| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology. 2022-09-28. PMID:36168076. |
several 5-ht receptor subtypes have been confirmed to be associated with nociception in the spinal cord, such as 5-ht1a receptor, 5-ht1b receptor, 5-ht2 receptor, 5-ht3 receptor, and 5-ht7 receptor. |
2022-09-28 |
2023-08-14 |
rat |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. Vascular pharmacology. vol 72. 2016-05-19. PMID:26003124. |
bolus of agonists α-methyl-5-ht (5-ht2), 1-pbg (5-ht3), cisapride (5-ht4), as-19 (5-ht7), cgs-12066b (5-ht1b) or 8-oh-dpat (5-ht1a) (0.0125μg/kg each). |
2016-05-19 |
2023-08-13 |
rat |
| Moe Igari, Hao-Wei Shen, Yoko Hagino, Setsu Fukushima, Yoshiyuki Kasahara, Klaus-Peter Lesch, Dennis L Murphy, Frank Scott Hall, George R Uhl, Kazutaka Ikeda, Nobuo Yaegashi, Ichiro Sor. Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25485646. |
the present experiments examined serotonergic roles in meth-induced locomotor sensitization by assessing: (a) the effect of serotonin transporter (sert; slc6a4) knockout (ko) on meth-induced locomotor sensitization; (b) extracellular monoamine levels in meth-treated animals as determined by in-vivo microdialysis; and (c) effects of serotonin (5-ht) receptor antagonists on meth-induced behavioral sensitization, with focus on effects of the 5-ht1b receptor antagonist sb 216641 and a comparison with the 5-ht2 receptor antagonist ketanserin. |
2015-09-03 |
2023-08-13 |
mouse |
| Yumi Sugimoto, Sachiko Furutani, Katsumi Nishimura, Atsuko Itoh, Takao Tanahashi, Hiroshi Nakajima, Hideo Oshiro, Shujian Sun, Jun Yamad. Antidepressant-like effects of neferine in the forced swimming test involve the serotonin1A (5-HT1A) receptor in mice. European journal of pharmacology. vol 634. issue 1-3. 2010-11-01. PMID:20176013. |
however, the 5-ht1b receptor antagonist, 3-[3-(dimethylamino)propyl]-4-hydroxy-n-[4-(4-pyridinyl)phenyl] benzamide dihydrochloride (gr 55562), the 5-ht2 receptor antagonist, 6-methyl-1-(methylethyl)-ergoline-8beta-carboxylic acid 2-hydroxy-1-methylpropyl ester (ly 53857), the 5-ht3 receptor antagonist, ondansetron and the 5-ht4 receptor antagonist, 4-amino-5-chloro-2-methoxy-benzoic acid 2-(diethylamino)ethyl ester (sdz 205,557) did not affect the anti-immobility effects of neferine. |
2010-11-01 |
2023-08-12 |
mouse |
| Araceli Sánchez-López, David Centurión, Jair Lozano-Cuenca, Enriqueta Muñoz-Islas, Luis E Cobos-Puc, Carlos M Villaló. [Role of serotonin receptors in vascular tone in the pithed rat]. Archivos de cardiologia de Mexico. vol 79 Suppl 2. 2010-06-03. PMID:20361490. |
thus, 5-ht-induced sympatho-inhibition has been shown to be: (i) unaffected by physiological saline or by the selective antagonists ritanserin (5-ht2), mdl72222 (5-ht3) or tropisetron (5-ht3/4); (ii) blocked by methysergide, a non-selective 5-ht1/2 receptor antagonist; and (iii) potently mimicked by 5-carboxamidotryptamine (5-ct), a non-selective 5-ht1 receptor agonist, as well as by the selective agonists 8-oh-dpat (5-ht1a), indorenate (5-ht1a), cp93,129 (5-ht1b), and sumatriptan (5-ht1b/1d). |
2010-06-03 |
2023-08-12 |
rat |
| E Calama, A V Ortíz de Urbina, A Morán, M L Martín, L San Romá. Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat. Clinical and experimental pharmacology & physiology. vol 32. issue 10. 2006-01-05. PMID:16173953. |
