| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Fukud. Novel hypothesis for the cause of panic disorder via the neuroepithelial bodies in the lung. Medical hypotheses. vol 64. issue 6. 2005-09-30. PMID:15823715. |
when 5-ht released from these cells along with bk cross the bbb, the release of 5-ht at the axonal terminals in the serotonergic neurons in the brain will be inhibited, since the 5-ht1 autoreceptor have a higher affinity for 5-ht than do the 5-ht2 receptors. |
2005-09-30 |
2023-08-12 |
Not clear |
| Laura J Boothman, Trevor Shar. A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control. Neuroreport. vol 16. issue 9. 2005-09-30. PMID:15931057. |
new data show that 5-hydroxytryptamine (5-ht) neurons of the dorsal raphe nucleus (drn) are subject to feedback control from 5-ht2 receptors, but the circuitry involved is uncertain. |
2005-09-30 |
2023-08-12 |
human |
| Laura J Boothman, Trevor Shar. A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control. Neuroreport. vol 16. issue 9. 2005-09-30. PMID:15931057. |
this study investigated whether 5-ht2 receptor agonism activates drn gamma-aminobutyric acid (gaba) neurons, which are known to inhibit neighbouring 5-ht neurons. |
2005-09-30 |
2023-08-12 |
human |
| Laura J Boothman, Trevor Shar. A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control. Neuroreport. vol 16. issue 9. 2005-09-30. PMID:15931057. |
these findings suggest that activated local gaba neurons may play an important role in 5-ht2 receptor-mediated feedback control of drn 5-ht neurons. |
2005-09-30 |
2023-08-12 |
human |
| Zhong-wei Zhang, Dany Arsenaul. Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex. The Journal of physiology. vol 566. issue Pt 2. 2005-09-27. PMID:15878946. |
the gain modulation by 5-ht was mediated by 5-ht2 receptors, and involved postsynaptic mechanisms. |
2005-09-27 |
2023-08-12 |
rat |
| Nonna A Otmakhova, Jennifer Lewey, Brent Asrican, John E Lisma. Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline. Journal of neurophysiology. vol 94. issue 2. 2005-09-22. PMID:15888529. |
of these, only the 5-ht7 and 5-ht2 antagonists produced weak but significant inhibition of 5-ht effect. |
2005-09-22 |
2023-08-12 |
Not clear |
| Nonna A Otmakhova, Jennifer Lewey, Brent Asrican, John E Lisma. Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline. Journal of neurophysiology. vol 94. issue 2. 2005-09-22. PMID:15888529. |
we conclude that ne inhibits the pp fepsp through postsynaptic action on alpha2-adrenoceptors and that 5-ht7, 5-ht2, and some other receptor may be involved in 5-ht action in pp. |
2005-09-22 |
2023-08-12 |
Not clear |
| G Ciurzynska, T W Deptuch, M Kurenko-Deptuch, E Wojtecka-Lukasik, A Witanowska, D Maslinska, K Tusinska, M Chciuk-Gornicka, M Gujski, S Maslinsk. Influence of serotonin and selective 5-HT2 and 5-HT3 receptor agonists on the haemodynamics of the isolated, constant pressure perfused rat heart. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 54 Suppl 1. 2005-09-07. PMID:15928842. |
influence of serotonin and selective 5-ht2 and 5-ht3 receptor agonists on the haemodynamics of the isolated, constant pressure perfused rat heart. |
2005-09-07 |
2023-08-12 |
rat |
| Catherine M Dempsey, Scott M Mackenzie, Andrew Gargus, Gabriela Blanco, Ji Ying Sz. Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior. Genetics. vol 169. issue 3. 2005-08-29. PMID:15654117. |
in contrast, deletion of ser-4, a 5ht2 receptor, confers significant resistance to imipramine while leaving the responses to 5ht or fluoxetine intact. |
2005-08-29 |
2023-08-12 |
caenorhabditis_elegans |
| Justin E Aldridge, Edward D Levin, Frederic J Seidler, Theodore A Slotki. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environmental health perspectives. vol 113. issue 5. 2005-08-16. PMID:15866758. |
after radial-arm acquisition training, we assessed the role of 5ht by challenging the animals with the 5ht2 receptor antagonist ketanserin. |
2005-08-16 |
2023-08-12 |
rat |
| Iu G Pliashkevich, G G Barsegian, N I Kisileva, D Iu Rusakov, V V Rozhanets, I G Dement'eva, N A Pliashkevic. [Effect of 1,2,3,4-tetrahydroimidazo[4,5-c]pyridine and 1,2,3,4-tetrahydroisoquinoline derivatives on the behavior and the brain receptor system in rats]. Eksperimental'naia i klinicheskaia farmakologiia. vol 68. issue 2. 2005-08-02. PMID:15934359. |
using the radioligand binding method, it was established that the treatment with compound i led to a decrease in the density of benzodiazepine receptors (b max of [3h]-flunitrazepam was 78% of the control level) and to a significant (148%) increase in the density of specific binding sites for [3h]-spiperone (reflecting the total density of dopamine (d2) and serotonin (5-ht2) receptors. |
