| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Alarcón-de-la-Lastra Romero, A López, M J Martín, C la Casa, V Motilv. Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds. Pharmacology. vol 54. issue 4. 1997-09-03. PMID:9211565. |
we suggest that 5-ht dependent mechanisms through 5-ht2 receptor blockade and 5-ht1 receptor activation could be also involved. |
1997-09-03 |
2023-08-12 |
rat |
| Z X Shi, W Xu, M K Selmanoff, J F Wilbe. Serotonin (5-HT) stimulates thyrotropin-releasing hormone (TRH) gene transcription in rat embryonic cardiomyocytes. Endocrine. vol 6. issue 2. 1997-08-29. PMID:9225129. |
a selective 5-ht2 receptor antagonist blocked 5-ht stimulation, whereas 5-ht agonist analogs caused augmentative effects when combined with 5-ht. |
1997-08-29 |
2023-08-12 |
rat |
| D Bakish, C L Hooper, M D Thornton, A Wiens, C A Miller, C A Thibaudea. Fast onset: an open study of the treatment of major depressive disorder with nefazodone and pindolol combination therapy. International clinical psychopharmacology. vol 12. issue 2. 1997-08-26. PMID:9219044. |
following on from the suggestion that nefazodone, a specific serotonin reuptake inhibitor and antagonist of 5-ht2, improves 5-ht1a-mediated transmission, we used a pindolol and nefazodone combination treatment for major depressive disorder. |
1997-08-26 |
2023-08-12 |
Not clear |
| S Guise, C Soubrouillard, O Bli. [Dopamine D2 and serotonin 5HT2 receptors: functions, interactions and clinical consequences in schizophrenia]. L'Encephale. vol 23 Spec No 2. 1997-08-26. PMID:9273300. |
[dopamine d2 and serotonin 5ht2 receptors: functions, interactions and clinical consequences in schizophrenia]. |
1997-08-26 |
2023-08-12 |
Not clear |
| E Aguilar, M Tena-Sempere, R Aguilar, D González, L Pinill. Interactions between N-methyl-D-aspartate, nitric oxide and serotonin in the control of prolactin secretion in prepubertal male rats. European journal of endocrinology. vol 137. issue 1. 1997-08-22. PMID:9242209. |
in experiment 5, males pretreated with vehicle or name were killed after administration of the precursor of serotonin synthesis 5-hydroxytryptophan (5-htp), the 5-ht1 receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) or the 5-ht2 agonist (+/-) 2,5-dimethoxy-4-iodoamphetamine hydrochloride (doi). |
1997-08-22 |
2023-08-12 |
rat |
| C F Hsiao, P R Trueblood, M S Levine, S H Chandle. Multiple effects of serotonin on membrane properties of trigeminal motoneurons in vitro. Journal of neurophysiology. vol 77. issue 6. 1997-08-19. PMID:9212246. |
the effects of 5-ht on membrane potential, input resistance, and i(h) were partially mimicked by 5-ht2 agonists and suppressed by 5-ht2 antagonists. |
1997-08-19 |
2023-08-12 |
Not clear |
| B Mahieu, D Souery, O Lipp, K Mendelbaum, G Verheyen, V De Maertelaer, C Van Broeckhoven, J Mendlewic. No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism. Psychiatry research. vol 70. issue 2. 1997-08-12. PMID:9194200. |
in particular, the role of the postsynaptic 5-hydroxytryptamine (serotonin) type 2 receptor (5-ht2) has been documented by several studies. |
1997-08-12 |
2023-08-12 |
Not clear |
| M L Mamede Rosa, W A Prad. Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat. Brain research. vol 757. issue 1. 1997-08-12. PMID:9200507. |
the 5-ht1 agonist 5-carboxamidotryptamine (19 and 38 nanomol) and the 5-ht1b agonist, cgs 12066b (1.12 and 2.24 nanomol), but not the non-selective 5-ht agonist m-cpp (41 to 164 nanomol), 5-ht2 agonist alpha-methylserotonin (36 and 72 nanomol) and 5-ht3 agonist 2-methylserotonin (36 and 72 nanomol), produced a dose-dependent antinociceptive effect. |
1997-08-12 |
2023-08-12 |
rat |
| J P Redrobe, M Bouri. Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test. European journal of pharmacology. vol 325. issue 2-3. 1997-08-04. PMID:9163559. |
the present study was designed to evaluate the roles of 5-ht2 and 5-ht3 receptors in the mouse forced swimming test, by using selective agonists and antagonists of 5-ht(2a/c) and 5-ht3 receptor sites. |
1997-08-04 |
2023-08-12 |
mouse |
| M T Salvador, M C Rodríguez-Yoldi, A I Alcalde, M J Rodríguez-Yold. 5-HT receptor subtypes involved in the serotonin-induced inhibition of L-leucine absorption in rabbit jejunum. Life sciences. vol 61. issue 3. 1997-08-04. PMID:9217291. |
the 5-ht antagonists, gr 113808a (5-ht4) at 2.5x10(-6) m and ritanserin (5-ht2) and ondansetron (5-ht3) at 2.5x10(-5) m completely blocked the effect of 5-ht. |
1997-08-04 |
2023-08-12 |
rabbit |
