| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E J Homan, H V Wikström, C J Gro. Molecular modeling of the dopamine D2 and serotonin 5-HT1A receptor binding modes of the enantiomers of 5-OMe-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 9. 1999-11-18. PMID:10530928. |
similarly, the selective serotonin 5-ht1a receptor agonist flesinoxan was employed for identifying the serotonin 5-ht1a receptor binding conformations of the enantiomers of 1. |
1999-11-18 |
2023-08-12 |
Not clear |
| E J Homan, H V Wikström, C J Gro. Molecular modeling of the dopamine D2 and serotonin 5-HT1A receptor binding modes of the enantiomers of 5-OMe-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 9. 1999-11-18. PMID:10530928. |
in the serotonin 5-ht1a receptor model, the benzamide phenyl rings of both enantiomers were involved in hydrophobic face-to-face interactions with phe112 in tm3, while their protonated nitrogen atoms formed a reinforced electrostatic interaction with asp116 in tm3. |
1999-11-18 |
2023-08-12 |
Not clear |
| E J Homan, H V Wikström, C J Gro. Molecular modeling of the dopamine D2 and serotonin 5-HT1A receptor binding modes of the enantiomers of 5-OMe-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 9. 1999-11-18. PMID:10530928. |
both enantiomers of 1 could form a hydrogen bond between their 5-methoxy substituent and thr200 in tm5, which may account for their full serotonin 5-ht1a receptor agonist properties. |
1999-11-18 |
2023-08-12 |
Not clear |
| S Ahlenius, K Larsso. Synergistic actions of the 5-HT1A receptor antagonist WAY-100635 and citalopram on male rat ejaculatory behavior. European journal of pharmacology. vol 379. issue 1. 1999-11-15. PMID:10499366. |
the selective serotonin re-uptake inhibitor citalopram (0-40 mg kg(-1), s.c., - 60 min) did not affect the male rat ejaculatory behavior, and there were no statistically significant effects of the 5-ht1a receptor antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexane carboxamide 3hcl (way-100635) (0.04-0.08 mg kg(-1), s.c., - 30 min). |
1999-11-15 |
2023-08-12 |
rat |
| S Ahlenius, K Larsso. Synergistic actions of the 5-HT1A receptor antagonist WAY-100635 and citalopram on male rat ejaculatory behavior. European journal of pharmacology. vol 379. issue 1. 1999-11-15. PMID:10499366. |
it is suggested that blockade of inhibitory 5-ht1a autoreceptors discloses inhibitory effects of the selective serotonin re-uptake inhibitor citalopram on male rat ejaculatory behavior mediated via stimulation of 5-ht1b receptors. |
1999-11-15 |
2023-08-12 |
rat |
| A Sparatore, M Goegan, A Cagnotto, F Sparator. 2-[4-[3-(4-aryl/heteroaryl-1-piperazinyl)propoxy]phenyl]-2H- benzotriazoles and their N-oxides as ligands for serotonin and dopamine receptors. Farmaco (Societa chimica italiana : 1989). vol 54. issue 6. 1999-11-10. PMID:10443019. |
the synthesized compounds were able to bind on some serotonin (5-ht1a, 5-ht2a) and dopamine (d2, d3) receptors, while displaying poor or no affinity for 5-ht1b, 5-ht2c, 5-ht3, and 5-ht4 subtypes. |
1999-11-10 |
2023-08-12 |
mouse |
| S Herges, D A Taylo. Modulation of cocaine-induced locomotor activity, rears and head bobs by application of WAY100635 into the dorsal and median raphe nuclei of the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494881. |
it may be suggested from these results that stimulation of somatodendritic 5-ht1a autoreceptors located in the dorsal raphe nucleus mediates an inhibitory effect on cocaine-induced locomotor activity and head bobs, whereas somatodendritic 5-ht1a autoreceptors in the median raphe nucleus are not involved in the inhibitory role of 5-ht on the stimulant effect of cocaine on locomotor activity and head bobs. |
1999-11-08 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
recent studies have demonstrated that antagonism of somatodendritic serotonin1a (5-ht1a) autoreceptors can potentiate the increase of extracellular 5-ht concentrations induced by selective serotonin reuptake inhibitors including fluoxetine. |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
the present study was conducted to uncover any functional difference between the 5-ht1a autoreceptors located on the cell bodies of 5-ht neurons in the dorsal (drn) and median (mrn) raphe nuclei. |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
