| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomas de Pauli. Perospirone (Sumitomo Pharmaceuticals). Current opinion in investigational drugs (London, England : 2000). vol 3. issue 1. 2002-12-17. PMID:12054062. |
perospirone is a serotonin 5-ht2 antagonist and dopamine d2 antagonist developed by sumitomo pharmaceuticals for the potential treatment of schizophrenia and other psychoses [381769]. |
2002-12-17 |
2023-08-12 |
Not clear |
| M Bourin, D J P David, P Jolliet, A Gardie. [Mechanism of action of antidepressants and therapeutic perspectives]. Therapie. vol 57. issue 4. 2002-12-10. PMID:12422559. |
developing drugs using innovative mechanisms such as directly acting on 5-ht receptors (5-ht1a agonists or 5-ht2 antagonists), would appear to be useful in the treatment of depression. |
2002-12-10 |
2023-08-12 |
Not clear |
| Norman L Keltner, Kelly M McAfee, Carey L Taylo. Mechanisms and treatments of SSRI-induced sexual dysfunction. Perspectives in psychiatric care. vol 38. issue 3. 2002-12-04. PMID:12385082. |
biochemical mechanisms suggested as causative include increased serotonin, particularly affecting 5ht2 and 5ht3 receptors; decreased dopamine; blockade of cholinergic and alpha-1 adrenergic receptors; inhibition of nitric oxide synthetase; and elevation of prolactin levels. |
2002-12-04 |
2023-08-12 |
Not clear |
| Xinyan Huang, Hong Xiao, Elizabeth B Rex, Robert J Hobson, William S Messer, Patricia R Komuniecki, Richard W Komunieck. Functional characterization of alternatively spliced 5-HT2 receptor isoforms from the pharynx and muscle of the parasitic nematode, Ascaris suum. Journal of neurochemistry. vol 83. issue 2. 2002-11-20. PMID:12423236. |
serotonin (5-ht) receptors play key regulatory roles in nematodes and alternatively spliced 5-ht2 receptor isoforms have been identified in the parasitic nematode, ascaris suum. |
2002-11-20 |
2023-08-12 |
human |
| Y Ozawa, N Okad. Alteration of serotonergic receptors in the brain stems of human patients with respiratory disorders. Neuropediatrics. vol 33. issue 3. 2002-10-16. PMID:12200744. |
we compared the developmental changes of 5-hydroxytryptamine (5-ht) 1 a and 5-ht2 a receptor immunoreactivity in the nuclei in relation to the cardiorespiratory or autonomic function in the human brain stem in sudden infant death syndrome (sids) and congenital central hypoventilation syndrome (cchs) patients and age-matched controls by means of immunohistochemical methods. |
2002-10-16 |
2023-08-12 |
human |
| John P Welsh, Dimitris G Placantonakis, Sarah I Warsetsky, Rolando G Marquez, Lana Bernstein, Sue A Aiche. The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity. Advances in neurology. vol 89. 2002-10-09. PMID:11968457. |
the effects of serotonin to suppress olivocerebellar rhythmicity are mediated by postsynaptic 5-ht2 receptors that reduce the magnitude of the low-threshold calcium conductance, it. |
2002-10-09 |
2023-08-12 |
human |
| S A Doggrel. Pharmacotherapy of intermittent claudication. Expert opinion on pharmacotherapy. vol 2. issue 11. 2002-09-26. PMID:11825312. |
naftidrofuryl, a serotonin (5-ht2) receptor antagonist and antiplatelet drug, is beneficial in claudicants. |
2002-09-26 |
2023-08-12 |
Not clear |
| M G Moldavan, A A Grodzinskaya, E F Solomko, M L Lomberh, S P Wasser, V M Storozhu. The effect of Psilocybe cubensis extract on hippocampal neurons in vitro. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 47. issue 6. 2002-07-30. PMID:11962085. |
inhibitory reactions induced by extract application were blocked by ritanserin in half of the tested units and were induced due to activation of 5-ht2 serotonin receptors. |
2002-07-30 |
2023-08-12 |
rat |
| Gerda Maria Saletu-Zyhlarz, Manal Hassan Abu-Bakr, Peter Anderer, Georg Gruber, Magdalena Mandl, Roland Strobl, Dietmar Gollner, Wolfgang Prause, Bernd Salet. Insomnia in depression: differences in objective and subjective sleep and awakening quality to normal controls and acute effects of trazodone. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 2. 2002-07-22. PMID:11817501. |
in a subsequent acute, placebo-controlled cross-over design study, the acute effects of 100 mg of trazodone, a serotonin reuptake inhibitor with a sedative action due to 5-ht2 and alpha1 receptor blockade, were investigated in the patients. |
2002-07-22 |
2023-08-12 |
Not clear |
| L Pinilla, L C González, M Tena-Sempere, E Aguila. Interactions between serotoninergic and aminoacidergic pathways in the control of PRL secretion in prepubertal male rats. Journal of physiology and biochemistry. vol 57. issue 3. 2002-07-12. PMID:11800286. |
for this purpose, 16 and 23-day old male rats were treated with 5-hydroxytryptophan (5-htp, precursor of serotonin synthesis) plus fluoxetine (blocker of serotonin reuptake), 8-oh-dpat (agonist of 5-ht1a receptors), doi and alpha-me-5-ht (agonists of 5-ht2 receptors), 1-phenylbiguanide (agonist of 5-ht3 receptors) alone or in combination with ampa (agonist of ampa receptors). |
