| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Turner, E A Rabiner, A Hammers, A Al-Chalabi, P M Grasby, C E Shaw, D J Brooks, P N Leig. [11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS. Brain : a journal of neurology. vol 128. issue Pt 4. 2005-04-20. PMID:15689356. |
way100635 binds selectively to the 5-hydroxytryptamine (5-ht1a) receptor, which is expressed on pyramidal neurones present throughout the cortex. |
2005-04-20 |
2023-08-12 |
human |
| Marian Joëls, Els Van Rie. Mineralocorticoid and glucocorticoid receptor-mediated effects on serotonergic transmission in health and disease. Annals of the New York Academy of Sciences. vol 1032. 2005-04-19. PMID:15677436. |
previously, we found that rises in the corticosterone level, as after acute stressors, enhance the response of hippocampal ca1 neurons to serotonin (5-ht), which hyperpolarizes the membrane via the 5-ht1a receptor. |
2005-04-19 |
2023-08-12 |
mouse |
| Marian Joëls, Els Van Rie. Mineralocorticoid and glucocorticoid receptor-mediated effects on serotonergic transmission in health and disease. Annals of the New York Academy of Sciences. vol 1032. 2005-04-19. PMID:15677436. |
in chronically stressed rats, we observed that 5-ht responses with both basal and high corticosterone levels are attenuated compared to those in the controls; 5-ht1a receptor expression was not altered. |
2005-04-19 |
2023-08-12 |
mouse |
| Marian Joëls, Els Van Rie. Mineralocorticoid and glucocorticoid receptor-mediated effects on serotonergic transmission in health and disease. Annals of the New York Academy of Sciences. vol 1032. 2005-04-19. PMID:15677436. |
finally, rats that for 24 h were deprived of their mother at postnatal day 3 exhibited attenuated 5-ht responses when tested at 3 months of age, in the absence of changes in the 5-ht1a receptor expression. |
2005-04-19 |
2023-08-12 |
mouse |
| Florence Clénet, Martine Hascoët, Gilles Fillion, Hervé Galons, Michel Bouri. Role of GABA-ergic and serotonergic systems in the anxiolytic-like mechanism of action of a 5-HT-moduline antagonist in the mouse elevated plus maze. Behavioural brain research. vol 158. issue 2. 2005-04-19. PMID:15698901. |
hg1 mechanism of action in the mouse elevated plus maze seems to associate a gaba-ergic component exerting a limited regulation of 5-ht neuronal activity and a major serotonergic component, which seems to implicate presynaptic 5-ht1a and 5-ht1b receptors. |
2005-04-19 |
2023-08-12 |
mouse |
| Scott F Stoltenber. Epistasis among presynaptic serotonergic system components. Behavior genetics. vol 35. issue 2. 2005-04-14. PMID:15685432. |
because 5-ht dysregulation is associated with several common psychiatric disorders, the potential for epistasis among genetic variants in the 5-ht transporter (sert), 5-ht1b terminal autoreceptor and the 5-ht1a somatodendritic autoreceptor should be examined. |
2005-04-14 |
2023-08-12 |
Not clear |
| Scott F Stoltenber. Epistasis among presynaptic serotonergic system components. Behavior genetics. vol 35. issue 2. 2005-04-14. PMID:15685432. |
parameters representing extracellular 5-ht clearance rates (sert), 5-ht release levels (5-ht1b) and inhibitory thresholds (the amount of extracellular 5-ht above which cell firing is inhibited, an indication of 5-ht1a autoreceptor sensitivity) were varied to simulate genetic deletion (i.e. |
2005-04-14 |
2023-08-12 |
Not clear |
| Tzuri Lifschytz, Eitan Gur, Bernard Lerer, Michael E Newma. Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589343. |
fluoxetine alone induced a trend towards desensitization of 5-ht1a autoreceptors as shown by a reduction in the effect of 8-oh-dpat to lower 5-ht levels in frontal cortex, and desensitized 5-ht1b autoreceptors in frontal cortex. |
2005-04-12 |
2023-08-12 |
rat |
| M Angels Fisas, Antonio Farré, Jorge Camarasa, Elena Escubed. Effects of lesopitron on the central nervous system arising from its interaction with 5-HT1A receptors. Pharmacology. vol 72. issue 2. 2005-04-08. PMID:15331910. |
lesopitron acts as a ligand for central serotonin 5-ht1a receptors. |
2005-04-08 |
2023-08-12 |
Not clear |
| M Angels Fisas, Antonio Farré, Jorge Camarasa, Elena Escubed. Effects of lesopitron on the central nervous system arising from its interaction with 5-HT1A receptors. Pharmacology. vol 72. issue 2. 2005-04-08. PMID:15331910. |
the ability of lesopitron to induce 5-ht syndrome reflects post-synaptic 5-ht1a receptor activation and the reversion of 8-ohdpat-induced 5-ht syndrome by lesopitron suggests a partial agonist effect on this receptor-type. |
2005-04-08 |
2023-08-12 |
Not clear |
| Martin B Keller, Frank J L Ruwe, Cecile J J G Janssens, J M Ad Sitsen, Riitta Jokinen, Janusz Janczewsk. Relapse prevention with gepirone ER in outpatients with major depression. Journal of clinical psychopharmacology. vol 25. issue 1. 2005-04-08. PMID:15643103. |
