All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Antoni Sastre-Coll, Susana Esteban, Jesús A García-Sevill. Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 3. 2002-07-22. PMID:11882917. the sensitivity of 5-ht1a serotonin receptors and alpha2-adrenoceptors (autoreceptors and heteroreceptors) modulating brain monoamine synthesis was investigated in rats during morphine treatment and after naloxone-precipitated withdrawal. 2002-07-22 2023-08-12 rat
Antoni Sastre-Coll, Susana Esteban, Jesús A García-Sevill. Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 3. 2002-07-22. PMID:11882917. in summary, we conclude that morphine addiction is associated with supersensitivity of 5-ht1a serotonin receptors and alpha2-adrenoceptors (autoreceptors and heteroreceptors) that modulate the synthesis of monoamines in brain. 2002-07-22 2023-08-12 rat
H Dhaene. Imaging the serotonergic system in depression. European archives of psychiatry and clinical neuroscience. vol 251 Suppl 2. 2002-07-17. PMID:11824843. currently, the available ligands permit the investigation of 5-ht2a and 5-ht1a receptors, the serotonin transporter and serotonin synthesis. 2002-07-17 2023-08-12 Not clear
H Elliott Albers, Mary Karom, Debra Smit. Serotonin and vasopressin interact in the hypothalamus to control communicative behavior. Neuroreport. vol 13. issue 7. 2002-07-16. PMID:12004193. in addition, the finding that 8-oh-dpat, cgs-12066a and sc53116 also inhibited avp-induced flank marking suggests that 5-ht could also inhibit flank marking by acting through 5-ht1a, 5-ht7, 5-ht1b and/or 5-ht4 receptor subtypes. 2002-07-16 2023-08-12 Not clear
L Pinilla, L C González, M Tena-Sempere, E Aguila. Interactions between serotoninergic and aminoacidergic pathways in the control of PRL secretion in prepubertal male rats. Journal of physiology and biochemistry. vol 57. issue 3. 2002-07-12. PMID:11800286. for this purpose, 16 and 23-day old male rats were treated with 5-hydroxytryptophan (5-htp, precursor of serotonin synthesis) plus fluoxetine (blocker of serotonin reuptake), 8-oh-dpat (agonist of 5-ht1a receptors), doi and alpha-me-5-ht (agonists of 5-ht2 receptors), 1-phenylbiguanide (agonist of 5-ht3 receptors) alone or in combination with ampa (agonist of ampa receptors). 2002-07-12 2023-08-12 rat
María L López-Rodríguez, Bruno Vicente, Xavier Deupi, Sergio Barrondo, Mireia Olivella, M José Morcillo, Bellinda Behamú, Juan A Ballesteros, Joan Sallés, Leonardo Pard. Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor. Molecular pharmacology. vol 62. issue 1. 2002-07-12. PMID:12065750. in this work, we evaluate the structural differences of transmembrane helix 3 in rhodopsin and the 5-hydroxytryptamine 1a (5-ht1a) receptor caused by their different amino acid sequence. 2002-07-12 2023-08-12 Not clear
Nicolas Costes, Isabelle Merlet, Luc Zimmer, Franck Lavenne, Luc Cinotti, Jacques Delforge, André Luxen, Jean-François Pujol, Didier Le Bar. Modeling [18 F]MPPF positron emission tomography kinetics for the determination of 5-hydroxytryptamine(1A) receptor concentration with multiinjection. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 22. issue 6. 2002-07-10. PMID:12045674. the selectivity of [18f]mppf (fluorine-18-labeled 4-(2;-methoxyphenyl)-1-[2;-(n-2"-pirydynyl)-p-fluorobenzamido]ethylpiperazine) for serotonergic 5-hydroxytryptamine(1a) (5-ht1a) receptors has been established in animals and humans. 2002-07-10 2023-08-12 Not clear
Cynthia L Bethea, Stephanie J Mirkes, Annetta Su, David Michelso. Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques. Psychoneuroendocrinology. vol 27. issue 4. 2002-06-28. PMID:11911997. we previously showed that estrogen (e) treatment of female macaques via silastic implant alters gene expression for tryptophan hydroxylase (tph), the serotonin reuptake transporter (sert) and the 5ht1a autoreceptor. 2002-06-28 2023-08-12 Not clear
A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. molecular dynamics of 5-ht1a and 5-ht2a serotonin receptors with methylated buspirone analogues. 2002-06-10 2023-08-12 Not clear
A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. in the present study experimentally determined ligand selectivity of three methylated buspirone analogues (denoted as mm2, mm5 and p55) towards 5-ht1a and 5-ht2a serotonin receptors was theoretically investigated on a molecular level. 2002-06-10 2023-08-12 Not clear
William C de Groa. Influence of central serotonergic mechanisms on lower urinary tract function. Urology. vol 59. issue 5 Suppl 1. 2002-05-29. PMID:12007520. although there is some evidence in the rat for serotonergic facilitation of voiding, most experiments in rats and cats indicate that activation of the central serotonergic system by 5-ht reuptake inhibitors, as well as by 5-ht1a and 5-ht2 receptor agonists, depresses reflex bladder contractions and increases the bladder volume threshold for inducing micturition. 2002-05-29 2023-08-12 rat
