| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Saucier, S J Morris, P R Alber. Endogenous serotonin-2A and -2C receptors in Balb/c-3T3 cells revealed in serotonin-free medium: desensitization and down-regulation by serotonin. Biochemical pharmacology. vol 56. issue 10. 1998-12-07. PMID:9825734. |
extended treatment (24-96 hr) with 5-ht induced a complete functional desensitization that was associated with a partial (60%) reduction in 5-ht2 receptor number, implicating both receptor down-regulation and post-receptor mechanisms in 5-ht-induced desensitization. |
1998-12-07 |
2023-08-12 |
Not clear |
| C Saucier, S J Morris, P R Alber. Endogenous serotonin-2A and -2C receptors in Balb/c-3T3 cells revealed in serotonin-free medium: desensitization and down-regulation by serotonin. Biochemical pharmacology. vol 56. issue 10. 1998-12-07. PMID:9825734. |
these results demonstrate that balb/c-3t3 cells express endogenous 5-ht2 receptors that are desensitized by the 5-ht present in normal serum, illustrating the importance of growth conditions in the identification of receptor responsiveness. |
1998-12-07 |
2023-08-12 |
Not clear |
| C Saucier, S J Morris, P R Alber. Endogenous serotonin-2A and -2C receptors in Balb/c-3T3 cells revealed in serotonin-free medium: desensitization and down-regulation by serotonin. Biochemical pharmacology. vol 56. issue 10. 1998-12-07. PMID:9825734. |
the lack of proliferative response to 5-ht in balb/c-3t3 suggests a putative role of desensitization as a "safety valve" to prevent abnormal cell growth during sustained 5-ht2 receptor activation. |
1998-12-07 |
2023-08-12 |
Not clear |
| L L Hwang, N J Du. 5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro. Journal of neurophysiology. vol 80. issue 3. 1998-12-03. PMID:9744919. |
the present study shows that, in the immature rat rvlm neurons, 5-ht causes a slow hyperpolarization and depolarization probably by interacting with 5-ht1a and 5-ht2 receptors, which are g-proteins coupled. |
1998-12-03 |
2023-08-12 |
rat |
| A Wolf, A Jackson, T Price, A Trevino, M Caldarola-Pastuszka, L Uphous. Attenuation of the lordosis-inhibiting effects of 8-OH-DPAT by TFMPP and quipazine. Brain research. vol 804. issue 2. 1998-11-16. PMID:9757039. |
although both quipazine and tfmpp act on multiple 5-ht receptors, they overlap in their agonist action at 5-ht2 receptors. |
1998-11-16 |
2023-08-12 |
rat |
| X Xu, K J Mille. Prevention of DOI-mediated wet dog shakes by inhibitors of nitric oxide synthase. Brain research. vol 804. issue 2. 1998-11-16. PMID:9757078. |
the data provides evidence that serotonin 5ht2 receptors are coupled to nnos activation in the rat brain. |
1998-11-16 |
2023-08-12 |
rat |
| L L Cheng, S J Wang, P W Gea. Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors. The European journal of neuroscience. vol 10. issue 6. 1998-11-09. PMID:9753102. |
in contrast, the selective 5-ht2 receptor antagonist ketanserin failed to affect the action of 5-ht. |
1998-11-09 |
2023-08-12 |
rat |
| M A Hertzberg, M E Feldman, J C Beckham, S D Moore, J R Davidso. Open trial of nefazodone for combat-related posttraumatic stress disorder. The Journal of clinical psychiatry. vol 59. issue 9. 1998-10-20. PMID:9771816. |
because of its ability to block 5-ht2 receptors postsynaptically and inhibit 5-ht reuptake presynaptically and/or its enhancement of sleep quality, nefazodone may be useful for symptom management in posttraumatic stress disorder (ptsd) patients. |
1998-10-20 |
2023-08-12 |
Not clear |
| T L Xu, Z P Pang, J S Li, N Akaik. 5-HT potentiation of the GABA(A) response in the rat sacral dorsal commissural neurones. British journal of pharmacology. vol 124. issue 4. 1998-10-02. PMID:9690871. |
in the presence of chelerythrine, 5-ht failed to potentiate igaba, suggesting that protein kinase c (pkc) is involved in the pathway through which the activation of the 5-ht2 receptor potentiates the igaba. |
1998-10-02 |
2023-08-12 |
rat |
| D J Bootle, J J Adcock, A G Ramag. The role of central 5-HT receptors in the bronchoconstriction evoked by inhaled capsaicin in anaesthetised guinea-pigs. Neuropharmacology. vol 37. issue 2. 1998-10-01. PMID:9680249. |
the effects of intracisternal (i.c) injections of the 5-ht1a receptor agonists, buspirone and 8-oh-dpat, and the antagonists way-100635; and (-)-pindolol, the 5-ht1b/1d receptor agonist sumatriptan and antagonist gr127935, the 5-ht2 receptor agonist doi and the antagonist cinanserin, the 5-ht3 receptor antagonist granisetron, the alpha-adrenoceptor agonist clonidine and the antagonist idazoxan, the d2 receptor antagonists (-)-sulpiride and the 5-ht uptake inhibitor fluoxetine on capsaicin-evoked increase in tracheal inflation pressure (bronchoconstriction) were investigated in alpha-chloralose anaesthetised, neuromuscularly blocked, artificially ventilated guinea-pigs. |
