| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yo Muraki, Akihiro Yamanaka, Natsuko Tsujino, Thomas S Kilduff, Katsutoshi Goto, Takeshi Sakura. Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 32. 2005-01-25. PMID:15306649. |
a 5-ht1a receptor agonist, 8-hydroxy-2-(dl-n-propyl-amino)tetralin, also evoked hyperpolarization on orexin neurons with potency comparable with 5-ht. |
2005-01-25 |
2023-08-12 |
mouse |
| Yo Muraki, Akihiro Yamanaka, Natsuko Tsujino, Thomas S Kilduff, Katsutoshi Goto, Takeshi Sakura. Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 32. 2005-01-25. PMID:15306649. |
moreover, 5-ht1a receptor-like immunoreactivity was observed on orexin neurons, and 5-ht transporter immunoreactive nerve endings are in close apposition to orexin neurons. |
2005-01-25 |
2023-08-12 |
mouse |
| Yo Muraki, Akihiro Yamanaka, Natsuko Tsujino, Thomas S Kilduff, Katsutoshi Goto, Takeshi Sakura. Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 32. 2005-01-25. PMID:15306649. |
these results indicate that 5-ht hyperpolarizes orexin neurons through the 5-ht1a receptor and subsequent activation of the girk and that this inhibitory serotonergic input to the orexin neurons is likely to be important for the physiological regulation of this neuropeptide system. |
2005-01-25 |
2023-08-12 |
mouse |
| Bankole A Johnso. Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment. CNS drugs. vol 18. issue 15. 2005-01-24. PMID:15581381. |
buspirone, a serotonin 5-ht1a partial agonist, does not appear to be an effective treatment for alcoholics without comorbid disease. |
2005-01-24 |
2023-08-12 |
Not clear |
| Darius K Shayegan, Stephen M Stah. Atypical antipsychotics: matching receptor profile to individual patient's clinical profile. CNS spectrums. vol 9. issue 10 Suppl 11. 2005-01-04. PMID:15475871. |
atypical antipsychotics are also a heterogeneous group of agents that have complex pharmacologic entities, acting upon multiple dopamine receptors (d2, d1, d3, and d4) and multiple serotonin receptors (5-ht2a, 5-ht2c, 5-ht1a, and 5-ht1d, among others). |
2005-01-04 |
2023-08-12 |
Not clear |
| Silvia Marinelli, Stephen A Schnell, Stephen P Hack, MacDonald J Christie, Martin W Wessendorf, Christopher W Vaugha. Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. Journal of neurophysiology. vol 92. issue 6. 2004-12-30. PMID:15254076. |
to clarify the physiological and pharmacological differences between the serotonergic and nonserotonergic neurons of the drn, their postsynaptic responses to 5-hydroxytryptamine (5-ht, serotonin) and to selective activation of 5-ht1a or 5-ht2a/c receptors and their action potential characteristics were determined using in vitro patch-clamp recordings. |
2004-12-30 |
2023-08-12 |
Not clear |
| Silvia Marinelli, Stephen A Schnell, Stephen P Hack, MacDonald J Christie, Martin W Wessendorf, Christopher W Vaugha. Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. Journal of neurophysiology. vol 92. issue 6. 2004-12-30. PMID:15254076. |
it was found that subpopulations of both serotonergic and nonserotonergic neurons responded to 5-ht with outward (i.e., inhibitory) and inward (i.e., excitatory) currents, responded to both 5-ht1a and 5-ht2a/c receptor activation with outward and inward currents, respectively, and displayed overlapping action potential characteristics. |
2004-12-30 |
2023-08-12 |
Not clear |
| David Dietz, Michael Vogel, Steven Rubin, Timothy Moran, Kathryn Carbone, Mikhail Pletniko. Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis. Journal of neurovirology. vol 10. issue 5. 2004-12-30. PMID:15385249. |
the present study sought to provide more insights into postnatal virus-associated alterations in 5-ht neurotransmission by evaluating the density of 5-ht1a receptors in the hippocampus and 5-ht2a receptors in the cortex, regional 5-ht tissue concentrations, behavioral responses to a 5-ht agonist, quipazine, and numbers of neurons in specific subfields of the hippocampus on days 7, 14, and 30 after neonatal bdv infection in lewis rats. |
2004-12-30 |
2023-08-12 |
rat |
| David Dietz, Michael Vogel, Steven Rubin, Timothy Moran, Kathryn Carbone, Mikhail Pletniko. Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis. Journal of neurovirology. vol 10. issue 5. 2004-12-30. PMID:15385249. |
neonatal bdv infection was found to be associated with a gradual increase in the density of 5-ht2a and 5-ht1a postsynaptic receptors followed by an elevation of 5-ht contents at both the levels of synaptic terminals (i.e., cortex and hippocampus) and cell bodies (i.e., raphe nuclei). |
2004-12-30 |
2023-08-12 |
