| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Ewa Poleszak, Weronika Stasiuk, Aleksandra Szopa, El\\xc5\\xbcbieta Wyska, Anna Serefko, Anna Oniszczuk, Sylwia Wo\\xc5\\x9bko, Katarzyna \\xc5\\x9awi\\xc4\\x85der, Piotr Wla\\xc5\\xb. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metabolic brain disease. vol 31. issue 4. 2018-01-12. PMID:26924124.' |
the observed effect of traxoprodil is only partially associated with serotonergic system and is independent of the effect on the 5-ht1a and 5-ht2 serotonin receptors. |
2018-01-12 |
2023-08-13 |
mouse |
| R Forcén, E Latorre, J Pardo, A I Alcalde, M D Murillo, L Gras. Toll-like receptors 2 and 4 exert opposite effects on the contractile response induced by serotonin in mouse colon: role of serotonin receptors. Experimental physiology. vol 101. issue 8. 2018-01-01. PMID:27282784. |
in wt, tlr2(-/-) and tlr2/4 dko mice, 5-ht2 , 5-ht3 , 5-ht4 and 5-ht7 receptor antagonists reduced or blocked the contractile response evoked by 5-ht. |
2018-01-01 |
2023-08-13 |
mouse |
| Ayaka Hori, Takashi Nishida, Shogo Takashiba, Satoshi Kubota, Masaharu Takigaw. Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes. PloS one. vol 12. issue 11. 2017-12-26. PMID:29145495. |
recently, it was reported that 5-ht2 receptors (5-ht2rs) were expressed in cartilage tissues lacking both vessels and neurons, suggesting possible novel functions of 5-ht during cartilage development and regeneration. |
2017-12-26 |
2023-08-13 |
human |
| Miku Aoki, Yoshihisa Watanabe, Kanji Yoshimoto, Atsushi Tsujimura, Toshiro Yamamoto, Narisato Kanamura, Masaki Tanak. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. The European journal of neuroscience. vol 43. issue 9. 2017-12-22. PMID:26950265. |
serotonin 2c receptors (5-ht2 c rs) are widely expressed in the central nervous system, and are associated with various neurological disorders. |
2017-12-22 |
2023-08-13 |
mouse |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morá. Chronic Sarpogrelate Treatment Reveals 5-HT7 Receptor in the Serotonergic Inhibition of the Rat Vagal Bradycardia. Journal of cardiovascular pharmacology. vol 69. issue 1. 2017-11-27. PMID:27676327. |
5-hydroxytryptamine (5-ht) modulates the cardiac parasympathetic neurotransmission, inhibiting the bradyarrhythmia by 5-ht2 receptor activation. |
2017-11-27 |
2023-08-13 |
rat |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morá. Chronic Sarpogrelate Treatment Reveals 5-HT7 Receptor in the Serotonergic Inhibition of the Rat Vagal Bradycardia. Journal of cardiovascular pharmacology. vol 69. issue 1. 2017-11-27. PMID:27676327. |
our outcomes suggest that blocking chronically 5-ht2 receptors modifies the serotonergic influence on cardiac vagal neurotransmission exhibiting 5-ht as an exclusively inhibitory agent via prejunctional 5-ht7 receptor. |
2017-11-27 |
2023-08-13 |
rat |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
physiological effects of 5-ht are mediated by about 15 serotoninergic receptors grouped into seven broad families (5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht5, 5-ht6, 5-ht7 receptor families). |
2017-09-20 |
2023-08-13 |
Not clear |
| Lingli Hu, Chunhua Liu, Minyan Dang, Bin Luo, Yiping Guo, Haitao Wan. Activation of 5-HT2A/2C receptors reduces the excitability of cultured cortical neurons. Neuroscience letters. vol 632. 2017-08-08. PMID:27585751. |
5-ht2 receptor among multiple subtypes of serotonin receptors contributes to the modulation of excitability, synaptic transmissions and plasticity. |
2017-08-08 |
2023-08-13 |
Not clear |
| Dalia M El-Tanbouly, Walaa Wadie, Rabab H Saye. Modulation of TGF-β/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice. Toxicology and applied pharmacology. vol 329. 2017-07-31. PMID:28623179. |
serotonin (5-ht) has been implicated as a key driver of liver fibrosis, acting via 5-ht2 receptor activation in the hepatic stellate cells. |
2017-07-31 |
2023-08-13 |
mouse |
| Adam J Prus, Laura E Wise, Alan L Pehrson, Scott D Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H Porte. Discriminative stimulus properties of 1.25mg/kg clozapine in rats: Mediation by serotonin 5-HT2 and dopamine D4 receptors. Brain research. vol 1648. issue Pt A. 2017-07-26. PMID:27502027. |
discriminative stimulus properties of 1.25mg/kg clozapine in rats: mediation by serotonin 5-ht2 and dopamine d4 receptors. |
2017-07-26 |
2023-08-13 |
rat |
