| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q Li, C Wichems, A Heils, K P Lesch, D L Murph. Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 21. 2001-02-22. PMID:11050108. |
reduction in the density and expression, but not g-protein coupling, of serotonin receptors (5-ht1a) in 5-ht transporter knock-out mice: gender and brain region differences. |
2001-02-22 |
2023-08-12 |
mouse |
| E Bagdy, I Kiraly, L G Harsin. Reciprocal innervation between serotonergic and GABAergic neurons in raphe nuclei of the rat. Neurochemical research. vol 25. issue 11. 2001-02-15. PMID:11071365. |
the 5-ht1a receptor agonist 8-oh-dpat (0.01 to 1 microm) and the 5-ht1b receptor agonist cgs-12066a (0.01 to 1 microm) inhibited the electrically stimulated [3h]serotonin and [3h]gaba release. |
2001-02-15 |
2023-08-12 |
rat |
| E Bagdy, I Kiraly, L G Harsin. Reciprocal innervation between serotonergic and GABAergic neurons in raphe nuclei of the rat. Neurochemical research. vol 25. issue 11. 2001-02-15. PMID:11071365. |
the 5-ht1a antagonist way-100135 (1 microm) was without effect on [3h]serotonin and [3h]gaba efflux by itself but it reversed the 8-oh-dpat-induced transmitter release inhibition. |
2001-02-15 |
2023-08-12 |
rat |
| M B Assié, W Koe. Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. European journal of pharmacology. vol 409. issue 2. 2001-02-15. PMID:11104831. |
estimation of apparent pa2 values for way 100635 at 5-ht1a receptors regulating 5-hydroxytryptamine release in anaesthetised rats. |
2001-02-15 |
2023-08-12 |
rat |
| M B Assié, W Koe. Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. European journal of pharmacology. vol 409. issue 2. 2001-02-15. PMID:11104831. |
5-ht1a receptor agonists decrease 5-hydroxytryptamine (5-ht) terminal release by activating somatodendritic 5-ht1a autoreceptors. |
2001-02-15 |
2023-08-12 |
rat |
| M B Assié, W Koe. Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. European journal of pharmacology. vol 409. issue 2. 2001-02-15. PMID:11104831. |
the present study was aimed at estimating apparent pa2 values for way 100635 to antagonise 5-ht1a receptor agonist-induced decrease in 5-ht release in rat hippocampus. |
2001-02-15 |
2023-08-12 |
rat |
| M B Assié, W Koe. Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. European journal of pharmacology. vol 409. issue 2. 2001-02-15. PMID:11104831. |
extracellular concentrations of 5-ht were measured in microdialysis samples after administration of cumulative doses of 5-ht1a receptor agonists with different intrinsic activity, alone or in the presence of increasing doses of way 100635. |
2001-02-15 |
2023-08-12 |
rat |
| M B Assié, W Koe. Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. European journal of pharmacology. vol 409. issue 2. 2001-02-15. PMID:11104831. |
taken together, the results are evidence that buspirone, s 14506 and 8-oh-dpat, administered in cumulative doses, decreased 5-ht release by activating similar 5-ht1a receptors, because a common apparent pa2 value was obtained for way 100635. |
2001-02-15 |
2023-08-12 |
rat |
| Y Q Zhang, X Gao, Y L Huang, G C W. Expression of 5-HT1A receptor mRNA in rat dorsal raphe nucleus and ventrolateral periaqueductal gray neurons after peripheral inflammation. Neuroreport. vol 11. issue 15. 2001-02-08. PMID:11059903. |
moderate 5-ht1a receptor mrna and 5-ht immunoreactive (5-ht-ir) double-labeled cells were observed in the drn and vlpag, suggesting that some of 5-ht1a receptors in the drn and vlpag may be autoreceptors. |
2001-02-08 |
2023-08-12 |
rat |
| N Haddjeri, G Lucas, P Blie. Role of cholinergic and GABAergic systems in the feedback inhibition of dorsal raphe 5-HT neurons. Neuroreport. vol 11. issue 15. 2001-02-08. PMID:11059909. |
several observations indicate that 5-ht1a receptors found on a long neuronal feedback loop, originating from the medial prefrontal cortex, regulate 5-ht neuronal firing. |
2001-02-08 |
2023-08-12 |
rat |
| N Haddjeri, G Lucas, P Blie. Role of cholinergic and GABAergic systems in the feedback inhibition of dorsal raphe 5-HT neurons. Neuroreport. vol 11. issue 15. 2001-02-08. PMID:11059909. |
in the present study, the muscarinic (m) receptor antagonists atropine and scopolamine as well as the m2 receptor antagonist af-dx 116, but not the preferential m1 receptor antagonist pirenzepine, reduced the suppressant effect of the 5-ht1a receptor agonist 8-oh-dpat on the spontaneous firing activity of rat dorsal raphe 5-ht neurons. |
