos levels during the brain growth spurt. PloS one. vol 15. issue 10. 2020-11-24. PMID:33007016. distinctively, in adult females, the effects indicated a hypoactive state: cpf exposure reduced 5-ht1a receptor binding in cerebral cortex, as well as serotonin transporter binding and choline acetyltransferase activity in brainstem. 2020-11-24 2023-08-13 mouse
O Gokdemir, C Cetinkaya, H Gumus, I Aksu, M Kiray, M Ates, A Kiray, B Baykara, B Baykara, A R Sisman, N Uysa. The effect of exercise on anxiety- and depression-like behavior of aged rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 95. issue 1. 2020-11-13. PMID:31264480. we assessed serum corticosterone levels; number of amygdala, hippocampus and prefrontal cortex cells; tissue serotonin and serotonin 1a (5-ht1a) levels. 2020-11-13 2023-08-13 rat
Jingjing Shao, Xiaoyan Zheng, Linlin Qu, Hui Zhang, Huifang Yuan, Junfeng Hui, Yu Mi, Pei Ma, Daidi Fa. Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model. Food & function. vol 11. issue 2. 2020-11-03. PMID:32052003. in addition, 5-htp, the precursor of 5-ht, could enhance the sleep effect of rg5 and rk1 in mice, and both rg5 and rk1 could up-regulate the expression of 5-ht1a. 2020-11-03 2023-08-13 mouse
Anna Partyka, Agnieszka Zagórska, Magdalena Kotańska, Maria Walczak, Magdalena Jastrzębska-Więsek, Joanna Knutelska, Marek Bednarski, Monika Głuch-Lutwin, Barbara Mordyl, Paulina Janiszewska, Anna Wesołowsk. Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists. PloS one. vol 15. issue 8. 2020-10-08. PMID:32764777. serotonin 5-ht1a receptor is considered as an interesting target of antidepressant therapy. 2020-10-08 2023-08-13 mouse
Anna Partyka, Agnieszka Zagórska, Magdalena Kotańska, Maria Walczak, Magdalena Jastrzębska-Więsek, Joanna Knutelska, Marek Bednarski, Monika Głuch-Lutwin, Barbara Mordyl, Paulina Janiszewska, Anna Wesołowsk. Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists. PloS one. vol 15. issue 8. 2020-10-08. PMID:32764777. in the present study, the intrinsic activity at different signaling pathways coupled to serotonin 5-ht1a receptor, antidepressant-like and pharmacokinetic properties, and the safety profile of two novel imidazopurine-2,4-dione derivatives, namely compounds az-853 (8-(4-(4-(2-fluorophenyl)piperazin-1-yl)butyl)-1,3-dimethyl-1h- imidazo[2,1-f]purine-2,4(3h,8h)-dione) and az-861 (1,3-dimethyl-8-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butyl)-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione), were studied in animal models through in vitro and in vivo experiments. 2020-10-08 2023-08-13 mouse
Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fux. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS omega. vol 2. issue 8. 2020-10-01. PMID:28920103. there are many 5-ht subtypes involved; some need to be blocked (e.g., 5-ht2a, 5-ht3, and 5-ht7), whereas others need to be activated (e.g., postjunctional 5-ht1a and 5-ht4). 2020-10-01 2023-08-13 Not clear
Zvi R Shapiro, Samantha Cerasiello, Loryn Hartshorne, Matthew S Matel. 5-HT1a Receptor Involvement in Temporal Memory and the Response to Temporal Ambiguity. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30018532. together, these data suggest that manipulations of 5ht transmission at the 5-ht1a receptor cause changes in the temporal pattern of responding that are consistent with alterations in temporal memory processes and responses to temporal ambiguity. 2020-10-01 2023-08-13 rat
Alia Sadiq, Isabella Menchetti, Ahmed Shah, Marc G Jeschke, Cassandra Belo, Wendolyn Carlos-Alcalde, Muhammad Qasim Hayat, Saeid Amini-Ni. 5-HT1A Receptor Function Makes Wound Healing a Happier Process. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30618734. the role of serotonin (5-hydroxytryptamine, 5-ht) and the 5-ht1a receptor has been established in the regeneration of tissues such as the liver and spinal motor neurons, prompting the investigation of the role of 5-ht1a receptor in skin healing. 2020-10-01 2023-08-13 mouse
Alia Sadiq, Isabella Menchetti, Ahmed Shah, Marc G Jeschke, Cassandra Belo, Wendolyn Carlos-Alcalde, Muhammad Qasim Hayat, Saeid Amini-Ni. 5-HT1A Receptor Function Makes Wound Healing a Happier Process. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30618734. collectively, these findings revealed that serotonin and 5-ht1a receptor play an important role during the healing process. 2020-10-01 2023-08-13 mouse
Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson Oa Botchway, Marong Fan. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105836. 5-hydroxytryptamine receptors 2a and 1a (5-ht2a and 5-ht1a receptors) are most closely related to anxiety-like behavior in post-traumatic stress disorder. 2020-10-01 2023-08-13 mouse
Faranak Vahid-Ansari, Min Zhang, Amin Zahrai, Paul R Alber. Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31114473. we focus on the 5-ht1a autoreceptor, which controls 5-ht activity, and the 5-ht1a heteroreceptor that mediates 5-ht actions. 2020-10-01 2023-08-13 mouse
Faranak Vahid-Ansari, Min Zhang, Amin Zahrai, Paul R Alber. Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31114473. we also present clinical data that show promise for identifying biomarkers of 5-ht activity, 5-ht1a regulation and regional changes in brain activity in mdd patients that may provide biomarkers for tailored interventions to overcome or bypass resistance to ssri treatment. 2020-10-01 2023-08-13 mouse