| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takayuki Ishiwata, Takehito Saito, Hiroshi Hasegawa, Toru Yazawa, Minoru Otokawa, Yasutsugu Aihar. Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats. Life sciences. vol 75. issue 22. 2004-10-21. PMID:15369702. |
we also perfused fluoxetine (5-ht re-uptake inhibitor) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat: 5-ht1a agonist) into the po/ah. |
2004-10-21 |
2023-08-12 |
rat |
| Marcel D Waldinger, Berend Olivie. Utility of selective serotonin reuptake inhibitors in premature ejaculation. Current opinion in investigational drugs (London, England : 2000). vol 5. issue 7. 2004-10-18. PMID:15298071. |
it is proposed that drug treatment of premature ejaculation should consist of 5-hydroxytryptamine (5-ht)2c receptor stimulation and/or 5-ht1a receptor inhibition. |
2004-10-18 |
2023-08-12 |
Not clear |
| G Drossopoulou, K Antoniou, E Kitraki, G Papathanasiou, E Papalexi, C Dalla, Z Papadopoulou-Daifot. Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats. Neuroscience. vol 126. issue 4. 2004-10-08. PMID:15207320. |
moreover, hypothalamic serotonin (5-ht)1a mrna levels were decreased in female rats while in male rats hippocampal 5-ht1a mrna levels were increased. |
2004-10-08 |
2023-08-12 |
rat |
| Hideo Tsukada, Dai Fukumoto, Shingo Nishiyama, Kengo Sato, Takeharu Kakiuch. Transient focal ischemia affects the cAMP second messenger system and coupled dopamine D1 and 5-HT1A receptors in the living monkey brain: a positron emission tomography study using microdialysis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 24. issue 8. 2004-10-08. PMID:15362720. |
using positron emission tomography (pet) and microdialysis, the present study showed that neuronal damages after transient focal ischemia was partly induced by hyperactivation of the cyclic adenosine 3',5'-monophosphate (camp) second messenger system through modulations of dopamine d, and serotonin 5-ht1a receptors in the living brains of cynomolgus monkeys. |
2004-10-08 |
2023-08-12 |
monkey |
| Mustapha Riad, Luc Zimmer, Latifa Rbah, Kenneth C Watkins, Michel Hamon, Laurent Descarrie. Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 23. 2004-09-24. PMID:15190115. |
because 5-ht1a receptors located on the soma dendrites of serotonin (5-ht) neurons normally mediate an inhibition of 5-ht firing and release, the desensitization of these autoreceptors is essential for obtaining an enhancement of 5-ht transmission after treatment with 5-ht reuptake inhibitors (ssris). |
2004-09-24 |
2023-08-12 |
rat |
| Adam M Gilbert, Gary P Stack, Ramaswamy Nilakantan, Jason Kodah, Megan Tran, Rosemary Scerni, Xiaojie Shi, Deborah L Smith, Terrance H Andre. Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane. Bioorganic & medicinal chemistry letters. vol 14. issue 2. 2004-09-21. PMID:14698193. |
modulation of selective serotonin reuptake inhibitor and 5-ht1a antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane. |
2004-09-21 |
2023-08-12 |
Not clear |
| Inmaculada Bellido, Anita C Hansson, Aurelio J Gómez-Luque, Beth Andbjer, Luigi F Agnati, Kjell Fux. Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194873. |
glucocorticoids, by enhancing dorsal raphe 5-ht1a autoreceptor function, may therefore cause reduced 5-ht neuronal activity and thus lead to a depressive state. |
2004-09-16 |
2023-08-12 |
rat |
| L Zimmer, M Riad, L Rbah, A Belkacem-Kahlouli, D Le Bars, B Renaud, L Descarrie. Toward brain imaging of serotonin 5-HT1A autoreceptor internalization. NeuroImage. vol 22. issue 3. 2004-09-16. PMID:15219613. |
toward brain imaging of serotonin 5-ht1a autoreceptor internalization. |
2004-09-16 |
2023-08-12 |
human |
| L Zimmer, M Riad, L Rbah, A Belkacem-Kahlouli, D Le Bars, B Renaud, L Descarrie. Toward brain imaging of serotonin 5-HT1A autoreceptor internalization. NeuroImage. vol 22. issue 3. 2004-09-16. PMID:15219613. |
5-ht1a receptors located on the cell body and dendrites of 5-ht neurons (autoreceptors) play a key role in this regard. |
2004-09-16 |
2023-08-12 |
human |
| A V Kukekova, L N Trut, I N Oskina, A V Kharlamova, S G Shikhevich, E F Kirkness, G D Aguirre, G M Aclan. A marker set for construction of a genetic map of the silver fox (Vulpes vulpes). The Journal of heredity. vol 95. issue 3. 2004-09-16. PMID:15220384. |
to begin to identify fox-specific single nucleotide polymorphisms (snps) in genes involved in the neurobiology of behavior, fox and dog orthologs of serotonin 5-ht1a and 5-ht1b receptor genes have been cloned. |
2004-09-16 |
2023-08-12 |
human |
| S T Bland, C Twining, M J Schmid, A Der-Avakian, L R Watkins, S F Maie. Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus. Neuroscience. vol 126. issue 3. 2004-09-14. PMID:15183519. |
is potentiation of morphine-induced da efflux in the nac was also dependent upon activation of 5-ht neurons in the drn because it was blocked by intra-drn microinjection of the 5-ht1a autoreceptor agonist 8-hydroxy-2-di-n-(propylamino)-tetralin (1 microg). |
