| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Richter, J Scholz, W Löscher, P H Tonner, F Wapple. Effects of the 5-HT2 receptor antagonist ritanserin on halothane-induced increase of inositol phosphates in porcine malignant hyperthermia. Naunyn-Schmiedeberg's archives of pharmacology. vol 354. issue 5. 1997-03-07. PMID:8938657. |
in order to examine if the increase of ips during halothane-induced mh may be related to an enhanced ip synthesis in response to activation of 5-ht2 (5-hydroxytryptamine) receptors, the effects of ritanserin, a selective 5-ht2 receptor antagonist, on ip levels were investigated. |
1997-03-07 |
2023-08-12 |
Not clear |
| E H Cook, B L Leventha. The serotonin system in autism. Current opinion in pediatrics. vol 8. issue 4. 1997-03-07. PMID:9053096. |
subjects with elevated whole blood serotonin levels have been shown to have elevated platelet serotonin transport into platelets and decreased serotonin 5-ht2 receptor binding. |
1997-03-07 |
2023-08-12 |
human |
| J Herrsted. New perspectives in antiemetic treatment. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. vol 4. issue 6. 1997-03-06. PMID:8961471. |
a possible antiemetic effect, achieved by interference with the "serotonergic system", is not restricted to antagonism at 5-ht3 receptors, however, but also includes agonism at 5-ht1a and 5-ht2 receptors, and serotonin synthesis inhibitors. |
1997-03-06 |
2023-08-12 |
Not clear |
| L E Ziganshina, A U Ziganshin, C H Hoyle, G Burnstoc. Acute paw oedema formation induced by ATP: re-evaluation of the mechanisms involved. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 45. issue 2. 1997-03-05. PMID:8907591. |
at 30 mu mol/kg 8-(p-sulfophenyl)theophylline (non-selective adenosine receptor antagonist), 3,7-dimethyl-1,1-propargylxanthine (adenosine a2 receptor antagonist), triprolidine (histamine h1 receptor antagonist), ranitidine (histamine h2 receptor antagonist) and ketanserin (5-hydroxytryptamine 5-ht2 receptor antagonist), but neither 8-cyclopentyl-1,3-dipropylxanthine (adenosine a1 receptor antagonist), nor indomethacin (cyclooxygenase inhibitor) inhibited the atp-induced swelling. |
1997-03-05 |
2023-08-12 |
mouse |
| M R Pranzatelli, I Galvan, P T Tailo. Human brainstem serotonin receptors: characterization and implications for subcortical myoclonus. Clinical neuropharmacology. vol 19. issue 6. 1997-03-05. PMID:8937789. |
we measured the density of subtypes of 5-ht1 and 5-ht2 receptors and the affinity of 5-ht and l-5-htp in vitro in the human brainstem and cortex, regions associated with subcortical and cortical myoclonus, respectively. |
1997-03-05 |
2023-08-12 |
human |
| T V Passaretti, B D Wilcox, J J Jeffre. Serotonin regulation of gene expression in uterine extracellular matrix: reciprocal effects on collagens and collagenase. Molecular and cellular endocrinology. vol 120. issue 2. 1997-02-24. PMID:8832571. |
selective 5-ht2 receptor agonists mimicked the effects of serotonin, while the effects of serotonin were blocked by 5-ht2 antagonists. |
1997-02-24 |
2023-08-12 |
rat |
| T V Passaretti, B D Wilcox, J J Jeffre. Serotonin regulation of gene expression in uterine extracellular matrix: reciprocal effects on collagens and collagenase. Molecular and cellular endocrinology. vol 120. issue 2. 1997-02-24. PMID:8832571. |
these results indicate that serotonin, previously shown to upregulate the interstitial collagenase gene, downregulates the gene for type i collagen and other extracellular matrix proteins, possibly by a novel mechanism of action downstream of 5-ht2 receptor binding. |
1997-02-24 |
2023-08-12 |
rat |
| A Merzak, S Koochekpour, M P Fillion, G Fillion, G J Pilkingto. Expression of serotonin receptors in human fetal astrocytes and glioma cell lines: a possible role in glioma cell proliferation and migration. Brain research. Molecular brain research. vol 41. issue 1-2. 1997-02-20. PMID:8883928. |
expression of seven serotonin or 5-hydroxytryptamine (5-ht) receptors (5-ht1d alpha, 5-ht1e, 5-ht2, 5-ht1a, 5-ht1c, 5-ht1d beta, and 5-ht6) was investigated in human normal fetal astrocytes and eight glioma cell lines by reverse transcription and polymerase chain reaction (rt-pcr). |
1997-02-20 |
2023-08-12 |
human |
| T L Xu, J Nabekura, N Akaik. Protein kinase C-mediated enhancement of glycine response in rat sacral dorsal commissural neurones by serotonin. The Journal of physiology. vol 496 ( Pt 2). 1997-02-19. PMID:8910232. |
3. alpha-methyl-5-ht mimicked and ketanserine blocked the 5-ht action on igly, thus indicating the 5-ht2 receptor-mediated enhancement. |
1997-02-19 |
2023-08-12 |
rat |
| A Dalpiaz, V Ferretti, P Gilli, V Bertolas. Stereochemistry of serotonin receptor ligands from crystallographic data. Crystal structures of NAN-190.HBr, 1-phenylbiguanide, MDL 72222 and mianserin.HCl and selectivity criteria towards 5-HT1, 5-HT2, and 5-HT3 receptor subtypes. Acta crystallographica. Section B, Structural science. vol 52 ( Pt 3). 1997-02-18. PMID:8767764. |
