| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Paolucci, N Berretta, A Tozzi, G Bernardi, N B Mercur. Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta. The European journal of neuroscience. vol 18. issue 10. 2004-01-26. PMID:14656323. |
no significant depression of the mglur-ipsc by 5-ht was observed in the presence of the 5-ht2 antagonist cinanserin or the 5-ht4 receptor antagonist rs 23597-190, whereas the 5-ht2c antagonist rs 102221 was ineffective. |
2004-01-26 |
2023-08-12 |
rat |
| Zhaoping Liu, E Bradshaw Bunney, Sarah B Appel, Mark S Brodi. Serotonin reduces the hyperpolarization-activated current (Ih) in ventral tegmental area dopamine neurons: involvement of 5-HT2 receptors and protein kinase C. Journal of neurophysiology. vol 90. issue 5. 2004-01-22. PMID:12890794. |
serotonin reduces the hyperpolarization-activated current (ih) in ventral tegmental area dopamine neurons: involvement of 5-ht2 receptors and protein kinase c. dopaminergic neurons of the ventral tegmental area (vta) have been implicated in the rewarding properties of drugs of abuse and in the etiology of schizophrenia; serotonin modulation of these neurons may play a role in these phenomena. |
2004-01-22 |
2023-08-12 |
rat |
| Zhaoping Liu, E Bradshaw Bunney, Sarah B Appel, Mark S Brodi. Serotonin reduces the hyperpolarization-activated current (Ih) in ventral tegmental area dopamine neurons: involvement of 5-HT2 receptors and protein kinase C. Journal of neurophysiology. vol 90. issue 5. 2004-01-22. PMID:12890794. |
these data support the conclusion that serotonin reduces ih in dopaminergic vta neurons by acting at serotonin 5-ht2 receptors, which activate protein kinase c. this reduction of ih may be physiologically important, as the selective inhibitor of ih, zd7288, significantly increased dopamine inhibition of firing rate of dopaminergic vta neurons, an effect that we previously demonstrated with serotonin. |
2004-01-22 |
2023-08-12 |
rat |
| C Spring, M Mevissen, M Reist, M Zulauf, A Steine. Modification of spontaneous contractility of smooth muscle preparations from the bovine abomasal antrum by serotonin receptor agonists. Journal of veterinary pharmacology and therapeutics. vol 26. issue 5. 2004-01-13. PMID:14633191. |
serotonin evoked a significant increase in the area under curve (auc), whilst the 5-ht2 receptor agonist alpha-m-5-ht significantly increased the auc and resting tone (rt). |
2004-01-13 |
2023-08-12 |
cattle |
| C Bishop, P D Walke. Combined intrastriatal dopamine D1 and serotonin 5-HT2 receptor stimulation reveals a mechanism for hyperlocomotion in 6-hydroxydopamine-lesioned rats. Neuroscience. vol 121. issue 3. 2004-01-09. PMID:14568025. |
combined intrastriatal dopamine d1 and serotonin 5-ht2 receptor stimulation reveals a mechanism for hyperlocomotion in 6-hydroxydopamine-lesioned rats. |
2004-01-09 |
2023-08-12 |
human |
| C Bishop, P D Walke. Combined intrastriatal dopamine D1 and serotonin 5-HT2 receptor stimulation reveals a mechanism for hyperlocomotion in 6-hydroxydopamine-lesioned rats. Neuroscience. vol 121. issue 3. 2004-01-09. PMID:14568025. |
loss of dopaminergic innervation to the striatum increases the sensitivity of dopamine (da) d1 and serotonin (5-ht) 5-ht2 receptor signaling. |
2004-01-09 |
2023-08-12 |
human |
| Han-Seong Jeong, Young Chai Lim, Tae Sun Kim, Tag Heo, Seung-Mun Jung, Yong Bum Cho, Jae Yeoul Jun, Jong-Seong Par. Excitatory effects of 5-hydroxytryptamine on the medial vestibular nuclear neuron via the 5-HT2 receptor. Neuroreport. vol 14. issue 15. 2004-01-05. PMID:14561938. |
excitatory effects of 5-hydroxytryptamine on the medial vestibular nuclear neuron via the 5-ht2 receptor. |
2004-01-05 |
2023-08-12 |
rat |
| Hannah C Kinney, Leslie L Randall, Lynn A Sleeper, Marian Willinger, Richard A Belliveau, Natasa Zec, Luciana A Rava, Laura Dominici, Solomon Iyasu, Bradley Randall, Donald Habbe, Harry Wilson, Frederick Mandell, Mary McClain, Thomas K Welt. Serotonergic brainstem abnormalities in Northern Plains Indians with the sudden infant death syndrome. Journal of neuropathology and experimental neurology. vol 62. issue 11. 2004-01-05. PMID:14656075. |
tritiated-lysergic acid diethylamide binding to 5-ht(1a-d) and 5-ht2 receptors was measured in 19 brainstem nuclei in 23 sids and 6 control infants using tissue receptor autoradiography. |
2004-01-05 |
2023-08-12 |
Not clear |
| Murat Oz, Li Zhang, Alessandro Rotondo, Hui Sun, Marisela Morale. Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors. Synapse (New York, N.Y.). vol 50. issue 4. 2003-12-19. PMID:14556235. |
magnitudes of maximal da induced currents were 42 +/- 3% of maximal 5-ht responses and blocked by the 5-ht2 antagonist, piperazine (1 microm). |
2003-12-19 |
2023-08-12 |
human |