2002-07-12 |
2023-08-12 |
rat |
| Hiroshi Yamada, Mitsuko Hayashi, Shunsuke Uehara, Mika Kinoshita, Akiko Muroyama, Masami Watanabe, Koji Takei, Yoshinori Moriyam. Norepinephrine triggers Ca2+-dependent exocytosis of 5-hydroxytryptamine from rat pinealocytes in culture. Journal of neurochemistry. vol 81. issue 3. 2002-07-05. PMID:12065661. |
5-ht is present in organelles distinct from l-glutamate-containing synaptic-like microvesicles as well as in the cytoplasm of pinealocytes, and is secreted upon stimulation by norepinephrine (ne) to enhance serotonin n-acetyltransferase activity via the 5-ht2 receptor. |
2002-07-05 |
2023-08-12 |
rat |
| G K Isbister, I M Whyt. Serotonin toxicity and malignant hyperthermia: role of 5-HT2 receptors. British journal of anaesthesia. vol 88. issue 4. 2002-06-25. PMID:12066745. |
serotonin toxicity and malignant hyperthermia: role of 5-ht2 receptors. |
2002-06-25 |
2023-08-12 |
Not clear |
| Hidehisa Yamashita, Shigeru Morinobu, Shigeto Yamawaki, Jun Horiguchi, Masatsugu Naga. Effect of risperidone on sleep in schizophrenia: a comparison with haloperidol. Psychiatry research. vol 109. issue 2. 2002-06-19. PMID:11927138. |
this difference in the effect on sleep between risperidone and haloperidol may be due to their differential actions on serotonin (5-ht2) receptors. |
2002-06-19 |
2023-08-12 |
Not clear |
| b' W Laso\\xc5\\x8. Neurochemical and pharmacological aspects of cocaine-induced seizures. Polish journal of pharmacology. vol 53. issue 1. 2002-06-13. PMID:11785913.' |
an involvement of serotonin 5-ht2, dopamine and sigma receptors in cocaine-induced seizures has also been proposed. |
2002-06-13 |
2023-08-12 |
Not clear |
| William C de Groa. Influence of central serotonergic mechanisms on lower urinary tract function. Urology. vol 59. issue 5 Suppl 1. 2002-05-29. PMID:12007520. |
although there is some evidence in the rat for serotonergic facilitation of voiding, most experiments in rats and cats indicate that activation of the central serotonergic system by 5-ht reuptake inhibitors, as well as by 5-ht1a and 5-ht2 receptor agonists, depresses reflex bladder contractions and increases the bladder volume threshold for inducing micturition. |
2002-05-29 |
2023-08-12 |
rat |
| R M Torack, J W Miller, K A Rot. Deafferentation-induced abnormal neurofilament phosphorylation in red nucleus neurones. Neuropathology and applied neurobiology. vol 27. issue 6. 2002-05-01. PMID:11903927. |
we previously developed a rodent model of hippocampal deafferentation involving bilateral destructive lesions of the ventrotegmental area (vta), septum of the medial forebrain and entorhinal cortex combined with pharmacological inhibition of serotonin 5-ht2 and dopamine d1 receptors. |
2002-05-01 |
2023-08-12 |
human |
| A L Montejo, G Llorca, J A Izquierdo, J L Carrasco, E Daniel, V Pérez-Sola, E Vicens, M Bousoño, S Sánchez-Iglesias, M Franco, A Cabezudo, V Rubio, M A Ortega, M Puigdellivol, J R Domenech, B Allué, C Sáez, B Mezquita, I Gálvez, L Pacheco, de Miguel . [Sexual dysfunction with antidepressive agents. Effect of the change to amineptine in patients with sexual dysfunction secondary to SSRI]. Actas espanolas de psiquiatria. vol 27. issue 1. 2002-04-23. PMID:10380144. |
this dysfunction appears to be related with the resulting increase in serotonin and with the stimulation of serotonin 5ht2 receptors. |
2002-04-23 |
2023-08-12 |
Not clear |
| Mark G Devlin, Arthur Christopoulo. Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum. Journal of neurochemistry. vol 80. issue 6. 2002-04-19. PMID:11953460. |
the effect of 5-ht on win 55,212-2 binding was inhibited by the 5-ht2 receptor antagonist ritanserin as well as gpp(nh)p, suggesting a dependence on the 5-ht2 receptor and on g protein-receptor interactions, respectively. |
2002-04-19 |
2023-08-12 |
rat |
| S D Gleason, V L Lucaites, H E Shannon, D L Nelson, J D Leande. m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors. Behavioural pharmacology. vol 12. issue 8. 2002-04-08. PMID:11856898. |
consistent with previous suggestions, a detailed pharmacological evaluation with selective antagonists for the 5-ht2 family of receptors supports a primary role for the 5-ht(2c) receptor, and not 5-ht(2a) or 5-ht(2b) receptors, in mediating the hypolocomotion produced by m-cpp. |
2002-04-08 |
2023-08-12 |
mouse |
| J Yamada, Y Sugimoto, M Ohkura, K Inou. Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT in frontal cortex induced by a 5-HT releasing drug, p-chloroamphetamine (PCA) in mice. Biological & pharmaceutical bulletin. vol 24. issue 10. 2002-03-19. PMID:11642332. |
effects of the 5-ht2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-ht in frontal cortex induced by a 5-ht releasing drug, p-chloroamphetamine (pca) in mice. |
2002-03-19 |
2023-08-12 |
mouse |