| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Ken. SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression. Lancet (London, England). vol 355. issue 9207. 2000-04-14. PMID:10752718. |
mirtazapine is a potent antagonist of central 2alpha-adrenergic autoreceptors, and heteroreceptors and is an antagonist of serotonin 5-ht2 and 5-ht3 receptors. |
2000-04-14 |
2023-08-12 |
Not clear |
| P C Davis, J Wong, O Gefver. Analysis and pharmacokinetics of quetiapine and two metabolites in human plasma using reversed-phase HPLC with ultraviolet and electrochemical detection. Journal of pharmaceutical and biomedical analysis. vol 20. issue 1-2. 2000-04-04. PMID:10704032. |
the present assay method was used to support a study comparing the pharmacokinetic profile of quetiapine with the time course of dopamine d2 and serotonin 5-ht2 receptor occupancy in the brain using positron emission tomography (pet). |
2000-04-04 |
2023-08-12 |
human |
| I D Hentall, P J Kurle, T R Whit. Correlations between serotonin level and single-cell firing in the rat's nucleus raphe magnus. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682715. |
methiothepin (intravenous, 1 mg/kg), whose serotonergic actions include 5-ht1 and 5-ht2 antagonism, typically raised serotonin levels (four of five cells) and always blocked inhibition by clomipramine (n = 3). |
2000-03-21 |
2023-08-12 |
rat |
| I D Hentall, P J Kurle, T R Whit. Correlations between serotonin level and single-cell firing in the rat's nucleus raphe magnus. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682715. |
the released serotonin could contribute to the inhibition of off(m) cells and excitation of on(m) cells by noxious stimulation, since inhibitory 5-ht1a receptors and excitatory 5-ht2 receptors, respectively, have previously been shown to dominate their serotonergic responses. |
2000-03-21 |
2023-08-12 |
rat |
| J A Worrel, P A Marken, S E Beckman, V L Ruehte. Atypical antipsychotic agents: a critical review. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 57. issue 3. 2000-03-09. PMID:10674777. |
atypical antipsychotics differ from typical psychotics in their "limbic-specific" dopamine type 2 (d2)-receptor binding and high ratio of serotonin type 2 (5-ht2)-receptor binding to d2 binding. |
2000-03-09 |
2023-08-12 |
Not clear |
| A R Volpe, G Fontecchio, M Carmignan. Regulatory role of bradykinin in the coronary and cerebral circulations and in systemic hemodynamics. Immunopharmacology. vol 44. issue 1-2. 2000-02-29. PMID:10604529. |
either hist or 5-ht potentiated (likely involving the h1 and 5-ht2 receptors, respectively) the activating effect of bk on kininase i (k1), thus increasing the availability of l-arginine for the synthesis of no. |
2000-02-29 |
2023-08-12 |
Not clear |
| A R Peirson, J W Heuchert, L Thomala, M Berk, H Plein, C R Cloninge. Relationship between serotonin and the temperament and character inventory. Psychiatry research. vol 89. issue 1. 2000-02-18. PMID:10643875. |
the concentration of serotonin required to produce half maximal ca2+ response (ec50) is indicative of 5-ht2 receptor sensitivity such that the lower the ec50 serotonin concentration, the greater the 5-ht2 receptor sensitivity. |
2000-02-18 |
2023-08-12 |
human |
| K Nakamura, H Kariyazono, Y Moriyama, H Toyohira, H Kubo, G Yotsumoto, A Taira, K Yamad. Effects of sarpogrelate hydrochloride on platelet aggregation, and its relation to the release of serotonin and P-selectin. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 10. issue 8. 2000-02-10. PMID:10636463. |
inhibitory effects of sarpogrelate hydrochloride (sarpogrelate), a 5-ht2 receptor antagonist, on platelet aggregation was examined as well as the relationship to serotonin and p-selectin, a platelet alpha-granule membrane glycoprotein. |
2000-02-10 |
2023-08-12 |
human |
| T Yamaguchi, T Nagasawa, M Satoh, Y Kuraish. Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice. Neuroscience research. vol 35. issue 2. 2000-01-21. PMID:10616911. |
itch-associated response induced by intradermal serotonin through 5-ht2 receptors in mice. |
2000-01-21 |
2023-08-12 |
mouse |
| T Yamaguchi, T Nagasawa, M Satoh, Y Kuraish. Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice. Neuroscience research. vol 35. issue 2. 2000-01-21. PMID:10616911. |
the 5-ht action may be mediated at least partly by cutaneous 5-ht2 receptors. |
2000-01-21 |
2023-08-12 |
mouse |
| G Remington, S A Chon. Conventional versus novel antipsychotics: changing concepts and clinical implications. Journal of psychiatry & neuroscience : JPN. vol 24. issue 5. 2000-01-20. PMID:10586534. |
