| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Balcells-Olivero, M S Cousins, L S Seide. Holtzman and Harlan Sprague-Dawley rats: differences in DRL 72-sec performance and 8-hydroxy-di-propylamino tetralin-induced hypothermia. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694929. |
a dose-response determination for the tricyclic antidepressants, imipramine and desipramine, the selective serotonin (5-hydroxytryptamine; 5-ht) reuptake inhibitor, fluoxetine, the 5-ht2 receptor antagonist, ketanserin, the 5-ht1a receptor agonist, (+/-)8-hydroxy-di-propylamino tetralin (8-oh-dpat) and the dopamine releasing compound, amphetamine, were assessed in both rat stocks. |
1998-09-02 |
2023-08-12 |
rat |
| E J Pappert, C G Goetz, G T Stebbins, M Belden, P M Carve. 5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes. European journal of pharmacology. vol 347. issue 1. 1998-09-01. PMID:9650847. |
guinea pigs were pre-treated with carbidopa (50 mg) followed by one of eight 5-ht antagonists: (-)-n-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenyl propionamide ((-)-way 100135) (5-ht1a), n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-n-(2-pyridyl)-cy clohexancarboxamide (way 100635) (5-ht1a), methiothepin mesylate (5-ht1/2), mesulergine hydrochloride (5-ht2a/2c), n[4-methoxy-3-(4-methyl-l-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2 ,4-oxadizol-3-yl) (gr 127935) (5-ht1d), trans-4-[(3z)3-(2-dimethylaminoethyl)oxyimino-3(2-fluorop hen yl) propen-1-yl]phenol, hemifumarate (sr 46349) (5-ht2), ondansetron hydrochloride (5-ht3), and [1-[2-[methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-meth oxy-1h-indole-3-carboxylate (gr 125487) (5-ht4). |
1998-09-01 |
2023-08-12 |
Not clear |
| J A Hardin, P D Brockway, D G Gal. Atrial natriuretic peptide-induced secretory responses in rabbit vs rat ileum. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 119. issue 3. 1998-08-24. PMID:9683416. |
in the rat, the effect of anp is mediated by seratonin (5-ht) acting through 5-ht2 receptors. |
1998-08-24 |
2023-08-12 |
rat |
| M Santiago, E R Matarredona, A Machado, J Can. Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum. Journal of neuroscience research. vol 52. issue 5. 1998-08-21. PMID:9632315. |
in vivo microdialysis was used to investigate the mechanism behind the increase in extracellular dopamine (da) induced by increase in extracellular serotonin (5-ht) level and 5-ht1 and 5-ht2 receptor activation. |
1998-08-21 |
2023-08-12 |
rat |
| M Santiago, E R Matarredona, A Machado, J Can. Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum. Journal of neuroscience research. vol 52. issue 5. 1998-08-21. PMID:9632315. |
the following serotoninergic drugs were perfused in the absence or presence of nomifensine (5 microm) or tetrodotoxin (ttx; 2 microm): clomipramine (10, 500 and 1,000 microm), a selective 5-ht reuptake inhibitor; 8-oh-dpat (50 and 500 microm), a 5-ht1a receptor agonist; and alpha-methyl-5-ht (1, 5 and 50 microm), a 5-ht2 receptor agonist. |
1998-08-21 |
2023-08-12 |
rat |
| M Santiago, E R Matarredona, A Machado, J Can. Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum. Journal of neuroscience research. vol 52. issue 5. 1998-08-21. PMID:9632315. |
these data seem to indicate that increase in extracellular 5-ht level and 5-ht1 and 5-ht2 receptor activation increase in vivo da extracellular output in the striatum mainly by a nonexocytotic mechanism involving da uptake sites and, secondarily, by activation of 5-ht receptors. |
1998-08-21 |
2023-08-12 |
rat |
| R Olin, R Klein, P A Ber. A randomised double-blind 16-week study of ritanserin in fibromyalgia syndrome: clinical outcome and analysis of autoantibodies to serotonin, gangliosides and phospholipids. Clinical rheumatology. vol 17. issue 2. 1998-08-11. PMID:9641502. |
