| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y J Karten, C M Stienstra, M Joël. Corticosteroid effects on serotonin responses in granule cells of the rat dentate gyrus. Journal of neuroendocrinology. vol 13. issue 3. 2001-05-03. PMID:11207937. |
in the present, intracellular recording study in vitro, we examined if the altered levels of 5-ht1a receptor mrna and protein are associated with changes in the response to 5-ht. |
2001-05-03 |
2023-08-12 |
rat |
| Y J Karten, C M Stienstra, M Joël. Corticosteroid effects on serotonin responses in granule cells of the rat dentate gyrus. Journal of neuroendocrinology. vol 13. issue 3. 2001-05-03. PMID:11207937. |
we found that the hyperpolarization and resistance decrease induced in granule cells by a submaximal (10 microm) dose of 5-ht were unaltered 2-4 days after adrenalectomy, indicating a dissociation between corticosteroid actions on 5-ht1a receptor mrna/protein levels and functional responses to 5-ht. |
2001-05-03 |
2023-08-12 |
rat |
| C Stenfors, H Yu, S B Ros. Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218075. |
depletion of 5-ht with reserpine markedly reduced the citalopram-induced decrease of 5-htp but not that evoked by the 5-ht1a receptor agonist 8-oh-dpat, which indicates that the presence of endogenous 5-ht is necessary for full effect of citalopram. |
2001-05-03 |
2023-08-12 |
mouse |
| C Stenfors, H Yu, S B Ros. Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218075. |
in contrast to the almost complete antagonism of the decrease in 5-ht synthesis induced by 8-oh-dpat, the 5-ht1a receptor antagonist way-100,635 only slightly affected the citalopram-evoked decrease in 5-ht synthesis. |
2001-05-03 |
2023-08-12 |
mouse |
| C Stenfors, H Yu, S B Ros. Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218075. |
combined treatment with 5-ht1a and 5-ht1b receptor antagonists did not produce any additive antagonistic effect on the citalopram-induced decrease in 5-ht synthesis. |
2001-05-03 |
2023-08-12 |
mouse |
| C Stenfors, H Yu, S B Ros. Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218075. |
it is concluded that the citalopram-induced decrease in 5-ht synthesis differs in sensitivity from that mediated by 5-ht1a or 5-ht1b receptor agonists and citalopram also seems to require endogenous 5-ht for its full effect. |
2001-05-03 |
2023-08-12 |
mouse |
| A Bronowska, I Sylte, Ø Edvardsen, R Østensen, A Leś, Z Chilmonczy. Theoretical models of interactions between buspirone analogues and 5-HT1A and 5-HT2A serotonin receptor subtypes. Acta poloniae pharmaceutica. vol 57 Suppl. 2001-05-03. PMID:11293260. |
in present study the structure-selectivity relationship of buspirone and six of its analogues towards 5-ht1a and 5-ht2a serotonin receptors was investigated on molecular level. |
2001-05-03 |
2023-08-12 |
human |
| D Dwyer, J Brownin. Endurance training in Wistar rats decreases receptor sensitivity to a serotonin agonist. Acta physiologica Scandinavica. vol 170. issue 3. 2001-04-05. PMID:11167306. |
improved resistance to the fatiguing effects of the serotonin agonist suggests desensitization of central serotonin receptors, probably the 5-ht1a receptors. |
2001-04-05 |
2023-08-12 |
rat |
| J Passchier, A van Waard. Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system. European journal of nuclear medicine. vol 28. issue 1. 2001-03-22. PMID:11202445. |
the 5-ht1a subtype of receptors for the neurotransmitter serotonin is predominantly located in the limbic forebrain and is involved in the modulation of emotion and the function of the hypothalamus. |
2001-03-22 |
2023-08-12 |
human |
| J Passchier, A van Waard. Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system. European journal of nuclear medicine. vol 28. issue 1. 2001-03-22. PMID:11202445. |
the high-affinity ligands way and dway produce excellent images of 5-ht1a receptor distribution in the brain (even the raphe nuclei are visualised), but they cannot be distributed to remote facilities and they probably cannot be used to measure changes in endogenous serotonin. |
2001-03-22 |
2023-08-12 |
human |
| K Pruus, T Skrebuhhova-Malmros, R Rudissaar, V Matto, L Allikmet. 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 51. issue 4 Pt 2. 2001-03-22. PMID:11220492. |
we have studied the effects of acute serotonin (5-ht) 5-ht1a receptor agonist buspirone (0.5, 1.0, 2.5 and 5.0 mg/kg, s.c.), gepirone (5.0 and 10 mg/kg, s.c.), and 8-oh-dpat (0.1, 0.25, and 0.5 mg/kg, i.p.) |
2001-03-22 |
2023-08-12 |
rat |
