| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Apeksha Parajulee, Kuglae Ki. Structural studies of serotonin receptor family. BMB reports. 2023-10-11. PMID:37817438. |
the functions of serotonin are mediated by a family of 5-ht receptors including 12 gpcrs belonging to six major families: 5-ht1, 5-ht2, 5-ht4, 5-ht5, 5-ht6 and 5-ht7. |
2023-10-11 |
2023-10-15 |
Not clear |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology. 2022-09-28. PMID:36168076. |
several 5-ht receptor subtypes have been confirmed to be associated with nociception in the spinal cord, such as 5-ht1a receptor, 5-ht1b receptor, 5-ht2 receptor, 5-ht3 receptor, and 5-ht7 receptor. |
2022-09-28 |
2023-08-14 |
rat |
| Qian Qian Liu, Xiao Xiao Yao, Shuo Hui Gao, Rui Li, Bing Jin Li, Wei Yang, Ran Ji Cu. Role of 5-HT receptors in neuropathic pain: potential therapeutic implications. Pharmacological research. vol 159. 2021-07-05. PMID:32464329. |
therefore, we summarized the recent findings on multiple subtypes of 5-ht receptors in both central and peripheral nervous system in neuropathic pain, particularly, 5-ht1, 5-ht2, 5-ht3 and 5-ht7 receptors. |
2021-07-05 |
2023-08-13 |
Not clear |
| Miguel A Núñez-Ochoa, Gustavo A Chiprés-Tinajero, Laura Medina-Cej. Evaluation of the hippocampal immunoreactivity of the serotonin 5-HT1A, 5-HT2 and 5-HT7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470771. |
evaluation of the hippocampal immunoreactivity of the serotonin 5-ht1a, 5-ht2 and 5-ht7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. |
2021-06-18 |
2023-08-13 |
rat |
| Miguel A Núñez-Ochoa, Gustavo A Chiprés-Tinajero, Laura Medina-Cej. Evaluation of the hippocampal immunoreactivity of the serotonin 5-HT1A, 5-HT2 and 5-HT7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470771. |
therefore, to gather more details about the state of the serotoninergic system in the hippocampus under an epileptogenic process, we studied the immunoreactivity of three 5-ht receptors (5-ht1a, 5-ht2 and 5-ht7) as well as the extracellular levels of 5-ht in the hippocampal tissue of epileptic rats with fr. |
2021-06-18 |
2023-08-13 |
rat |
| Jose Luis Cortes-Altamirano, Adriana Olmos-Hernandez, Herlinda Bonilla Jaime, Paul Carrillo-Mora, Cindy Bandala, Samuel Reyes-Long, Alfonso Alfaro-Rodrígue. Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role in the Modulation of Pain Response in the Central Nervous System. Current neuropharmacology. vol 16. issue 2. 2018-10-01. PMID:28901281. |
on the other hand, several researches reported that serotonin modulates nociceptive response through 5-ht1, 5-ht2, 5-ht3, and 5-ht7 receptors in the central nervous system (cns). |
2018-10-01 |
2023-08-13 |
Not clear |
| R Forcén, E Latorre, J Pardo, A I Alcalde, M D Murillo, L Gras. Toll-like receptors 2 and 4 exert opposite effects on the contractile response induced by serotonin in mouse colon: role of serotonin receptors. Experimental physiology. vol 101. issue 8. 2018-01-01. PMID:27282784. |
in wt, tlr2(-/-) and tlr2/4 dko mice, 5-ht2 , 5-ht3 , 5-ht4 and 5-ht7 receptor antagonists reduced or blocked the contractile response evoked by 5-ht. |
2018-01-01 |
2023-08-13 |
mouse |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morá. Chronic Sarpogrelate Treatment Reveals 5-HT7 Receptor in the Serotonergic Inhibition of the Rat Vagal Bradycardia. Journal of cardiovascular pharmacology. vol 69. issue 1. 2017-11-27. PMID:27676327. |