2004-09-14 |
2023-08-12 |
rat |
| Pablo V Escribá, Andrés Ozaita, Jesús A García-Sevill. Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 8. 2004-09-08. PMID:15199368. |
we found that the expressions of alpha2a-adrenoceptors, 5-ht1a, 5-ht2a serotonin receptors, and mu-opioid receptors were elevated in the post-mortem brains of these suicide victims with respect to matched controls. |
2004-09-08 |
2023-08-12 |
human |
| Yahong Zhang, Thackery S Gray, Deborah N D'Souza, Gonzalo A Carrasco, Katerina J Damjanoska, Bertalan Dudas, Francisca Garcia, Gina M Zainelli, Nicole R Sullivan Hanley, George Battaglia, Nancy A Muma, Louis D Van de Ka. Desensitization of 5-HT1A receptors by 5-HT2A receptors in neuroendocrine neurons in vivo. The Journal of pharmacology and experimental therapeutics. vol 310. issue 1. 2004-09-07. PMID:15064330. |
the 5-ht(2a/2c) receptor agonist (-)doi [(-)-1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane hcl] (1 mg/kg s.c.) injected 2 h prior to (+)8-oh-dpat significantly reduced the oxytocin and acth responses to (+)8-oh-dpat, producing a heterologous desensitization of the 5-ht1a receptors. |
2004-09-07 |
2023-08-12 |
rat |
| Vitali A Bouryi, David I Lewi. The modulation by 5-HT of glutamatergic inputs from the raphe pallidus to rat hypoglossal motoneurones, in vitro. The Journal of physiology. vol 553. issue Pt 3. 2004-08-31. PMID:14555716. |
5-ht reduced these epscs to 50.0 +/- 13 % of control (p < 0.001), as did the 5-ht1a agonist, 8-oh-dpat (52.5 +/- 17 %, p < 0.001) and the 5-ht1b agonist, cp 93129 (40.6 +/- 29 %, p < 0.01). |
2004-08-31 |
2023-08-12 |
rat |
| Vitali A Bouryi, David I Lewi. The modulation by 5-HT of glutamatergic inputs from the raphe pallidus to rat hypoglossal motoneurones, in vitro. The Journal of physiology. vol 553. issue Pt 3. 2004-08-31. PMID:14555716. |
these data demonstrate that raphe pallidus inputs to hypoglossal motoneurones are predominantly glutamatergic in nature, with 5-ht decreasing the release of glutamate from these projections as a result of activation of 5-ht1a and/or 5-ht1b receptors located on presynaptic terminals. |
2004-08-31 |
2023-08-12 |
rat |
| Mary J Druse, Nuzhath F Tajuddin, Roberta A Gillespie, Elizabeth Dickson, Mohammed Atieh, Constance A Pietrzak, Phong T L. The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons. Brain research. Developmental brain research. vol 150. issue 2. 2004-08-23. PMID:15158072. |
previously, this laboratory showed that in utero and in vitro ethanol exposure significantly reduces developing serotonin (5-ht) neurons and that treatment with a 5-ht1a agonist such as buspirone or ipsapirone prevents the ethanol-associated loss. |
2004-08-23 |
2023-08-12 |
Not clear |
| Masafumi Ogaw. Pharmacological treatments of cerebellar ataxia. Cerebellum (London, England). vol 3. issue 2. 2004-08-23. PMID:15233578. |
a levorotatory form of hydroxytryptophan (a serotonin precursor), a serotoninergic 5-ht1a agonist, a serotoninergic 5-ht3 antagonist, and a serotonin reuptake inhibitor were also used for the therapy for ataxia. |
2004-08-23 |
2023-08-12 |
Not clear |
| Laszlo G Harsing, Ibolya Prauda, Jozsef Barkoczy, Peter Matyus, Zsolt Jurany. A 5-HT7 heteroreceptor-mediated inhibition of [3H]serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction. Neurochemical research. vol 29. issue 8. 2004-08-19. PMID:15260125. |
the inhibitory effect of 5-ct on [3h]5-ht overflow was weakly antagonized by 10 microm of way-100635, a 5-ht1a receptor antagonist (ic50 6.65 +/- 0.56 nm, apparent pa2 4.99). |
2004-08-19 |
2023-08-12 |
rat |
| Laszlo G Harsing, Ibolya Prauda, Jozsef Barkoczy, Peter Matyus, Zsolt Jurany. A 5-HT7 heteroreceptor-mediated inhibition of [3H]serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction. Neurochemical research. vol 29. issue 8. 2004-08-19. PMID:15260125. |
these findings indicate that 5-ct inhibits [3h]5-ht overflow from raphe nuclei slices of the rat by stimulation of 5-ht7 and 5-ht(1b/1d receptors, whereas the role of 5-ht1a receptors in this inhibition is less pronounced. |
2004-08-19 |
2023-08-12 |
rat |
| Antoni Nasal, Adam Bucinski, Tomasz Baczek, Anna Wojdelk. Prediction of the affinity of the newly synthesised azapirone derivatives for 5-HT1A receptors based on artificial neural network analysis of chromatographic retention data and calculation chemistry parameters. Combinatorial chemistry & high throughput screening. vol 7. issue 4. 2004-08-17. PMID:15200379. |
the performance of artificial neural network (ann) in predicting the affinity of a series of 65 new azapirone derivatives for rat brain serotonin 5-ht1a receptors based on high-performance liquid chromatography (hplc) retention data and on non-empirical structural parameters of the compounds' was studied. |
2004-08-17 |
2023-08-12 |
rat |