| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Bakis. The patient with comorbid depression and anxiety: the unmet need. The Journal of clinical psychiatry. vol 60 Suppl 6. 1999-05-13. PMID:10235121. |
a range of effective pharmacotherapeutic strategies are available, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, the 5-ht2 blocker nefazodone, and the serotonin-norepinephrine reuptake inhibitor venlafaxine. |
1999-05-13 |
2023-08-12 |
Not clear |
| A A Bell, B L Butz, R H Alpe. Cardiovascular responses produced by microinjection of serotonin-receptor agonists into the paraventricular nucleus in conscious rats. Journal of cardiovascular pharmacology. vol 33. issue 2. 1999-05-06. PMID:10028923. |
these data suggest that 5-ht neurons projecting from the raphe nuclei to or near the pvn can participate in the central control of the cardiovascular system by way of 5-ht2 receptors. |
1999-05-06 |
2023-08-12 |
rat |
| R B Ostroff, J C Nelso. Risperidone augmentation of selective serotonin reuptake inhibitors in major depression. The Journal of clinical psychiatry. vol 60. issue 4. 1999-05-06. PMID:10221288. |
preclinical data suggest 5-ht2 antagonists may enhance the action of serotonin. |
1999-05-06 |
2023-08-12 |
Not clear |
| K Takemura, K Takada, S Mameya, M Kaibara, K Taniyam. Regional and functional differences of 5-hydroxytryptamine-receptor subtypes in guinea pig stomach. Japanese journal of pharmacology. vol 79. issue 1. 1999-05-04. PMID:10082316. |
in the guinea pig stomach, the fundus possesses relaxant 5-ht1 receptor < contractile 5-ht2 receptors and caused the contractile response to 5-ht. |
1999-05-04 |
2023-08-12 |
Not clear |
| K Takemura, K Takada, S Mameya, M Kaibara, K Taniyam. Regional and functional differences of 5-hydroxytryptamine-receptor subtypes in guinea pig stomach. Japanese journal of pharmacology. vol 79. issue 1. 1999-05-04. PMID:10082316. |
the corpus possesses relaxant 5-ht1 receptors and relaxant receptors other than 5-ht1, 5-ht2, 5-ht3 and 5-ht4 receptors > contractile 5-ht4 receptor, and therefore 5-ht caused relaxations. |
1999-05-04 |
2023-08-12 |
Not clear |
| K Takemura, K Takada, S Mameya, M Kaibara, K Taniyam. Regional and functional differences of 5-hydroxytryptamine-receptor subtypes in guinea pig stomach. Japanese journal of pharmacology. vol 79. issue 1. 1999-05-04. PMID:10082316. |
the antrum possesses relaxant 5-ht1 receptor < contractile 5-ht2, 5-ht3 and 5-ht4 receptors, and thus 5-ht caused contractions. |
1999-05-04 |
2023-08-12 |
Not clear |
| V V Vorob'ev, E R Akhmetova, G I Kovale. [The participation of the 5-HT1 and 5-HT2 subtypes of the serotonin receptors in the formation of the frequency component in the EEG of non-narcotized rats]. Eksperimental'naia i klinicheskaia farmakologiia. vol 62. issue 1. 1999-04-30. PMID:10198758. |
[the participation of the 5-ht1 and 5-ht2 subtypes of the serotonin receptors in the formation of the frequency component in the eeg of non-narcotized rats]. |
1999-04-30 |
2023-08-12 |
rat |
| J A Harvey, S E Welsh, H Hood, A G Roman. Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism. Psychopharmacology. vol 141. issue 2. 1999-04-13. PMID:9952040. |
this study examined the role of the serotonin 5-ht2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (nm) reflex of the rabbit. |
1999-04-13 |
2023-08-12 |
rabbit |
| G J Basura, P D Walke. Differential sensitivity of tachykinin vs. enkephalin gene expression in the posterior striatum in response to acute p-chloroamphetamine treatment during postnatal development. Brain research. Developmental brain research. vol 112. issue 1. 1999-04-13. PMID:9974171. |
given its predominance in the caudal regions of the striatum, 5-ht neurotransmission at the 5-ht2 receptor is suggested to play a central role in this mechanism. |
1999-04-13 |
2023-08-12 |
Not clear |
| F F Hamdan, M D Ungrin, M Abramovitz, P Ribeir. Characterization of a novel serotonin receptor from Caenorhabditis elegans: cloning and expression of two splice variants. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098838. |