our outcomes suggest that blocking chronically 5-ht2 receptors modifies the serotonergic influence on cardiac vagal neurotransmission exhibiting 5-ht as an exclusively inhibitory agent via prejunctional 5-ht7 receptor. |
2017-11-27 |
2023-08-13 |
rat |
| Karolina Pytka, Anna Partyka, Magdalena Jastrzębska-Więsek, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Grzegorz Kazek, Anna Rapacz, Adrian Olczyk, Adam Gałuszka, Marian Błachuta, Anna Waszkielewicz, Henryk Marona, Jacek Sapa, Barbara Filipek, Anna Wesołowsk. Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models. PloS one. vol 10. issue 11. 2016-06-13. PMID:26554929. |
our results indicate that hbk-14 and hbk-15 possess high or moderate affinity for serotonergic 5-ht2, adrenergic α1, and dopaminergic d2 receptors as well as being full 5-ht1a and 5-ht7 receptor antagonists. |
2016-06-13 |
2023-08-13 |
mouse |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. Vascular pharmacology. vol 72. 2016-05-19. PMID:26003124. |
bolus of agonists α-methyl-5-ht (5-ht2), 1-pbg (5-ht3), cisapride (5-ht4), as-19 (5-ht7), cgs-12066b (5-ht1b) or 8-oh-dpat (5-ht1a) (0.0125μg/kg each). |
2016-05-19 |
2023-08-13 |
rat |
| Yunpeng Du, Megan Cramer, Chieh Allen Lee, Jie Tang, Arivalagan Muthusamy, David A Antonetti, Hui Jin, Krzysztof Palczewski, Timothy S Ker. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25667222. |
this response was reduced or ablated by pharmacologic inhibition of the α1-ar (a gq-coupled receptor) or gs-coupled serotonin (5-ht2, 5-ht4, 5-ht6, and 5-ht7) receptors or by activation of the gi-coupled α2-ar. |
2015-07-30 |
2023-08-13 |
mouse |
| Takehiro Nakamura, Tetsuya Ikeda, Ryuichiro Takeda, Kaori Igawa, Rumi Naono-Nakayama, Sumio Sakoda, Toshikazu Nishimori, Yasushi Ishid. The role of spinal serotonin receptor and alpha adrenoceptor on the antiallodynic effects induced by intrathecal milnacipran in chronic constriction injury rats. European journal of pharmacology. vol 738. 2015-04-06. PMID:24876059. |
thus, we examined the effects of prazosin as an α1 adrenoceptor antagonist, yohimbine as an α2 adrenoceptor antagonist, metergoline as a 5-ht1, 5-ht2 and 5-ht7 receptor antagonist, cyanopindolol as a 5-ht1a/1b receptor antagonist, ketanserin as a 5-ht2 receptor antagonist, and ondansetoron as a 5-ht3 receptor antagonist on the antiallodynic effect of milnacipran in neuropathic rats with chronic constriction injury (cci). |
2015-04-06 |
2023-08-13 |
rat |
| Urszula Sławińska, Krzysztof Miazga, Larry M Jorda. The role of serotonin in the control of locomotor movements and strategies for restoring locomotion after spinal cord injury. Acta neurobiologiae experimentalis. vol 74. issue 2. 2015-04-06. PMID:24993627. |
specifically, using defined serotonergic agonists the 5-ht2 receptors can be stimulated to control cpg activation as well as motoneuron output, while 5-ht7 receptors to control activity of the locomotor cpg. |
2015-04-06 |
2023-08-13 |
rat |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Luis San Román, Asunción Morá. The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats. European journal of pharmacology. vol 731. 2014-12-03. PMID:24675150. |
we have demonstrated that the antagonism of 5-ht2 receptors produces an enhancement of serotonergic sympathoinhibitory effect by 5-ht1d and 5-ht7 activation. |
