| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonios Dougalis, George Lees, C Robin Ganelli. The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. Neuropharmacology. vol 46. issue 1. 2004-04-05. PMID:14654098. |
in summary, cis-oleamide failed to modulate metabotropic responses to exogenous 5-ht in this microelectrode study at concentrations well in excess of those reported to modulate 5-ht1a and 5-ht2a/c systems in earlier studies. |
2004-04-05 |
2023-08-12 |
rat |
| Andria L Del Tredici, Hans H Schiffer, Ethan S Burstein, Jelveh Lameh, Nina Mohell, Uli Hacksell, Mark R Brann, David M Weine. Pharmacology of polymorphic variants of the human 5-HT1A receptor. Biochemical pharmacology. vol 67. issue 3. 2004-04-05. PMID:15037200. |
the 5-ht1a receptor is a critical mediator of serotonergic (5-ht) function. |
2004-04-05 |
2023-08-12 |
human |
| Andria L Del Tredici, Hans H Schiffer, Ethan S Burstein, Jelveh Lameh, Nina Mohell, Uli Hacksell, Mark R Brann, David M Weine. Pharmacology of polymorphic variants of the human 5-HT1A receptor. Biochemical pharmacology. vol 67. issue 3. 2004-04-05. PMID:15037200. |
these data suggest a previously unappreciated role for transmembrane 1 in mediating 5-ht response at the 5-ht1a receptor. |
2004-04-05 |
2023-08-12 |
human |
| Antonio L López-Figueroa, Camille S Norton, Manuel O López-Figueroa, Denise Armellini-Dodel, Sharon Burke, Huda Akil, Juan F López, Stanley J Watso. Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biological psychiatry. vol 55. issue 3. 2004-04-01. PMID:14744462. |
serotonin 5-ht1a, 5-ht1b, and 5-ht2a receptor mrna expression in subjects with major depression, bipolar disorder, and schizophrenia. |
2004-04-01 |
2023-08-12 |
human |
| P M Boers, C Donaldson, A S Zagami, G A Lamber. Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy. Cephalalgia : an international journal of headache. vol 24. issue 2. 2004-03-24. PMID:14728705. |
naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-ht1a and 5-ht(1b/1d) receptors in the cat: implications for migraine therapy. |
2004-03-24 |
2023-08-12 |
cat |
| P M Boers, C Donaldson, A S Zagami, G A Lamber. Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy. Cephalalgia : an international journal of headache. vol 24. issue 2. 2004-03-24. PMID:14728705. |
the triptans are agonists at serotonin (5-ht)1b/1d receptors; however, they are also active at 5-ht1a and 5-ht1f receptors. |
2004-03-24 |
2023-08-12 |
cat |
| P M Boers, C Donaldson, A S Zagami, G A Lamber. Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy. Cephalalgia : an international journal of headache. vol 24. issue 2. 2004-03-24. PMID:14728705. |
the effect of naratriptan was significantly attenuated by application of either the 5-ht(1b/1d) receptor antagonist gr-127935 (p<0.001) or the 5-ht1a antagonist way-100635 (p<0.05). |
2004-03-24 |
2023-08-12 |
cat |
| P M Boers, C Donaldson, A S Zagami, G A Lamber. Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy. Cephalalgia : an international journal of headache. vol 24. issue 2. 2004-03-24. PMID:14728705. |
these results indicate that naratriptan has a central effect in the trigeminovascular system, selectively inhibiting afferent activity in craniovascular neurones, via both 5-ht(1b/1d) and 5-ht1a receptors. |
2004-03-24 |
2023-08-12 |
cat |
| W W Blessin. 5-hydroxytryptamine 1A receptor activation reduces cutaneous vasoconstriction and fever associated with the acute inflammatory response in rabbits. Neuroscience. vol 123. issue 1. 2004-03-23. PMID:14667435. |
5-hydroxytryptamine(1a) (5-ht1a) receptor activation reduces body temperature partially by dilating the thermoregulatory cutaneous vascular bed, thereby increasing heat transfer to the environment. |
2004-03-23 |
2023-08-12 |
Not clear |
| Elizabeth Winan. Aripiprazole. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 60. issue 23. 2004-03-19. PMID:14686220. |
unlike other antipsychotics, aripiprazole demonstrates mixed d2 and serotonin (5-ht1a) receptor agonist-antagonist activity that is hypothesized to improve schlzophrenia's positive and negative symptoms; the drug has been referred to as a dopamine-serotonin stabilizer. |
2004-03-19 |
2023-08-12 |
Not clear |