A Evrard, I Malagié, A-M Laporte, C Boni, N Hanoun, A-C Trillat, I Seif, E De Maeyer, A Gardier, M Hamon, J Adrie. Altered regulation of the 5-HT system in the brain of MAO-A knock-out mice. The European journal of neuroscience. vol 15. issue 5. 2002-05-23. PMID:11906526. altogether, these data indicate that, in mao-a knock-out mice, the enhancement of extracellular 5-ht levels induces a down-regulation of the 5-ht transporter, and a desensitization of 5-ht1a autoreceptors which allows the maintenance of tonic activity of 5-ht neurons in the drn. 2002-05-23 2023-08-12 mouse
Margaret S Wilson, Robert J Ham. Effects of fluoxetine on the 5-HT1A receptor and recovery of cognitive function after traumatic brain injury in rats. American journal of physical medicine & rehabilitation. vol 81. issue 5. 2002-05-16. PMID:11964577. this study examined the effects of chronic administration of fluoxetine, a selective serotonin reuptake inhibitor, on cognitive performance and 5-ht1a receptor immunoreactivity following traumatic brain injury. 2002-05-16 2023-08-12 rat
M Bauer, A Heinz, P C Whybro. Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain. Molecular psychiatry. vol 7. issue 2. 2002-05-14. PMID:11840307. in the majority of studies, the effects of thyroid hormone administration in animals with experimentally-induced hypothyroid states include an increase in cortical 5-ht concentrations and a desensitization of autoinhibitory 5-ht1a receptors in the raphe area, resulting in disinhibition of cortical and hippocampal 5-ht release. 2002-05-14 2023-08-12 Not clear
M Bourin, M Hascoë. Drug mechanisms in anxiety. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 2. 2002-04-30. PMID:11816841. alternative approaches to the treatment of anxiety include the following: (i) antidepressants such as the selective serotonin reuptake inhibitors (ssris), which are active in treating most anxiety disorders, including gad; (ii) metabotropic glutamate (mglur2) receptor agonists, which negatively modulate glutamate neurotransmission, and crf antagonists, which have been proposed to exhibit anxiolytic properties; (iii) 5-ht1a receptor agonists which have demonstrated anxiolytic effects in clinical studies, although preclinical studies have reported weak or variable effects; (iv) 5-ht moduline antagonists, as well as 5-ht2c receptor antagonists, which may have anxiolytic properties; and, finally, (v) other approaches which are under investigation, including cck2 antagonists. 2002-04-30 2023-08-12 Not clear
Taku Amano, Hiroaki Matsubayashi, Masashi Sas. [Alteration of neuronal activities following repeated administration of stimulants]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 37. issue 1. 2002-04-16. PMID:11915303. releases and syntheses of da, na and 5-ht are inhibited by the monoamine per se via their autoreceptors such as d2, alpha 2 and 5-ht1a receptors, respectively. 2002-04-16 2023-08-12 rat
G S Sonavane, V P Sarveiya, V S Kasture, S B Kastur. Anxiogenic activity of Myristica fragrans seeds. Pharmacology, biochemistry, and behavior. vol 71. issue 1-2. 2002-04-05. PMID:11812528. inhibition of anxiolytic activity of ondansetron (5-ht3 receptor antagonist), buspirone (5-ht1a receptor agonist), and diazepam [acting on gamma-aminobutyric acid (gabaa) receptor] suggests a nonspecific anxiogenic activity of tm and also a link between 5-ht and gaba systems in the anxiogenic activity of tm. 2002-04-05 2023-08-12 mouse
Luc Zimmer, Gweltas Mauger, Didier Le Bars, Gregory Bonmarchand, André Luxen, Jean-François Pujo. Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis. Journal of neurochemistry. vol 80. issue 2. 2002-04-04. PMID:11902118. effect of endogenous serotonin on the binding of the 5-ht1a pet ligand 18f-mppf in the rat hippocampus: kinetic beta measurements combined with microdialysis. 2002-04-04 2023-08-12 human
Luc Zimmer, Gweltas Mauger, Didier Le Bars, Gregory Bonmarchand, André Luxen, Jean-François Pujo. Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis. Journal of neurochemistry. vol 80. issue 2. 2002-04-04. PMID:11902118. by using a combination of an original beta+-sensitive intracerebral probe and microdialysis, the effect of increased endogenous serotonin on specific binding of 18f-mppf [4-(2'-methoxyphenyl)-1-[2'-[n-(2"-pyridinyl)-p-fluorobenzamido]ethyl]piperazine] to the serotonin-1a (5-ht1a) receptors was investigated in the hippocampus of the anaesthetized rat. 2002-04-04 2023-08-12 human
A M Coelho, L Jacob, J Fioramonti, L Buen. Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. The Journal of pharmacy and pharmacology. vol 53. issue 10. 2002-04-02. PMID:11697552. this study was designed to evaluate the pharmacological properties of alverine citrate in a rat model of rectal hyperalgesia induced by 5-htp (5-ht precursor) and by a selective 5-ht1a agonist (8-oh-dpat) and to compare this activity with a reference 5-ht1a antagonist (way 100635). 2002-04-02 2023-08-12 rat