the effects of 5-ht were mimicked by 5-carboxamidotryptamine (a 5-ht1 receptor agonist) and l-694 247 (a selective 5-ht1d receptor agonist), but not by 8-hydroxy-2-dipropylaminotetralin (a 5-ht1a receptor agonist), cgs-12066b (a 5-ht1b receptor agonist), alpha-methyl-5-ht (a 5-ht2 receptor agonist), 1-(3-chlorophenyl) piperazine (a 5-ht2c receptor agonist) or 1-phenylbiguanide (a 5-ht3 receptor agonist). |
2006-01-05 |
2023-08-12 |
rat |
| Mounira Banasr, Micheline Hery, Richard Printemps, Annie Daszut. Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 3. 2004-04-14. PMID:14872203. |
the 5-ht1a, 5-ht1b, and 5-ht2 receptor subtypes were chosen for their implication in depression and their location in/or next to these regions. |
2004-04-14 |
2023-08-12 |
Not clear |
| A M S Kindlundh, J Lindblom, L Bergström, F Nyber. The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain. Neuroscience. vol 119. issue 1. 2003-07-28. PMID:12763073. |
the anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5ht1b and 5ht2 receptors in the male rat brain. |
2003-07-28 |
2023-08-12 |
rat |
| Gurpreet Kaur, Shrinivas K Kulkarn. Studies on modulation of feeding behavior by atypical antipsychotics in female mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 2. 2002-07-22. PMID:11817504. |
further, clozapine-induced hyperphagia was significantly (p<.05) reversed after treatment with skf 38393 (dopamine d1 agonist), quinpirole (dopamine d2 agonist) and quipazine (5-ht1b, 5-ht2 and 5-ht3 agonist). |
2002-07-22 |
2023-08-12 |
mouse |
| D Centurión, A Sánchez-López, M I Ortiz, P De Vries, P R Saxena, C M Villaló. Mediation of 5-HT-induced internal carotid vasodilatation in GR127935- and ritanserin-pretreated dogs by 5-HT7 receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 2. 2001-02-02. PMID:10961380. |
the vasoconstrictor effects of 5-hydroxytryptamine (5-ht) in the internal carotid bed of anaesthetised dogs with bilateral vagosympathectomy are mainly mediated by both 5-ht1b and 5-ht2 receptors. |
2001-02-02 |
2023-08-12 |
Not clear |
| T Gnecchi-Ruscone, X Bernard, P Pierre, D Anderson, N Legg, H Enahoro, P D Winter, A Crisp, J A Melin, P G Camic. Effect of naratriptan on myocardial blood flow and coronary vasodilator reserve in migraineurs. Neurology. vol 55. issue 1. 2000-08-07. PMID:10891912. |
the selective 5ht1b/1d agonist naratriptan has no significant activity at 5ht2 receptors; however, like all 5ht1b/1d agonists developed for the acute treatment of migraine, naratriptan could potentially constrict coronary arteries by activation of 5ht1b receptors. |
2000-08-07 |
2023-08-12 |
Not clear |
| D G Rainni. Serotonergic modulation of neurotransmission in the rat basolateral amygdala. Journal of neurophysiology. vol 82. issue 1. 1999-08-10. PMID:10400936. |
the effect of 5-ht was mimicked by the 5-ht2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-ht), but not by the 5-ht1a receptor agonist, (+/-) 8-hydroxydipropylaminotetralin hydrobromide (8-oh-dpat), or the 5-ht1b agonist, cgs 12066a. |
1999-08-10 |
2023-08-12 |
rat |
| A W Wilson, J C Neill, B Costal. An investigation into the effects of 5-HT agonists and receptor antagonists on ethanol self-administration in the rat. Alcohol (Fayetteville, N.Y.). vol 16. issue 3. 1999-05-24. PMID:9744857. |
