| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Coelho, L Jacob, J Fioramonti, L Buen. Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. The Journal of pharmacy and pharmacology. vol 53. issue 10. 2002-04-02. PMID:11697552. |
this study was designed to evaluate the pharmacological properties of alverine citrate in a rat model of rectal hyperalgesia induced by 5-htp (5-ht precursor) and by a selective 5-ht1a agonist (8-oh-dpat) and to compare this activity with a reference 5-ht1a antagonist (way 100635). |
2002-04-02 |
2023-08-12 |
rat |
| P S Naidu, S K Kulkarn. Effect of 5-HT1A and 5-HT2A/2C receptor modulation on neuroleptic-induced vacuous chewing movements. European journal of pharmacology. vol 428. issue 1. 2002-04-02. PMID:11779040. |
these findings indicate that the serotonergic system, and particularly 5-ht1a and 5-ht2a/2c receptors, may be involved in haloperidol-induced orofacial dyskinesia, and that 5-ht receptors may provide novel targets for the development of drugs that can be used to reverse or prevent the extrapyramidal side effects associated with long-term antipsychotic treatment. |
2002-04-02 |
2023-08-12 |
rat |
| Maxime Richer, René Hen, Pierre Blie. Modification of serotonin neuron properties in mice lacking 5-HT1A receptors. European journal of pharmacology. vol 435. issue 2-3. 2002-03-27. PMID:11821026. |
using null mutant mice for the 5-ht1a receptor (5-ht1a-/-), extracellular electrophysiological recordings were first conducted to evaluate the impact of its genetic deletion on the firing rate of dorsal raphe 5-hydroxytryptamine (5-ht) neurons. |
2002-03-27 |
2023-08-12 |
mouse |
| Maxime Richer, René Hen, Pierre Blie. Modification of serotonin neuron properties in mice lacking 5-HT1A receptors. European journal of pharmacology. vol 435. issue 2-3. 2002-03-27. PMID:11821026. |
in conclusion, the loss of control of the 5-ht1a autoreceptor in 5-ht1a-/- mice lead to a significant enhancement of 5-ht neuronal firing, but it did not alter 5-ht or norepinephrine release in any of the brain structures examined. |
2002-03-27 |
2023-08-12 |
mouse |
| D A McQueen, D H Overstreet, P A Ardayfio, R L Commissari. Acoustic startle, conditioned startle potentiation and the effects of 8-OH-DPAT and buspirone in rats selectively bred for differences in 8-OH-DPAT-induced hypothermia. Behavioural pharmacology. vol 12. issue 6-7. 2002-03-20. PMID:11742145. |
it is possible that this genetically-based difference in sensitivity to the hypothermic effects of the 5-ht1a agonist is associated with a change in other behaviours modulated by 5-ht neurotransmission. |
2002-03-20 |
2023-08-12 |
rat |
| S E Hopwood, C A Owesson, L F Callado, D P McLaughlin, J A Stamfor. Effects of chronic tramadol on pre- and post-synaptic measures of monoamine function. Journal of psychopharmacology (Oxford, England). vol 15. issue 3. 2002-03-18. PMID:11565620. |
the selective 5-ht1a agonist 8-oh-dpat reduced 5-ht efflux in both drn and mrn. |
2002-03-18 |
2023-08-12 |
rat |
| C Odlind, I Reenilä, P T Männistö, J Ekblom, P Hansel. The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat. Pflugers Archiv : European journal of physiology. vol 442. issue 4. 2002-01-25. PMID:11510881. |
the response was unaltered if 5-hydroxytryptamine receptors (5-ht1a) were blocked during mao inhibition. |
2002-01-25 |
2023-08-12 |
rat |
| E Jaunay, V Gaillac, J D Guelf. [Serotonin syndrome. Which treatment and when?]. Presse medicale (Paris, France : 1983). vol 30. issue 34. 2002-01-22. PMID:11760601. |
the physiopathological hypothesis is principally supported by excess stimulation of the central (5ht1a) serotonin receptors. |
2002-01-22 |
2023-08-12 |
Not clear |
| F Bibbiani, J D Oh, T N Chas. Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models. Neurology. vol 57. issue 10. 2002-01-17. PMID:11723272. |
serotonin 5-ht1a agonist improves motor complications in rodent and primate parkinsonian models. |
2002-01-17 |
2023-08-12 |
Not clear |
| A V Kulikov, R Jeanningr. The effects of hypothyroidism on 5-HT1A and 5-HT2A receptors and the serotonin transporter protein in the rat brain. Neuroscience and behavioral physiology. vol 31. issue 4. 2002-01-09. PMID:11508497. |
the effects of hypothyroidism on 5-ht1a and 5-ht2a receptors and the serotonin transporter protein in the rat brain. |
2002-01-09 |
2023-08-12 |
rat |
| C Schmeer, F Obregón, M Urbina, L Lim. Further characterization of 5-HT1A receptors in the goldfish retina: role of cyclic AMP in the regulation of the in vitro outgrowth of retinal explants. Neurochemical research. vol 26. issue 3. 2002-01-02. PMID:11495544. |
the presence of serotonin 5-ht1a receptors and their physiological role were further characterized in the goldfish retina. |
2002-01-02 |
