| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Hayashi, B Mendelson, K D Phelan, R D Skinner, E Garcia-Ril. Developmental changes in serotonergic receptor-mediated modulation of embryonic chick motoneurons in vitro. Brain research. Developmental brain research. vol 102. issue 1. 1997-11-19. PMID:9298231. |
bath application of serotonin (5-ht) and its agonists 5-carboxamido-tryptamine (5-ct, a 5-ht1 agonist) and alpha-methyl 5-ht (a 5-ht2 agonist) produced hyperpolarizing responses accompanied by decreased input resistance in all e12 motoneurons studied. |
1997-11-19 |
2023-08-12 |
chicken |
| D S Greene, R H Barbhaiy. Clinical pharmacokinetics of nefazodone. Clinical pharmacokinetics. vol 33. issue 4. 1997-11-19. PMID:9342502. |
nefazodone blocks the serotonin 5-ht2 receptors and reversibly inhibits serotonin reuptake in vivo. |
1997-11-19 |
2023-08-12 |
Not clear |
| L Pinilla, M Tena-Sempere, E Aguila. Role of serotoninergic receptors in gonadotropin secretion in male rats. Journal of endocrinological investigation. vol 20. issue 7. 1997-10-30. PMID:9309540. |
in the present work we analyzed in prepubertal and adult male rats the fsh and lh responses after administration of the following drugs: 5-hydroxy-l-tryptophan (5-htp), precursor of 5-ht synthesis, the 5-ht1 receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), the 5-ht2 receptor agonists alpha-methylserotonin maleate (alpha-ch3-ht) and (+/-)-doi hydrochloride (doi), the 5-ht3 agonists, quipazine-n-methyldimaleate (quip), 2 methyl-serotonin maleate (2-ch3-ht), trimethylserotonin iodide (5-htq) and 1-phenylbiguanide (phe). |
1997-10-30 |
2023-08-12 |
rat |
| D Nut. Mirtazapine: pharmacology in relation to adverse effects. Acta psychiatrica Scandinavica. Supplementum. vol 391. 1997-10-23. PMID:9265949. |
the unique pharmacology of mirtazapine means that it has a very different side effect profile from the tricyclic antidepressants, producing less alpha 1 adrenergic and muscarinic blockade, and the selective serotonin reuptake inhibitors (ssris) and the serotonin-noradrenaline reuptake inhibitors (snris), causing much less nausea and sexual dysfunction by virtue of its blockade of 5-ht2 and 5-ht3 receptors. |
1997-10-23 |
2023-08-12 |
Not clear |
| J N Joyce, S G Goldsmith, E V Gurevic. Limbic circuits and monoamine receptors: dissecting the effects of antipsychotics from disease processes. Journal of psychiatric research. vol 31. issue 2. 1997-10-23. PMID:9278186. |
it also led to a reduction in the number of 5-ht2 receptors in some regions of the pfc without modifying the concentration of 5-ht(1a) receptors. |
1997-10-23 |
2023-08-12 |
Not clear |
| A M Szczepanik, C A Wilmo. Effects of ritanserin on haloperidol-induced dopamine (D2) receptor up-regulation in the rat. Neuroscience letters. vol 231. issue 2. 1997-10-23. PMID:9291148. |
or both ritanserin and haloperidol for 19 days to determine whether chronic administration of the serotonin (5ht2) antagonist ritanserin affects d2 receptor up-regulation produced by haloperidol. |
1997-10-23 |
2023-08-12 |
rat |
| S E George, P J Bungay, L H Naylo. Functional coupling of endogenous serotonin (5-HT1B) and calcitonin (C1a) receptors in CHO cells to a cyclic AMP-responsive luciferase reporter gene. Journal of neurochemistry. vol 69. issue 3. 1997-09-25. PMID:9282953. |