rat |
| Sarah J Bailey, Miklos Tot. Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT-mediated regulation of GABA(A) receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 28. 2004-12-13. PMID:15254090. |
variability in the benzodiazepine response of serotonin 5-ht1a receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-ht-mediated regulation of gaba(a) receptors. |
2004-12-13 |
2023-08-12 |
mouse |
| Thomas Hussenether, Harald Hübner, Peter Gmeiner, Reinhard Troschüt. Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing. Bioorganic & medicinal chemistry. vol 12. issue 10. 2004-12-10. PMID:15110844. |
for the most promising compounds, intrinsic activity and binding properties to serotonin 5-ht1a and 5-ht2 were also determined. |
2004-12-10 |
2023-08-12 |
Not clear |
| Isabelle Cloëz-Tayarani, Usamah S Kayyali, Barry L Fanburg, Jean-Marc Cavaillo. 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors. Life sciences. vol 76. issue 4. 2004-12-07. PMID:15530505. |
5-ht activates erk map kinase in cultured-human peripheral blood mononuclear cells via 5-ht1a receptors. |
2004-12-07 |
2023-08-12 |
human |
| Isabelle Cloëz-Tayarani, Usamah S Kayyali, Barry L Fanburg, Jean-Marc Cavaillo. 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors. Life sciences. vol 76. issue 4. 2004-12-07. PMID:15530505. |
the effect of 5-ht on erk activation appeared to be mediated through the activation of 5-ht1a receptors since similar results were obtained with r-+-8-hydroxy-dpat, a selective 5-ht1a receptor agonist and way100635, a selective 5-ht1a receptor antagonist, reversed the 5-ht and the r-+-8-hydroxy-dpat effects. |
2004-12-07 |
2023-08-12 |
human |
| Isabelle Cloëz-Tayarani, Usamah S Kayyali, Barry L Fanburg, Jean-Marc Cavaillo. 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors. Life sciences. vol 76. issue 4. 2004-12-07. PMID:15530505. |
our results indicate that 5-ht activates erk, but not p38, map kinase of human pbmc via a 5-ht1a receptor. |
2004-12-07 |
2023-08-12 |
human |
| Vanessa de Paula Soares, Hélio Zangross. Involvement of 5-HT1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze. Brain research bulletin. vol 64. issue 2. 2004-11-29. PMID:15342106. |
both 5-ht1a, 5-ht2a and 5-ht2c receptors seem to mediate the inhibitory action of serotonin on escape. |
2004-11-29 |
2023-08-12 |
rat |
| Tracy Swainston Harrison, Caroline M Perr. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. vol 64. issue 15. 2004-11-15. PMID:15257633. |
pharmacological properties: aripiprazole is a quinolinone derivative with a high affinity for dopamine d2 and d3 receptors, and serotonin 5-ht1a, 5-ht2a and 5-ht2b receptors. |
2004-11-15 |
2023-08-12 |
human |
| Tracy Swainston Harrison, Caroline M Perr. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. vol 64. issue 15. 2004-11-15. PMID:15257633. |
at serotonin 5-ht1a receptors, in vitro studies have shown that aripiprazole acts as a partial agonist whereas at serotonin 5-ht2a receptors aripiprazole is an antagonist. |
2004-11-15 |
2023-08-12 |
human |
| Baojun Gu, Kenneth J Olejar, Jerome P Reiter, Karl B Thor, Paul C Dolbe. Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury. The Journal of pharmacology and experimental therapeutics. vol 310. issue 3. 2004-11-01. PMID:15152026. |
the serotonin (5-hydroxytryptamine1a) 5-ht1a receptor agonist 8-oh-dpat [(r)- (+)-8-hydroxy-2-(di-n-propylamino)tetralin] inhibits bladder activity under nociceptive but not innocuous conditions in cats with an intact spinal cord, suggestive of an effect on primary afferent c fibers or their targets. |
2004-11-01 |
2023-08-12 |
Not clear |
| Lars H Pinborg, Karen H Adams, Stig Yndgaard, Steen G Hasselbalch, Søren Holm, Heidi Kristiansen, Olaf B Paulson, Gitte M Knudse. [18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 24. issue 9. 2004-10-29. PMID:15356424. |
to reduce 5-ht1a-mediated autoinhibition of cortical 5-ht release, four of the seven subjects were pretreated with the partial 5-ht1a agonist pindolol for 3 days at an increasing oral dose (25 mg on the day of scanning). |
2004-10-29 |
2023-08-12 |
human |
| Eitan Gur, Bernard Lerer, Louis D van de Kar, Michael E Newma. Chronic rTMS induces subsensitivity of post-synaptic 5-HT1A receptors in rat hypothalamus. The international journal of neuropsychopharmacology. vol 7. issue 3. 2004-10-27. PMID:14741057. |
chronic administration of several antidepressants, notably the selective serotonin re-uptake inhibitors (ssris) induces sub-sensitivity of post-synaptic 5-ht1a receptors in the hypothalamus. |
2004-10-27 |
2023-08-12 |
rat |