| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. |
(s)- and (r)-5 had high affinities for dopamine d2a, d3, and serotonin 5-ht1a receptors, moderate affinities for alpha1-adrenergic and serotonin 5-ht2 receptors, and no affinity (ki > 1000 nm) for the other receptor subtypes. |
1999-10-12 |
2023-08-12 |
rat |
| B K Boyarsky, W Haque, M R Rouleau, R M Hirschfel. Sexual functioning in depressed outpatients taking mirtazapine. Depression and anxiety. vol 9. issue 4. 1999-10-07. PMID:10431683. |
this dysfunction may be exacerbated by stimulation of post-synaptic serotonin 5ht2 receptors, a side-effect of most widely-used antidepressant medications, especially the selective serotonin reuptake inhibitors (ssris). |
1999-10-07 |
2023-08-12 |
Not clear |
| B K Boyarsky, W Haque, M R Rouleau, R M Hirschfel. Sexual functioning in depressed outpatients taking mirtazapine. Depression and anxiety. vol 9. issue 4. 1999-10-07. PMID:10431683. |
mirtazapine is an atypical antidepressant with alpha 2 adrenergic antagonist and serotonin 5-ht2 and 5-ht3 receptor-blocking activity. |
1999-10-07 |
2023-08-12 |
Not clear |
| F Lovren, X F Li, J Lytton, C Triggl. Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery. British journal of pharmacology. vol 127. issue 5. 1999-10-05. PMID:10455272. |
5-ht1-like and 5-ht2 receptors have both been described to mediate contractions to 5-ht in the human umbilical artery (hua). |
1999-10-05 |
2023-08-12 |
human |
| F Lovren, X F Li, J Lytton, C Triggl. Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery. British journal of pharmacology. vol 127. issue 5. 1999-10-05. PMID:10455272. |
several 5-ht2 selective receptor antagonists (spiperone, cyproheptadine, pirenperone) competitively inhibited responses to 5-ht. |
1999-10-05 |
2023-08-12 |
human |
| J R Backstrom, M S Chang, H Chu, C M Niswender, E Sanders-Bus. Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432492. |
with the advent of molecular and cellular techniques, we are beginning to understand the complexity of lsd's actions at the serotonin 5-ht2 family of receptors. |
1999-09-17 |
2023-08-12 |
Not clear |
| K Lee, A K Dixon, R D Pinnoc. Serotonin depolarizes hippocampal interneurones in the rat stratum oriens by interaction with 5HT2 receptors. Neuroscience letters. vol 270. issue 1. 1999-09-16. PMID:10454145. |
serotonin depolarizes hippocampal interneurones in the rat stratum oriens by interaction with 5ht2 receptors. |
1999-09-16 |
2023-08-12 |
rat |
| K Takada, Y Sakurai-Yamashita, K Yamashita, M Kaibara, Y Hamada, Y Nakane, K Hioki, K Taniyam. Regional difference in correlation of 5-HT4 receptor distribution with cholinergic transmission in the guinea pig stomach. European journal of pharmacology. vol 374. issue 3. 1999-09-13. PMID:10422794. |
in mucosa-free preparations treated with 5-ht1, 5-ht2 and 5-ht3 receptor antagonists, 5-ht (10(-8)-10(-6) m) potentiated the electrically stimulated (0.5 hz, 1 ms) outflow of [3h]acetylcholine from antrum and corpus strips preloaded with [3h]choline, but not from fundus strips, and the potentiation was antagonized by sb204070, (1-n-butyl-4-piperidinyl) methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate. |
1999-09-13 |
2023-08-12 |
Not clear |
| U Henning, K Krieger, A Klimk. Specific binding of 3H-spiperone to peripheral blood cells: relevance for the interpretation of binding studies in psychiatric disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 2. 1999-08-17. PMID:10368866. |
the pharmacological profile of the high-affinity 3h-spiperone binding site is clearly different from the dopamine d2 and d4, serotonin 5-ht2 histamine h1 and noradrenergic alpha1 and alpha2 receptor, respectively. |
1999-08-17 |
2023-08-12 |
Not clear |
| J M Gorma. Mirtazapine: clinical overview. The Journal of clinical psychiatry. vol 60 Suppl 17. 1999-08-17. PMID:10446735. |
the rapid increase in serotonin (5-ht) synaptic levels by blockade of alpha2-heteroreceptors indirectly enhances 5-ht1a-mediated neurotransmission since 5-ht2 and 5-ht3 are blocked by mirtazapine. |
1999-08-17 |
2023-08-12 |
Not clear |
| M E Thas. Antidepressant treatment of the depressed patient with insomnia. The Journal of clinical psychiatry. vol 60 Suppl 17. 1999-08-17. PMID:10446739. |