the response to 5-ht was reversed by the 5-ht1 receptor antagonists cyanopindolol and pindolol, but not the 5-ht2 receptor antagonist ketanserin. |
1997-09-25 |
2023-08-12 |
Not clear |
| K Tamura, T Kanzaki, Y Saito, M Otabe, Y Saito, N Morisak. Serotonin (5-hydroxytryptamine, 5-HT) enhances migration of rat aortic smooth muscle cells through 5-HT2 receptors. Atherosclerosis. vol 132. issue 2. 1997-09-23. PMID:9242958. |
serotonin (5-hydroxytryptamine, 5-ht) enhances migration of rat aortic smooth muscle cells through 5-ht2 receptors. |
1997-09-23 |
2023-08-12 |
rat |
| K Tamura, T Kanzaki, Y Saito, M Otabe, Y Saito, N Morisak. Serotonin (5-hydroxytryptamine, 5-HT) enhances migration of rat aortic smooth muscle cells through 5-HT2 receptors. Atherosclerosis. vol 132. issue 2. 1997-09-23. PMID:9242958. |
moreover, serotonin effects were completely abolished by a selective inhibitor of the 5-ht2 receptor (mci-9042), indicating that serotonin effects were mediated through the 5-ht2 receptor pathway. |
1997-09-23 |
2023-08-12 |
rat |
| K Tamura, T Kanzaki, Y Saito, M Otabe, Y Saito, N Morisak. Serotonin (5-hydroxytryptamine, 5-HT) enhances migration of rat aortic smooth muscle cells through 5-HT2 receptors. Atherosclerosis. vol 132. issue 2. 1997-09-23. PMID:9242958. |
finally, serotonin effects were also abolished by a phospholipase c inhibitor, u73122, suggesting that the 5-ht2 receptor mediated signal of serotonin was transduced by plc. |
1997-09-23 |
2023-08-12 |
rat |
| A Morán, C Velasco, M L Martín, L San Romá. Renal vasoconstrictor response to 5-hydroxytryptamine in the in situ autoperfused rat kidney: involvement of angiotensin II and the 5-HT2 receptor activation. European journal of pharmacology. vol 330. issue 2-3. 1997-09-22. PMID:9253955. |
renal vasoconstrictor response to 5-hydroxytryptamine in the in situ autoperfused rat kidney: involvement of angiotensin ii and the 5-ht2 receptor activation. |
1997-09-22 |
2023-08-12 |
rat |
| S Samnick, W Brandau, G Nölken, H J Gerhards, O Schobe. Preparation of 8-[3-(4-fluorobenzoyl)-propyl]-1-(4-[123I] iodobenzoyl)-1,3,8-triazaspiro[4,5]decan-4-one: a novel selective serotonin 5-HT2 receptor agent. Nuclear medicine and biology. vol 24. issue 4. 1997-09-18. PMID:9257327. |
preparation of 8-[3-(4-fluorobenzoyl)-propyl]-1-(4-[123i] iodobenzoyl)-1,3,8-triazaspiro[4,5]decan-4-one: a novel selective serotonin 5-ht2 receptor agent. |
1997-09-18 |
2023-08-12 |
rat |
| S Samnick, W Brandau, G Nölken, H J Gerhards, O Schobe. Preparation of 8-[3-(4-fluorobenzoyl)-propyl]-1-(4-[123I] iodobenzoyl)-1,3,8-triazaspiro[4,5]decan-4-one: a novel selective serotonin 5-HT2 receptor agent. Nuclear medicine and biology. vol 24. issue 4. 1997-09-18. PMID:9257327. |
in our attempt to develop radioiodinated serotonin 5-ht2 receptor imaging agents for routine clinical application with single photon emission computed tomography (spect), the [123i]iodinated compound 8-[3-(4-fluorobenzoyl)-propyl]1-(4-[123i]iodobenzoyl)- 1,3,8-triazaspiro[4,5]decan-4-one [123i]ibsp was prepared via no-carrier-added cu(i)-assisted radio-iododebromination in acetic acid, followed by purification by means of reversed-phase hplc in 70-90% radiochemical yield and high specific activities at a total synthesis time of 50 min. |
1997-09-18 |
2023-08-12 |
rat |
