| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Läer, F Remmers, H Scholz, B Stein, F U Müller, J Neuman. Receptor mechanisms involved in the 5-HT-induced inotropic action in the rat isolated atrium. British journal of pharmacology. vol 123. issue 6. 1998-05-28. PMID:9559903. |
in contrast, the 5-ht2 receptor antagonist ketanserin (5 nm, 50 nm, 1 microm) resulted in a concentration-dependent diminution of the positive inotropic effect of 5-ht in rat left atria. |
1998-05-28 |
2023-08-12 |
rat |
| G Ronsisvalle, A Marrazzo, O Prezzavento, L Pasquinucci, F Vittorio, V Pittalà, M S Pappalardo, S Cacciaguerra, S Spampinat. (+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties. Journal of medicinal chemistry. vol 41. issue 10. 1998-05-28. PMID:9572883. |
a series of (+)-cis-n-normetazocine derivatives has been described, and their affinities for sigma1, sigma2, and phencyclidine (pcp) sites and opioid, muscarinic (m2), dopamine (d2), and serotonin (5-ht2) receptors were evaluated. |
1998-05-28 |
2023-08-12 |
mouse |
| S Feldman, J Weidenfel. The excitatory effects of the amygdala on hypothalamo-pituitary-adrenocortical responses are mediated by hypothalamic norepinephrine, serotonin, and CRF-41. Brain research bulletin. vol 45. issue 4. 1998-05-21. PMID:9527013. |
these results indicate that the facilitatory effects of the amg on the hpa axis are mediated by hypothalamic ne via alpha1 receptors and by 5-ht via 5-ht2 receptors, as well as by crf-41 in the paraventricular nucleus. |
1998-05-21 |
2023-08-12 |
rat |
| S D Gleason, H E Shanno. Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice. European journal of pharmacology. vol 341. issue 2-3. 1998-05-21. PMID:9543230. |
the present study investigated the effects of m-cpp alone and in the presence of the 5-ht2 receptor antagonist 6-methyl-1-(-methyethyl)-ergoline-8beta-carboxylic acid 2-hydroxy-1-methylpropyl ester maleate (ly53857), the 5-ht1a receptor antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-n-(2pyridinyl)c yclohexanecarboxamide trihydrochloride (way 100,635), and the 5-ht(1b/1d) receptor antagonist 2'-methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-corbox ylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]amide (gr 127935) on locomotor activity. |
1998-05-21 |
2023-08-12 |
mouse |
| T Kakigami, T Usui, K Tsukamoto, T Kataok. Synthesis and structure-activity relationship of 3-Substituted benzamide, benzo [b]furan-7-carboxamide, 2,3-dihydrobenzo[b]furan-77-carboxamide, and indole-5-carboxamide derivatives as selective serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 46. issue 1. 1998-05-13. PMID:9468636. |
furthermore, 8a hemifumarate was free from dopamine d1, d2, serotonin 5-ht1, 5-ht2 and muscarine m1, m2 receptor binding activity in the in in vitro tests. |
1998-05-13 |
2023-08-12 |
Not clear |
| M A Cruz, V Gallardo, P Miguel, G Carrasco, C Gonzále. Mediation by 5-HT2 receptors of 5-hydroxytryptamine-induced contractions of human placental vein. General pharmacology. vol 30. issue 4. 1998-05-12. PMID:9522163. |
however, ketanserin (10(-7) to 10(-6) m), a 5-ht2 receptor antagonist, induced significant inhibition of the concentration-response curve to 5-ht. |
1998-05-12 |
2023-08-12 |
human |
| O Gefvert, M Bergström, B Långström, T Lundberg, L Lindström, R Yate. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology. vol 135. issue 2. 1998-05-08. PMID:9497016. |
quetiapine (seroquel) is a novel antipsychotic with an atypical profile in animal models and a relatively short plasma half-life of 2.5 5 h. in the present study, we used pet to compare the time course of blockade of dopamine d2 and serotonin 5ht2 receptors of quetiapine using c11-raclopride and c11-n-methyl-spiperone as ligands, parallel to monitoring plasma drug concentrations. |
1998-05-08 |
2023-08-12 |
human |
| O Gefvert, M Bergström, B Långström, T Lundberg, L Lindström, R Yate. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology. vol 135. issue 2. 1998-05-08. PMID:9497016. |
serotonin 5ht2 receptor blockade in the frontal cortex was 72% after 2 h, which declined to 50% after 26 h. the terminal plasma half-life of quetiapine was 5.3 h. clinically, our eight patients had good antipsychotic effect without any extrapyramidal side-effects. |
1998-05-08 |
2023-08-12 |
human |
| O Gefvert, M Bergström, B Långström, T Lundberg, L Lindström, R Yate. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology. vol 135. issue 2. 1998-05-08. PMID:9497016. |
a more prolonged blockade of the serotonin 5ht2 receptors was found in the frontal cortex, with receptor occupancy half-life of 27 h. compared to clozapine, as demonstrated in other studies, quetiapine has much the same ratio of d2/5ht2 occupancy. |
1998-05-08 |
2023-08-12 |
human |
| A A Malayev, E A Debsk. Serotonin modulates induced synaptic activity in the optic tectum of the frog. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507107. |