2001-02-08 |
2023-08-12 |
rat |
| B A Heidenreich, T C Napie. Effects of serotonergic 5-HT1A and 5-HT1B ligands on ventral pallidal neuronal activity. Neuroreport. vol 11. issue 13. 2001-01-25. PMID:11006953. |
to clarify the role of the 5-ht system in limbic outputs, the present study compared the effects of the 5-ht1a agonist 8-oh-dpat and the 5-ht1b agonist cp-94253 with the non-selective 5-ht agonist tfmpp on the firing rate of ventral pallidal (vp) neurons recorded in chloral hydrate-anesthetized rats. |
2001-01-25 |
2023-08-12 |
rat |
| E Gur, B Lerer, E Dremencov, M E Newma. Chronic repetitive transcranial magnetic stimulation induces subsensitivity of presynaptic serotonergic autoreceptor activity in rat brain. Neuroreport. vol 11. issue 13. 2001-01-25. PMID:11006967. |
basal 5-ht levels, and the effects of challenges with the 5-ht1a receptor agonist 8-oh-dpat and the 5-ht1b antagonist gr 127935 on 5-ht levels were determined using in vivo microdialysis. |
2001-01-25 |
2023-08-12 |
rat |
| A Siddiqui, K Kotecha, A M Salicioni, V Kalia, J F Murray, C A Wilso. Serotonin inhibits luteinizing hormone release via 5-HT1A receptors in the zona incerta of ovariectomised, anaesthetised rats primed with steroids. Neuroendocrinology. vol 72. issue 5. 2001-01-25. PMID:11124584. |
serotonin inhibits luteinizing hormone release via 5-ht1a receptors in the zona incerta of ovariectomised, anaesthetised rats primed with steroids. |
2001-01-25 |
2023-08-12 |
rat |
| A Siddiqui, K Kotecha, A M Salicioni, V Kalia, J F Murray, C A Wilso. Serotonin inhibits luteinizing hormone release via 5-HT1A receptors in the zona incerta of ovariectomised, anaesthetised rats primed with steroids. Neuroendocrinology. vol 72. issue 5. 2001-01-25. PMID:11124584. |
these results indicate that 5-ht in the zi exerts its inhibitory effect on lh release via 5-ht1a receptors but that another 5-ht subtype may also be involved. |
2001-01-25 |
2023-08-12 |
rat |
| E G Meloni, M Davi. Synergistic enhancement of the acoustic startle reflex by dopamine D1 and 5-HT1A agonists and corresponding changes in c-Fos expression in the dorsal raphe of rats. Psychopharmacology. vol 151. issue 4. 2001-01-18. PMID:11026743. |
because others have shown that systemic administration of the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat) reduces 5-ht levels throughout the brain, we tested the effects of 8-oh-dpat on the enhancement of the acoustic startle reflex by the dopamine d1 receptor agonist skf 82958. |
2001-01-18 |
2023-08-12 |
rat |
| E Richelson, T Soude. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life sciences. vol 68. issue 1. 2001-01-11. PMID:11132243. |
using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (k(d)s) for nine new antipsychotic drugs (iloperidone, melperone, olanzapine, org 5222, quetiapine, risperidone, sertindole, ziprasidone, and zotepine), one metabolite of a new drug (9-oh-risperidone), and three older antipsychotics (clozapine, haloperidol, and pimozide) at nine different receptors (alpha1-adrenergic, alpha2-adrenergic, dopamine d2, histamine h1, muscarinic, and serotonin 5-ht1a, 5-ht1d, 5-ht2a, and 5-ht2c receptors). |
2001-01-11 |
2023-08-12 |
human |
| G Engberg, S Erhardt, T Sharp, M Hajó. Nicotine inhibits firing activity of dorsal raphe 5-HT neurones in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 1. 2001-01-08. PMID:10935531. |
the inhibition of 5-ht neurones was also blocked with a selective 5-ht1a receptor antagonist (way 100635; 0.1 mg/kg, i.v. |
2001-01-08 |
2023-08-12 |
rat |
| J M Casanovas, O Berton, P Celada, F Artiga. In vivo actions of the selective 5-HT1A receptor agonist BAY x 3702 on serotonergic cell firing and release. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 3. 2001-01-05. PMID:10997727. |
overall, these results indicate that the systemic administration of bay x 3702 reduces the 5-ht release with high potency through the activation of midbrain 5-ht1a receptors. |
2001-01-05 |
2023-08-12 |
rat |
| J F Czachura, K Rasmusse. Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 3. 2001-01-05. PMID:10997729. |
these results support the hypothesis that desensitization of the 5-ht1a receptor and consequent recovery of firing of 5-ht cells in the dorsal raphe nucleus plays a role in the delayed therapeutic onset of fluoxetine. |
2001-01-05 |
2023-08-12 |
rat |