| Jesse A May, Hwang-Hsing Chen, Andrew Rusinko, Vincent M Lynch, Najam A Sharif, Marsha A McLaughli. A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. Journal of medicinal chemistry. vol 46. issue 19. 2003-11-10. PMID:12954071. |
serotonin 5-ht2 receptor agonists have recently been shown to be effective in lowering intraocular pressure in nonhuman primates and represent a potential new class of antiglaucoma agents. |
2003-11-10 |
2023-08-12 |
monkey |
| T S Gan'shin. [Neurotransmitter mechanism of the tropoxin effect in comparison with other antimigraine preparations]. Eksperimental'naia i klinicheskaia farmakologiia. vol 66. issue 3. 2003-11-03. PMID:12924226. |
the 5ht2 receptor blocker ketanserin significantly reduces the cerebrovascular effects of serotonin, while the 5ht3 receptor blocker tropisetron shows no such activity. |
2003-11-03 |
2023-08-12 |
Not clear |
| Peter P Fong, Caroline M Philbert, Brian J Robert. Putative serotonin reuptake inhibitor-induced spawning and parturition in freshwater bivalves is inhibited by mammalian 5-HT2 receptor antagonists. Journal of experimental zoology. Part A, Comparative experimental biology. vol 298. issue 1. 2003-10-07. PMID:12840841. |
putative serotonin reuptake inhibitor-induced spawning and parturition in freshwater bivalves is inhibited by mammalian 5-ht2 receptor antagonists. |
2003-10-07 |
2023-08-12 |
Not clear |
| Alexis Hattox, Ying Li, Asaf Kelle. Serotonin regulates rhythmic whisking. Neuron. vol 39. issue 2. 2003-08-18. PMID:12873389. |
in response to exogenous serotonin, wfmns recorded in vitro fire rhythmically at whisking frequencies, and selective 5-ht2 or 5-ht3 receptor antagonists suppress this rhythmic firing. |
2003-08-18 |
2023-08-12 |
Not clear |
| Alfredo Menese. Involvement of 5-HT(2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism? Cellular and molecular neurobiology. vol 22. issue 5-6. 2003-08-13. PMID:12585687. |
the 5-ht2 receptors subdivision into the 5-ht(2a/2b/2c) subtypes along with the advent of the selective antagonists has allowed a more detailed investigation on the role and therapeutic significance of these subtypes in cognitive functions. |
2003-08-13 |
2023-08-12 |
Not clear |
| H Jørgensen, A Kjaer, U Knigge, M Møller, J Warber. Serotonin stimulates hypothalamic mRNA expression and local release of neurohypophysial peptides. Journal of neuroendocrinology. vol 15. issue 6. 2003-08-13. PMID:12716407. |
vasopressin mrna in the pvn was increased only via the 5-ht2 receptor, whereas vasopressin mrna in the son does not seem to be affected by 5-ht stimulation. |
2003-08-13 |
2023-08-12 |
rat |
| Jesse A May, Marsha A McLaughlin, Najam A Sharif, Mark R Hellberg, Thomas R Dea. Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12676887. |
evaluation of the ocular hypotensive response of serotonin 5-ht1a and 5-ht2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. |
2003-07-24 |
2023-08-12 |
human |
| Craig R Rush, William W Stoops, Lon R Hays, Paul E A Glaser, Lon S Hay. Risperidone attenuates the discriminative-stimulus effects of d-amphetamine in humans. The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12676890. |
future studies should compare the behavioral effects of d-amphetamine after pretreatment with a selective d2 dopamine (e.g., haloperidol) or 5-ht2 serotonin (e.g., ritanserin) antagonist to determine the relative contribution of dopamine and serotonin systems in mediating the behavioral effects of stimulants in humans. |
2003-07-24 |
2023-08-12 |
Not clear |
| Andrew C McCreary, Malgorzata Filip, Kathryn A Cunningha. Discriminative stimulus properties of (+/-)-fenfluramine: the role of 5-HT2 receptor subtypes. Behavioral neuroscience. vol 117. issue 2. 2003-06-04. PMID:12708517. |
the role of serotonin 5-ht2 receptors (5-ht2r) in the discriminative stimulus effects of fenfluramine was investigated. |
2003-06-04 |
2023-08-12 |
rat |
| H Jørgensen, U Knigge, A Kjaer, M Møller, J Warber. Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. Journal of neuroendocrinology. vol 14. issue 10. 2003-06-03. PMID:12372003. |
the neurotransmitter serotonin (5-ht) stimulates adrenocorticotropic hormone (acth) secretion from the anterior pituitary gland via activation of central 5-ht1 and 5-ht2 receptors. |
2003-06-03 |
2023-08-12 |
rat |
| Zhong-Wei Zhan. Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716945. |
the excitatory effects of 5-ht at younger ages were attributed to 5-ht2a receptors because the effects were mimicked by the 5-ht2 agonist alpha-methyl-5-ht but not by the 5-ht3 agonist 1-(m-chlorophenyl)-biguanide, nor by the 5-ht2b/2c agonist 1-(3-chlorophenyl)piperazine, and were blocked by the 5-ht2a antagonists ketanserin and alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol. |
2003-05-30 |
2023-08-12 |
rat |