1998-10-01 |
2023-08-12 |
Not clear |
| B Grella, M Dukat, R Young, M Teitler, K Herrick-Davis, C B Gauthier, R A Glenno. Investigation of hallucinogenic and related beta-carbolines. Drug and alcohol dependence. vol 50. issue 2. 1998-09-29. PMID:9649961. |
classical hallucinogens bind at 5-ht2 serotonin receptors and these receptors are thought to play a role in their mechanism of action. |
1998-09-29 |
2023-08-12 |
human |
| F Navas, F L Tang, L T Schaller, M H Norma. Analogues of the potential antipsychotic agent 1192U90: amide modifications. Bioorganic & medicinal chemistry. vol 6. issue 6. 1998-09-29. PMID:9681147. |
analogues of 2-amino-n-(4-(4-(1,2-benzisothiazol-3-yl)-l-piperazinyl) -butyl)benzamide hydrochloride (1192u90) were prepared and evaluated in receptor binding assays for the dopamine d2, serotonin 5-ht1a, and serotonin 5-ht2 receptors. |
1998-09-29 |
2023-08-12 |
Not clear |
| H Schwörer, G Ramador. Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 5. 1998-09-28. PMID:9650808. |
the 5-ht1a receptor agonist (+)-8-hydroxy-dipropylaminotetralin (8-oh-dpat, 1 micromol/l) and the 5-ht2 receptor agonist alpha-methyl-5-ht (1 micromol/l) increased 5-ht release by 40% in about 60% of the human preparations. |
1998-09-28 |
2023-08-12 |
human |
| S Feldman, M E Newman, E Gur, J Weidenfel. Role of serotonin in the amygdala in hypothalamo-pituitary-adrenocortical responses. Neuroreport. vol 9. issue 9. 1998-09-25. PMID:9674583. |
these results indicate that amg 5-ht has an important role in the activation of the hpa axis following neural stimulation and that 5-ht2 receptors are involved. |
1998-09-25 |
2023-08-12 |
rat |
| M Zivin, L Sprah, D Ske. Antiparkinsonian potential of interaction of LEK-8829 with bromocriptine. European journal of pharmacology. vol 349. issue 2-3. 1998-09-23. PMID:9671092. |
the ergoline derivative, lek-8829 (9,10-didehydro-n-methyl-(2-propynyl)-6-methyl-8-aminomethylerg oline), has been proposed as a potential atypical antipsychotic drug with antagonistic actions at dopamine d2 and serotonin 5-ht2 and 5-ht1a receptors (krisch et al., 1994, 1996). |
1998-09-23 |
2023-08-12 |
rat |
| J Hardcastle, P T Hardcastl. 5-Hydroxytryptamine-induced secretion by rat jejunum in-vitro involves several 5-hydroxytryptamine receptor subtypes. The Journal of pharmacy and pharmacology. vol 50. issue 5. 1998-09-21. PMID:9643448. |
mianserin, a 5-ht1, 5-ht2 and 5-ht3 antagonist, and renzapride, a 5-ht1 and 5-ht3 antagonist, both reduced the maximum response to 5-ht, but 5-htp-dp, a 5-ht1 antagonist, was without effect. |
1998-09-21 |
2023-08-12 |
rat |
| Z Csaba, V Csernus, I Gerenda. Intratesticular serotonin affects steroidogenesis in the rat testis. Journal of neuroendocrinology. vol 10. issue 5. 1998-09-18. PMID:9663651. |
the effect of intratesticular administration of serotonin (5-ht), ketanserin (5-ht2 receptor antagonist), and 5,7-dihydroxytryptamine (5,7-dht) (the neurotoxin that destroys serotoninergic neural elements) on steroidogenesis was studied in immature and adult rats. |
1998-09-18 |
2023-08-12 |
rat |
| Z Csaba, V Csernus, I Gerenda. Intratesticular serotonin affects steroidogenesis in the rat testis. Journal of neuroendocrinology. vol 10. issue 5. 1998-09-18. PMID:9663651. |
data also suggest that, in both age groups, the effect of 5-ht is mediated through 5-ht2 receptors. |
1998-09-18 |
2023-08-12 |
rat |
| L Sundin, W Davison, M Forster, M Axelsso. A role of 5-HT2 receptors in the gill vasculature of the antarctic fish Pagothenia borchgrevinki. The Journal of experimental biology. vol 201. issue Pt 14. 1998-09-09. PMID:9639587. |
pre-branchial injection of serotonin (5-hydroxytryptamine, 5-ht) or the 5-ht2 receptor agonist alpha-methylserotonin increased the branchial vascular resistance and ventral aortic pressure, while the 5-ht1 receptor agonist piperazine was without effect. |
1998-09-09 |
2023-08-12 |
Not clear |
| L Sundin, W Davison, M Forster, M Axelsso. A role of 5-HT2 receptors in the gill vasculature of the antarctic fish Pagothenia borchgrevinki. The Journal of experimental biology. vol 201. issue Pt 14. 1998-09-09. PMID:9639587. |
the branchial vasoconstriction produced by serotonin injection was completely blocked by the 5-ht1/5-ht2 receptor antagonist methysergide and the branchial vasoconstriction produced by width="9" height="12" align="bottom" naturalsizeflag= alpha-methylserotonin injection was completely blocked by the specific 5-ht2 receptor antagonist ly53857. |
1998-09-09 |
2023-08-12 |
Not clear |