| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tahira Perveen, Roomana Rafiq, Saida Haider, Darakhshan J Halee. Increased serotonergic functions following adminstration of 1-(1-naphthyl) piperazine in propranolol injected rats. Pakistan journal of pharmaceutical sciences. vol 19. issue 3. 2006-10-19. PMID:16935825. |
1-(1-naphthyl) piperazine (1-np) a derivative of quipazine has serotonin antagonist activity at 5-ht2 and agonist activity at 5-ht1 site. |
2006-10-19 |
2023-08-12 |
rat |
| P J Harvey, X Li, Y Li, D J Bennet. 5-HT2 receptor activation facilitates a persistent sodium current and repetitive firing in spinal motoneurons of rats with and without chronic spinal cord injury. Journal of neurophysiology. vol 96. issue 3. 2006-10-06. PMID:16707714. |
in motoneurons from acute spinal rats, moderately high doses of 5-ht (> or = 10 microm), or the 5-ht2 receptor agonist doi (> or = 30 microm), significantly increased the total pic, hyperpolarized the pic onset voltage, and hyperpolarized the spike threshold, whereas lower doses had no effect. |
2006-10-06 |
2023-08-12 |
rat |
| P J Harvey, X Li, Y Li, D J Bennet. 5-HT2 receptor activation facilitates a persistent sodium current and repetitive firing in spinal motoneurons of rats with and without chronic spinal cord injury. Journal of neurophysiology. vol 96. issue 3. 2006-10-06. PMID:16707714. |
therefore 5-ht2 receptor activation facilitated the na pic, whereas other 5-ht receptors modulated vm and rm. |
2006-10-06 |
2023-08-12 |
rat |
| Pierre Brown, Charles R Gerfe. Plasticity within striatal direct pathway neurons after neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-HT2 receptors to the ERK 1/2 map kinase pathway. The Journal of comparative neurology. vol 498. issue 3. 2006-10-03. PMID:16871540. |
plasticity within striatal direct pathway neurons after neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-ht2 receptors to the erk 1/2 map kinase pathway. |
2006-10-03 |
2023-08-12 |
Not clear |
| Pierre Brown, Charles R Gerfe. Plasticity within striatal direct pathway neurons after neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-HT2 receptors to the ERK 1/2 map kinase pathway. The Journal of comparative neurology. vol 498. issue 3. 2006-10-03. PMID:16871540. |
chloroamphetamine-induced 5-ht release or direct stimulation of striatal 5-ht2 receptors via the 5-ht2 agonist doi, produced robust erk1/2 phosphorylation throughout the dorsal striatum of neonatal lesioned animals, a response not observed within the intact striatum. |
2006-10-03 |
2023-08-12 |
Not clear |
| Luciane H Gargaglioni, Kênia C Bícego, Tatiane B Nucci, Luiz G S Branc. Serotoninergic receptors in the anteroventral preoptic region modulate the hypoxic ventilatory response. Respiratory physiology & neurobiology. vol 153. issue 1. 2006-09-29. PMID:16310416. |
once 5-ht is involved in the hypoxic ventilatory response (hvr), we investigated the participation of the 5-ht receptors (5-ht1, 5-ht2 and 5-ht7) in the avpo in the hvr. |
2006-09-29 |
2023-08-12 |
rat |
| Hyun-Sok Kim, Hyun-Jong Jang, Kwang-Hyun Cho, Sang June Hahn, Myung-Jun Kim, Shin Hee Yoon, Yang-Hyeok Jo, Myung-Suk Kim, Duck-Joo Rhi. Serotonin inhibits the induction of NMDA receptor-dependent long-term potentiation in the rat primary visual cortex. Brain research. vol 1103. issue 1. 2006-09-28. PMID:16784733. |
based on these findings, we conclude that nmdar-dependent ltp is specifically inhibited by coactivation of 5-ht1a and 5-ht2 receptors with the increase in 5-ht levels in the rat visual cortex at the end of the critical period. |
2006-09-28 |
2023-08-12 |
rat |
| George K Papadimas, Konstantinos N Tzirogiannis, Georgios I Panoutsopoulos, Maria D Demonakou, Spyridon D Skaltsas, Rosa I Hereti, Zeta Papadopoulou-Daifoti, Michael G Mykoniati. Effect of serotonin receptor 2 blockage on liver regeneration after partial hepatectomy in the rat liver. Liver international : official journal of the International Association for the Study of the Liver. vol 26. issue 3. 2006-09-22. PMID:16584399. |
the effect of serotonin receptor 2 blockade (5-ht(2)) on liver regeneration after 30-34% and 60-70% partial hepatectomy in the rat liver was investigated. |
2006-09-22 |
2023-08-12 |
rat |
| Reuven Sandy. Serotonergic mechanisms in amyotrophic lateral sclerosis. The International journal of neuroscience. vol 116. issue 7. 2006-09-05. PMID:16861147. |
in fact, 5ht1a and 5ht2 receptor agonists have been shown to prevent glutamate-induced neurotoxicity in primary cortical cell cultures and the 5-ht precursor 5-hydroxytryptophan (5-htp) improved locomotor function and survival of transgenic sod1 g93a mice, an animal model of als. |
2006-09-05 |
2023-08-12 |
mouse |
| S Delion, S Chalon, J Hérault, D Guilloteau, J C Besnard, G Duran. Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. The Journal of nutrition. vol 124. issue 12. 2006-08-03. PMID:16856329. |
