All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
R L Djavadian, E Wielkopolska, K Turlejsk. Postnatal treatment with NAN-190 but not with 5-HT1A receptor agonists retards growth of the rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 23. issue 5. 2005-09-26. PMID:16026684. therefore, the results of injecting nan-190 to the rat pups point to a deficit of trophic developmental influences of serotonin, adding new arguments for the hypothesis of a trophic role of 5-ht1a receptors in the brain development. 2005-09-26 2023-08-12 rat
R V Gaikwad, R K Gaonkar, S A Jadhav, V M Thorat, J H Jadhav, J J Balsar. Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats. Indian journal of experimental biology. vol 43. issue 7. 2005-09-15. PMID:16053268. such type of behavioural syndrome is induced by 8-hydroxy-2- (di-n-propylamino) tetralin (8-oh-dpat) by directly stimulating the central postsynaptic 5-hydroxytryptamine (5-ht, serotonin) receptors of the 5-ht1a type. 2005-09-15 2023-08-12 rat
R V Gaikwad, R K Gaonkar, S A Jadhav, V M Thorat, J H Jadhav, J J Balsar. Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats. Indian journal of experimental biology. vol 43. issue 7. 2005-09-15. PMID:16053268. this indicates that dextromethorphan induces the behavioural syndrome by releasing 5-ht from serotonergic neurons with resultant activation of the postsynaptic 5-ht1a receptors by the released 5-ht. 2005-09-15 2023-08-12 rat
Joanna Iskra-Jopa, Krystyna Gołembiowska, Anna Dziubina, Marcin Cybulski, Beata Duszyńska, Zdzisław Chilmonczy. In-vivo effects of the 1,2,4-piperazine derivatives MM5 and MC1, putative 5-HT agonists, on dopamine and serotonin release in rat prefrontal cortex. The Journal of pharmacy and pharmacology. vol 57. issue 2. 2005-09-14. PMID:15720784. like the selective 5-ht1a agonist 8-oh-dpat (0.1 mg kg(-1)), mm5 given peripherally (30 mg kg(-1)) decreased the extracellular 5-ht level in rat prefrontal cortex, while mc1 suppressed 5-ht release at a higher dose (40 mg kg(-1)), but not at a lower one (30 mg kg(-1)). 2005-09-14 2023-08-12 mouse
Joanna Iskra-Jopa, Krystyna Gołembiowska, Anna Dziubina, Marcin Cybulski, Beata Duszyńska, Zdzisław Chilmonczy. In-vivo effects of the 1,2,4-piperazine derivatives MM5 and MC1, putative 5-HT agonists, on dopamine and serotonin release in rat prefrontal cortex. The Journal of pharmacy and pharmacology. vol 57. issue 2. 2005-09-14. PMID:15720784. mc1 seems to possess moderate agonist activity at 5-ht1a and 5-ht2a receptors, while acting on 5-ht release in the rat prefrontal cortex. 2005-09-14 2023-08-12 mouse
Ursula F Bailer, Guido K Frank, Shannan E Henry, Julie C Price, Carolyn C Meltzer, Lisa Weissfeld, Chester A Mathis, Wayne C Drevets, Angela Wagner, Jessica Hoge, Scott K Ziolko, Claire W McConaha, Walter H Kay. Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635. Archives of general psychiatry. vol 62. issue 9. 2005-09-14. PMID:16143735. altered brain serotonin 5-ht1a receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11c]way-100635. 2005-09-14 2023-08-12 Not clear
F J Alvarez-Pérez, M Roca, E Martorell, A M Espino, M M Usón, A Figuerola, J Ballabrig. [Serotonin syndrome: report of two cases and review of the literature]. Revista de neurologia. vol 40. issue 3. 2005-09-12. PMID:15750901. however, there is a complication of unknown incidence related to treatment with drugs that increase the stimulation of 5-ht1a serotonin receptors, called serotonin syndrome (ss). 2005-09-12 2023-08-12 human
Shaun Jordan, Ruoyan Chen, Vuk Koprivica, Ronald Hamilton, Richard E Whitehead, Katsura Tottori, Tetsuro Kikuch. In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. European journal of pharmacology. vol 517. issue 3. 2005-09-12. PMID:15985260. this study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate (opc-14523) at rat and human serotonin (5-ht) 5-ht1a receptors and binding affinity of opc-14523 at human frontocortical 5-ht1a receptors. 2005-09-12 2023-08-12 human
Shaun Jordan, Ruoyan Chen, Vuk Koprivica, Ronald Hamilton, Richard E Whitehead, Katsura Tottori, Tetsuro Kikuch. In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. European journal of pharmacology. vol 517. issue 3. 2005-09-12. PMID:15985260. opc-14523 also behaved as a partial agonist in its stimulation of [35s]gtpgammas binding to membranes from rat hippocampus (pec50=7.60+/-0.23, emax=41.1% of the effect of 10 microm (+)8-oh-dpat), human frontal cortex (pec50=7.89+/-0.08; emax=64% of the effect of 10 microm (+)8-oh-dpat), and chinese hamster ovary cells expressing cloned human 5-ht1a receptors (pec50=8.0+/-0.11; emax=85.5% of the effect of 10 microm 5-ht), and all of these effects of opc-14523 were blocked by way-100635. 2005-09-12 2023-08-12 human