| S Samnick, W Brandau, G Nölken, H J Gerhards, O Schobe. Preparation of 8-[3-(4-fluorobenzoyl)-propyl]-1-(4-[123I] iodobenzoyl)-1,3,8-triazaspiro[4,5]decan-4-one: a novel selective serotonin 5-HT2 receptor agent. Nuclear medicine and biology. vol 24. issue 4. 1997-09-18. PMID:9257327. |
competitive binding studies on rat brain membranes using [3h]ketanserin, [3h]sch23390, and [3h]spiperone as radioligands (for 5-ht2, d1 and d2 receptors, respectively) indicated that ibsp has high affinity and selectivity for the serotonin 5-ht2 receptor (ki = 7.0 nm) over the dopamine d2 (ki = 153 nm) and d1 receptors (ki = 265 nm). |
1997-09-18 |
2023-08-12 |
rat |
| E A Pehek, Y B. Ritanserin administration potentiates amphetamine-stimulated dopamine release in the rat prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 4. 1997-09-17. PMID:9194148. |
administration of serotonin 5-ht2 receptor antagonists increases the basal release of dopamine in the mesocorticolimbic pathway. |
1997-09-17 |
2023-08-12 |
rat |
| M N Subhash, S Jagadees. Imipramine-induced changes in 5-HT2 receptor sites and inositoltrisphosphate levels in rat brain. Neurochemical research. vol 22. issue 9. 1997-09-12. PMID:9251098. |
in conclusion, imipramine acts at presynaptic site by blocking the reuptake of serotonin and at post synaptic site it downregulates 5-ht2 sites with decreased ip3 levels after chronic exposure. |
1997-09-12 |
2023-08-12 |
rat |
| M S Kleven, M B Assié, W Koe. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262338. |
to characterize their in vivo 5-hydroxytryptamine (5-ht)2a antagonist properties, the ability of the putative mixed 5-ht1a agonists/5-ht(2a,2c) antagonists (n-(29(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)tricyclo(3.3.1.1(3,7) ) decane-1-carboxamide (wy-50,324), (2-(4-(4,4-bis(4-fluorophenyl)butyl)-1-piperazinyl)-3-pyridinecarboxy lic acid hydrochloride (fg5974), 9,10-didehydro-n-(2-propynyl)-6-methylergoline-8b-carboxamid e (lek-8804) and trans-1,3,4,a5,10b-hexahydro10-methoxy-4-propyl-2h-(1)benzopyra nol[3,4-b]pyridine (cgs 18102a) to antagonize both head twitches and discriminative stimulus (ds) effects produced by (+/-)-2,5-dimethoxy-4-iodoamphetamine (doi) in rats were compared with those of the 5-ht2 antagonists ketanserin and ritanserin, and the 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and buspirone. |
1997-09-11 |
2023-08-12 |
rat |
| D Pawlak, J Małyszko, M Myśliwiec, A Takada, W Buczk. Effect of DV-7028, a novel serotonin 5-HT2 receptor antagonist on the cardiovascular system in rats. Acta physiologica Hungarica. vol 84. issue 3. 1997-09-05. PMID:9219625. |
effect of dv-7028, a novel serotonin 5-ht2 receptor antagonist on the cardiovascular system in rats. |
1997-09-05 |
2023-08-12 |
rat |
| C Moret, M Brile. Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 2-3. 1997-09-03. PMID:9203078. |
neither the 5-ht2 agonist, (+/-)1-(2,5-dimethoxy-4-indophenyl)-2-aminopropane (doi) nor the 5-ht2 antagonist, ritanserin, had any effect on the synthesis of 5-ht. |
1997-09-03 |
2023-08-12 |
rat |
| C Moret, M Brile. Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 2-3. 1997-09-03. PMID:9203078. |
these results suggest that the effect of citalopram on the synthesis of 5-ht is not mediated by 5-ht1a or 5-ht2 receptors and that other receptors may be involved. |
1997-09-03 |
2023-08-12 |
rat |