stimulation of serotonin-2 (5-ht2) receptors is thought to underlie insomnia and changes in sleep architecture seen with selective serotonin reuptake inhibitors (ssris) or serotonin-norepinephrine reuptake inhibitors (snris). |
1999-08-17 |
2023-08-12 |
Not clear |
| L N Yatham, P F Liddle, J Dennie, I S Shiah, M J Adam, C J Lane, R W Lam, T J Rut. Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone. Archives of general psychiatry. vol 56. issue 8. 1999-08-11. PMID:10435604. |
preclinical studies have shown that long-term administration of various antidepressants causes down-regulation of brain serotonin 2 (5-ht2) receptors in rodents, but it is unknown if similar changes occur following antidepressant treatment in depressed patients. |
1999-08-11 |
2023-08-12 |
Not clear |
| D G Rainni. Serotonergic modulation of neurotransmission in the rat basolateral amygdala. Journal of neurophysiology. vol 82. issue 1. 1999-08-10. PMID:10400936. |
the effect of 5-ht was mimicked by the 5-ht2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-ht), but not by the 5-ht1a receptor agonist, (+/-) 8-hydroxydipropylaminotetralin hydrobromide (8-oh-dpat), or the 5-ht1b agonist, cgs 12066a. |
1999-08-10 |
2023-08-12 |
rat |
| D G Rainni. Serotonergic modulation of neurotransmission in the rat basolateral amygdala. Journal of neurophysiology. vol 82. issue 1. 1999-08-10. PMID:10400936. |
these results suggest that acute serotonin release would directly activate gabaergic interneurons of the bla, via an activation of 5-ht2 receptors, and increase the frequency of inhibitory synaptic events in projection neurons. |
1999-08-10 |
2023-08-12 |
rat |
| K K Fitzgerald, D H Sane. Serotonergic modulation of synapses in the developing gerbil lateral superior olive. Journal of neurophysiology. vol 81. issue 6. 1999-08-05. PMID:10368394. |
a 5-ht2 agonist, alpha-me-5-ht, reproduced all the observed effects of 5-ht (psc depression as well as induction of spontaneous ipscs), whereas a 5-ht2 antagonist, ketanserin, blocked the induction of spontaneous ipscs. |
1999-08-05 |
2023-08-12 |
Not clear |
| S Gidener, M Gümüştekin, Z Kirkal. Pharmacological analysis of 5-hydroxytryptamine effects on human isolated ureter. Pharmacological research. vol 39. issue 6. 1999-08-05. PMID:10373245. |
in the present study the receptor mediating the contractile response to 5-ht in the human upper ureter could not be clearly designated 5-ht1-like, 5-ht2, 5-ht3or 5-ht4. |
1999-08-05 |
2023-08-12 |
human |
| J S Kuo, H T Li, N N Lin, C S Yang, F C Chen. Dorsal facial area of cat medulla; 5-HT2 action on glutamate release in regulating common carotid blood flow. Neuroscience letters. vol 266. issue 2. 1999-08-03. PMID:10353346. |
glutamate concentration was dose-dependently decreased by perfusion of 5-ht or doi, a 5-ht2 agonist, but not by 5-ct, a 5-ht1 agonist. |
1999-08-03 |
2023-08-12 |
cat |
| J S Kuo, H T Li, N N Lin, C S Yang, F C Chen. Dorsal facial area of cat medulla; 5-HT2 action on glutamate release in regulating common carotid blood flow. Neuroscience letters. vol 266. issue 2. 1999-08-03. PMID:10353346. |
in conclusion, 5-ht may inhibit glutamate release via 5-ht2 receptor in dfa, resulting in the reduction of cca blood flow. |
1999-08-03 |
2023-08-12 |
cat |
| C Wu, P Dias, S Kumar, J M Lauder, S Sing. Differential expression of serotonin 5-HT2 receptors during rat embryogenesis. Developmental neuroscience. vol 21. issue 1. 1999-07-14. PMID:10077698. |
differential expression of serotonin 5-ht2 receptors during rat embryogenesis. |
1999-07-14 |
2023-08-12 |
rat |
| E Toscano, G Romero, C Oset, J Del Rí. Pharmacological characteristics and regulation of 5-HT receptor-stimulated phosphoinositide hydrolysis in the rat spinal cord. General pharmacology. vol 32. issue 3. 1999-07-09. PMID:10211591. |
the effect of either 5-ht or doi is blocked by selective 5-ht2a receptor antagonists such as spiperone and ketanserin and more markedly by mixed 5-ht2 receptor antagonists, such as ritanserin, methysergide and mesulergine, with higher affinity at the 2c subtype. |
1999-07-09 |
2023-08-12 |
rat |