| M A Vremec, J C Bornstein, C E Wright, A Humphre. Differential effects of omega-conotoxin GVIA on cholinergic and non-cholinergic secretomotor neurones in the guinea-pig small intestine. British journal of pharmacology. vol 121. issue 2. 1997-07-16. PMID:9154332. |
non-cholinergic secretomotor neurones were preferentially stimulated with 100 nm 5-hydroxytryptamine (5-ht), while cholinergic secretomotor neurones were preferentially stimulated with 3 microm 5-ht in the presence of the 5-ht2 receptor antagonist ketanserin (30 nm). |
1997-07-16 |
2023-08-12 |
Not clear |
| P P Gleason, R L Conigliar. Neuroleptic malignant syndrome with risperidone. Pharmacotherapy. vol 17. issue 3. 1997-07-15. PMID:9165568. |
risperidone, a benzisoxazole derivative antipsychotic, has high serotonin 5-ht2 receptor blockade and dose-related d2 receptor blockade. |
1997-07-15 |
2023-08-12 |
Not clear |
| J N Wilkin. Pharmacotherapy of schizophrenia patients with comorbid substance abuse. Schizophrenia bulletin. vol 23. issue 2. 1997-07-15. PMID:9165632. |
new generations of neuroleptics with serotonin (5-ht2) receptor antagonism and/or 5-ht1a agonist activity may reduce substance abuse in schizophrenia patients who self-medicate negative symptoms or neuroleptic side effects. |
1997-07-15 |
2023-08-12 |
Not clear |
| E Mattiuz, R Franklin, T Gillespie, A Murphy, J Bernstein, A Chiu, T Hotten, K Kassahu. Disposition and metabolism of olanzapine in mice, dogs, and rhesus monkeys. Drug metabolism and disposition: the biological fate of chemicals. vol 25. issue 5. 1997-07-14. PMID:9152596. |
olanzapine (olz) is a novel antipsychotic agent with a high affinity for serotonin (5-ht2), dopamine (d1/d2/d4), muscarinic (m1-m5), adrenergic (alpha 1), and histamine (h1) receptors. |
1997-07-14 |
2023-08-12 |
mouse |
| B H Harve. The neurobiology and pharmacology of depression. A comparative overview of serotonin selective antidepressants. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. vol 87. issue 4 Suppl. 1997-07-07. PMID:9180828. |
the first of these 'designer drugs', were the selective serotonin (5-ht) re-uptake inhibitors (ssris), followed more recently by venlafaxine and nefazodone which, in addition to 5-ht uptake, also target noradrenaline (na) uptake and 5-ht2 receptors, respectively. |
1997-07-07 |
2023-08-12 |
Not clear |
| K Matsumoto, M Mizowaki, S Thongpraditchote, Y Murakami, H Watanab. alpha2-Adrenoceptor antagonists reverse the 5-HT2 receptor antagonist suppression of head-twitch behavior in mice. Pharmacology, biochemistry, and behavior. vol 56. issue 3. 1997-07-03. PMID:9077577. |
we investigated the effect of alpha2-adrenoceptor antagonists on the suppressive action of 5-ht2 receptor antagonists in mice pretreated with the noradrenaline toxin 6-hydroxydopamine (6-ohda) or the 5-ht synthesis inhibitor p-chlorophenylalanine (p-cpa). |
1997-07-03 |
2023-08-12 |
mouse |
| K G Lampin. Response of native and stimulated collateral vessels to serotonin. The American journal of physiology. vol 272. issue 5 Pt 2. 1997-06-27. PMID:9176312. |
dilation in response to serotonin was enhanced by inhibition of 5-hydroxytryptamine (5-ht)2 receptors with ketanserin and blocked by nonselective 5-ht1 and 5-ht2 receptors with methiothepin. |
1997-06-27 |
2023-08-12 |
Not clear |
| K G Lampin. Response of native and stimulated collateral vessels to serotonin. The American journal of physiology. vol 272. issue 5 Pt 2. 1997-06-27. PMID:9176312. |
responses to serotonin involve a balance between dilation mediated by 5-ht1 receptors and constriction mediated by 5-ht2 receptors. |
1997-06-27 |
2023-08-12 |
Not clear |
| M C Ritz, F R Georg. Cocaine-induced convulsions: pharmacological antagonism at serotonergic, muscarinic and sigma receptors. Psychopharmacology. vol 129. issue 4. 1997-06-19. PMID:9085399. |
the 5-ht reuptake inhibitor fluoxetine enhanced the occurrence and severity of convulsions produced by 100 mg/kg (-) cocaine, while the 5-ht2 receptor antagonists cinanserin, ketanserin and pirenperone antagonized cocaine-induced convulsions in a dose-dependent manner. |
1997-06-19 |
2023-08-12 |
Not clear |
| M C Ritz, F R Georg. Cocaine-induced convulsions: pharmacological antagonism at serotonergic, muscarinic and sigma receptors. Psychopharmacology. vol 129. issue 4. 1997-06-19. PMID:9085399. |
thus, of the cns binding sites with which cocaine is known to interact, the results are consistent with the conclusion that 5-ht transporters and 5-ht2 receptor sites appear to be direct and primary sites related to cocaine-induced convulsions, while m1 and sigma binding sites appear to play important but secondary and modulatory roles in this response. |
1997-06-19 |
2023-08-12 |
Not clear |