| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Barman, J R Pauly, C M Isale. Canine pulmonary vasoreactivity to serotonin: role of protein kinase C and tyrosine kinase. The American journal of physiology. vol 272. issue 2 Pt 2. 1997-04-22. PMID:9124433. |
these results indicate that the canine pulmonary vascular response to 5-ht involves activation of 5-ht2 receptors and suggests that this receptor signal transduction pathway involves protein kinase c and tyrosine kinase and the activation of voltage-dependent ca2+ channels. |
1997-04-22 |
2023-08-12 |
dog |
| W N Henley, F Vladi. Hypothyroid-induced changes in autonomic control have a central serotonergic component. The American journal of physiology. vol 272. issue 2 Pt 2. 1997-04-22. PMID:9124453. |
three experiments were conducted in unanesthetized rats made hypothyroid (hypo) or maintained as euthyroid controls (eu) to examine general cardiovascular responsiveness [experiment i (exp i)]; responsiveness to a serotonin (5-ht2) agonist, dl-2,5-dimethoxy-4-iodoamphetamine [doi intracerebroventricularly; experiment ii (exp ii)]; or responsiveness to a 5-ht(1a) agonist dl-8-hydroxydipropyl-aminotetralin hydrobromide [8-oh-dpat intracerebroventricularly; experiment iii (exp iii)]. |
1997-04-22 |
2023-08-12 |
rat |
| G Soslau, M Silverberg, I Brodsky, P P McCart. ATP modification of serotonin-induced contraction of the rat pulmonary artery. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 214. issue 3. 1997-04-16. PMID:9083256. |
the possible presence of 5ht2 and 5ht1a receptor types in the rat pulmonary artery was demonstrated by vasoconstrictions induced by 5ht and (+)-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide (dpat). |
1997-04-16 |
2023-08-12 |
rat |
| K Kyozuka, R Deguchi, N Yoshida, M Yamashit. Change in intracellular Ca2+ is not involved in serotonin-induced meiosis reinitiation from the first prophase in oocytes of the marine bivalve Crassostrea gigas. Developmental biology. vol 182. issue 1. 1997-04-14. PMID:9073441. |
among 5-ht agonists tested, only alpha-methyl 5-ht, a 5-ht2 agonist, induced gvbd although it was 1000 times less sensitive than 5-ht. |
1997-04-14 |
2023-08-12 |
Not clear |
| G L Stimmel, J A Dopheide, S M Stah. Mirtazapine: an antidepressant with noradrenergic and specific serotonergic effects. Pharmacotherapy. vol 17. issue 1. 1997-04-08. PMID:9017762. |
it is an antagonist of presynaptic alpha 2-adrenergic autoreceptors and heteroreceptors on both norepinephrine and serotonin (5-ht) presynaptic axons, plus is a potent antagonist of postsynaptic 5-ht2 and 5-ht3 receptors. |
1997-04-08 |
2023-08-12 |
Not clear |
| J R Moiseiwitsch, J M Laude. Regulation of gene expression in cultured embryonic mouse mandibular mesenchyme by serotonin antagonists. Anatomy and embryology. vol 195. issue 1. 1997-04-04. PMID:9006717. |
the differential effects of antagonists suggest that in vivo, 5-ht could: (1) promote expression of cartilage core protein by activation of 5-ht3 or 5-ht1a receptors, (2) inhibit production of tenascin by activation of multiple receptors, (3) promote or inhibit synthesis of s-100 beta by activation of 5-ht3 or 5-ht2 receptors, respectively. |
1997-04-04 |
2023-08-12 |
mouse |
| T Tsuji, D A Coo. Effect of ketanserin on 5-hydroxytryptamine-induced constriction in isolated, perfused canine basilar arteries exposed to blood. Acta neurochirurgica. vol 138. issue 9. 1997-04-02. PMID:8911550. |
it is suggested that the augmentation of cerebrovascular responses to 5-ht in the early stage immediately after subarachnoid haemorrhage (sah) might be mediated by 5-ht2 receptors at least in part. |
1997-04-02 |
2023-08-12 |
Not clear |
| T A Lutz, E Del Prete, B Walzer, E Scharre. The histaminergic, but not the serotoninergic, system mediates amylin's anorectic effect. Peptides. vol 17. issue 8. 1997-04-02. PMID:8971926. |
in 12- or 24-h food-deprived rats, blockade of central and peripheral serotonin (5-ht) receptors with the 5-ht1 and 5-ht2 receptor antagonist metergoline (0.5 or 0.05 mg/kg, ip, respectively) did not seem to influence the anorectic effect of ip injected amylin (1 microgram/kg). |
1997-04-02 |
2023-08-12 |
rat |
| D Bakish, P Cavazzoni, J Chudzik, A Ravindran, P D Hrdin. Effects of selective serotonin reuptake inhibitors on platelet serotonin parameters in major depressive disorder. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018388. |
the effects of treatment with serotonin (5-ht) reuptake inhibitors on platelet 5-ht2 receptors, 5-ht reuptake sites an 5-ht uptake were studied in a double-blind trial comparing two selective serotonin reuptake inhibitors (ssri), paroxetine, and fluoxetine, for the treatment of major depression. |
1997-04-02 |
2023-08-12 |
Not clear |
| D Bakish, P Cavazzoni, J Chudzik, A Ravindran, P D Hrdin. Effects of selective serotonin reuptake inhibitors on platelet serotonin parameters in major depressive disorder. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018388. |
