| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Faranak Vahid-Ansari, Min Zhang, Amin Zahrai, Paul R Alber. Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31114473. |
we also present clinical data that show promise for identifying biomarkers of 5-ht activity, 5-ht1a regulation and regional changes in brain activity in mdd patients that may provide biomarkers for tailored interventions to overcome or bypass resistance to ssri treatment. |
2020-10-01 |
2023-08-13 |
mouse |
| Faranak Vahid-Ansari, Min Zhang, Amin Zahrai, Paul R Alber. Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31114473. |
we identify a series of potential strategies including inhibiting 5-ht auto-inhibition, stimulating 5-ht1a heteroreceptors, other monoamine systems, or cortical stimulation to overcome ssri resistance. |
2020-10-01 |
2023-08-13 |
mouse |
| Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinina, Gordon A Bar. Differences Between the Prenatal Effects of Fluoxetine or Buspirone Alone or in Combination on Pain and Affective Behaviors in Prenatally Stressed Male and Female Rats. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31244623. |
the selective serotonin reuptake inhibitor fluoxetine and the 5-ht1a receptor agonist buspirone are used to treat depression and anxiety. |
2020-10-01 |
2023-08-13 |
rat |
| Chara A Zika, Ioannis Nicolaou, Antonis Gavalas, George V Rekatas, Ekaterini Tani, Vassilis J Demopoulo. Behavioral and antioxidant activity of a tosylbenz[g]indolamine derivative. A proposed better profile for a potential antipsychotic agent. Annals of general hospital psychiatry. vol 3. issue 1. 2020-09-30. PMID:14711381. |
in a previous study we have shown that an indolamine molecule expresses a moderate binding affinity at the dopamine d2 and serotonin 5-ht1a receptors in in vitro competition binding assays. |
2020-09-30 |
2023-08-12 |
rat |
| Ping Yang, Liang Li, Xue-Jun Liu, Xiong Cai, Mei-Zhen Sun, Jun-Feng He, Guang Zeng, Hui-Yong Huan. Effect of Chaihu-Shugan-San on the mRNA expression of the 5-HT1A receptor and cellular proliferation in the hippocampus of epileptic rats with depression. Experimental and therapeutic medicine. vol 11. issue 1. 2020-09-30. PMID:26889228. |
the mrna expression levels of the 5-hydroxytryptamine 1a (5-ht1a) receptor and the number of 5-bromo-2'-deoxyuridine (brdu)-labeled cells in the hippocampal dentate gyrus were detected using reverse transcription-quantitative polymerase chain reaction and immunohistochemical analysis, respectively. |
2020-09-30 |
2023-08-13 |
rat |
| Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinina, Anna M Aloisi, Gordon A Bar. Long-Term Effects of Chronic Buspirone during Adolescence Reduce the Adverse Influences of Neonatal Inflammatory Pain and Stress on Adaptive Behavior in Adult Male Rats. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:28184190. |
we tested whether these alterations have long-lasting effects and if those effects can be improved by the 5-hydroxytryptamine 1a (5-ht1a) receptor agonist buspirone injected chronically during the adolescent period. |
2020-09-30 |
2023-08-13 |
rat |
| Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Yun-Hee Sung, Baek-Vin Li. Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats. Journal of exercise rehabilitation. vol 13. issue 2. 2020-09-30. PMID:28503522. |
forced swimming test, immunohistochemistry for serotonin (5-hydroxytryptamine, 5-ht), tryptophan hydroxylase (tph), and western blot for serotonin 1a (5-ht1a) receptor were conducted. |
2020-09-30 |
2023-08-13 |
rat |
| Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Yun-Hee Sung, Baek-Vin Li. Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats. Journal of exercise rehabilitation. vol 13. issue 2. 2020-09-30. PMID:28503522. |
5-ht, tph, and 5-ht1a receptor expressions in the dorsal raphe were suppressed by rotenone injection and treadmill exercise increased the expressions of 5-ht, tph, and 5-ht1a receptor in the rotenone-injected rats. |
2020-09-30 |
2023-08-13 |
rat |
| Nicola Maggio, Efrat Shavit Stein, Menahem Sega. Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29467619. |
serotonin, possibly acting at a 5ht1a receptor, or fenfluramine (ffa), which causes release of serotonin from its native terminals, mimicked the effect of cbd. |
2020-09-30 |
2023-08-13 |
mouse |
| Yueh-Ming Tai, Chih-Yuan Ko, Chen-Cheng Lin, Yu-Yue Wan, Jing-Yi Chung, Yia-Ping Li. Effects of 5HT1A Activation on Gating Profile Following 5HT Depletion in Rats Lacking Social Attachment Since Weanling. Psychiatry investigation. vol 15. issue 2. 2020-09-30. PMID:29475221. |
effects of 5ht1a activation on gating profile following 5ht depletion in rats lacking social attachment since weanling. |
2020-09-30 |
2023-08-13 |
rat |
| Yueh-Ming Tai, Chih-Yuan Ko, Chen-Cheng Lin, Yu-Yue Wan, Jing-Yi Chung, Yia-Ping Li. Effects of 5HT1A Activation on Gating Profile Following 5HT Depletion in Rats Lacking Social Attachment Since Weanling. Psychiatry investigation. vol 15. issue 2. 2020-09-30. PMID:29475221. |
