| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Costall, R J Naylo. The influence of 5-HT2 and 5-HT4 receptor antagonists to modify drug induced disinhibitory effects in the mouse light/dark test. British journal of pharmacology. vol 122. issue 6. 1998-02-23. PMID:9401775. |
it was concluded that in bkw mice (a) the failure of 5-ht2 and 5-ht4 receptor antagonists when administered alone to modify behaviour in the light/dark test indicates an absence of an endogenous 5-ht tone at the 5-ht2 and 5-ht4 receptors and (b) the enhancement by the 5-ht2 receptor antagonists and attenuation by the 5-ht4 receptor antagonists of drug-induced disinhibition indicates a plurality of 5-ht receptor involvement in the mediation of drug-induced disinhibitory profiles in the mouse. |
1998-02-23 |
2023-08-12 |
mouse |
| B R Tuladhar, M Kaisar, R J Naylo. Evidence for a 5-HT3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum. British journal of pharmacology. vol 122. issue 6. 1998-02-23. PMID:9401783. |
the concentration-response curve to mucosally applied 5-ht was not altered by the mucosally applied 5-ht1/2 receptor antagonist methiothepine (0.1 microm), the 5-ht2 receptor antagonist ritanserin (0.1 microm) or the 5-ht4 receptor antagonist sb 204070 (0.1 microm). |
1998-02-23 |
2023-08-12 |
Not clear |
| F Biver, D Wikler, F Lotstra, P Damhaut, S Goldman, J Mendlewic. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British journal of psychiatry : the journal of mental science. vol 171. 1998-02-23. PMID:9463603. |
serotonin 5-ht2 receptor imaging in major depression: focal changes in orbito-insular cortex. |
1998-02-23 |
2023-08-12 |
Not clear |
| F Biver, D Wikler, F Lotstra, P Damhaut, S Goldman, J Mendlewic. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British journal of psychiatry : the journal of mental science. vol 171. 1998-02-23. PMID:9463603. |
we studied type-2 serotonin (5-ht2) receptors in the brain of patients with major depression. |
1998-02-23 |
2023-08-12 |
Not clear |
| J Hardcastle, P T Hardcastl. Several receptor subtypes contribute to 5-hydroxytryptamine-induced secretion by rat ileum in-vitro. The Journal of pharmacy and pharmacology. vol 49. issue 11. 1998-02-17. PMID:9401948. |
ketanserin, a 5-ht2 antagonist, had a small effect on the actions of 5-methoxytryptamine in intact, but not stripped, sheets and no effect on the response to 5-ht in either preparation. |
1998-02-17 |
2023-08-12 |
rat |
| M Kato, A Nishida, Y Aga, J Kita, Y Kudo, H Narita, T End. Pharmacokinetic and pharmacodynamic evaluation of central effect of the novel antiallergic agent betotastine besilate. Arzneimittel-Forschung. vol 47. issue 10. 1998-02-05. PMID:9368705. |
in vitro receptor binding assays demonstrated that betotastine is a highly specific histamine h1 receptor ligand, having no significant binding affinity for histamine h3, adrenergic alpha 1, alpha 2, beta, dopamine d2l, serotonin 5-ht2, muscarinic, and benzodiazepine receptors. |
1998-02-05 |
2023-08-12 |
mouse |
| M I Gonzalez, P Greengrass, M Russell, C A Wilso. Comparison of serotonin receptor numbers and activity in specific hypothalamic areas of sexually active and inactive female rats. Neuroendocrinology. vol 66. issue 6. 1998-02-05. PMID:9430444. |
both 5-ht activity and 5-ht2 receptors are decreased in the vmn, arc and zi of receptive animals. |
1998-02-05 |
2023-08-12 |
rat |
| M R Briejer, C Mathis, J A Schuurke. 5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 9. issue 4. 1998-02-04. PMID:9430791. |
5-ht and alpha-methyl-5-ht equipotently induced contractions, whereas 5-methoxytryptamine and 2-methyl-5-ht (partial agonist) were less potent; this rank order of potency suggests involvement of a 5-ht2 receptor. |
1998-02-04 |
2023-08-12 |
rat |
| M R Briejer, C Mathis, J A Schuurke. 5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 9. issue 4. 1998-02-04. PMID:9430791. |
neither tetrodotoxin nor atropine affected the contraction to 5-ht, suggesting a smooth muscle localization of these 5-ht2 receptors. |
1998-02-04 |
2023-08-12 |
rat |
| M R Briejer, C Mathis, J A Schuurke. 5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 9. issue 4. 1998-02-04. PMID:9430791. |
comparison of the affinities of these compounds for the various 5-ht2 receptor subtypes revealed that the receptor involved in the contractions to 5-ht most closely resembles the 5-ht2a receptor. |
1998-02-04 |
2023-08-12 |
rat |
| M B Hansen, E Skadhaug. Signal transduction pathways for serotonin as an intestinal secretagogue. Comparative biochemistry and physiology. Part A, Physiology. vol 118. issue 2. 1998-01-14. PMID:9366057. |