the aim of the study was to evaluate in a double-blind manner the effect of the long-acting 5-hydroxytryptamine 2 (5-ht2)-receptor blocker ritanserin on clinical symptoms in patients with fibromyalgia syndrome (fm) and on production of antibodies to serotonin, gangliosides and phospholipids, recently shown to have a high incidence in this disease. |
1998-08-11 |
2023-08-12 |
Not clear |
| C Tournois, V Mutel, P Manivet, J M Launay, O Kellerman. Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism. The Journal of biological chemistry. vol 273. issue 28. 1998-08-06. PMID:9651340. |
we took advantage of a serotonergic cell line to elucidate cross-talks between 5-ht receptors and to demonstrate the involvement of two 5-ht2 receptor subtypes in the regulation of 5-ht1b/1d function. |
1998-08-06 |
2023-08-12 |
Not clear |
| T Tanaka, J Ishigooka, S Watanabe, E Nagata, S Miur. Partial inhibition of reverse tolerance by a high dose of ritanserin or low dose of haloperidol in methamphetamine-sensitized rat. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 18. issue 1. 1998-07-22. PMID:9592805. |
this result suggested that the interactions between 5-ht and dopamine (da) neurons are complex, and that 5-ht2 antagonism may inhibit or disinhibit da neurons depending on the level of d2 blockade. |
1998-07-22 |
2023-08-12 |
rat |
| S Kapur, R B Zipursky, G Remington, C Jones, J DaSilva, A A Wilson, S Houl. 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. The American journal of psychiatry. vol 155. issue 7. 1998-07-21. PMID:9659858. |
the purpose of this study was to investigate olanzapine's binding to the serotonin 5-ht2 and dopamine d2 receptors in schizophrenic patients being treated with clinically relevant doses. |
1998-07-21 |
2023-08-12 |
Not clear |
| M Hirafuji, A Nezu, Y Kanai, T Ebihara, F Kawahara, A Tanimura, M Minam. Effect of 5-hydroxytryptamine on intracellular calcium dynamics in cultured rat vascular smooth muscle cells. Research communications in molecular pathology and pharmacology. vol 99. issue 3. 1998-07-07. PMID:9591325. |
these results suggest that, in cultured rat aortic smooth muscle cells, 5-ht increases [ca2+]i via 5-ht2 receptor subtype by inducing influx of extracellular ca2+ partially through l-type voltage-dependent ca2+ channel, as well as by mobilizing ca2+ from its intracellular stores. |
1998-07-07 |
2023-08-12 |
rat |
| W Shi, C G Wang, R J Dandurand, D H Eidelman, R P Miche. Differential responses of pulmonary arteries and veins to histamine and 5-HT in lung explants of guinea-pigs. British journal of pharmacology. vol 123. issue 8. 1998-07-07. PMID:9605557. |
contractions to 5-ht were abolished in arteries and markedly reduced in veins by the 5-ht2 antagonist ketanserin (10(-4) m); l-noarg potentiated the maximal responses of arteries but not of veins; indomethacin increased the maximal responses of arteries but reduced them in veins. |
1998-07-07 |
2023-08-12 |
Not clear |
| P R Germonpré, G F Joos, R A Pauwel. Modulation by 5-HT1A receptors of the 5-HT2 receptor-mediated tachykinin-induced contraction of the rat trachea in vitro. British journal of pharmacology. vol 123. issue 8. 1998-07-07. PMID:9605563. |
the selective 5-ht2 receptor antagonist ketanserin (0.1 microm) produced an almost complete inhibition of the contractions caused by nka (n=4, p<0.0001, two-way anova), and a significant rightward shift of the concentration-response curve to 5-ht (n=8, p<0.001, two-way anova). |
1998-07-07 |
2023-08-12 |
rat |
| R Pakala, C R Benedic. Effect of serotonin and thromboxane A2 on endothelial cell proliferation: effect of specific receptor antagonists. The Journal of laboratory and clinical medicine. vol 131. issue 6. 1998-07-02. PMID:9626988. |
