| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Laakmann, J Hennig, T Baghai, C Schül. Influence of mirtazapine on salivary cortisol in depressed patients. Neuropsychobiology. vol 47. issue 1. 2003-05-15. PMID:12606843. |
unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-ht2 and 5-ht3 receptors, and at histaminergic h1 receptors. |
2003-05-15 |
2023-08-12 |
human |
| Rolf Larisch, Ansgar Klimke, Kurt Hamacher, Uwe Henning, Sorour Estalji, Thomas Hohlfeld, Henning Vosberg, Marco Tosch, Wolfgang Gaebel, Heinz H Coenen, Hans Wilhelm Müller-Gärtne. Influence of synaptic serotonin level on [18F]altanserin binding to 5HT2 receptors in man. Behavioural brain research. vol 139. issue 1-2. 2003-05-02. PMID:12642173. |
influence of synaptic serotonin level on [18f]altanserin binding to 5ht2 receptors in man. |
2003-05-02 |
2023-08-12 |
human |
| Anne Nosjean, Michel Hamon, Michèle Darmo. 5-HT2A receptors are expressed by catecholaminergic neurons in the rat nucleus tractus solitarii. Neuroreport. vol 13. issue 17. 2003-04-15. PMID:12488828. |
within the nucleus tractus solitarii (nts), serotonin (5-ht) exerts modulatory effects on central mechanisms controlling autonomic functions, notably through the stimulation of 5-ht2 receptors. |
2003-04-15 |
2023-08-12 |
rat |
| M Mackowiak, A Chocyk, M Sanak, A Czyrak, K Fijał, K Wedzon. DOI, an agonist of 5-HT2A/2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 53. issue 3. 2003-03-27. PMID:12369737. |
the hallucinogenic effect of doi, serotonin 5-ht2a/2c receptor agonist, is known to be associated with the activation of cortical 5-ht2 receptors. |
2003-03-27 |
2023-08-12 |
rat |
| Akira Yoshida, Yasuko S-Yamashita, Muneshige Kaibara, Kohtaro Taniyama, Nobuyuki Tanak. 5-Hydroxytryptamine receptors, especially the 5-HT4 receptor, in guinea pig urinary bladder. Japanese journal of pharmacology. vol 89. issue 4. 2003-03-18. PMID:12233812. |
thus, the contractile response to 5-ht was mediated by activations of 5-ht2, 5-ht3 and 5-ht4 receptors. |
2003-03-18 |
2023-08-12 |
Not clear |
| Akira Yoshida, Yasuko S-Yamashita, Muneshige Kaibara, Kohtaro Taniyama, Nobuyuki Tanak. 5-Hydroxytryptamine receptors, especially the 5-HT4 receptor, in guinea pig urinary bladder. Japanese journal of pharmacology. vol 89. issue 4. 2003-03-18. PMID:12233812. |
the 5-ht2 receptor may be a property of high affinity to 5-ht and located on the smooth muscle cells. |
2003-03-18 |
2023-08-12 |
Not clear |
| S W Schwarzacher, A Pestean, S Günther, K Ballany. Serotonergic modulation of respiratory motoneurons and interneurons in brainstem slices of perinatal rats. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453495. |
bath application and iontophoresis of the 5-ht2 receptor agonist -methyl-hydroxytryptamine mimicked the effects of 5-ht. |
2003-03-12 |
2023-08-12 |
rat |
| F P Monne. Functional cooperation between neurosteroids and D2 dopamine antagonists on KCl-evoked [3H]noradrenaline release: modulation by calcium channel blockers. Journal of neuroendocrinology. vol 14. issue 12. 2003-03-12. PMID:12472876. |
according to our previous report showing that the butyrophenone, spiperone, slightly enhances the evoked release of [3h]-noradrenaline ([3h]na) in the presence of these sulphated steroids, the present study was carried out to document the putative interplay between steroids and spiperone, which is known to be a prototypic d2 dopamine antagonist and also a 5-ht2 serotonin antagonist. |
2003-03-12 |
2023-08-12 |
rat |
| F P Monne. Functional cooperation between neurosteroids and D2 dopamine antagonists on KCl-evoked [3H]noradrenaline release: modulation by calcium channel blockers. Journal of neuroendocrinology. vol 14. issue 12. 2003-03-12. PMID:12472876. |
the selective 5-ht2 serotonin antagonist ritanserine was ineffective, whereas sulpiride, a selective d2 dopamine antagonist mimicked the action of spiperone, thus suggesting that the blockade of d2 dopamine receptors accounted for the modulatory effect of spiperone on neurosteroid-induced modulation of evoked [3h]na release. |
2003-03-12 |
2023-08-12 |
rat |
| Miyuki Ota, Keiji Mori, Akira Nakashima, Yoko S Kaneko, Kentaro Fujiwara, Mitsuyasu Itoh, Akio Nagasaka, Akira Ot. Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats. Clinical and experimental pharmacology & physiology. vol 29. issue 11. 2003-03-05. PMID:12366389. |
risperidone is an atypical antipsychotic drug that possesses 5-hydroxytryptamine 5-ht2 receptor antagonism combined with milder dopamine d2 receptor antagonism. |
2003-03-05 |
2023-08-12 |
rat |