2014-12-03 |
2023-08-12 |
rat |
| Naoki Hiramatsu, Yukio Ago, Shigeru Hasebe, Akira Nishimura, Kazuya Mori, Kazuhiro Takuma, Toshio Matsud. Synergistic effect of 5-HT1A and σ1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency. Neuropharmacology. vol 75. 2014-08-19. PMID:23851260. |
this enhancement of da release was blocked by way100635 (a 5-ht1a receptor antagonist), but not by ritanserin (a 5-ht2 receptor antagonist), azasetron (a 5-ht3 receptor antagonist) or sb269970 (a 5-ht7 receptor antagonist). |
2014-08-19 |
2023-08-12 |
mouse |
| W J Xu, Y Zhao, F Q Huo, J Q Du, J S Tan. Involvement of ventrolateral orbital cortex 5-HT 1-7 receptors in 5-HT induced depression of spared nerve injury allodynia. Neuroscience. vol 238. 2013-10-17. PMID:23485814. |
the present study examined the roles of ventrolateral orbital cortex (vlo) 5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht5, 5-ht6 and 5-ht7 receptor subtypes in mediating 5-ht-induced antiallodynic actions in the rat spared nerve injury (sni) pain model. |
2013-10-17 |
2023-08-12 |
rat |
| W J Xu, Y Zhao, F Q Huo, J Q Du, J S Tan. Involvement of ventrolateral orbital cortex 5-HT 1-7 receptors in 5-HT induced depression of spared nerve injury allodynia. Neuroscience. vol 238. 2013-10-17. PMID:23485814. |
microinjection of selective 5-ht1a, 5-ht2, 5-ht3, 5-ht4, 5-ht5a, 5-ht6 and 5-ht7 receptor antagonists, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190) (10μg), cyproheptadine (50ng), granisetron hydrochloride (granisetron) (10μg), 1-[2-[(methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl1-methyl-1h-indole-3-carboxylate (gr113808) (5μg), sb699551 dihydrochloride (sb699551) (10μg), sb258585 dihydrochloride (sb258585) (2μg) or sb269970 hydrochloride (sb269970) (10μg) into the vlo 5-min prior to 5-ht (10μg) injection, all antagonized the 5-ht-induced inhibition of allodynia. |
2013-10-17 |
2023-08-12 |
rat |
| Arnaud Goolaerts, Jérémie Roux, Michael T Ganter, Vadim Shlyonsky, Ahmed Chraibi, Renauld Stéphane, Frédérique Mies, Michael A Matthay, Robert Naeije, Sarah Sariban-Sohraby, Marybeth Howard, Jean-Francois Pitte. Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel. American journal of respiratory cell and molecular biology. vol 43. issue 1. 2010-07-15. PMID:19717814. |
in addition, the stimulation of 5-ht1r (5-ht receptor 1), 5-ht2r (5-ht receptor 2), 5-ht4r (5-ht receptor 4), and 5-ht7r (5-ht receptor 7) failed to reproduce the 5-ht effect on amiloride-sensitive sodium transport. |
2010-07-15 |
2023-08-12 |
mouse |
| T B Nucci, L G S Branco, L H Gargaglion. 5-HT1A, but not 5-HT2 and 5-HT7, receptors in the nucleus raphe magnus modulate hypoxia-induced hyperpnoea. Acta physiologica (Oxford, England). vol 193. issue 4. 2008-08-20. PMID:18363900. |
5-ht1a, but not 5-ht2 and 5-ht7, receptors in the nucleus raphe magnus modulate hypoxia-induced hyperpnoea. |
2008-08-20 |
2023-08-12 |
Not clear |
| Anna Moskwa, Patrycja Boznańsk. [Role of serotonin in the pathophysiology of the irritable bowel syndrome]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 7-8. 2008-02-08. PMID:18175558. |
serotonin is secreted by enterochromaffin (ec) cells and acts on receptors located on smooth muscles, enterocytes and nerves (5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht7). |
2008-02-08 |
2023-08-12 |
Not clear |