| S Hashimot. [Anxiolytic effects of serotonin reuptake inhibitors and their mechanism of action]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 75. issue 6. 2001-03-15. PMID:11193934. |
from these findings, it is indicated that 1) 5-ht reuptake inhibitors decrease anxiety, 2) 5-ht release is increased at the nerve terminal under anxiety conditions, 3) the elevation of 5-ht levels in the terminal has an anxiolytic action which is closely related to the pharmacological effects of ssri-class of anxiolytics, and 4) 5-ht1a receptor antagonist enhances the antifreezing effect of ssri by blocking the autoreceptor-mediated negative feedback mechanisms of 5-ht neurons. |
2001-03-15 |
2023-08-12 |
rat |
| P Blier, F V Abbot. Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain. Journal of psychiatry & neuroscience : JPN. vol 26. issue 1. 2001-03-15. PMID:11212592. |
in major depression, an increase in 5-ht1a transmission is thought to be a crucial determinant of the antidepressant response, whereas an enhancement of 5-ht2 transmission in the orbitofrontal cortex may mediate the therapeutic effect of 5-ht reuptake inhibitors in obsessive-compulsive disorder (ocd). |
2001-03-15 |
2023-08-12 |
Not clear |
| P J Winsauer, J M Moerschbaeche. Differential effects of 5-HT agonists and antagonists on the repeated acquisition and performance of response sequences in monkeys. Behavioural pharmacology. vol 11. issue 7-8. 2001-03-08. PMID:11198126. |
as a means of characterizing the role of 5-ht1a and 5-ht2a receptors in learning, 5-hydroxytryptamine (5-ht) agonists and antagonists with selective affinities for each receptor subtype (i.e. |
2001-03-08 |
2023-08-12 |
monkey |
| P J Winsauer, J M Moerschbaeche. Differential effects of 5-HT agonists and antagonists on the repeated acquisition and performance of response sequences in monkeys. Behavioural pharmacology. vol 11. issue 7-8. 2001-03-08. PMID:11198126. |
together, these results suggest that 5-ht is capable of disrupting learning in monkeys through actions at both the 5-ht1a and 5-ht2a receptors, and that 5-ht2a receptor antagonism does not unilaterally modify the effects produced by 5-hta1a receptor activation. |
2001-03-08 |
2023-08-12 |
monkey |
| R Dall'Olio, O Gandolfi, R Gagg. D-Cycloserine, a positive modulator of NMDA receptors, inhibits serotonergic function. Behavioural pharmacology. vol 11. issue 7-8. 2001-03-08. PMID:11198134. |
the administration of the n-methyl-d-aspartate (nmda)-associated glycine recognition site agonist d-cycloserine (dcs) to rats inhibited the head shakes and the forepaw treading induced by the serotonin (5ht) precursor, l-5-hydroxy-tryptophan [(-)5htp], as well as the forepaw treading and motility elicited by the selective 5ht1a receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat). |
2001-03-08 |
2023-08-12 |
rat |
| V Contesse, H Lefebvre, S Lenglet, J M Kuhn, C Delarue, H Vaudr. Role of 5-HT in the regulation of the brain-pituitary-adrenal axis: effects of 5-HT on adrenocortical cells. Canadian journal of physiology and pharmacology. vol 78. issue 12. 2001-03-01. PMID:11149386. |
in particular, 5-ht has been shown to control the activity of hypothalamic crf neurons and pituitary corticotrope cells through activation of 5-ht1a and (or) 5-ht(2a/2c) receptor subtypes. |
2001-03-01 |
2023-08-12 |
mouse |
| A M Oficialdegui, J Martinez, S Pérez, B Heras, M Irurzun, J A Palop, R Tordera, B Lasheras, J del Río, A Mong. Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism. Farmaco (Societa chimica italiana : 1989). vol 55. issue 5. 2001-02-22. PMID:10983279. |
design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-ht1a receptor antagonism. |
2001-02-22 |
2023-08-12 |
Not clear |
| A M Oficialdegui, J Martinez, S Pérez, B Heras, M Irurzun, J A Palop, R Tordera, B Lasheras, J del Río, A Mong. Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism. Farmaco (Societa chimica italiana : 1989). vol 55. issue 5. 2001-02-22. PMID:10983279. |
it has been suggested that the combination of a selective serotonin reuptake inhibitor (ssri) and a 5-ht1a receptor antagonist may facilitate the onset of the ssris antidepressant action. |
2001-02-22 |
2023-08-12 |
Not clear |
| A M Oficialdegui, J Martinez, S Pérez, B Heras, M Irurzun, J A Palop, R Tordera, B Lasheras, J del Río, A Mong. Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism. Farmaco (Societa chimica italiana : 1989). vol 55. issue 5. 2001-02-22. PMID:10983279. |
compounds were evaluated for in vitro affinity at 5-ht1a receptors and 5-ht transporter. |
2001-02-22 |
2023-08-12 |
Not clear |