| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Arborelius, L Linnér, C Wallsten, S Ahlenius, T H Svensso. Partial 5-HT1A receptor agonist properties of (-)pindolol in combination with citalopram on serotonergic dorsal raphe cell firing in vivo. Psychopharmacology. vol 151. issue 1. 2000-12-28. PMID:10958120. |
it has been postulated that pindolol enhances the antidepressant effect of ssris by blocking somatodendritic 5-ht1a autoreceptors, thus antagonizing the ssri-induced feedback inhibition of midbrain 5-ht cell firing. |
2000-12-28 |
2023-08-12 |
Not clear |
| L Arborelius, L Linnér, C Wallsten, S Ahlenius, T H Svensso. Partial 5-HT1A receptor agonist properties of (-)pindolol in combination with citalopram on serotonergic dorsal raphe cell firing in vivo. Psychopharmacology. vol 151. issue 1. 2000-12-28. PMID:10958120. |
a recent study, however, found that pindolol suppresses the firing rate of central 5-ht cells, suggesting that the compound possesses agonistic activity at 5-ht1a autoreceptors. |
2000-12-28 |
2023-08-12 |
Not clear |
| M Maćkowiak, A Czyrak, K Wedzon. [The involvement of 5-HT1a serotonin receptors in the pathophysiology and pharmacotherapy of schizophrenia]. Psychiatria polska. vol 34. issue 4. 2000-12-15. PMID:11059260. |
[the involvement of 5-ht1a serotonin receptors in the pathophysiology and pharmacotherapy of schizophrenia]. |
2000-12-15 |
2023-08-12 |
rat |
| M Maćkowiak, A Czyrak, K Wedzon. [The involvement of 5-HT1a serotonin receptors in the pathophysiology and pharmacotherapy of schizophrenia]. Psychiatria polska. vol 34. issue 4. 2000-12-15. PMID:11059260. |
this article presents preclinical data concerning the role of 5-ht1a serotonin receptors in the modulation of cortical dopamine system and in psychotomimetic effects of non-competitive nmda receptor antagonists. |
2000-12-15 |
2023-08-12 |
rat |
| S Nakad. [Effects of (+/-)-pindolol over increased extracellular 5-HT level induced by fluvoxamine: regional difference in effect among the raphe, dorsal hippocampus and prefrontal cortex as measured by in vivo microdialysis technique]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 20. issue 2. 2000-11-30. PMID:11062862. |
our present study has addressed the possibility that (+/-)-pindolol, which is a non-selective beta-adrenoceptor antagonist/somatodendritic 5-ht1a autoreceptor antagonist, might have the ability to enhance the level of extracellular 5-ht when used with selective serotonin reuptake inhibitor (ssri; i.e., fluvoxamine). |
2000-11-30 |
2023-08-12 |
rat |
| F Chen, A J Lawrenc. 5-HT transporter sites and 5-HT1A and 5-HT3 receptors in Fawn-Hooded rats: a quantitative autoradiography study. Alcoholism, clinical and experimental research. vol 24. issue 7. 2000-11-28. PMID:10924015. |
5-ht transporter sites and 5-ht1a and 5-ht3 receptors in fawn-hooded rats: a quantitative autoradiography study. |
2000-11-28 |
2023-08-12 |
rat |
| F Chen, A J Lawrenc. 5-HT transporter sites and 5-HT1A and 5-HT3 receptors in Fawn-Hooded rats: a quantitative autoradiography study. Alcoholism, clinical and experimental research. vol 24. issue 7. 2000-11-28. PMID:10924015. |
the neuroanatomical profiles of 5-ht1a receptors, 5-ht3 receptors, and 5-ht transporters (5-htt) in the brain of the fawn-hooded (fh) rat, particularly mesocorticolimbic regions, are not fully elucidated. |
2000-11-28 |
2023-08-12 |
rat |
| K Wedzony, M Maćkowiak, W Zajaczkowski, K Fijał, A Chocyk, A Czyra. WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027920. |
way 100135, an antagonist of 5-ht1a serotonin receptors, attenuates psychotomimetic effects of mk-801. |
2000-11-21 |
2023-08-12 |
rat |
| S Hjorth, H J Bengtsson, A Kullberg, D Carlzon, H Peilot, S B Auerbac. Serotonin autoreceptor function and antidepressant drug action. Journal of psychopharmacology (Oxford, England). vol 14. issue 2. 2000-11-16. PMID:10890313. |
first, our data are consistent with the primacy of 5-ht1a autoreceptors in restraining the elevation of 5-ht levels induced by ssris, whereas nerve terminal 5-ht1b autoreceptors appear to have an accessory role in this regard. |
2000-11-16 |
2023-08-12 |
rat |
| S Hjorth, H J Bengtsson, A Kullberg, D Carlzon, H Peilot, S B Auerbac. Serotonin autoreceptor function and antidepressant drug action. Journal of psychopharmacology (Oxford, England). vol 14. issue 2. 2000-11-16. PMID:10890313. |
in particular, emerging data suggest that somatodendritic 5-ht1a autoreceptor- and nerve terminal 5-ht1b autoreceptor-mediated feedback may be relatively more important in the control of 5-ht output in dorsal raphe-frontal cortex and median raphe-dorsal hippocampus systems, respectively. |
2000-11-16 |
2023-08-12 |
rat |
| A Zahorodna, K Tokarski, M Bija. [Electrophysiologic tests for testing the effects of antidepressant drugs and corticosterone on reactivity of serotonin receptors in the hippocampus]. Postepy higieny i medycyny doswiadczalnej. vol 54. issue 3. 2000-11-13. PMID:10941273. |