however, an antagonist of 5-ht1a receptors, way100635, subsequently injected (s.c.) at 1 mg/kg brought the 5-ht concentrations to similar levels in the pfc (332%) and dhp (308%). |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
in conclusion, the present study demonstrated that the antagonist of 5-ht1a receptors, way100635, produced a more robust potentiation in the fluoxetine-induced 5-ht increases in the pfc than dhp. |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
since pfc and dhp are predominately innervated by 5-ht neurons located in the drn and mrn respectively, this result may indicate a functional difference between the 5-ht1a autoreceptors located on the cell bodies of 5-ht neurons in the drn and mrn. |
1999-11-02 |
2023-08-12 |
rat |
| C A Fornal, F J Martín, A Mendlin, C W Metzler, B Bjorvatn, B L Jacob. Pindolol increases extracellular 5-HT while inhibiting serotonergic neuronal activity. European journal of pharmacology. vol 377. issue 2-3. 1999-10-27. PMID:10456429. |
the subsequent administration of way-100635 [n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)cycloh exanecarboxamide] (0.2 mg/kg, s.c.), a selective 5-ht1a receptor antagonist, blocked pindolol-induced neuronal suppression and potentiated 5-ht output. |
1999-10-27 |
2023-08-12 |
Not clear |
| L L Murphy, B A Adrian, M Kohl. Inhibition of luteinizing hormone secretion by delta9-tetrahydrocannabinol in the ovariectomized rat: effect of pretreatment with neurotransmitter or neuropeptide receptor antagonists. Steroids. vol 64. issue 9. 1999-10-26. PMID:10503726. |
furthermore, the ability of a relatively nonspecific serotonin 5-ht(1a/1b) receptor antagonist pindolol (4 mg/kg, s.c.) or the specific 5-ht1a receptor antagonist way-100635 (1 mg/kg, s.c.) to significantly attenuate thc-induced lh suppression indicates that activation of serotonergic 5-ht1a receptors may be an important mode by which thc causes inhibition of lh release in the ovariectomized rat. |
1999-10-26 |
2023-08-12 |
rat |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
enhancement of 5-ht1b and 5-ht1d receptor antagonist effects on extracellular 5-ht levels in the guinea-pig brain following concurrent 5-ht1a or 5-ht re-uptake site blockade. |
1999-10-25 |
2023-08-12 |
Not clear |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
the effects of selective serotonin re-uptake inhibitor (ssri), paroxetine, and 5-ht1a, 5-ht1b and 5-ht1b/1d receptor antagonists on in vivo extracellular 5-ht levels in the guinea-pig frontal cortex and dorsal hippocampus were investigated using the technique of microdialysis. |
1999-10-25 |
2023-08-12 |
Not clear |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
in the dorsal hippocampus, whilst 5-ht1a receptor antagonism elicited by administration of way 100635 had no effect, both 5-ht1b and mixed 5-ht1b/1d receptor blockade significantly increased extracellular 5-ht levels. |
1999-10-25 |
2023-08-12 |
Not clear |
| P F Ferrari, S Lowther, H Tidbury, P Greengrass, C A Wilson, R W Horto. The influence of gender and age on neonatal rat hypothalamic 5-HT1A and 5-HT2A receptors. Cellular and molecular neurobiology. vol 19. issue 6. 1999-10-21. PMID:10456237. |
the results suggest that the sexual dimorphism in 5-ht turnover is predominantly presynaptic, relating to altered synthesis and/or release, and is not of sufficient magnitude or duration to produce adaptive responses in postsynaptic 5-ht1a or 5-ht2a receptors. |
1999-10-21 |
2023-08-12 |
rat |
| J R Raymond, Y V Mukhin, T W Gettys, M N Garnovskay. The recombinant 5-HT1A receptor: G protein coupling and signalling pathways. British journal of pharmacology. vol 127. issue 8. 1999-10-21. PMID:10482904. |
the 5-hydroxytryptamine 5-ht1a receptor was one of the first g protein coupled receptors whose cdna and gene were isolated by molecular cloning methods. |
1999-10-21 |
2023-08-12 |
Not clear |
| S Koyama, C Kubo, J S Rhee, N Akaik. Presynaptic serotonergic inhibition of GABAergic synaptic transmission in mechanically dissociated rat basolateral amygdala neurons. The Journal of physiology. vol 518 ( Pt 2). 1999-10-20. PMID:10381597. |
we conclude that 5-ht inhibits gabaergic mipscs by inactivating the ac-camp signal transduction pathway via a g-protein-coupled 5-ht1a receptor and this intracellular pathway directly acts on the gaba-releasing process independent of k+ and ca2+ channels in the presynaptic nerve terminals. |
1999-10-20 |
2023-08-12 |
rat |