| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Krebs-Thomson, M A Geye. Evidence for a functional interaction between 5-HT1A and 5-HT2 receptors in rats. Psychopharmacology. vol 140. issue 1. 1999-02-25. PMID:9862404. |
evidence of a functional interaction between serotonin 5-ht1a and 5-ht2 receptor subtypes has been compromised by incomplete experimental designs and conflicting data. |
1999-02-25 |
2023-08-12 |
rat |
| P A Sargent, D J Quested, P J Cowe. Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors. Psychopharmacology. vol 140. issue 1. 1999-02-25. PMID:9862411. |
the cortisol response to 5-htp was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (ssris), enhances this 5-ht2 receptor mediated response. |
1999-02-25 |
2023-08-12 |
Not clear |
| A J Sleight, F G Boess, M Bös, A Bourso. The putative 5-ht6 receptor: localization and function. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928244. |
until recently, the majority of actions of the neurotransmitter 5-hydroxytryptamine (5-ht) were generally believed to be mediated by members of the 5-ht1, 5-ht2, 5-ht3 and 5-ht4 receptor families. |
1999-02-25 |
2023-08-12 |
Not clear |
| S Kapur, R B Zipursky, G Remingto. Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia. The American journal of psychiatry. vol 156. issue 2. 1999-02-25. PMID:9989565. |
the purpose of this study was to compare the d2 and serotonin 5-ht2 receptor occupancies of these drugs in patients receiving multiple-dose, steady-state regimens. |
1999-02-25 |
2023-08-12 |
Not clear |
| N Bonhomme, E Esposit. Involvement of serotonin and dopamine in the mechanism of action of novel antidepressant drugs: a review. Journal of clinical psychopharmacology. vol 18. issue 6. 1999-02-18. PMID:9864076. |
in this article, studies reporting the biochemical, behavioral, and clinical effects of tricyclic antidepressants (tcas), monoamine oxidase inhibitors (maois), selective serotonin reuptake inhibitors (ssris), selective blockers of presynaptic dopamine (da) receptors, and antagonists of serotonin-2 (5-hydroxytryptamine-2 [5-ht2]) receptors were reviewed. |
1999-02-18 |
2023-08-12 |
Not clear |
| J L Goren, G M Levi. Quetiapine, an atypical antipsychotic. Pharmacotherapy. vol 18. issue 6. 1999-02-10. PMID:9855315. |
in fact, a defining characteristic of atypical agents is a higher ratio of serotonin (5ht2) receptor blockade to d2 receptor blockade. |
1999-02-10 |
2023-08-12 |
Not clear |
| H Kanerva, H Huuskonen, A Alhonen-Raatesalmi, T Nevalainen, A Urtt. Pharmacokinetics of deramciclane in dogs after single oral and intravenous dosing and multiple oral dosing. Biopharmaceutics & drug disposition. vol 19. issue 8. 1999-02-05. PMID:9840215. |
the pharmacokinetics of a new serotonin 5-ht2 antagonist, deramciclane, was studied. |
1999-02-05 |
2023-08-12 |
Not clear |
| R Lewis, S Kapur, C Jones, J DaSilva, G M Brown, A A Wilson, S Houle, R B Zipursk. Serotonin 5-HT2 receptors in schizophrenia: a PET study using [18F]setoperone in neuroleptic-naive patients and normal subjects. The American journal of psychiatry. vol 156. issue 1. 1999-01-27. PMID:9892300. |
serotonin 5-ht2 receptors in schizophrenia: a pet study using [18f]setoperone in neuroleptic-naive patients and normal subjects. |
1999-01-27 |
2023-08-12 |
human |
| R Lewis, S Kapur, C Jones, J DaSilva, G M Brown, A A Wilson, S Houle, R B Zipursk. Serotonin 5-HT2 receptors in schizophrenia: a PET study using [18F]setoperone in neuroleptic-naive patients and normal subjects. The American journal of psychiatry. vol 156. issue 1. 1999-01-27. PMID:9892300. |
several postmortem studies have reported a decreased density of serotonin 5-ht2 receptors in the prefrontal cortex in schizophrenia. |
1999-01-27 |
2023-08-12 |
human |
| J A Hey, R Aslanian, D C Bolser, R W Chapman, R W Egan, C A Rizzo, N Y Shih, X Fernandez, R L McLeod, R West, W Kreutne. Studies on the pharmacology of the novel histamine H3 receptor agonist Sch 50971. Arzneimittel-Forschung. vol 48. issue 9. 1999-01-19. PMID:9793613. |
sch 50971 has low affinity (ic50's > 10 mumol/l) for histamine h1, dopamine d1 and d2, serotonin 5-ht2 and muscarinic cholinergic receptors. |
1999-01-19 |
2023-08-12 |
human |
| T Back, R Prado, W Zhao, B D Watson, M D Ginsber. Ritanserin, a 5-HT2 receptor antagonist, increases subcortical blood flow following photothrombotic middle cerebral artery occlusion in rats. Neurological research. vol 20. issue 7. 1998-12-30. PMID:9785594. |