antidepressant treatment did not significantly alter the density of 5-ht reuptake sites, labelled with [3h]paroxetine, or 5-ht2 receptors, labelled with [3h]lsd. |
1997-04-02 |
2023-08-12 |
Not clear |
| A Rydzewski, T Urano, T Hachiya, H Kaneko, S Baba, Y Takada, A Takad. The effect of a 5HT2 receptor antagonist sarpogrelate (MCI-9042) treatment on platelet function in Buerger's disease. Thrombosis research. vol 84. issue 6. 1997-03-25. PMID:8987165. |
the effect of a new, specific 5-ht2 receptor antagonist sarpogrelate (mci-9042) treatment on platelet function and serotonin levels in both plasma and whole blood in buerger's disease, was assessed in a pilot study. |
1997-03-25 |
2023-08-12 |
Not clear |
| Y Nishimura, A Suzuk. Enhanced contractile responses mediated by different 5-HT receptor subtypes in basilar arteries, superior mesenteric arteries and thoracic aortas from stroke-prone spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. Supplement. vol 22. issue 1. 1997-03-25. PMID:9072460. |
ketanserin (a 5-ht2 antagonist) produced a biphasic displacement of the concentration-response curves for 5-ht in ba of wky and shrsp but elicited a parallel rightward shift of the 5-ht curve in sma and ta of the two groups. |
1997-03-25 |
2023-08-12 |
rat |
| Y Nishimura, A Suzuk. Enhanced contractile responses mediated by different 5-HT receptor subtypes in basilar arteries, superior mesenteric arteries and thoracic aortas from stroke-prone spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. Supplement. vol 22. issue 1. 1997-03-25. PMID:9072460. |
these results suggest that the hyperresponsiveness to 5-ht found in shrsp arteries may be mediated by different 5-ht receptor subtypes, that is, by 5-ht1 in ba and by 5-ht2 in sma and ta. |
1997-03-25 |
2023-08-12 |
rat |
| A Srikiatkhachorn, M Anthon. Serotonin receptor adaptation in patients with analgesic-induced headache. Cephalalgia : an international journal of headache. vol 16. issue 6. 1997-03-20. PMID:8902250. |
to assess the plasticity of 5ht2 serotonin receptors in this condition, we investigated receptor binding by the platelet membrane in patients with analgesic-induced headache (aih), migraine and non-headache controls. |
1997-03-20 |
2023-08-12 |
Not clear |
| A Srikiatkhachorn, M Anthon. Serotonin receptor adaptation in patients with analgesic-induced headache. Cephalalgia : an international journal of headache. vol 16. issue 6. 1997-03-20. PMID:8902250. |
based on these findings, we suggest that up-regulation of 5ht2 serotonin receptors may be a possible mechanism of headache transformation in patients with aih. |
1997-03-20 |
2023-08-12 |
Not clear |
| L A Pini, G Vitale, A Ottani, M Sandrin. Naloxone-reversible antinociception by paracetamol in the rat. The Journal of pharmacology and experimental therapeutics. vol 280. issue 2. 1997-03-17. PMID:9023309. |
moreover, it induced a significant increase in brain serotonin (5-ht) concentration and a reduction in the number of 5-ht2 receptors in cortical membranes. |
1997-03-17 |
2023-08-12 |
rat |
| L A Pini, G Vitale, A Ottani, M Sandrin. Naloxone-reversible antinociception by paracetamol in the rat. The Journal of pharmacology and experimental therapeutics. vol 280. issue 2. 1997-03-17. PMID:9023309. |
at the same time, naloxone prevented the increase in 5-ht concentration in the central nervous system and the reduction in 5-ht2 receptors in cortical membranes. |
1997-03-17 |
2023-08-12 |
rat |
| Z Y Yang, B Perry, J Mukherje. Fluorinated benzazepines: 1. Synthesis, radiosynthesis and biological evaluation of a series of substituted benzazepines as potential radiotracers for positron emission tomographic studies of dopamine D-1 receptors. Nuclear medicine and biology. vol 23. issue 6. 1997-03-10. PMID:8940723. |
binding affinities of the compounds for dopamine d1, d2, and serotonin 5-ht2 receptor sites in rat brain homogenates were measured. |
1997-03-10 |
2023-08-12 |
rat |
| Z Y Yang, B Perry, J Mukherje. Fluorinated benzazepines: 1. Synthesis, radiosynthesis and biological evaluation of a series of substituted benzazepines as potential radiotracers for positron emission tomographic studies of dopamine D-1 receptors. Nuclear medicine and biology. vol 23. issue 6. 1997-03-10. PMID:8940723. |
the affinity of sch 38548 for dopamine d1 receptors was found to be 0.53 +/- 0.46 nm, whereas lower affinities (in the micromolar range) for dopamine d2 and serotonin 5-ht2 receptors were found. |
1997-03-10 |
2023-08-12 |
rat |
| Z Y Yang, B Perry, J Mukherje. Fluorinated benzazepines: 1. Synthesis, radiosynthesis and biological evaluation of a series of substituted benzazepines as potential radiotracers for positron emission tomographic studies of dopamine D-1 receptors. Nuclear medicine and biology. vol 23. issue 6. 1997-03-10. PMID:8940723. |
all four fluorinated derivatives exhibited weak binding at d2 and serotonin 5-ht2 receptors. |
1997-03-10 |
2023-08-12 |
rat |