| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Toscano, G Romero, C Oset, J Del Rí. Pharmacological characteristics and regulation of 5-HT receptor-stimulated phosphoinositide hydrolysis in the rat spinal cord. General pharmacology. vol 32. issue 3. 1999-07-09. PMID:10211591. |
after neonatal injection of 5,7-dihydroxytryptamine, which results in a marked loss of 5-ht content in the cord, 5-ht and 5-ht2 receptor agonists also enhance pi breakdown without a concomitant change in receptor number. |
1999-07-09 |
2023-08-12 |
rat |
| J F Cheer, A K Cadogan, C A Marsden, K C Fone, D A Kendal. Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors. Neuropharmacology. vol 38. issue 4. 1999-07-02. PMID:10221757. |
in vitro, oleamide and hu210 enhanced the high affinity binding of 5-ht to 5-ht2 receptors on rat cerebral cortex membranes labelled with 3h-ketanserin. |
1999-07-02 |
2023-08-12 |
rat |
| P B Bergqvist, J Dong, P Blie. Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. Psychopharmacology. vol 143. issue 1. 1999-07-02. PMID:10227084. |
these results suggest that the 5-ht2 response in the ofc is more akin to the 5-ht2c subtype and that the deleterious effect sometimes observed with high doses of risperidone and clozapine may be due to a decrease in 5-ht neurotransmission. |
1999-07-02 |
2023-08-12 |
rat |
| M Takeda, K Tsukamoto, Y Mizutani, T Suzuki, K Taniyam. Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. Japanese journal of pharmacology. vol 79. issue 2. 1999-06-29. PMID:10202856. |
the receptor binding assay showed that sk-951 bound to the 5-ht3 receptor with a high affinity, to the 5-ht4 receptor with relatively higher affinity and to the muscarinic m2 receptor with a low affinity, but not to dopamine d1 and d2 and serotonin 5-ht1 and 5-ht2 and muscarinic m1 and m3 receptors. |
1999-06-29 |
2023-08-12 |
rat |
| H S Kim, I S Park, H K Lim, H S Cho. NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in PCPA-treated mice. Archives of pharmacal research. vol 22. issue 2. 1999-06-28. PMID:10230499. |
previous work in our laboratory has shown that the n-methyl-d-aspartate (nmda) receptor antagonists, ap-5, cpp, mk-801, ketamine, dextrorphan and dextromethorphan cause a pronounced enhancement of 5-hydroxytryptamine (5-ht)-induced head-twitch response (htr) in intact mice, suggesting the involvement of nmda receptors in the glutamatergic modulation of serotonergic function at the postsynaptic 5-ht2 receptors. |
1999-06-28 |
2023-08-12 |
mouse |
| H S Kim, I S Park, H K Lim, H S Cho. NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in PCPA-treated mice. Archives of pharmacal research. vol 22. issue 2. 1999-06-28. PMID:10230499. |
in addition, the enhancement of 5-ht-induced htr was inhibited by a dopamine agonist, apomorphine, nmda receptor antagonist, nmda and a serotonin 5-ht2 receptor antagonist, cyproheptadine, in pcpa-treated mice. |
1999-06-28 |
2023-08-12 |
mouse |
| M L Wadenberg, K A Young, J T Richter, P B Hick. Effects of local application of 5-hydroxytryptamine into the dorsal or median raphe nuclei on haloperidol-induced catalepsy in the rat. Neuropharmacology. vol 38. issue 1. 1999-06-24. PMID:10193906. |
the anticataleptic effects observed at the later observation time could be due to stimulation of postsynaptic 5-ht2 receptors following diffusion of 5-ht into 5-ht2 receptor rich areas of the brain. |
1999-06-24 |
2023-08-12 |
rat |
| A Gobert, M J Milla. Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats. Neuropharmacology. vol 38. issue 2. 1999-06-24. PMID:10218874. |
the 5-ht2 receptor agonist, doi, dose-dependently (0.16-10.0 mg/kg, s.c.) increased dialysate levels of dopamine (da) and noradrenaline (na), but not 5-ht, in the frontal cortex (fcx) of freely-moving rats. |
1999-06-24 |
2023-08-12 |
rat |
| D Q Xiao, J S Tang, B Yuan, H Ji. Inhibitory effects of 5-hydroxytryptamine microinjection into thalamic nucleus submedius on rat tail flick reflex are mediated by 5-HT2 receptors. Neuroscience letters. vol 260. issue 2. 1999-06-18. PMID:10025705. |
inhibitory effects of 5-hydroxytryptamine microinjection into thalamic nucleus submedius on rat tail flick reflex are mediated by 5-ht2 receptors. |
1999-06-18 |
2023-08-12 |
rat |
| D Q Xiao, J S Tang, B Yuan, H Ji. Inhibitory effects of 5-hydroxytryptamine microinjection into thalamic nucleus submedius on rat tail flick reflex are mediated by 5-HT2 receptors. Neuroscience letters. vol 260. issue 2. 1999-06-18. PMID:10025705. |
these results suggest that 5-ht application to the sm may activate sm neurons through the 5-ht2 receptors leading to activation of the brainstem descending inhibitory system via the vlo and depression of the nociceptive information at the spinal level. |
