| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J McLoughlin, P G Strang. Mechanisms of agonism and inverse agonism at serotonin 5-HT1A receptors. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617139. |
mechanisms of agonist and inverse agonist action at the serotonin 5-ht1a receptor have been studied using the modulation of guanosine 5'-o-(3-[35s]thiotriphosphate) ([35s]gtpgammas) binding in membranes of chinese hamster ovary (cho) cells expressing the receptor (cho-5-hta1a cells). |
2000-01-18 |
2023-08-12 |
Not clear |
| M Héry, A Sémont, M P Fache, M Faudon, F Hér. The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617146. |
exposure of raphe cells to 5-ht, (+/-)-8 hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat; a 5-ht1a agonist), or citalopram induced a significant decrease in number of gr binding sites. |
2000-01-18 |
2023-08-12 |
rat |
| A Evrard, A M Laporte, M Chastanet, R Hen, M Hamon, J Adrie. 5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knock-out mice. The European journal of neuroscience. vol 11. issue 11. 1999-12-28. PMID:10583471. |
intravenous administration of the 5-ht reuptake inhibitor citalopram or the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) induced a dose-dependent inhibition of 5-ht neuronal firing which could be reversed by the selective 5-ht1a antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)cyclohe xane carboxamide (way 100635). |
1999-12-28 |
2023-08-12 |
mouse |
| A Evrard, A M Laporte, M Chastanet, R Hen, M Hamon, J Adrie. 5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knock-out mice. The European journal of neuroscience. vol 11. issue 11. 1999-12-28. PMID:10583471. |
altogether, these data indicate that in the mouse, the firing of 5-ht neurons in the dorsal raphe nucleus is under both an inhibitory control through 5-ht1a receptors and an excitatory influence through 5-ht1b receptors. |
1999-12-28 |
2023-08-12 |
mouse |
| O Stork, H Welzl, C T Wotjak, D Hoyer, M Delling, H Cremer, M Schachne. Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. Journal of neurobiology. vol 40. issue 3. 1999-12-20. PMID:10440734. |
however, 5-ht1a receptor binding and tissue content of serotonin and its metabolite 5-hydroxyindolacetic acid were found unaltered in every brain area of ncam-/- mice investigated, indicating that expression of 5-ht1a receptors as well as synthesis and release of serotonin are largely unchanged in ncam-/- mice. |
1999-12-20 |
2023-08-12 |
mouse |
| M B van Niel, M S Beer, J L Castro, S K Cheng, D C Evans, A Heald, L Hitzel, P Hunt, R Mortishire-Smith, D O'Connor, A P Watt, A M MacLeo. Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands. Bioorganic & medicinal chemistry letters. vol 9. issue 22. 1999-12-20. PMID:10576696. |
this resulted in the identification of 5 as a ligand with dual affinity for 5-ht1a and serotonin reuptake receptors which shows excellent pharmacokinetic parameters. |
1999-12-20 |
2023-08-12 |
Not clear |
| P B Hedlund, M J Carson, J G Sutcliffe, E A Thoma. Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochemical pharmacology. vol 58. issue 11. 1999-12-17. PMID:10571256. |
oleamide belongs to a family of amidated lipids with diverse biological activities, including sleep induction and signaling modulation of several 5-hydroxytryptamine (5-ht) receptor subtypes, including 5-ht1a, 5-ht2a/2c, and 5-ht7. |
1999-12-17 |
2023-08-12 |
Not clear |
| T Hendricks, N Francis, D Fyodorov, E S Deneri. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575032. |
conserved pet-1 binding sites are present in or near the promoter regions of the human and mouse 5-ht1a receptor, serotonin transporter, tryptophan hydroxylase, and aromatic l-amino acid decarboxylase genes whose expression is characteristic of the serotonergic neuron phenotype. |
1999-12-17 |
2023-08-12 |
mouse |
| M L Wadenberg, P B Hick. The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics? Neuroscience and biobehavioral reviews. vol 23. issue 6. 1999-12-13. PMID:10541060. |
in addition, the role of dopamine (da) d2, serotonin (5-ht)2a/2c, alpha1, 5-ht1a, da d4, muscarinic and glutamate receptors in the suppression of car induced by various classes of drugs is evaluated. |
1999-12-13 |
2023-08-12 |
rat |
| B Alessandri, E Tsuchida, R M Bulloc. The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat. Brain research. vol 845. issue 2. 1999-12-10. PMID:10536203. |
we tested the neuroprotective effect of a novel, high affinity serotonin (5-ht1a) agonist, bay x3702, in a rat model of acute subdural hematoma (asdh). |
1999-12-10 |
2023-08-12 |
rat |