2005-08-02 |
2023-08-12 |
rat |
| Luciano Minuzzi, George G Nomikos, Mark R Wade, Svend B Jensen, Aage K Olsen, Paul Cummin. Interaction between LSD and dopamine D2/3 binding sites in pig brain. Synapse (New York, N.Y.). vol 56. issue 4. 2005-07-29. PMID:15803496. |
the psychoactive properties of the hallucinogen lsd have frequently been attributed to high affinity interactions with serotonin 5ht2 receptors in brain. |
2005-07-29 |
2023-08-12 |
rat |
| N A Keks, C Culhan. Risperidone (Risperdal): clinical experience with a new antipsychosis drug. Expert opinion on investigational drugs. vol 8. issue 4. 2005-07-21. PMID:15992090. |
risperidone (risperdal) is a benzisoxazole derivative with a high affinity for serotonin 5-ht2 and dopamine d2 receptors, and some affinity for alpha- adrenergic, histamine h1 and dopamine d1 receptors. |
2005-07-21 |
2023-08-12 |
Not clear |
| Luciane H Gargaglioni, Alexandre A Steiner, Luiz G S Branc. Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia. Brain research. vol 1044. issue 1. 2005-07-15. PMID:15862785. |
thus, we investigated the participation of the 5-ht receptors (5-ht1, 5-ht2, and 5-ht7) in the avpo in hypoxic hypothermia. |
2005-07-15 |
2023-08-12 |
rat |
| Luciane H Gargaglioni, Alexandre A Steiner, Luiz G S Branc. Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia. Brain research. vol 1044. issue 1. 2005-07-15. PMID:15862785. |
to this end, tb of conscious wistar rats was monitored by biotelemetry before and after intra-avpo microinjection of methysergide (a 5-ht1 and 5-ht2 receptor antagonist, 0.2 and 2 microg/100 nl), way-100635 (a 5-ht(1a) receptor antagonist, 0.3 and 3 microg/100 nl), and sb-269970 (a 5-ht7 receptor antagonist, 0.4 and 4 micro/100 nl), followed by 60 min of hypoxia exposure (7% o2). |
2005-07-15 |
2023-08-12 |
rat |
| M Barresi, G Li Volsi, F Licata, L Ciranna, F Santangel. Effects of 5-hydroxytryptamine on the neuronal firing rate of bulbar reticular neurons. Archives italiennes de biologie. vol 143. issue 1. 2005-07-14. PMID:15844666. |
both excitatory and inhibitory responses to 5-ht were partially or totally blocked by the application of 5-ht2 receptor antagonist ketanserin. |
2005-07-14 |
2023-08-12 |
rat |
| Jinling Xie, Serghei Dernovici, Paula Ribeir. Mutagenesis analysis of the serotonin 5-HT2C receptor and a Caenorhabditis elegans 5-HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-HT2 receptors. Journal of neurochemistry. vol 92. issue 2. 2005-05-26. PMID:15663485. |
mutagenesis analysis of the serotonin 5-ht2c receptor and a caenorhabditis elegans 5-ht2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-ht2 receptors. |
2005-05-26 |
2023-08-12 |
rat |
| Jinling Xie, Serghei Dernovici, Paula Ribeir. Mutagenesis analysis of the serotonin 5-HT2C receptor and a Caenorhabditis elegans 5-HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-HT2 receptors. Journal of neurochemistry. vol 92. issue 2. 2005-05-26. PMID:15663485. |
an alignment of serotonin [5-hydroxytryptamine (5-ht)] g protein-coupled receptors identified a lysine at position 4.45 (helix 4) and a small polar residue (serine or cysteine) at 7.45 (helix 7) that occur exclusively in the 5-ht2 receptor family. |
2005-05-26 |
2023-08-12 |
rat |
| E Calama, A Morán, A V Ortiz de Urbina, M L Martín, L San Romá. Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats. Pharmacology. vol 71. issue 2. 2005-05-19. PMID:15118345. |
intra-arterial administration of the highest doses (50-1,000 ng/kg) produced a vasoconstrictor effect that was inhibited by ritanserin (a selective 5-ht2 receptor antagonist), sb 206553 (a selective 5-ht(2b/2c) receptor antagonist) and spiperone (a nonspecific 5-ht(1/2a) receptor antagonist), and was mimicked by alpha-methyl-5-ht (a selective 5-ht2 receptor agonist) and m-cpp (a selective 5-ht2c receptor agonist), but not by the intra-arterial administration of bw 723c86, a selective 5ht2b receptor agonist. |
2005-05-19 |
2023-08-12 |
rat |
| Takeshi Sugiuar, Klaus Bielefeldt, G F Gebhar. TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 43. 2005-05-19. PMID:15509739. |
5-ht (1 microm) significantly increased capsaicin-evoked (100 nm) and proton-evoked (ph 5.5) currents 1.6- and 4.7-fold, respectively, and significantly decreased the threshold temperature for heat current activation from 42 to 38 degrees c. the enhancement of trpv1 by 5-ht was significantly attenuated by selective 5-ht2 and 5-ht4 receptor antagonists, but not by a 5-ht3 receptor antagonist. |
2005-05-19 |
2023-08-12 |
mouse |