clozapine, the first novel antipsychotic, has relatively low activity at d2 receptors, a high affinity for d4 receptors and a greater 5-ht2 (serotonin) than d2 antagonism. |
2000-01-20 |
2023-08-12 |
Not clear |
| M Héry, A Sémont, M P Fache, M Faudon, F Hér. The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617146. |
exposure of hippocampal cells to 5-ht, (+/-)-2,5-dimethoxy-4-iodoamphetamine (doi; a 5-ht2 agonist), or citalopram resulted in an increase in number of gr binding sites. |
2000-01-18 |
2023-08-12 |
rat |
| P Sarchielli, A Alberti, S Russo, M Codini, R Panico, A Floridi, V Galla. Nitric oxide pathway, Ca2+, and serotonin content in platelets from patients suffering from chronic daily headache. Cephalalgia : an international journal of headache. vol 19. issue 9. 2000-01-13. PMID:10595291. |
an alteration in serotonin concentration has been found in patients with chronic headache caused by abuse of analgesic substances as well as an up-regulation of 5ht2 platelet receptors, which has been correlated with chronicization of the headache. |
2000-01-13 |
2023-08-12 |
Not clear |
| S Kapur, R Cho, C Jones, G McKay, R B Zipursk. Is amoxapine an atypical antipsychotic? Positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy. Biological psychiatry. vol 45. issue 9. 2000-01-05. PMID:10331115. |
all currently available atypical antipsychotics have, at clinically relevant doses: i) high serotonin (5-ht)2 occupancy; ii) greater 5-ht2 than dopamine (d)2 occupancy; and iii) a higher incidence of extrapyramidal side effects when their d2 occupancy exceeds 80%. |
2000-01-05 |
2023-08-12 |
Not clear |
| J C Horton, J D Trob. Akinetopsia from nefazodone toxicity. American journal of ophthalmology. vol 128. issue 4. 1999-12-08. PMID:10577608. |
to investigate two cases of selective impairment of motion perception (akinetopsia) induced by toxicity from the antidepressant nefazodone, a new drug that blocks serotonin reuptake and antagonizes 5-ht2 receptors. |
1999-12-08 |
2023-08-12 |
Not clear |
| K Zhang, F I Tarazi, N S Kula, R J Baldessarini, J L Neumeye. Selective alkylatation of dopamine D2 and D4 receptors in rat brain by N-(p-isothiocyanatophenethyl)spiperone. Neuroscience letters. vol 274. issue 3. 1999-12-06. PMID:10548413. |
nips also alkylated both receptors dose-dependently in vivo, with no effect on dopamine d1-like or serotonin 5-ht2 receptors at a dose that occluded 75% of d2 and d4 receptors. |
1999-12-06 |
2023-08-12 |
rat |
| D J Nutt, S Forshall, C Bell, A Rich, J Sandford, J Nash, S Argyropoulo. Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9 Suppl 3. 1999-11-23. PMID:10523062. |
variations within the ssri drug class, such as the selectivity ratios for serotonin versus noradrenaline uptake, elimination half-life, and affinity for the 5-ht2 receptor have been identified and may be important determinants of efficacy, side effects and clinical use. |
1999-11-23 |
2023-08-12 |
Not clear |
| J N DaSilva, R A Schwartz, E R Greenwald, C M Lourenco, A A Wilson, S Houl. Dopamine D1 agonist R-[11C]SKF 82957: synthesis and in vivo characterization in rats. Nuclear medicine and biology. vol 26. issue 5. 1999-11-22. PMID:10473192. |
r-[11c]skf 82957 exhibited high in vivo binding selectivity for d1 receptors in rats, because only high doses of d1 competitors, but not d2 or serotonin (5-ht2) blockers, significantly reduced the radioactivity levels in all brain areas. |
1999-11-22 |
2023-08-12 |
rat |
| G Laakmann, C Schüle, T Baghai, E Waldvoge. Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects. Psychoneuroendocrinology. vol 24. issue 7. 1999-10-21. PMID:10451911. |
mirtazapine is a new antidepressant agent which does not inhibit the reuptake of norepinephrine or serotonin but is an antagonist of presynaptic and, presumably, postsynaptic alpha 2-receptors as well as an antagonist of postsynaptic 5-ht2 and 5-ht3-receptors. |
1999-10-21 |
2023-08-12 |
human |
| E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. |
the optically pure enantiomers of the potential atypical antipsychotic agents 5-methoxy-2-[n-(2-benzamidoethyl)-n-n-propylamino]tetralin (5-ome-bpat, 5) and 5-methoxy-2-{n-[2-(2,6-dimethoxy)benzamidoethyl]-n-n-propylamino}t etralin [5-ome-(2,6-di-ome)-bpat, 6] were synthesized and evaluated for their in vitro binding affinities at alpha1-, alpha2-, and beta-adrenergic, muscarinic, dopamine d1, d2a, and d3, and serotonin 5-ht1a and 5-ht2 receptors. |
1999-10-12 |
2023-08-12 |
rat |