when endothelial cells were preincubated with ly281067 (a 5-ht2 receptor antagonist) or ridogrel (a combined txa2 synthase inhibitor and receptor antagonist), ly281067 blocked the mitogenic effect of 5-ht and ridogrel blocked the potentiating effect of u46619 on 5-ht2-induced tritiated thymidine incorporation. |
1998-07-02 |
2023-08-12 |
Not clear |
| M T Lin, H J Tsay, W H Su, F Y Chue. Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function. The American journal of physiology. vol 274. issue 5. 1998-06-24. PMID:9644038. |
the results indicate that elevating the 5-ht levels in the hypothalamus activates postsynaptic 5-ht2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5-ht1a receptors in the hypothalamus reduces the endogenous 5-ht release and results in hypothermic effects. |
1998-06-24 |
2023-08-12 |
rat |
| S M Dyer, I S de la Lande, D B Frewin, R J Hea. 5-Hydroxytryptamine-induced contraction of the marmoset aorta is mediated by a 5-HT1-like receptor. Clinical and experimental pharmacology & physiology. vol 25. issue 3-4. 1998-06-15. PMID:9590577. |
5-hydroxytryptamine (5-ht) exerts both contractile and relaxant effects in the marmoset isolated aorta, actions that are unaffected by the 5-ht2 antagonist ketanserin. |
1998-06-15 |
2023-08-12 |
marmoset |
| M J Mijnster, Y Galis-de Graaf, P Voor. Serotonergic regulation of neuropeptide and glutamic acid decarboxylase mRNA levels in the rat striatum and globus pallidus: studies with fluoxetine and DOI. Brain research. Molecular brain research. vol 54. issue 1. 1998-06-10. PMID:9526047. |
the serotonergic regulation of neuropeptide and glutamic acid decarboxylase (gad) mrna level in the rat basal ganglia was investigated by determining the effects of chronic treatment with the serotonin uptake blocker fluoxetine and the serotonin 5-ht2 agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrobromide (doi). |
1998-06-10 |
2023-08-12 |
rat |
| M J Mijnster, Y Galis-de Graaf, P Voor. Serotonergic regulation of neuropeptide and glutamic acid decarboxylase mRNA levels in the rat striatum and globus pallidus: studies with fluoxetine and DOI. Brain research. Molecular brain research. vol 54. issue 1. 1998-06-10. PMID:9526047. |
our results further show that preproenkephalin mrna is not affected by chronic 5-ht2 receptor stimulation, indicating that the fluoxetine-induced decrease in preproenkephalin mrna levels involves other 5-ht receptors than the 5-ht2 receptor. |
1998-06-10 |
2023-08-12 |
rat |
| K Krebs-Thomson, V Lehmann-Masten, S Naiem, M P Paulus, M A Geye. Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotonin. European journal of pharmacology. vol 343. issue 2-3. 1998-06-09. PMID:9570460. |
to test the hypothesis that serotonergic modulation of the effects of phencyclidine (pcp) are due to circuit- rather than receptor-based interactions between glutamatergic and serotonergic systems, multivariate profiles of rat behavior were assessed after treatments with the 5-hydroxytryptamine (5-ht) 5-ht2 receptor antagonist ketanserin (1.0 mg/kg), the 5-ht2 receptor agonist (1(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) (doi; 0.27 mg/kg), various doses of pcp (0.75 to 10.125 mg/kg), or combinations thereof. |
1998-06-09 |
2023-08-12 |
rat |
| R Y Shen, R Andrad. 5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 285. issue 2. 1998-06-08. PMID:9580630. |
the ability of 5-ht to increase gabaergic synaptic activity in the presence of 5-ht3 receptor blockade was mimicked by the selective 5-ht2 agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and blocked by the selective 5-ht2 antagonist ketanserin. |
1998-06-08 |
2023-08-12 |
rat |