it has been proposed that the reversal of serotonin-mediated vasoconstriction accounts for the neuroprotective effect of serotonin (5-ht2) receptor blockade in focal cerebral ischemia. |
1998-12-30 |
2023-08-12 |
rat |
| G Vitale, L A Pini, A Ottani, M Sandrin. Effect of acetylsalicylic acid on formalin test and on serotonin system in the rat brain. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809474. |
increased serotonin (5-ht) content in rat brain but did not modify the number or the affinity of 5-ht1a receptors in the pons and the cerebral cortex, whereas the number of cortical 5-ht2 receptors decreased significantly. |
1998-12-23 |
2023-08-12 |
rat |
| G Vitale, L A Pini, A Ottani, M Sandrin. Effect of acetylsalicylic acid on formalin test and on serotonin system in the rat brain. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809474. |
pretreatment with parachlorophenylaline (100 mg/kg/day for 4 days) depleted 5-ht brain content but modified neither the serum levels of salicylates nor the 5-ht2 cortical receptor characteristics, and it abolished the antinociceptive effect of asa, 400 mg/kg, in the first phase of the formalin test. |
1998-12-23 |
2023-08-12 |
rat |
| M Beato, A Nistr. Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842733. |
by means of electrophysiological recordings from multiple ventral roots we demonstrated that the decrease caused by 5-ht in nmda-induced periodicity was dose-dependent, enhanced after pharmacological blocking of 5-ht2 excitatory receptors, and imitated by pharmacological agonists of the 5-ht1 receptor family. |
1998-12-22 |
2023-08-12 |
rat |
| M Beato, A Nistr. Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842733. |
it is concluded that the principal inhibitory action of 5-ht on the spinal locomotor network was mediated by certain subtypes of the 5-ht1 receptor class, which tends to oppose the 5-ht2 receptor-mediated excitation of the same network. |
1998-12-22 |
2023-08-12 |
rat |
| I Morecroft, M R MacLea. 5-hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries. British journal of pharmacology. vol 125. issue 1. 1998-12-18. PMID:9776346. |
vasoconstrictor responses to 5-ht, 5-carboxamidotryptamine (5-ct, 5-ht1 receptor agonist), alpha-methyl-5-ht (5-ht2 receptor agonist) and sumatriptan (5-ht1d/1b receptor agonist) were studied in fetal, 0-24 h, 4 day, 7 day and adult rabbit pulmonary resistance arteries (pras), alone and in the presence of the no synthase inhibitor nomega-nitro-l-arginine methylester (l-name). |
1998-12-18 |
2023-08-12 |
rabbit |
| S Samnick, N Remy, S Ametamey, J B Bader, W Brandau, C M Kirsc. 123I-MSP and F[11C]MSP: new selective 5-HT2A receptor radiopharmaceuticals for in vivo studies of neuronal 5-HT2 serotonin receptors. Synthesis, in vitro binding study with unlabelled analogues and preliminary in vivo evaluation in mice. Life sciences. vol 63. issue 22. 1998-12-18. PMID:9839544. |
123i-msp and f[11c]msp: new selective 5-ht2a receptor radiopharmaceuticals for in vivo studies of neuronal 5-ht2 serotonin receptors. |
1998-12-18 |
2023-08-12 |
mouse |
| C M Villalón, F J López-Muñoz, M Perusquía, J A Terró. External carotid effects of 2-(2-aminoethyl)-quinoline (D-1997) in vagosympathectomized dogs. European journal of pharmacology. vol 356. issue 1. 1998-12-14. PMID:9761419. |
serotonin (5-hydroxytryptamine; 5-ht) elicits external carotid vasoconstriction in vagosympathectomized dogs via 5-ht1b/1d receptors and a mechanism unrelated to the 5-ht1, 5-ht2, 5-ht3 and 5-ht4 types. |
1998-12-14 |
2023-08-12 |
Not clear |
| M Sandrini, A Ottani, G Vitale, L A Pin. Acetylsalicylic acid potentiates the antinociceptive effect of morphine in the rat: involvement of the central serotonergic system. European journal of pharmacology. vol 355. issue 2-3. 1998-12-11. PMID:9760027. |
and morphine (3 mg/kg s.c.) was administered and the pain threshold was evaluated in the hot-plate and formalin tests, and 5-ht2 receptor binding capacity, 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) levels were measured in the cortex and pontine areas of the brain. |
1998-12-11 |
2023-08-12 |
rat |
| M Sandrini, A Ottani, G Vitale, L A Pin. Acetylsalicylic acid potentiates the antinociceptive effect of morphine in the rat: involvement of the central serotonergic system. European journal of pharmacology. vol 355. issue 2-3. 1998-12-11. PMID:9760027. |
the combination of acetylsalicylic acid and morphine had an analgesic effect in both tests that was associated with an increase in 5-ht levels and a decrease in 5-ht2 receptors in the cortex. |
1998-12-11 |
2023-08-12 |
rat |