| Y Wada, N Hirao, J Shiraishi, M Nakamura, Y Koshin. Pindolol potentiates the effect of fluoxetine on hippocampal seizures in rats. Neuroscience letters. vol 267. issue 1. 1999-12-06. PMID:10400249. |
recent studies have shown that behavioral and neurochemical changes induced by selective serotonin (5-ht) reuptake inhibitors such as fluoxetine are potentiated by coadministration of a 5-ht1a receptor antagonist. |
1999-12-06 |
2023-08-12 |
rat |
| V L Arvanov, X Liang, A Russo, R Y Wan. LSD and DOB: interaction with 5-HT2A receptors to inhibit NMDA receptor-mediated transmission in the rat prefrontal cortex. The European journal of neuroscience. vol 11. issue 9. 1999-11-24. PMID:10510170. |
both the phenethylamine hallucinogen (-)-1-2, 5-dimethoxy-4-bromophenyl-2-aminopropane (dob), a selective serotonin 5-ht2a,2c receptor agonist, and the indoleamine hallucinogen d-lysergic acid diethylamide (lsd, which binds to 5-ht1a, 1b, 1d, 1e, 1f, 2a, 2c, 5, 6, 7, dopamine d1 and d2, and alpha1 and alpha2 adrenergic receptors), but not their non-hallucinogenic congeners, inhibited n-methyl-d-aspartate (nmda)-induced inward current and nmda receptor-mediated synaptic responses evoked by electrical stimulation of the forceps minor in pyramidal cells of the prefrontal cortical slices. |
1999-11-24 |
2023-08-12 |
rat |
| V L Arvanov, X Liang, A Russo, R Y Wan. LSD and DOB: interaction with 5-HT2A receptors to inhibit NMDA receptor-mediated transmission in the rat prefrontal cortex. The European journal of neuroscience. vol 11. issue 9. 1999-11-24. PMID:10510170. |
the inhibitory effect of hallucinogens was mimicked by 5-ht in the presence of selective 5-ht1a and 5-ht3 receptor antagonists. |
1999-11-24 |
2023-08-12 |
rat |
| C F Ferris, T Stolberg, Y Delvill. Serotonin regulation of aggressive behavior in male golden hamsters (Mesocricetus auratus). Behavioral neuroscience. vol 113. issue 4. 1999-11-22. PMID:10495088. |
retrogradely labeled 5-ht neurons were found within the dorsal, median, and caudal linear raphe nuclei and are suspected to inhibit avp-facilitated offensive aggression by an activation of 5-ht1a receptors in the ah. |
1999-11-22 |
2023-08-12 |
Not clear |
| N Haddjeri, C Ortemann, C de Montigny, P Blie. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 5. 1999-11-22. PMID:10523050. |
effect of sustained administration of the 5-ht1a receptor agonist flesinoxan on rat 5-ht neurotransmission. |
1999-11-22 |
2023-08-12 |
rat |
| N Haddjeri, C Ortemann, C de Montigny, P Blie. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 5. 1999-11-22. PMID:10523050. |
this recovery of firing was associated with a 3-fold shift to the right of the dose-response curve of the effect of the 5-ht autoreceptor agonist lysergic acid diethylamide on the firing activity of 5-ht neurons, indicating a desensitization of somatodendritic 5-ht1a autoreceptors. |
1999-11-22 |
2023-08-12 |
rat |
| N Haddjeri, C Ortemann, C de Montigny, P Blie. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 5. 1999-11-22. PMID:10523050. |
at the postsynaptic level, long-term treatment with flesinoxan (5 mg/kg/day x 14 days) did not modify the responsiveness of dorsal hippocampus ca3 pyramidal neurons to microiontophoretic applications of 5-ht and flesinoxan nor to endogenous 5-ht released by the electrical stimulation of the ascending 5-ht pathway, indicating an unchanged sensitivity of postsynaptic 5-ht1a receptors. |
1999-11-22 |
2023-08-12 |
rat |
| N Haddjeri, C Ortemann, C de Montigny, P Blie. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 5. 1999-11-22. PMID:10523050. |
in conclusion, as for selective 5-ht re-uptake inhibitors, monoamine oxidase inhibitors and 5-ht1a receptor agonists, flesinoxan produced most of the adaptive changes exerted by these antidepressant drugs on the 5-ht system. |
1999-11-22 |
2023-08-12 |
rat |
| E J Homan, H V Wikström, C J Gro. Molecular modeling of the dopamine D2 and serotonin 5-HT1A receptor binding modes of the enantiomers of 5-OMe-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 9. 1999-11-18. PMID:10530928. |
molecular modeling of the dopamine d2 and serotonin 5-ht1a receptor binding modes of the enantiomers of 5-ome-bpat. |
1999-11-18 |
2023-08-12 |
Not clear |
| E J Homan, H V Wikström, C J Gro. Molecular modeling of the dopamine D2 and serotonin 5-HT1A receptor binding modes of the enantiomers of 5-OMe-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 9. 1999-11-18. PMID:10530928. |
molecular modeling studies were undertaken in order to elucidate the possible dopamine d2 and serotonin 5-ht1a receptor binding modes of the enantiomers of 5-methoxy-2-[n-(2-benzamidoethyl)-n-n-propylamino]tetralin (5-ome-bpat, 1). |
1999-11-18 |
2023-08-12 |
Not clear |