we therefore aimed to examine the effects of 5ht1a activation on acoustic startle response (asr) and prepulse inhibition (ppi) in ir rats in a condition of compromised presynaptic 5-ht functions. |
2020-09-30 |
2023-08-13 |
rat |
| Kuo-Jung Chang, Yu-Jung Chen, Jing-Yi Chung, Chen-Cheng Lin, Yia-Ping Li. Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling. Psychiatry investigation. vol 15. issue 10. 2020-09-30. PMID:30301302. |
effects of 5ht1a activation on depression profile following 5-ht depletion in rats lacking social attachment since weanling. |
2020-09-30 |
2023-08-13 |
rat |
| Kuo-Jung Chang, Yu-Jung Chen, Jing-Yi Chung, Chen-Cheng Lin, Yia-Ping Li. Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling. Psychiatry investigation. vol 15. issue 10. 2020-09-30. PMID:30301302. |
the present study aims to examine the effects of 5ht1a activation on forced swim test (fst) in ir rats following 5-ht depletion. |
2020-09-30 |
2023-08-13 |
rat |
| Efstathios Garoflos, Theofanis Panagiotaropoulos, Stavroula Pondiki, Antonios Stamatakis, Eleni Philippidis, Fotini Stylianopoulo. Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states. Annals of general psychiatry. vol 4. 2020-09-29. PMID:15876359. |
in the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (gr), mineralocorticoid (mr) and type 1a serotonin (5-ht1a) receptors, as well as brain derived neurotrophic factor (bdnf), and on circulating leptin levels, of male rats. |
2020-09-29 |
2023-08-12 |
rat |
| Lakshmi N Yatham, Eduard Vieta, Roger S McIntyre, Rakesh Jain, Mehul Patel, Willie Earle. Broad Efficacy of Cariprazine on Depressive Symptoms in Bipolar Disorder and the Clinical Implications. The primary care companion for CNS disorders. vol 22. issue 5. 2020-09-29. PMID:32942346. |
cariprazine, a dopamine d₃-preferring d₃/d₂ receptor partial agonist with serotonin 5-ht1a receptor partial agonist and serotonin 5-ht2a antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shrikant S Kolan, Tommy Lidström, Tomás Mediavilla, Andy Dernstedt, Sofie Degerman, Magnus Hultdin, Karl Björk, Daniel Marcellino, Mattias N E Forsel. Growth-inhibition of cell lines derived from B cell lymphomas through antagonism of serotonin receptor signaling. Scientific reports. vol 9. issue 1. 2020-09-28. PMID:30862884. |
neurotransmitters such as serotonin and dopamine influence activation of b cells and the effects of a selective serotonin 1a receptor (5ht1a) antagonist on growth of a number of b cell-derived lymphoma cell lines were investigated. |
2020-09-28 |
2023-08-13 |
human |
| Stefano Espinoza, Ilya Sukhanov, Evgeniya V Efimova, Alena Kozlova, Kristina A Antonova, Placido Illiano, Damiana Leo, Natalia Merkulyeva, Daria Kalinina, Pavel Musienko, Anna Rocchi, Liudmila Mus, Tatiana D Sotnikova, Raul R Gainetdino. Trace Amine-Associated Receptor 5 Provides Olfactory Input Into Limbic Brain Areas and Modulates Emotional Behaviors and Serotonin Transmission. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32194374. |
taar5-ko mice also showed significant decreases in the tissue levels of serotonin and its metabolite in several brain areas and were more sensitive to the hypothermic action of serotonin 5-ht1a receptor agonist 8-hydroxy-2-(di- |
2020-09-28 |
2023-08-13 |
mouse |
| Gabriel Araujo Tavares, Amada Torres, Julliet Araujo de Souz. Early Life Stress and the Onset of Obesity: Proof of MicroRNAs' Involvement Through Modulation of Serotonin and Dopamine Systems' Homeostasis. Frontiers in physiology. vol 11. 2020-09-28. PMID:32848865. |
the first pieces of evidence highlight the presence of the mir-16 in the regulation of the serotonin transporter (sert) as well as the receptors 1a (5ht1a) and 2a (5ht2a). |
2020-09-28 |
2023-08-13 |
Not clear |
| Deblina Dey, Vipan K Parihar, Gergely G Szabo, Peter M Klein, Jenny Tran, Jonathan Moayyad, Faizy Ahmed, Quynh-Anh Nguyen, Alexandria Murry, David Merriott, Brandon Nguyen, Jodi Goldman, Maria C Angulo, Daniele Piomelli, Ivan Soltesz, Janet E Baulch, Charles L Limol. Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. Radiation research. vol 193. issue 5. 2020-09-14. PMID:32134362. |
relevant to the known roles of the serotonin axis in mood disorders, we found that 5ht1a serotonin receptor levels were decreased by ∼50% in the hippocampus at both early and late time points, and a 37% decrease in serotonin levels was observed at 15 weeks postirradiation. |
2020-09-14 |
2023-08-13 |
mouse |
| Christoph U Correl. Current Treatment Options and Emerging Agents for Schizophrenia. The Journal of clinical psychiatry. vol 81. issue 3. 2020-09-14. PMID:32297721. |
mechanisms of action that are under investigation include dopamine d3 antagonism/serotonin 5-ht1a partial agonism; combined dopamine, serotonin, and glutamate modulation; phosphodiesterase 10a inhibition; trace amine-associated receptor-1 (taar1) agonism plus 5-ht1a agonism; 5-ht2a inverse agonism; sigma-2/5-ht2a antagonism; d-amino acid oxidase (daao) inhibition; glycine transporter-1 inhibition; vesicular monoamine transporter-2 antagonism; mu opioid antagonism added to olanzapine; and novel long-acting injectable antipsychotic formulations. |
2020-09-14 |
2023-08-13 |
Not clear |