long-term feeding of the (n-3)-deficient diet induced a significantly higher 5-ht2 receptor density in the frontal cortex compared with the control rats without any difference in the endogenous serotonin concentrations. |
2006-08-03 |
2023-08-12 |
rat |
| Sharon Rosenzweig-Lipson, Jean Zhang, Hossein Mazandarani, Boyd L Harrison, Annmarie Sabb, Joan Sabalski, Gary Stack, Greg Welmaker, James E Barrett, John Dunlo. Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503. Brain research. vol 1073-1074. 2006-07-19. PMID:16430874. |
way-161503 ((4ar)-8,9-dichloro-2,3,4,4a-tetrahydro-1h-pyrazino[1,2-a]quinoxalin-5(6h)-one), a 5-ht(2b/c) receptor agonist, was characterized in vitro using stable chinese hamster ovary cell lines expressing each of the human 5-ht2 receptors and in vivo in animal models of obesity. |
2006-07-19 |
2023-08-12 |
mouse |
| Miyuki Yamamoto, Jing Ji Jin, Zhihong Wu, Michiko Abe, Yasuharu Tabara, Tokihisa Nagai, Eiji Yamasaki, Michiya Igase, Katsuhiko Kohara, Tetsuro Miki, Jun Nakur. Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese. Hypertension research : official journal of the Japanese Society of Hypertension. vol 29. issue 4. 2006-07-12. PMID:16778329. |
serotonin has been implicated in the pathogenesis of hypertension because of its ability to induce vasoconstriction via stimulation of serotonin 2 (5-ht2) receptors. |
2006-07-12 |
2023-08-12 |
human |
| Elizabeth A Pehek, Christine Nocjar, Bryan L Roth, Tara A Byrd, Omar S Mabrou. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 2. 2006-07-06. PMID:15999145. |
the mechanism(s) by which serotonin modulates dopamine release in the medial prefrontal cortex is not known, although studies suggest an involvement of 5-ht2 family receptors. |
2006-07-06 |
2023-08-12 |
rat |
| David Centurión, Suneet Mehotra, Araceli Sánchez-López, Saurabh Gupta, Antoinette MaassenVanDenBrink, Carlos M Villaló. Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat. European journal of pharmacology. vol 535. issue 1-3. 2006-06-21. PMID:16545797. |
these ligands included: methiothepin, methysergide and metergoline (5-ht(1)/5-ht2); way-100635, buspirone, ipsapirone and 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (5-ht(1a)); gr127935 (5-ht(1b/1d)); ketanserin, ritanserin, spiperone and pizotifen (5-ht2); granisetron and metoclopramide (5-ht3); tropisetron (5-ht3/5-ht4); ergotamine (5-ht(1b/1d), 5-ht(5a/5b)); clozapine (5-ht6/5-ht7); as well as ly215840 and mesulergine (5-ht2/5-ht7). |
2006-06-21 |
2023-08-12 |
rat |
| W Wolfgang Fleischhacke. Aripiprazole. Expert opinion on pharmacotherapy. vol 6. issue 12. 2006-06-01. PMID:16197361. |
partial agonism of the d2 dopamine and 5ht1a serotonin receptors, and antagonism of the 5ht2 serotonin receptor are believed to be the functional basis of its therapeutic efficacy. |
2006-06-01 |
2023-08-12 |
Not clear |
| Craig Blomeley, Enrico Bracc. Excitatory effects of serotonin on rat striatal cholinergic interneurones. The Journal of physiology. vol 569. issue Pt 3. 2006-05-04. PMID:16269435. |
selective agonists of 5-ht(1a), 5-ht3, 5-ht4 and 5-ht7 receptors did not affect cholinergic interneurone firing, while the 5-ht2 receptor agonist alpha-methyl-5-ht (30 microm) mimicked the excitatory effects of serotonin. |
2006-05-04 |
2023-08-12 |
rat |
| Craig Blomeley, Enrico Bracc. Excitatory effects of serotonin on rat striatal cholinergic interneurones. The Journal of physiology. vol 569. issue Pt 3. 2006-05-04. PMID:16269435. |
consistently, the 5-ht2 receptor antagonist ketanserin (10 microm) fully blocked the excitatory effects of serotonin. |
2006-05-04 |
2023-08-12 |
rat |
| Craig Blomeley, Enrico Bracc. Excitatory effects of serotonin on rat striatal cholinergic interneurones. The Journal of physiology. vol 569. issue Pt 3. 2006-05-04. PMID:16269435. |
these results show that 5-ht exerts a powerful excitatory control on cholinergic interneurones via 5-ht2 receptors, by suppressing the ahps associated with two distinct calcium-activated potassium currents. |
2006-05-04 |
2023-08-12 |
rat |
| Lu Long, Margaret R MacLean, Trina K Jeffery, Ian Morecroft, Xudong Yang, Nung Rudarakanchana, Mark Southwood, Victoria James, Richard C Trembath, Nicholas W Morrel. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circulation research. vol 98. issue 6. 2006-04-13. PMID:16497988. |
in addition, pulmonary, but not systemic, resistance arteries from bmpr2(+/-) mice exhibited increased contractile responses to serotonin mediated by both 5-ht2 and 5-ht1 receptors. |
2006-04-13 |
2023-08-12 |
mouse |
| Jing Liu, Xing-Quan Ji, Xing-Zu Zh. Comparison of psychic emergence reactions after (+/-)-ketamine and (+)-ketamine in mice. Life sciences. vol 78. issue 16. 2006-04-11. PMID:16289139. |
in receptor binding test, (+)-ketamine showed a higher affinity for nmda receptor than that of (+/-)-ketamine, while (+)-ketamine and (+/-)-ketamine showed no affinity for dopamine d2 and serotonin 5-ht2 receptor. |
2006-04-11 |
2023-08-12 |
mouse |