Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
J Yamada, Y Sugimoto, M Ohkura, K Inou. Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT in frontal cortex induced by a 5-HT releasing drug, p-chloroamphetamine (PCA) in mice. Biological & pharmaceutical bulletin. vol 24. issue 10. 2002-03-19. PMID:11642332. |
effects of the 5-ht2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-ht induced by the 5-ht-releasing drug, p-chloroamphetamine (pca) were investigated. |
2002-03-19 |
2023-08-12 |
mouse |
N H Prins, L M Akkermans, R A Lefebvre, J A Schuurke. Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle. British journal of pharmacology. vol 134. issue 6. 2002-03-15. PMID:11704657. |
there were non-significant trends of the selective 5-ht3 receptor antagonist granisetron (1 microm), and methysergide (1 microm; preventing interactions of 5-ht with 5-ht1, 5-ht2, 5-ht5, 5-ht6 and 5-ht7 receptors) to increase the response to 5-ht. |
2002-03-15 |
2023-08-12 |
dog |
R L Cooper, R J Chase, J Tabo. Altered responsiveness to 5-HT at the crayfish neuromuscular junction due to chronic p-CPA and m-CPP treatment. Brain research. vol 916. issue 1-2. 2002-01-14. PMID:11597601. |
injections of the 5-ht1 and 5-ht2 vertebrate receptor agonist, 1-(3-chlorophenyl) piperazine dihydrochloride (m-cpp), for 1 week resulted in a decreased responsiveness to application of 5-ht. |
2002-01-14 |
2023-08-12 |
Not clear |
V G Kolpakov, T A Alekhina, N N Barykina, V F Chugui, N K Popov. Some physiological manifestations of the activity of the gene controlling the predisposition to pendulum-like movements in rats. Neuroscience and behavioral physiology. vol 31. issue 3. 2001-12-04. PMID:11430576. |
the physiological actions of the gene controlling the predisposition to stereotypic hyperkinesia in the form of pendulum-like movements (pm) and, probably, a form of spontaneous nystagmus in rats with albinism are manifest as a number of behavioral characteristics (total motor activity, emotionality, startle reflex intensity, sensitivity to serotonin 5-ht2 receptors as assessed in terms of the intensity of head twitching, and predisposition to cataleptic responses). |
2001-12-04 |
2023-08-12 |
rat |
B Bobula, A Zahorodna, M Bija. Different receptor subtypes are involved in the serotonin-induced modulation of epileptiform activity in rat frontal cortex in vitro. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 52. issue 2. 2001-12-04. PMID:11453105. |
the excitatory action of 5-ht, which predominates, is mediated mainly by 5-ht2 receptors. |
2001-12-04 |
2023-08-12 |
rat |
M D Waldinger, A H Zwinderman, B Olivie. Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone. Journal of clinical psychopharmacology. vol 21. issue 3. 2001-11-01. PMID:11386492. |
a double-blind, placebo-controlled study in men with lifelong rapid ejaculation was performed to assess the effects of two selective serotonin (5-ht) reuptake inhibitors--paroxetine and sertraline--and the 5-ht2 antagonist and 5-ht/noradrenaline reuptake inhibitor nefazodone on the latency to ejaculate. |
2001-11-01 |
2023-08-12 |
Not clear |
L D Sanford, W K Hunt, R J Ross, A I Pack, A R Morriso. Central administration of a 5-HT2 receptor agonist and antagonist: lack of effect on rapid eye movement sleep and pgo waves. Sleep research online : SRO. vol 1. issue 2. 2001-10-18. PMID:11382861. |
we microinfused the relatively specific 5-ht2 agonist, doi (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane), the relatively specific 5-ht2 antagonist, ketanserin, and the nonspecific 5-ht antagonist, methysergide, locally into the peribrachial region of ppt in cats and monitored behavioral state and pgo waves. |
2001-10-18 |
2023-08-12 |
rat |
L D Sanford, W K Hunt, R J Ross, A I Pack, A R Morriso. Central administration of a 5-HT2 receptor agonist and antagonist: lack of effect on rapid eye movement sleep and pgo waves. Sleep research online : SRO. vol 1. issue 2. 2001-10-18. PMID:11382861. |
these results suggest that 5-ht2 receptors associated with cholinergic cells are minimally involved in the control of behavioral state and, together with the recent findings of others, suggest that 5-ht may not modulate pgo wave generation via direct action on cholinergic neurons in ppt/ldt, a departure from the long-held but minimally-tested view. |
2001-10-18 |
2023-08-12 |
rat |
M Matsumoto, M Yoshiok. [Intracellular signal transduction mediated via 5-HT and NA receptors]. Nihon rinsho. Japanese journal of clinical medicine. vol 59. issue 8. 2001-10-18. PMID:11519141. |
these pathways are elevated via 5-ht and/or na receptors which directly couple to the camp system(5-ht4,6,7 receptors or beta adrenoceptors), or via receptors that lead to activation of ca(2+)-dependent protein kinase(5-ht2 receptors or alpha 1 adrenoceptors). |
2001-10-18 |
2023-08-12 |
Not clear |
P Retama. [Antidepressant psychopharmacotherapy]. Revista medica de Chile. vol 129. issue 7. 2001-10-18. PMID:11552452. |