these results demonstrate that, under the present experimental conditions, activation of central 5-ht1a, 5-ht1b, and 5-ht2 receptors reduced ethanol intake and reinforced behaviour in an operant paradigm. |
1999-05-24 |
2023-08-12 |
rat |
| J Watson, S Brough, M C Coldwell, T Gager, M Ho, A J Hunter, J Jerman, D N Middlemiss, G J Riley, A M Brow. Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 125. issue 7. 1999-04-01. PMID:9884068. |
these studies indicate that xanomeline is a potent agonist at 5-ht1a and 5-ht1b receptors and an antagonist at 5-ht2 receptor subtypes. |
1999-04-01 |
2023-08-12 |
human |
| J Yamada, Y Sugimoto, T Noma, T Yoshikaw. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. European journal of pharmacology. vol 359. issue 1. 1999-02-08. PMID:9831297. |
these results indicate that 5-ct-induced hyperglycemia is elicited by facilitation of adrenaline release from the adrenal gland and that 5-ct-induced hyperglycemia is mediated by the 5-ht7 receptor unrelated to 5-ht1a, 5-ht1b, 5-ht2, 5-ht3, 5-ht4 or 5-ht5 receptors. |
1999-02-08 |
2023-08-12 |
rat |
| J S Silvestre, J M Palacios, A G Fernandez, M F O'Neil. Comparison of effects of a range of 5-HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats. Journal of psychopharmacology (Oxford, England). vol 12. issue 2. 1998-11-06. PMID:9694030. |
non-specific reductions in fluid consumption were induced by the 5-ht1b agonist ru 24969 (0.1-1.0mg/kg) and the 5-ht2 antagonist ritanserin (1.0-6.0 mg/kg). |
1998-11-06 |
2023-08-12 |
rat |
| J S Silvestre, J M Palacios, A G Fernandez, M F O'Neil. Comparison of effects of a range of 5-HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats. Journal of psychopharmacology (Oxford, England). vol 12. issue 2. 1998-11-06. PMID:9694030. |
these studies thus confirm the potential for decreasing ethanol consumption and ethanol preference of 5-ht1a agonists and 5-ht3 antagonists, but failed to find any selective effects for agents acting at 5-ht1b or 5-ht2 receptors. |
1998-11-06 |
2023-08-12 |
rat |
| B J Keck, J M Lakosk. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) administration for studies of 5-HT1A receptor binding site inactivation and turnover. Brain research. Brain research protocols. vol 1. issue 4. 1997-12-10. PMID:9384817. |
while age-related declines in the number of 5-ht1b and 5-ht2 receptors have been reported, little information is available describing the region-specific effects of aging on the functional dynamics of equilibrium binding at 5-ht receptors, including the 5-ht1a receptor subtype. |
1997-12-10 |
2023-08-12 |
human |
| M L Mamede Rosa, W A Prad. Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat. Brain research. vol 757. issue 1. 1997-08-12. PMID:9200507. |
the 5-ht1 agonist 5-carboxamidotryptamine (19 and 38 nanomol) and the 5-ht1b agonist, cgs 12066b (1.12 and 2.24 nanomol), but not the non-selective 5-ht agonist m-cpp (41 to 164 nanomol), 5-ht2 agonist alpha-methylserotonin (36 and 72 nanomol) and 5-ht3 agonist 2-methylserotonin (36 and 72 nanomol), produced a dose-dependent antinociceptive effect. |
1997-08-12 |
2023-08-12 |
rat |
| I M Stanford, M G Lace. Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 23. 1997-01-06. PMID:8922413. |
this inward current was blocked by the 5-ht2 receptor antagonist ritanserin, whereas the ipsc depression was blocked by the 5-ht1b receptor antagonist pindolol. |
1997-01-06 |
2023-08-12 |
rat |