to evaluate long-term efficacy and tolerability of the serotonin 5-ht1a receptor agonist, gepirone extended release (er), a multicenter, randomized, placebo-controlled relapse prevention study was performed in patients with recurrent major depression (dsm-iv criteria). |
2005-04-08 |
2023-08-12 |
Not clear |
| Justin E Aldridge, Armando Meyer, Frederic J Seidler, Theodore A Slotki. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicology and applied pharmacology. vol 203. issue 2. 2005-04-08. PMID:15710174. |
although neither treatment affected growth or viability, each elicited similar alterations in factors that are critical to the function of the 5ht synapse: 5ht1a receptors, 5ht2 receptors, and the presynaptic 5ht transporter (5htt). |
2005-04-08 |
2023-08-12 |
human |
| Laurent Bardin, Marie-Bernadette Assié, Martine Pélissou, Isabelle Royer-Urios, Adrian Newman-Tancredi, Jean-Paul Ribet, François Sautel, Wouter Koek, Francis C Colpaer. Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT1A) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship with 5-HT1A receptor occupancy and kinetic parameters. The Journal of pharmacology and experimental therapeutics. vol 312. issue 3. 2005-04-05. PMID:15528450. |
dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1a (5-ht1a) agonist f 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship with 5-ht1a receptor occupancy and kinetic parameters. |
2005-04-05 |
2023-08-12 |
rat |
| Anthony J Cleare, Cristina Messa, Eugenii A Rabiner, Paul M Grasb. Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635. Biological psychiatry. vol 57. issue 3. 2005-04-01. PMID:15691524. |
research from neuroendocrine challenge and other indirect studies has suggested increased central 5-ht function in chronic fatigue syndrome (cfs) and increased 5-ht1a receptor sensitivity. |
2005-04-01 |
2023-08-12 |
Not clear |
| Mathieu Wolff, Pierre Costet, Cornelius Gross, René Hen, Louis Segu, Marie-Christine Buho. Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519675. |
to investigate whether the effects of 5-ht via 5-ht1a receptors on learning are age-sensitive, we evaluated the performance of young-adult (3 months old) and aged (22 months old) 5-ht1a knockout (ko) mice and their homologous wild types (wt) in the hippocampal-dependent spatial reference memory version of the morris water maze. |
2005-03-30 |
2023-08-12 |
mouse |
| Mathieu Wolff, Pierre Costet, Cornelius Gross, René Hen, Louis Segu, Marie-Christine Buho. Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519675. |
these results are consistent with a possible prevalence of 5-ht1a raphe functions in learning and memory abilities of young-adult animals, since the effects of the mutation on mice performance (impairment) are opposite to those found after intra-raphe injection of 5-ht1a agonists (facilitation), and with data showing increased activity of 5-ht neurons in 5-ht1ako mice. |
2005-03-30 |
2023-08-12 |
mouse |
| Afshin Ghavami, Rachel A Hunt, Michael A Olsen, Jie Zhang, Deborah L Smith, Sachin Kalgaonkar, Zia Rahman, Kathleen H Youn. Differential effects of regulator of G protein signaling (RGS) proteins on serotonin 5-HT1A, 5-HT2A, and dopamine D2 receptor-mediated signaling and adenylyl cyclase activity. Cellular signalling. vol 16. issue 6. 2005-03-23. PMID:15093612. |
differential effects of regulator of g protein signaling (rgs) proteins on serotonin 5-ht1a, 5-ht2a, and dopamine d2 receptor-mediated signaling and adenylyl cyclase activity. |
2005-03-23 |
2023-08-12 |
Not clear |
| Robert Adamec, Gerd D Bartoszyk, Paul Burto. Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats. European journal of pharmacology. vol 504. issue 1-2. 2005-03-23. PMID:15507223. |
emd 68843, a serotonin reuptake inhibitor with selective presynaptic 5-ht1a receptor agonistic properties. |
2005-03-23 |
2023-08-12 |
rat |
| Tobias Lehr, Rudolf Schip. An antagonistic 5-HT receptor system in the auricles of the systemic heart complex of Sepia officinalis L. (Cephalopoda) shows 5-HT1 and 5-HT4 subtype properties. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 138. issue 2. 2005-03-15. PMID:15450869. |
in pharmacological bioassays on isolated ring-shaped auricle preparations of sepia officinalis, the action of the specific 5-hydroxytryptamine (5-ht) agonists 8-oh-dpat (5-ht1a), cp-93129 (5-ht1b), tfmpp (5-ht1b) and rs-67333 (5-ht4) on these autonomously contractile compartments was studied. |
2005-03-15 |
2023-08-12 |
Not clear |
| Alberto Javier Ramos, María Dolores Rubio, Cristina Defagot, Lotta Hischberg, Marcelo J Villar, Alicia Brusc. The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization. Brain research. vol 1030. issue 2. 2005-03-08. PMID:15571670. |
serotonin 1a (5ht1a) receptor agonists have shown neuroprotective properties in different models of central nervous system injury. |
2005-03-08 |
2023-08-12 |
rat |