Kimberly J Dougherty, B Anne Bannatyne, Elzbieta Jankowska, Piotr Krutki, David J Maxwel. Membrane receptors involved in modulation of responses of spinal dorsal horn interneurons evoked by feline group II muscle afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 3. 2005-08-18. PMID:15659594. modulatory actions of a metabotropic 5-ht1a&7 membrane receptor agonist and antagonist [(+/-)-8-hydroxy-2-(di-n-propylamino)-tetralin; n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexane-carboxamide] and an ionotropic 5-ht3 membrane receptor agonist and antagonist [2-methyl-serotonin (2-me 5-ht); n-(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2h-1,4-benzoxazine-8-carboxamide hydrochloride] were investigated on dorsal horn interneurons mediating reflex actions of group ii muscle afferents. 2005-08-18 2023-08-12 Not clear
Tushar D Patel, Feng C Zho. Ontogeny of 5-HT1A receptor expression in the developing hippocampus. Brain research. Developmental brain research. vol 157. issue 1. 2005-08-12. PMID:15939084. in recent years, a number of pharmacological studies have suggested a role for the serotonin 1a (5ht1a) receptor subtype in mediating the developmental effects of 5-ht in the hippocampus. 2005-08-12 2023-08-12 rat
Tushar D Patel, Feng C Zho. Ontogeny of 5-HT1A receptor expression in the developing hippocampus. Brain research. Developmental brain research. vol 157. issue 1. 2005-08-12. PMID:15939084. these findings demonstrate that the 5-ht1a receptor is positioned to mediate developmental effects of serotonin in the hippocampus. 2005-08-12 2023-08-12 rat
Laurence J Mignon, William A Wol. 8-hydroxy-2-(di-n-propylamino)tetralin reduces striatal glutamate in an animal model of Parkinson's disease. Neuroreport. vol 16. issue 7. 2005-08-09. PMID:15858409. using in-vivo microdialysis, we examined the effect of the serotonin 5-ht1a agonist r-(+)-8-hydroxy-2-(di-n-propylamino)tetralin on striatal extracellular excitatory amino acids in an animal model of parkinson's disease. 2005-08-09 2023-08-12 rat
Andrzej J Bojarski, Maria H Paluchowska, Beata Duszyńska, Aleksandra Kłodzińska, Ewa Tatarczyńska, Ewa Chojnacka-Wójci. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics. Bioorganic & medicinal chemistry. vol 13. issue 6. 2005-08-02. PMID:15727878. 1-aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-ht1a, 5-ht2a, 5-ht7), alpha1-adrenergic, and dopaminergic d2 receptors, and in vivo 5-ht1a functional characteristics. 2005-08-02 2023-08-12 mouse
G V Idova, M A Cheĭdo, S M Davydov. [Activation and blocking of 5-HT1A receptors influence on the immune response in CBA mice]. Eksperimental'naia i klinicheskaia farmakologiia. vol 68. issue 1. 2005-08-02. PMID:15786964. 5-ht1a type serotonin receptors influence the immunomodulating action of the selective preparations 8-oh-dpat (5-ht1a receptor agonist) and way-100635 (5-ht1a receptor antagonist) in cba mice. 2005-08-02 2023-08-12 mouse
Walter H Kaye, Guido K Frank, Ursula F Bailer, Shannan E Henry, Carolyn C Meltzer, Julie C Price, Chester A Mathis, Angela Wagne. Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies. Physiology & behavior. vol 85. issue 1. 2005-07-29. PMID:15869768. in specific, recent studies using pet with serotonin specific radioligands implicate alterations of 5-ht1a and 5-ht2a receptors and the 5-ht transporter. 2005-07-29 2023-08-12 human
Tamiko Tachibana, Makoto Endoh, Naoki Fujiwara, Tokio Naw. Receptors and transporter for serotonin in Merkel cell-nerve endings in the rat sinus hair follicle. An immunohistochemical study. Archives of histology and cytology. vol 68. issue 1. 2005-07-22. PMID:15827375. for this purpose, we used antibodies for the 5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c and 5-ht3 receptors, and for the 5-ht transporter, as well as antibodies for cytokeratin 20 (as a marker of merkel cells) and neurofilament h (a marker of type i sensory nerve terminals). 2005-07-22 2023-08-12 rat
G K Pal, N Kannan, Pravati Pa. Effects of injection of serotonin into nucleus caudatus on food and water intake and body weight in albino rats. Indian journal of physiology and pharmacology. vol 48. issue 4. 2005-07-22. PMID:15907052. in the present study, serotonin hydrochloride, buspirone (the serotonin 5-ht1a agonist) and ondensetron (the 5ht3 antagonist) were injected into nucleus caudatus through stereotaxically implanted cannulae in three different dosages (1, 2 and 5 microg) and their effects on 24 h food and water intake, and body weight were recorded. 2005-07-22 2023-08-12 rat
C L Bethea, J M Streicher, S J Mirkes, R L Sanchez, A P Reddy, J L Camero. Serotonin-related gene expression in female monkeys with individual sensitivity to stress. Neuroscience. vol 132. issue 1. 2005-07-20. PMID:15780474. in situ hybridization and quantitative image analysis was used to measure mrnas coding for sert (serotonin transporter), 5ht1a autoreceptor, mao-a and mao-b (monoamine oxidases) at six levels of the dorsal raphe nucleus (drn). 2005-07-20 2023-08-12 monkey
C L Bethea, J M Streicher, S J Mirkes, R L Sanchez, A P Reddy, J L Camero. Serotonin-related gene expression in female monkeys with individual sensitivity to stress. Neuroscience. vol 132. issue 1. 2005-07-20. PMID:15780474. thus, all serotonin-related mrnas examined in the dorsal raphe to date were lower (sert, mao-a) or exhibited a lower trend (5ht1a, mao-b) in the stress sensitive animals, which probably reflects the lower number of serotonin neurons present. 2005-07-20 2023-08-12 monkey