alpha-methylserotonin, a nonselective agonist of 5-ht2 receptors, also blocked polysynaptic responses but was less effective than either serotonin or 5-ct in blocking monosynaptic ones. |
1998-04-29 |
2023-08-12 |
Not clear |
| S Moyanova, R Kirov, V Ivanov. Power spectral electroencephalogram analysis of the effects of ritanserin in freely moving rats during quiet waking. Methods and findings in experimental and clinical pharmacology. vol 19. issue 9. 1998-04-27. PMID:9500124. |
the results favor the view of the excitatory modulating action of serotonin mediated via cortical 5-ht2 receptors and suggest that ritanserin could cause a faster transition from waking to sleep. |
1998-04-27 |
2023-08-12 |
rat |
| L Gold, T Back, G Arnold, J Dreier, K M Einhäupl, U Reuter, U Dirnag. Cortical spreading depression-associated hyperemia in rats: involvement of serotonin. Brain research. vol 783. issue 2. 1998-04-13. PMID:9507121. |
we focused on the 5-ht2 receptor, which is engaged in 5-ht induced small arteriolar relaxation in cats, as well as on the 5-ht1d/1b receptor, the binding site of the potent antimigraine drug sumatriptan. |
1998-04-13 |
2023-08-12 |
rat |
| L Gold, T Back, G Arnold, J Dreier, K M Einhäupl, U Reuter, U Dirnag. Cortical spreading depression-associated hyperemia in rats: involvement of serotonin. Brain research. vol 783. issue 2. 1998-04-13. PMID:9507121. |
we conclude that serotonin is, probably via 5-ht2 receptors, involved in the modulation of the regional cerebral blood flow increase during csd. |
1998-04-13 |
2023-08-12 |
rat |
| M E Apfelbau. Role of vasoactive intestinal peptide and 5-HT2 receptor subtype in serotonin stimulation of basal and thyrotropin-releasing-hormone-induced prolactin release in vitro from rat pituitary cells. Neuroendocrinology. vol 67. issue 1. 1998-04-03. PMID:9485168. |
role of vasoactive intestinal peptide and 5-ht2 receptor subtype in serotonin stimulation of basal and thyrotropin-releasing-hormone-induced prolactin release in vitro from rat pituitary cells. |
1998-04-03 |
2023-08-12 |
rat |
| M E Apfelbau. Role of vasoactive intestinal peptide and 5-HT2 receptor subtype in serotonin stimulation of basal and thyrotropin-releasing-hormone-induced prolactin release in vitro from rat pituitary cells. Neuroendocrinology. vol 67. issue 1. 1998-04-03. PMID:9485168. |
in the present report, the participation of an autoparacrine action of vip in the stimulatory effects of 5-ht and the involvement of the 5-ht2 receptor type in mediating serotonin-induced prl release have been examined. |
1998-04-03 |
2023-08-12 |
rat |
| M E Apfelbau. Role of vasoactive intestinal peptide and 5-HT2 receptor subtype in serotonin stimulation of basal and thyrotropin-releasing-hormone-induced prolactin release in vitro from rat pituitary cells. Neuroendocrinology. vol 67. issue 1. 1998-04-03. PMID:9485168. |
addition of the 5-ht2 receptor antagonist, ketanserin (1 microm) into the incubation medium resulted in the loss of cellular responsiveness to 5-ht, preventing not only the stimulatory effect of 5-ht on the basal but also on the trh-induced prl release. |
1998-04-03 |
2023-08-12 |
rat |
| M E Apfelbau. Role of vasoactive intestinal peptide and 5-HT2 receptor subtype in serotonin stimulation of basal and thyrotropin-releasing-hormone-induced prolactin release in vitro from rat pituitary cells. Neuroendocrinology. vol 67. issue 1. 1998-04-03. PMID:9485168. |
in addition, it was shown that ketanserin completely antagonizes prl response to 5-ht, indicating the involvement of the 5-ht2 receptor type in mediating prl release. |
1998-04-03 |
2023-08-12 |
rat |
| M Narayan, G Anderson, J Cellar, R T Mallison, L H Price, J C Nelso. Serotonin transporter-blocking properties of nefazodone assessed by measurement of platelet serotonin. Journal of clinical psychopharmacology. vol 18. issue 1. 1998-04-02. PMID:9472845. |
this study aims to determine whether the newly introduced serotonin type 2 (5-ht2) antagonist nefazodone has serotonin (5-ht) transporter-blocking properties at clinical doses in depressed patients. |
1998-04-02 |
2023-08-12 |
Not clear |
| D E Dobbin. Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb. The American journal of physiology. vol 274. issue 2. 1998-03-17. PMID:9486270. |
these data indicate that the lymphatic smooth muscle contraction produced by 5-ht is mediated both by lymphatic alpha-adrenoreceptors and 5-ht2 receptors. |
1998-03-17 |
2023-08-12 |
Not clear |
| N Chairungsrilerd, K I Furukawa, T Ohta, S Nozoe, Y Ohizum. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 1. 1998-03-11. PMID:9459569. |
5-ht amplified, adp-induced aggregation of rabbit platelets (5-ht2a) was inhibited by gamma-mangostin (ic50 = 0.29 microm), whereas that induced by thrombin was not affected, nor did gamma-mangostin affect 5-ht-induced contraction of the guinea-pig ileum (5-ht3)in the presence of 5-ht1, 5-ht2 and 5-ht4 receptor antagonists. |
1998-03-11 |
2023-08-12 |
rat |