2023-08-12 |
Not clear |
| C Schmeer, F Obregón, M Urbina, L Lim. Further characterization of 5-HT1A receptors in the goldfish retina: role of cyclic AMP in the regulation of the in vitro outgrowth of retinal explants. Neurochemical research. vol 26. issue 3. 2002-01-02. PMID:11495544. |
this study supports previous findings about the role of serotonin as a regulator of axonal outgrowth during in vitro regeneration of the goldfish retina and demonstrates that this effect is mediated, at least in part, by 5-ht1a receptors through a mechanism which involves an increase of cyclic amp levels. |
2002-01-02 |
2023-08-12 |
Not clear |
| M T Lin, F Y Chueh, M T Hsie. The hypothermic effects of dl-tetrahydropalmatine in rats. Neuroscience letters. vol 315. issue 1-2. 2001-12-26. PMID:11711213. |
the thp- induced hypothermia was significantly attenuated in rats with brain 5-ht depletion produced by control injection of 5,7-dihydroxytryptamine or in rats with 5-ht2a receptor activation produced by 1-(2,5-dimethoxy-4-iodophenyl) -2-aminopropane, or in rats with 5-ht1a receptor antagonist produced by (-)-pindolol. |
2001-12-26 |
2023-08-12 |
rat |
| C Halldi. Serotonin 5-HT1A receptor imaging in the human brain with positron-emission tomography: coordination and the standardization and dissemination of methodology. Journal of clinical pharmacology. vol 41. issue S7. 2001-12-07. PMID:11452735. |
serotonin 5-ht1a receptor imaging in the human brain with positron-emission tomography: coordination and the standardization and dissemination of methodology. |
2001-12-07 |
2023-08-12 |
human |
| J M Monti, H Jantos, D Monti, F Alvariñ. Dorsal raphe nucleus administration of 5-HT1A receptor agonist and antagonists: effect on rapid eye movement sleep in the rat. Sleep research online : SRO. vol 3. issue 1. 2001-12-04. PMID:11382897. |
in addition, they favor the proposal that microinjection of 5-ht1a receptor antagonists into the drn would suppress 5-ht inhibition and reduce rems. |
2001-12-04 |
2023-08-12 |
rat |
| A Boido, C C Boido, F Sparator. Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes. Farmaco (Societa chimica italiana : 1989). vol 56. issue 4. 2001-12-04. PMID:11421254. |
the synthesized compounds displayed from moderate to good affinity to the serotonin 5-ht1a receptor and only modest or poor affinity to the dopamine d2 receptor, similar to buspirone. |
2001-12-04 |
2023-08-12 |
mouse |
| B Bobula, A Zahorodna, M Bija. Different receptor subtypes are involved in the serotonin-induced modulation of epileptiform activity in rat frontal cortex in vitro. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 52. issue 2. 2001-12-04. PMID:11453105. |
in the presence of ketanserin, 5-ht decreased the discharge rate; a similar effect was observed when the 5-ht1a receptor agonist 8-oh-dpat or the 5-ht1b receptor agonist cgs-12066b was applied. |
2001-12-04 |
2023-08-12 |
rat |
| E del Olmo, A Pazo. Aminergic receptors during the development of the human brain: the contribution of in vitro imaging techniques. Journal of chemical neuroanatomy. vol 22. issue 1-2. 2001-11-01. PMID:11470558. |
(3) during the developmental process, some receptors, which are early and sometimes transiently expressed, play important thophic roles in the regulation of neuronal development: this is the case with the serotonin 5-ht1a receptors, which attain peak levels of hyperexpression over the hippocampus (dentate gyrus, dendritic areas of ca fields) and the raphe nuclei and show a transient expression in the cerebellum, around the 25 week of gestational age. |
2001-11-01 |
2023-08-12 |
human |
| G G Kinney, M T Taber, V K Gribkof. The augmentation hypothesis for improvement of antidepressant therapy: is pindolol a suitable candidate for testing the ability of 5HT1A receptor antagonists to enhance SSRI efficacy and onset latency? Molecular neurobiology. vol 21. issue 3. 2001-10-18. PMID:11379796. |
one hypothesis suggests that this delay in efficacy is due to a paradoxical decrease in serotonergic (5-ht) neuronal impulse flow and release, following activation of inhibitory presynaptic 5-ht1a autoreceptors, following acute administration of ssris. |
2001-10-18 |
2023-08-12 |
Not clear |
| G G Kinney, M T Taber, V K Gribkof. The augmentation hypothesis for improvement of antidepressant therapy: is pindolol a suitable candidate for testing the ability of 5HT1A receptor antagonists to enhance SSRI efficacy and onset latency? Molecular neurobiology. vol 21. issue 3. 2001-10-18. PMID:11379796. |
according to the hypothesis, efficacy is seen only when this impulse flow is restored following desensitization of 5-ht1a autoreceptors and coincident increases in postsynaptic 5-ht levels are achieved. |
2001-10-18 |
2023-08-12 |
Not clear |