| N H Bhanji, H C Margolese, M Saint-Laurent, G Chouinar. Dysphoric mania induced by high-dose mirtazapine: a case for 'norepinephrine syndrome'? International clinical psychopharmacology. vol 17. issue 6. 2003-02-25. PMID:12409687. |
histamine h2 receptors are also antagonized, as are postsynaptic serotonin 5-ht2 and 5-ht3 receptors, leading to serotonergic activity primarily via 5-ht1a receptors. |
2003-02-25 |
2023-08-12 |
human |
| Jun Yamada, Yumi Sugimot. Differential effects of the 5-HT2 receptor antagonist on the anti-immobility effects of noradrenaline and serotonin reuptake inhibitors in the forced swimming test. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468041. |
differential effects of the 5-ht2 receptor antagonist on the anti-immobility effects of noradrenaline and serotonin reuptake inhibitors in the forced swimming test. |
2003-02-25 |
2023-08-12 |
mouse |
| Nicole Aymard, Annie Viala, Marie-Noelle Clement, Marc Jacquot, Marie-Noelle Vacheron, Jacques Gauillard, Francois Carol. Long-term pharmacoclinical follow-up in schizophrenic patients treated with risperidone. Plasma and red blood cell concentrations of risperidone and its 9-hydroxymetabolite and their relationship to whole blood serotonin and tryptophan, plasma homovanillic acid, 5-hydroxyindoleacetic acid, dihydroxyphenylethyleneglycol and clinical evaluations. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 5. 2003-02-11. PMID:12369274. |
risp is one of the newer atypical antipsychotic drugs with potent serotonin (5ht2), moderate d2 and real alpha 1-alpha 2 adrenoreceptor antagonistic effects. |
2003-02-11 |
2023-08-12 |
Not clear |
| Gregory J Basura, Kwaku D Nantwi, Harry G Goshgaria. Theophylline-induced respiratory recovery following cervical spinal cord hemisection is augmented by serotonin 2 receptor stimulation. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426040. |
we have previously demonstrated separate therapeutic roles for theophylline, and more recently serotonin (5-ht) as modulators to phrenic nerve motor recovery; mechanisms that likely occur via adenosine a1 and 5-ht2 receptors, respectively. |
2003-01-29 |
2023-08-12 |
rat |
| Cornelius Schüle, Thomas Baghai, Martin Bidlingmaier, Christian Strasburger, Gregor Laakman. Endocrinological effects of mirtazapine in healthy volunteers. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502011. |
unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin (5-ht) but acts as an antagonist at presynaptic alpha2-receptors and at postsynaptic 5-ht2, 5-ht3 and histamine h1-receptors. |
2003-01-27 |
2023-08-12 |
human |
| Carlos A Bolaños, George H Trksak, Ori S Cohen, Denise Jackso. Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502023. |
additionally, we assessed the impact of monoaminergic receptor stimulation on evoked ach release by superfusion with selective 5-ht2, 5-ht3 and d2 receptor antagonists in the presence of flu-induced and exogenous 5-ht and measuring the capacity of these drugs to reverse inhibitory effects of 5-ht. |
2003-01-27 |
2023-08-12 |
rat |
| Carlos A Bolaños, George H Trksak, Ori S Cohen, Denise Jackso. Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502023. |
inhibition of ach release by 5-ht appears to be mediated by a complex relationship between 5-ht2, 5-ht3 and d2 receptor regulation, as the blockade of any of these receptors reversed the inhibitory effects of flu on ach release. |
2003-01-27 |
2023-08-12 |
rat |
| Jennifer Chlan-Fourney, Paula Ashe, Kirk Nylen, Augusto V Juorio, Xin Min L. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain research. vol 954. issue 1. 2003-01-24. PMID:12393228. |
apart from their differential propensities to block dopamine d2 and serotonin 5-ht2 receptors, the molecular mechanisms underlying the clinical efficacy of typical and atypical antipsychotics in schizophrenia are largely unknown. |
2003-01-24 |
2023-08-12 |
rat |
| Jie Xu, Bo Jian, Richard Chu, Zhibin Lu, Quanyi Li, John Dunlop, Sharon Rosenzweig-Lipson, Paul McGonigle, Robert J Levy, Bruce Lian. Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells. The American journal of pathology. vol 161. issue 6. 2003-01-16. PMID:12466135. |
serotonin mechanisms in heart valve disease ii: the 5-ht2 receptor and its signaling pathway in aortic valve interstitial cells. |
2003-01-16 |
2023-08-12 |
human |
| Zhen Ya. Regulation of GABAergic inhibition by serotonin signaling in prefrontal cortex: molecular mechanisms and functional implications. Molecular neurobiology. vol 26. issue 2-3. 2002-12-24. PMID:12428756. |
on the presynaptic side, gabaergic inhibition is regulated by 5-ht through the activation of 5-ht2, 5-ht1, and 5-ht3 receptors on gabaergic intereneurons. |
2002-12-24 |
2023-08-12 |
Not clear |