5-ht mediates intestinal secretion through activation of at least the epithelial 5-ht2, and neuronal 5-ht3, and 5-ht4 receptors in the submucosal plexus, including a reflex arc. |
1998-01-14 |
2023-08-12 |
human |
| M Shimpo, U Ikeda, Y Maeda, K Kurosaki, K Okada, T Saito, K Shimad. Serotonin inhibits nitric oxide synthesis in rat vascular smooth muscle cells stimulated with interleukin-1. European journal of pharmacology. vol 338. issue 1. 1998-01-14. PMID:9408009. |
addition of the 5-ht2 receptor antagonist ketanserin, but not the 5-ht1a receptor antagonist spiroxatrine, inhibited the effect of 5-ht. |
1998-01-14 |
2023-08-12 |
rat |
| M Shimpo, U Ikeda, Y Maeda, K Kurosaki, K Okada, T Saito, K Shimad. Serotonin inhibits nitric oxide synthesis in rat vascular smooth muscle cells stimulated with interleukin-1. European journal of pharmacology. vol 338. issue 1. 1998-01-14. PMID:9408009. |
these results indicate that 5-ht acts on 5-ht2 receptors and inhibits no synthesis in interleukin-1beta-stimulated vascular smooth muscle cells at least partially through a protein kinase c-dependent pathway. |
1998-01-14 |
2023-08-12 |
rat |
| M B Knable, A Heinz, T Raedler, D R Weinberge. Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels. Psychiatry research. vol 75. issue 2. 1997-12-16. PMID:9351491. |
risperidone is an antipsychotic drug with high affinity at dopamine d2 and serotonin 5-ht2 receptors. |
1997-12-16 |
2023-08-12 |
human |
| S Varanasi, J Chi, R L Stephen. 5-CT or DOI augments TRH analog-induced gastric acid secretion at the dorsal vagal complex. The American journal of physiology. vol 273. issue 5. 1997-12-16. PMID:9374800. |
coinjection of rx with the 5-ht agonists 5-carboxyamidotryptamine (5-ct) or (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (doi; 5-ht2 agonist) produced a 183 or 103% increase in gastric acid output compared with the rx injection alone. |
1997-12-16 |
2023-08-12 |
rat |
| J M Miguez, V Simonneaux, P Peve. The role of the intracellular and extracellular serotonin in the regulation of melatonin production in rat pinealocytes. Journal of pineal research. vol 23. issue 2. 1997-12-11. PMID:9392444. |
on the other hand, the present study shows that the incubation of pineal cells with high concentrations of 5-ht or with a selective 5-ht2 receptor agonist, alpha-methyl-5-hydroxytryptamine, reverses partially the inhibitory effect of pcpa on the iso-stimulated melatonin synthesis. |
1997-12-11 |
2023-08-12 |
rat |
| B J Keck, J M Lakosk. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) administration for studies of 5-HT1A receptor binding site inactivation and turnover. Brain research. Brain research protocols. vol 1. issue 4. 1997-12-10. PMID:9384817. |
while age-related declines in the number of 5-ht1b and 5-ht2 receptors have been reported, little information is available describing the region-specific effects of aging on the functional dynamics of equilibrium binding at 5-ht receptors, including the 5-ht1a receptor subtype. |
1997-12-10 |
2023-08-12 |
human |
| J Cerdà, T R Petrino, M J Greenberg, R A Wallac. Pharmacology of the serotonergic inhibition of steroid-induced reinitiation of oocyte meiosis in the teleost Fundulus heteroclitus. Molecular reproduction and development. vol 48. issue 2. 1997-12-02. PMID:9291479. |
the pharmacological profile of these 5-ht receptors is different from those of any known mammalian 5-ht receptor, although they showed some similarities to the 5-ht1a, 5-ht2, and 5-ht3 receptors, as well as to 5-ht receptors on oocytes of some bivalve molluscs. |
1997-12-02 |
2023-08-12 |
Not clear |
| N C Coimbra, M L Brandã. Effects of 5-HT2 receptors blockade on fear-induced analgesia elicited by electrical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal gray. Behavioural brain research. vol 87. issue 1. 1997-11-26. PMID:9331477. |
since methysergide is a non-specific antagonist of 5-ht receptors and ketanserin acts with a high degree of specificity at 5-ht2 receptors the present results suggest that activation of 5-ht2 receptors may be implicated in the antinociception induced by midbrain tectum stimulation. |
1997-11-26 |
2023-08-12 |
Not clear |
| S Kapur, R Zipursky, G Remington, C Jones, G McKay, S Houl. PET evidence that loxapine is an equipotent blocker of 5-HT2 and D2 receptors: implications for the therapeutics of schizophrenia. The American journal of psychiatry. vol 154. issue 11. 1997-11-20. PMID:9356559. |
loxapine, a dibenzoxazepine antipsychotic, is closely related to clozapine and shares clozapine's high affinity for binding to serotonin 5-ht2 and dopamine d4 receptors. |
1997-11-20 |
2023-08-12 |
Not clear |