when transiently expressed in cos-7 cells, 5-ht2ce exhibited 5-ht binding activity and activated ca2+-mediated signaling in a manner analogous to other 5-ht2 receptors. |
1999-04-13 |
2023-08-12 |
caenorhabditis_elegans |
| T Ishida, S Kawashima, K Hirata, M Yokoyam. Nitric oxide is produced via 5-HT1B and 5-HT2B receptor activation in human coronary artery endothelial cells. The Kobe journal of medical sciences. vol 44. issue 2. 1999-03-29. PMID:10036860. |
a selective 5-ht2 agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (doi, 0.01-10 mumol/l) also mimicked the effect of 5-ht. |
1999-03-29 |
2023-08-12 |
human |
| D Ben-Shachar, H Gazawi, J Riboyad-Levin, E Klei. Chronic repetitive transcranial magnetic stimulation alters beta-adrenergic and 5-HT2 receptor characteristics in rat brain. Brain research. vol 816. issue 1. 1999-03-25. PMID:9878693. |
in this study the effects of repeated rtms on rat brain noradrenaline, dopamine, serotonin and their metabolites levels, as well as on beta-adrenergic and 5-ht2 receptor characteristics were studied. |
1999-03-25 |
2023-08-12 |
rat |
| A Menese. Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory. Reviews in the neurosciences. vol 9. issue 4. 1999-03-23. PMID:9886142. |
emerging evidence also indicates that 5-ht1a and 5-ht4 receptor agonists, as well as, 5-ht1a antagonists, 5-ht2 antagonists, 5-ht3 antagonists and 5-ht uptake inhibitors may have therapeutic utility in the treatment of alzheimer's disease and amnesia. |
1999-03-23 |
2023-08-12 |
Not clear |
| H Liston, L Bennett, B Usher, J Napp. The association of the combination of sumatriptan and methysergide in myocardial infarction in a premenopausal woman. Archives of internal medicine. vol 159. issue 5. 1999-03-22. PMID:10074961. |
methysergide is primarily a serotonin type 2 (5-ht2) antagonist, although it does act as a partial agonist at 5-ht1 receptors. |
1999-03-22 |
2023-08-12 |
Not clear |
| A Linden, D Desmecht, H Amory, P Lekeu. Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves. Veterinary journal (London, England : 1997). vol 157. issue 1. 1999-03-17. PMID:10030126. |
the purpose of the present study was to determine whether the cardiovascular response to 5-ht in calves was attributable to 5-ht2 receptors. |
1999-03-17 |
2023-08-12 |
cattle |
| A Linden, D Desmecht, H Amory, P Lekeu. Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves. Veterinary journal (London, England : 1997). vol 157. issue 1. 1999-03-17. PMID:10030126. |
a specific 5-ht2 antagonist (metrenperone, 0.05 mg/kg) was administered intramuscular to six unsedated friesian calves 30 min before the animals were given a 5-min intravenous 5-ht infusion. |
1999-03-17 |
2023-08-12 |
cattle |
| W M Abi-Saab, M Bubser, R H Roth, A Y Deutc. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 1. 1999-03-15. PMID:9885788. |
these data indicate that serotonin, operating through a 5-ht2 receptor, acutely activates gabaergic interneurons in the prefrontal cortex. |
1999-03-15 |
2023-08-12 |
rat |
| M Verbeke, J Van de Voorde, L de Ridder, N Lameir. Beneficial effect of serotonin 5-HT2-receptor antagonism on renal blood flow autoregulation in cyclosporin-treated rats. Journal of the American Society of Nephrology : JASN. vol 10. issue 1. 1999-03-11. PMID:9890306. |
renal blood flow (rbf) autoregulation reappears in postischemic rat kidneys during serotonin (5-ht2) antagonism. |
1999-03-11 |
2023-08-12 |
rat |
| S Hood, D Birnie, A Nasser, W S Hilli. Effect of ketanserin on central haemodynamics and coronary circulation. Journal of cardiovascular pharmacology. vol 32. issue 6. 1999-03-05. PMID:9869505. |
ketanserin is a selective 5-hydroxytryptamine (5-ht2) antagonist with vasodilator properties in the systemic and pulmonary circulation. |
1999-03-05 |
2023-08-12 |
Not clear |
| H Zhong, M Zhang, C A Nurs. Electrophysiological characterization of 5-HT receptors on rat petrosal neurons in dissociated cell culture. Brain research. vol 816. issue 2. 1999-03-04. PMID:9878879. |
in the minority ( approximately 6%) population of neurons which responded to 5-ht with a conductance decrease, the depolarization was blocked by the 5-ht2 receptor antagonist, ketanserin (50 microm). |
1999-03-04 |
2023-08-12 |
rat |