| Kurt Rasmussen, Andrew C McCreary, Elaine A Shank. Attenuation of the effects of fluoxetine on serotonergic neuronal activity by pindolol in rats. Neuroscience letters. vol 355. issue 1-2. 2004-03-16. PMID:14729220. |
based on its proposed ability to block the effect of selective serotonin reuptake inhibitors (ssris) on the firing rate of serotonergic neurons, the 5-ht1a partial agonist/beta-adrenergic antagonist pindolol has been examined in clinical trials for its ability to enhance the efficacy of ssris. |
2004-03-16 |
2023-08-12 |
rat |
| E F Carvalho-Netto, R L Nunes-de-Souz. Use of the elevated T-maze to study anxiety in mice. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684253. |
the 5-ht1a partial receptor agonist buspirone (1.0-2.0 mg/kg) and the 5-ht releaser fenfluramine (0.15-0.30 mg/kg) impaired iaa and facilitated escape, while the full 5-ht1a receptor agonist, 8-oh-dpat (0.05-0.1 mg/kg) and the 5-ht(2b/2c) receptor antagonist, ser 082 (0.5-2.0 mg/kg) failed to modify either response. |
2004-03-01 |
2023-08-12 |
mouse |
| Petros N Karamanakos, Periklis Pappas, Marios Marselo. Involvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptors. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684260. |
in striatum and hypothalamus, which are known to be rich in postsynaptic 5-ht1a receptors, we found a significant time-dependent increase of 5-ht, correlated with the clearly enhanced locomotor activity of the animals. |
2004-03-01 |
2023-08-12 |
rat |
| Petros N Karamanakos, Periklis Pappas, Marios Marselo. Involvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptors. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684260. |
on the contrary, in midbrain, where presynaptic 5-ht1a receptors are dominating, no changes could be detected in 5-ht. |
2004-03-01 |
2023-08-12 |
rat |
| Petros N Karamanakos, Periklis Pappas, Marios Marselo. Involvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptors. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684260. |
in support of a role in receptor specificity, pretreatment with the 5-ht1a receptor agonist 8-oh-dpat (1.25 mg/kg, i.p., two times) or with the 5-ht(1a/b) receptor antagonist pindolol (30 mg/kg, i.p., two times), enhanced or blocked, respectively, the hyperlocomotion induced by cpa. |
2004-03-01 |
2023-08-12 |
rat |
| M Freire-Garabal, M J Núñez, J Balboa, P López-Delgado, R Gallego, T García-Caballero, M D Fernández-Roel, J Brenlla, M Rey-Ménde. Serotonin upregulates the activity of phagocytosis through 5-HT1A receptors. British journal of pharmacology. vol 139. issue 2. 2004-02-27. PMID:12770951. |
serotonin upregulates the activity of phagocytosis through 5-ht1a receptors. |
2004-02-27 |
2023-08-12 |
mouse |
| D N D'Souza, Y Zhang, F Garcia, G Battaglia, L D Van de Ka. Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet. American journal of physiology. Regulatory, integrative and comparative physiology. vol 286. issue 2. 2004-02-27. PMID:14604841. |
we hypothesized that the regulation of postsynaptic 5-ht1a receptors is dependent on the levels of 5-ht in the synapse. |
2004-02-27 |
2023-08-12 |
rat |
| D N D'Souza, Y Zhang, F Garcia, G Battaglia, L D Van de Ka. Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet. American journal of physiology. Regulatory, integrative and comparative physiology. vol 286. issue 2. 2004-02-27. PMID:14604841. |
these data suggest that a reserve of 5-ht enables fluoxetine to desensitize postsynaptic 5-ht1a receptors in the hypothalamus. |
2004-02-27 |
2023-08-12 |
rat |
| b' R Navin\\xc3\\xa9s, E G\\xc3\\xb3mez, C Gast\\xc3\\xb. [The 5-HT1A receptors: from molecular biology to neuropsychiatric symptoms]. Actas espanolas de psiquiatria. vol 31. issue 5. 2004-02-24. PMID:14557952.' |
on stimulation of 5-ht1a autoreceptors, they regulate serotonin release in the distal regions of the neuron by inhibitory firing activity. |
2004-02-24 |
2023-08-12 |
Not clear |
| Meredith J Regina, Jerrold C Winter, Richard A Rabi. Characterization of a novel effect of serotonin 5-HT1A and 5-HT2A receptors: increasing cGMP levels in rat frontal cortex. Neuropharmacology. vol 45. issue 8. 2004-02-11. PMID:14614947. |
characterization of a novel effect of serotonin 5-ht1a and 5-ht2a receptors: increasing cgmp levels in rat frontal cortex. |
2004-02-11 |
2023-08-12 |
rat |