| Björn Hansson, Anya Medina, Claes Fryklund, Malin Fex, Karin G Stenkul. Serotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells. Biochemical and biophysical research communications. vol 474. issue 2. 2017-05-10. PMID:27109474. |
similar to 5-ht, 5-ht2 receptor agonists reduced lipolysis while 5-ht1 receptor agonists rather decreased non-stimulated and insulin-stimulated glucose uptake. |
2017-05-10 |
2023-08-13 |
rat |
| Samah M Elaidy, Soha S Essaw. The antifibrotic effects of alveolar macrophages 5-HT2C receptors blockade on bleomycin-induced pulmonary fibrosis in rats. Pharmacological reports : PR. vol 68. issue 6. 2017-03-23. PMID:27686964. |
lung serotonin (5-ht) content is increased during pulmonary fibrosis with the implication of 5-ht2 receptors in the pathogenesis. |
2017-03-23 |
2023-08-13 |
rat |
| C Grasso, G Li Volsi, M Barres. Serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-HT1A and 5-HT2 receptors. Archives italiennes de biologie. vol 154. issue 2-3. 2017-03-15. PMID:27918061. |
serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-ht1a and 5-ht2 receptors. |
2017-03-15 |
2023-08-13 |
rat |
| C Grasso, G Li Volsi, M Barres. Serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-HT1A and 5-HT2 receptors. Archives italiennes de biologie. vol 154. issue 2-3. 2017-03-15. PMID:27918061. |
to ascertain the specificity of the effects induced by 5-ht, we utilized 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) and alpha-methyl-5-hydroxytryptamine (α-met-5-ht), agonists for 5-ht1a and 5-ht2 receptors, respectively. |
2017-03-15 |
2023-08-13 |
rat |
| C Grasso, G Li Volsi, M Barres. Serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-HT1A and 5-HT2 receptors. Archives italiennes de biologie. vol 154. issue 2-3. 2017-03-15. PMID:27918061. |
these results indicate that 5-ht is able to modulate the background firing activity of gn neurons by 5-ht1a and 5-ht2 receptors. |
2017-03-15 |
2023-08-13 |
rat |
| Anna Löfdahl, Kristina Rydell-Törmänen, Catharina Müller, C Martina Holst, Lena Thiman, Gunilla Ekström, Christina Wenglén, Anna-Karin Larsson-Callerfelt, Gunilla Westergren-Thorsso. 5-HT2B receptor antagonists attenuate myofibroblast differentiation and subsequent fibrotic responses in vitro and in vivo. Physiological reports. vol 4. issue 15. 2017-03-13. PMID:27482070. |
the pathological mechanisms are not well known, however serotonin (5-ht) and 5-ht class 2 (5-ht2) receptors have been associated with fibrosis. |
2017-03-13 |
2023-08-13 |
mouse |
| Liam Roberts, Loretta Ford, Neel Patel, J Allister Vale, Sally M Bradberr. 11 analytically confirmed cases of mexedrone use among polydrug users. Clinical toxicology (Philadelphia, Pa.). vol 55. issue 3. 2017-03-06. PMID:28075189. |
mexedrone inhibits the re-uptake of serotonin and dopamine in a dose-dependent manner and has affinity for serotonin and dopamine membrane transporters and receptors (5-ht2 and d2 receptors), producing sympathomimetic effects similar to amfetamines. |
2017-03-06 |
2023-08-13 |
Not clear |
| Aram Rasul, Husameldin El-Nour, Sol-Britt Lonne-Rahm, Oscar Fransson, Charlotta Johansson, Björn Johansson, Marwe Zubeidi, Emma Seeberg, Diana Radu Djurfeldt, Efrain C Azmitia, Klas Nordlin. Serotonergic Markers in Atopic Dermatitis. Acta dermato-venereologica. vol 96. issue 6. 2017-01-13. PMID:26831833. |
biopsies were taken from lesional and non-lesional ad skin, and investigated for expression of serotonin, its receptors 5-ht1a and 5-ht2, and serotonin transporter protein (sert), using immunohistochemistry. |
2017-01-13 |
2023-08-13 |
Not clear |
| Haitao Wang, Lingli Hu, Chunhua Liu, Zhenghui Su, Lihui Wang, Guangjin Pan, Yiping Guo, Jufang H. 5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons. Scientific reports. vol 6. 2017-01-10. PMID:26837719. |
serotonin increased the frequency of miniature inhibitory postsynaptic currents (mipscs), which could be mimicked by α-methylserotonin, a 5-ht2 receptor agonist. |
2017-01-10 |
2023-08-13 |
human |
| Haitao Wang, Lingli Hu, Chunhua Liu, Zhenghui Su, Lihui Wang, Guangjin Pan, Yiping Guo, Jufang H. 5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons. Scientific reports. vol 6. 2017-01-10. PMID:26837719. |
these findings suggested that in ips-derived human neurons serotonin postsynaptically reduced gabaa receptor function through 5-ht2a/c receptors, but presynaptically other 5-ht2 receptors counteracted the action of 5-ht2a/c receptors. |
2017-01-10 |
2023-08-13 |
human |