tricyclics, non selective mao inhibitors, reversible mao inhibitors, selective serotonin reuptake inhibitors, dopamine and noradrenalin reuptake inhibitors, 5-ht2 blockers with serotonin reuptake blocking effect, serotonin, noradrenalin and dopamine reuptake inhibitors, alfa 2 receptor blockers and 5-ht/2-3 inhibitors are the eight available types of antidepressants. |
2001-10-18 |
2023-08-12 |
Not clear |
S P Vickers, C T Dourish, G A Kennet. Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology. vol 41. issue 2. 2001-10-11. PMID:11489456. |
the present series of studies is the first to investigate the pharmacological mechanisms underlying d-fenfluramine- and d-norfenfluramine-induced hypophagia in the rat using highly selective serotonin 5-ht2 receptor antagonists. |
2001-10-11 |
2023-08-12 |
rat |
R Larisch, A Klimke, F Mayoral, K Hamacher, H R Herzog, H Vosberg, M Tosch, W Gaebel, F Rivas, H H Coenen, H W Müller-Gärtne. Disturbance of serotonin 5HT2 receptors in remitted patients suffering from hereditary depressive disorder. Nuklearmedizin. Nuclear medicine. vol 40. issue 4. 2001-10-11. PMID:11556203. |
disturbance of serotonin 5ht2 receptors in remitted patients suffering from hereditary depressive disorder. |
2001-10-11 |
2023-08-12 |
Not clear |
T Watanabe, R Pakala, T Katagiri, C R Benedic. Lipid peroxidation product 4-hydroxy-2-nonenal acts synergistically with serotonin in inducing vascular smooth muscle cell proliferation. Atherosclerosis. vol 155. issue 1. 2001-05-10. PMID:11223424. |
a 5-ht2 receptor antagonist ly 281067 (10 microg/ml) and pertussis toxin (10 ng/ml) inhibited the mitogenic effect of 5-ht only. |
2001-05-10 |
2023-08-12 |
rabbit |
E M Chapin, R Andrad. A 5-HT(7) receptor-mediated depolarization in the anterodorsal thalamus. I. Pharmacological characterization. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259568. |
we found that the 5-ht1 and 5-ht7 agonists 5-carboxamidotryptamine (5-ct) and 5-methoxytryptamine mimicked the response to 5-ht, whereas the 5-ht2 agonist 2,5-dimethoxy-4-iodoamphetamine did not. |
2001-05-03 |
2023-08-12 |
Not clear |
S Kapur, G Remingto. Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia. Annual review of medicine. vol 52. 2001-04-26. PMID:11160792. |
however, a preferential action on serotonin 5-ht2 or d4 receptors, or a more rapid dissociation from the dopamine d2 receptor, may account for atypicality. |
2001-04-26 |
2023-08-12 |
Not clear |
T Wetterlin. Bodyweight gain with atypical antipsychotics. A comparative review. Drug safety. vol 24. issue 1. 2001-04-19. PMID:11219487. |
the relative receptor affinities of the atypical antipsychotics for histamine h1 receptors as well as the ratio of their affinity for serotonin 5-ht2 and dopamine d2 receptors appear to be the most robust correlate of bodyweight gain. |
2001-04-19 |
2023-08-12 |
Not clear |
V K Bhargava, L Sah. Serotonergic mechanism in imipramine induced antinociception in rat tail flick test. Indian journal of physiology and pharmacology. vol 45. issue 1. 2001-04-12. PMID:11211562. |
therefore, we explored the effect of serotonergic system on imipramine induced antinociception by using 5-hydroxytryptamine-3 (5ht3) receptor antagonist ondansetron and 5-hydroxytryptamine-2 (5ht2) receptor antagonist mianserine, and depletion of brain 5-hydroxytryptamine (5ht) with p-chlorophenyl alanine (pcpa). |
2001-04-12 |
2023-08-12 |
human |
P Blier, F V Abbot. Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain. Journal of psychiatry & neuroscience : JPN. vol 26. issue 1. 2001-03-15. PMID:11212592. |
in major depression, an increase in 5-ht1a transmission is thought to be a crucial determinant of the antidepressant response, whereas an enhancement of 5-ht2 transmission in the orbitofrontal cortex may mediate the therapeutic effect of 5-ht reuptake inhibitors in obsessive-compulsive disorder (ocd). |
2001-03-15 |
2023-08-12 |
Not clear |
R Ramasubbu, A Ravindran, Y Lapierr. Serotonin and dopamine antagonism in obsessive-compulsive disorder: effect of atypical antipsychotic drugs. Pharmacopsychiatry. vol 33. issue 6. 2001-03-08. PMID:11147933. |
given their higher affinity for serotonin 5ht2 receptors than dopamine d2 receptors, it has been speculated that atypical antipsychotics may induce obsessive-compulsive (oc) symptoms, even at low doses, due to high 5ht2 antagonism, whereas improvement in oc symptoms is thought to occur only at high doses due to high d2 antagonism. |
2001-03-08 |
2023-08-12 |
Not clear |
V Contesse, H Lefebvre, S Lenglet, J M Kuhn, C Delarue, H Vaudr. Role of 5-HT in the regulation of the brain-pituitary-adrenal axis: effects of 5-HT on adrenocortical cells. Canadian journal of physiology and pharmacology. vol 78. issue 12. 2001-03-01. PMID:11149386. |
5-ht, acting through 5-ht2 receptors, can also trigger the renin-angiotensin system by stimulating renin secretion and consequently can enhance aldosterone production. |
2001-03-01 |
2023-08-12 |
mouse |