1999-06-18 |
2023-08-12 |
rat |
| G B Varty, V P Bakshi, M A Geye. M100907, a serotonin 5-HT2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 4. 1999-06-03. PMID:10088132. |
in a recent study using wistar rats, the serotonergic 5-ht2 receptor antagonists ketanserin and risperidone reduced the disruptive effects of the noncompetitive n-methyl-d-aspartate (nmda) antagonist dizocilpine on prepulse inhibition (ppi), suggesting that there is an interaction between serotonin and glutamate in the modulation of ppi. |
1999-06-03 |
2023-08-12 |
rat |
| T Ishida, K Hirata, T Sakoda, S Kawashima, H Akita, M Yokoyam. Identification of mRNA for 5-HT1 and 5-HT2 receptor subtypes in human coronary arteries. Cardiovascular research. vol 41. issue 1. 1999-06-03. PMID:10325974. |
although pharmacological studies have indicated that serotonin (5-ht)-evoked contraction of the human coronary artery is mediated by 5-ht1-like and 5-ht2 receptors, the gene expression of 5-ht receptors is still unclear. |
1999-06-03 |
2023-08-12 |
human |
| H Sarhan, I Cloëz-Tayarani, O Massot, M P Fillion, G Fillio. 5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 1. 1999-06-01. PMID:9933149. |
[+/-]8-oh-dpat, a 5-ht(1a) receptor agonist, [+/-]doi, a 5-ht2 receptor agonist, and 2-methyl-5-hydroxytryptamine, a 5-ht3 receptor agonist, at concentrations ranging from 0.01 microm to 100 microm did not show any significant effect. |
1999-06-01 |
2023-08-12 |
rat |
| G Catalano, M C Catalano, N B Tumarki. Nefazodone overdose: a case report. Clinical neuropharmacology. vol 22. issue 1. 1999-05-28. PMID:10047937. |
it is a phenylpiperazine derivative that inhibits the reuptake of both norepinephrine and serotonin and antagonizes the 5ht2 and alpha-one adrenergic receptors. |
1999-05-28 |
2023-08-12 |
Not clear |
| P J Fletcher, K M Kort. Activation of 5-HT1B receptors in the nucleus accumbens reduces amphetamine-induced enhancement of responding for conditioned reward. Psychopharmacology. vol 142. issue 2. 1999-05-27. PMID:10102769. |
the present studies examined the 5-ht receptor involved in this effect by investigating the effects of 5-ht agonists with differing affinities for 5-ht1 and 5-ht2 receptors on d-amphetamine-induced potentiation of responding for cr. |
1999-05-27 |
2023-08-12 |
rat |
| W M Glaze. Does loxapine have "atypical" properties? Clinical evidence. The Journal of clinical psychiatry. vol 60 Suppl 10. 1999-05-27. PMID:10340686. |
given findings at a pharmacologic level that loxapine has a ratio of serotonin (5-ht2) and dopamine (d2) binding affinity similar to that of the atypical antipsychotics, 1 review data at a clinical level to see if this agent has correlating effects on symptoms and behaviors. |
1999-05-27 |
2023-08-12 |
Not clear |
| H Plein, M Ber. The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 1-2. 1999-05-26. PMID:10082235. |
the failure of this study to find enhanced sensitivity of 5-ht2 receptors in panic disorder is compatible with the findings of previous challenge studies that found no consistent dysregulation of serotonin in panic disorder. |
1999-05-26 |
2023-08-12 |
human |
| G K Aghajanian, G J Mare. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain research. vol 825. issue 1-2. 1999-05-26. PMID:10216183. |
although the early, synchronous component of electrically evoked epscs was reduced while 5-ht was being applied, late, nonsynchronous components were enhanced during 5-ht washout and also by the 5-ht2 partial agonist 1-(2,5-dimethoxy-4-iodophenyl-2-aminopropane (doi); the effect of doi was blocked by a selective 5-ht2a antagonist (mdl 100,907). |
1999-05-26 |
2023-08-12 |
rat |
| W J McBride, T K L. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Critical reviews in neurobiology. vol 12. issue 4. 1999-05-24. PMID:10348615. |
systemic administration of agents that (1) increase synaptic levels of serotonin (5-ht) or dopamine (da); (2) activate 5-ht1a, 5-ht2, d2, d3, or gaba(a) receptors; or (3) block opioid and 5-ht3 receptors decrease ethanol intake in most animal models. |
1999-05-24 |
2023-08-12 |
rat |
| A Mizuno, N Inomata, M Miya, T Kamei, M Shibata, T Tatsuoka, M Yoshida, C Takiguchi, T Miyazak. Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chemical & pharmaceutical bulletin. vol 47. issue 2. 1999-05-17. PMID:10071857. |
a series of 1-aminoalkyl-pyrrolo[2,3-c]azepin-8-one derivatives was synthesized and evaluated as alpha 1 adrenergic and serotonin 2 (5-ht2) receptor antagonists, with the aim of finding a novel antihypertensive agent potently exhibiting both activities. |
1999-05-17 |
2023-08-12 |
rat |