activity of hippocampal cells can be modulated by 5-ht via inhibitory 5-ht1a and excitatory 5-ht4 receptors. |
2000-11-13 |
2023-08-12 |
Not clear |
| N Haddjeri, P Blie. Effects of sustained (+/-)pindolol administration on serotonin neurotransmission in rats. Journal of psychiatry & neuroscience : JPN. vol 25. issue 4. 2000-11-07. PMID:11022403. |
given reports that (+/-)pindolol, a beta-adrenergic-5-ht1a/1b receptor antagonist, accelerates the onset of the therapeutic effect of certain antidepressant drugs in major depression, the aim of this study was to assess the effect of sustained (+/-)pindolol administration on the sensitivity of pre- and postsynaptic 5-ht1a receptors, terminal 5-ht1b autoreceptors and on overall 5-ht neurotransmission. |
2000-11-07 |
2023-08-12 |
rat |
| C M Villalón, D Centurión, G Bravo, P De Vries, P R Saxena, M I Orti. Further pharmacological analysis of the orphan 5-HT receptors mediating feline vasodepressor responses: close resemblance to the 5-HT7, receptor. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 6. 2000-10-19. PMID:10882042. |
administration of the antagonists gr127935 (5-ht(ib/id); 30 microg/kg), tropisetron (5-ht3/4; 3000 microg/kg), (+/-)-pindolol (beta-adrenergic and 5-ht1a; 4000 microg/kg) or equivalent volumes of physiological saline. |
2000-10-19 |
2023-08-12 |
Not clear |
| P Piguet, M E Stoeckel, R Schlichte. Synaptically released 5-HT modulates the activity of tonically discharging neuronal populations in the rostral ventral medulla (RVM). The European journal of neuroscience. vol 12. issue 8. 2000-10-19. PMID:10971610. |
focal electrical stimulation revealed the existence of a functional monoaminergic input onto rvm neurons which was mediated by endogenous 5-ht acting at inhibitory 5-ht1a receptors but did not involve noradrenergic neurotransmission. |
2000-10-19 |
2023-08-12 |
rat |
| V Fabre, C Beaufour, A Evrard, A Rioux, N Hanoun, K P Lesch, D L Murphy, L Lanfumey, M Hamon, M P Martre. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947809. |
altered expression and functions of serotonin 5-ht1a and 5-ht1b receptors in knock-out mice lacking the 5-ht transporter. |
2000-09-19 |
2023-08-12 |
mouse |
| V Fabre, C Beaufour, A Evrard, A Rioux, N Hanoun, K P Lesch, D L Murphy, L Lanfumey, M Hamon, M P Martre. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947809. |
possible adaptive changes in 5-ht neurotransmission in knock-out mice that do not express the 5-ht transporter were investigated with special focus on 5-ht1a and 5-ht1b receptors. |
2000-09-19 |
2023-08-12 |
mouse |
| V Fabre, C Beaufour, A Evrard, A Rioux, N Hanoun, K P Lesch, D L Murphy, L Lanfumey, M Hamon, M P Martre. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947809. |
as expected from actions mediated by functional 5-ht1a and 5-ht1b autoreceptors, a decrease in brain 5-ht turnover rate after i.p. |
2000-09-19 |
2023-08-12 |
mouse |
| V Fabre, C Beaufour, A Evrard, A Rioux, N Hanoun, K P Lesch, D L Murphy, L Lanfumey, M Hamon, M P Martre. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947809. |
administration of ipsapirone (a 5-ht1a agonist), and an increased 5-ht outflow in the substantia nigra upon local application of gr 127935 (a 5-ht1b/1d antagonist) were observed in 5-htt+/+ mice. |
2000-09-19 |
2023-08-12 |
mouse |
| A Sémont, M Fache, F Héry, M Faudon, F Youssouf, M Hér. Regulation of central corticosteroid receptors following short-term activation of serotonin transmission by 5-hydroxy-L-tryptophan or fluoxetine. Journal of neuroendocrinology. vol 12. issue 8. 2000-09-06. PMID:10929085. |
it is hypothesized that the delayed maximal increase in extracellular 5-ht contents after fluoxetine treatment, due to negative feedback regulations induced by the activation of 5-ht1a and 5-ht1b autoreceptors, is not the primary cause for the delayed normalization of corticosteroid receptor numbers that regulates the hpa axis functioning. |
2000-09-06 |
2023-08-12 |
rat |
| M D Zhelyazkova-Savova, N Negre. Isoteoline, a putative serotonin antagonist, inhibits meta -chlorophenylpiperazine, but not 1-(2, -dimethoxy-4-iodphenyl)-2-aminopropane and 8-hydroxy-2-(di-n-propylamino)-tetraline-induced increase of serum prolactin levels. Pharmacological research. vol 42. issue 1. 2000-08-24. PMID:10860641. |
ist was given intraperitoneally to adult male rats at doses of 0.25, 1 and 4 mg kg(-1)alone and 30 min prior to the injection of three 5-ht agonists with preferential affinity for various receptor subtypes: meta -chlorophenylpiperazine (m cpp) for 5-ht2c; 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) for 5-ht2a and 8-hydroxy-2-(di- n -propylamino)tetralin (8-oh-dpat) for 5-ht1a. |
2000-08-24 |
2023-08-12 |
rat |