a systematic structural analysis of the present compounds and others known to interact with the 5-ht1, 5-ht2 and 5-ht3 receptors allows to identify their similarities with the endogenous ligand serotonin (5-ht) and the stereochemical differences which determine selectivity for the various receptor subtypes. |
1997-02-18 |
2023-08-12 |
Not clear |
| S B Kasture, S N Mandhane, C T Chopd. Baclofen-induced catatonia: modification by serotonergic agents. Neuropharmacology. vol 35. issue 5. 1997-02-13. PMID:8887967. |
the 5-ht synthesis inhibitor pcpa (150 x 2 mg/kg), the non-specific 5-ht antagonist cyproheptadine (5 mg/kg), the 5-ht1a/1b antagonist pindolol (3 mg/kg) and the 5-ht2 antagonist sulpiride (20 mg/kg) enhanced baclofen-induced catatonia. |
1997-02-13 |
2023-08-12 |
rat |
| M Bourin, M Hascoet, P Deguira. 5-HTP induced diarrhea as a carcinoid syndrome model in mice? Fundamental & clinical pharmacology. vol 10. issue 5. 1997-02-13. PMID:8902548. |
among the 5-ht antagonists used in interaction with 5-ht, only these of the 5-ht3 type (ondansetron, granisetron, tropisetron) and, to a lesser extent 5-ht2 type (ritanserin), decreased the diarrhea induced by 5-htp. |
1997-02-13 |
2023-08-12 |
mouse |
| C A Martin, M Félétou, M Lonchampt, C Dacquet, A Dhainaut, E Cane. In vitro pharmacological effects of S 12370 (2-[4-benzhydryloxypiperidinoethyl]isoxindole; an antibronchoconstrictor agent) in normal and sensitized tissue. Fundamental & clinical pharmacology. vol 10. issue 5. 1997-02-13. PMID:8902549. |
in binding experiments, s 12370 exhibited similar affinity for m1, m2, m3, m4 muscarinic receptors and also recognized 5-ht2 serotonin and h1 histamine receptor subtypes. |
1997-02-13 |
2023-08-12 |
rat |
| M L Wadenberg, S Ahleniu. Antagonism by the 5-HT2A/C receptor agonist DOI of raclopride-induced catalepsy in the rat. European journal of pharmacology. vol 294. issue 1. 1997-02-12. PMID:8788438. |
the fact that 5-htp, in the presence of benserazide and zimeldine, enhanced raclopride-induced catalepsy suggests the possibility of postsynaptic 5-ht receptors acting in opposition to the 5-ht1 and 5-ht2 receptors, as regards extrapyramidal motor functions in the rat. |
1997-02-12 |
2023-08-12 |
rat |
| A D Bonev, M T Nelso. Vasoconstrictors inhibit ATP-sensitive K+ channels in arterial smooth muscle through protein kinase C. The Journal of general physiology. vol 108. issue 4. 1997-02-11. PMID:8894979. |
stimulation of npy-, alpha 1-, serotonin (5-ht2)-, and histamine (h1)-receptors inhibited katp currents by 40-56%. |
1997-02-11 |
2023-08-12 |
human |
| J A Terró. The relaxant 5-HT receptor in the dog coronary artery smooth muscle: pharmacological resemblance to the cloned 5-ht7 receptor subtype. British journal of pharmacology. vol 118. issue 6. 1997-02-06. PMID:8832067. |
the relaxant effect of 5-hydroxytryptamine (5-ht) in the dog isolated coronary artery deprived of endothelium is mediated by a receptor unrelated to the 5-ht1, 5-ht2, 5-ht3 or 5-ht4 types. |
1997-02-06 |
2023-08-12 |
dog |
| T Blank, R Zwart, I Nijholt, J Spies. Serotonin 5-HT2 receptor activation potentiates N-methyl-D-aspartate receptor-mediated ion currents by a protein kinase C-dependent mechanism. Journal of neuroscience research. vol 45. issue 2. 1997-02-06. PMID:8843032. |
serotonin 5-ht2 receptor activation potentiates n-methyl-d-aspartate receptor-mediated ion currents by a protein kinase c-dependent mechanism. |
1997-02-06 |
2023-08-12 |
rat |
| T Blank, R Zwart, I Nijholt, J Spies. Serotonin 5-HT2 receptor activation potentiates N-methyl-D-aspartate receptor-mediated ion currents by a protein kinase C-dependent mechanism. Journal of neuroscience research. vol 45. issue 2. 1997-02-06. PMID:8843032. |
the serotonin receptor involved was identified as a 5-ht2 receptor subtype by the finding that 200 nm of the selective 5-ht2 receptor agonist alpha-methyl-5-hydroxytryptamine mimicked the potentiation of nmda-induced ion currents by serotonin. |
1997-02-06 |
2023-08-12 |
rat |
| T Blank, R Zwart, I Nijholt, J Spies. Serotonin 5-HT2 receptor activation potentiates N-methyl-D-aspartate receptor-mediated ion currents by a protein kinase C-dependent mechanism. Journal of neuroscience research. vol 45. issue 2. 1997-02-06. PMID:8843032. |
furthermore, the observed potentiation was significantly reduced by co-application of serotonin with 100 microm of the selective 5-ht2 receptor antagonist ketanserin. |
1997-02-06 |
2023-08-12 |
rat |
| B Rörig, B Suto. Serotonin regulates gap junction coupling in the developing rat somatosensory cortex. The European journal of neuroscience. vol 8. issue 8. 1997-02-06. PMID:8921259. |
the uncoupling effect of 5-ht was mimicked by 5-ht2 receptor agonists and antagonized by the 5-ht2 receptor antagonist ritanserin, indicating that 5-ht suppressed gap junction coupling via activation of 5-ht2 class receptors. |
1997-02-06 |
2023-08-12 |
rat |