All Relations between 5-ht receptor 2 and serotonin

Publication Sentence Publish Date Extraction Date Species
Kota Naito, Hajime Moteki, Mitsutoshi Kimura, Hideshi Natsume, Masahiko Ogihar. Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes. Biological & pharmaceutical bulletin. vol 39. issue 4. 2017-01-06. PMID:26804134. the mechanism of serotonin 5-ht2 receptor subtype-stimulated dna synthesis and proliferation was investigated in primary cultures of adult rat hepatocytes to elucidate the intracellular signal transduction pathways. 2017-01-06 2023-08-13 rat
Bin Luo, Lingli Hu, Chunhua Liu, Yiping Guo, Haitao Wan. Activation of 5-HT2A/C receptor reduces glycine receptor-mediated currents in cultured auditory cortical neurons. Amino acids. vol 48. issue 2. 2016-12-13. PMID:26371055. serotonin could broadly modulate many ion channels through activating 5-ht2 receptor, but whether cortical glyrs are subjected to serotonergic modulation remains unexplored. 2016-12-13 2023-08-13 Not clear
J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. 5-ht2 receptor blockade exhibits 5-ht vasodilator effects via nitric oxide, prostacyclin and atp-sensitive potassium channels in rat renal vasculature. 2016-12-13 2023-08-13 rat
J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. the aim of this study was to determine whether orally sarpogrelate (selective 5-ht2 antagonist) treatment (30 mg/kg/day; 14 days) could modify 5-ht renal vasoconstrictor responses, characterizing 5-ht receptors and mediator mechanisms involved in serotonergic responses in the in situ autoperfused rat kidney. 2016-12-13 2023-08-13 rat
Melissa A Papesh, Laura M Hurle. Modulation of auditory brainstem responses by serotonin and specific serotonin receptors. Hearing research. vol 332. 2016-12-13. PMID:26688176. using a mouse model, we investigated the consequences of systemic serotonin depletion, as well as the selective stimulation and suppression of the 5-ht1 and 5-ht2 receptors, on abr latency and amplitude. 2016-12-13 2023-08-13 mouse
Jihua Fu, Shaoxin Ma, Xin Li, Shanshan An, Tao Li, Keke Guo, Min Lin, Wei Qu, Shanshan Wang, Xinyue Dong, Xiaoyu Han, Ting Fu, Xinping Huang, Tianying Wang, Siyu H. Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884719. long-term stress with hyperglucocorticoidemia-induced hepatic steatosis with vldl overproduction is dependent on both 5-ht2 receptor and 5-ht synthesis in liver. 2016-12-13 2023-08-13 rat
Jihua Fu, Shaoxin Ma, Xin Li, Shanshan An, Tao Li, Keke Guo, Min Lin, Wei Qu, Shanshan Wang, Xinyue Dong, Xiaoyu Han, Ting Fu, Xinping Huang, Tianying Wang, Siyu H. Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884719. lts with hyperglucocorticoidemia induced hepatic 5-ht synthetic increase with tryptophan hydroxylase 1 (tph1) up-regulation, and 5-ht2 receptor (5-ht2r, including 5-ht2a, 2b receptor) up-regulation in liver and visceral adipose, as well as hepatic mtor activation with triglycerides and vldl overproduction with steatosis, and visceral adipose lipolytic increase with high blood free fatty acids (ffas) level. 2016-12-13 2023-08-13 rat
Zana R Majeed, Esraa Abdeljaber, Robin Soveland, Kristin Cornwell, Aubrey Bankemper, Felicitas Koch, Robin L Coope. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural plasticity. vol 2016. 2016-12-13. PMID:26989517. 5-ht2 receptor activation mediates a modulatory role in a sensory-motor circuit, and the activation of 5-ht neurons can suppress the neural circuit activity, while fluoxetine can significantly decrease the sensory-motor activity. 2016-12-13 2023-08-13 drosophila_melanogaster
Jean-François Perrie. Modulation of motoneuron activity by serotonin. Danish medical journal. vol 63. issue 2. 2016-11-07. PMID:26836802. in parallel, serotonin binds to 5-ht2 receptors, which promotes the low-threshold l-type ca(2+) channels. 2016-11-07 2023-08-13 Not clear
Susanne Nikolaus, Hans-Wilhelm Müller, Hubertus Hautze. Different patterns of 5-HT receptor and transporter dysfunction in neuropsychiatric disorders--a comparative analysis of in vivo imaging findings. Reviews in the neurosciences. vol 27. issue 1. 2016-10-20. PMID:26376220. we conducted a pubmed search, which provided a total of 136 in vivo studies with pet and spect, in which 5-ht synthesis, 5-ht transporter binding, 5-ht1 receptor binding or 5-ht2 receptor binding in patients with the primary diagnosis of acute ad, mdd, bd or sz was compared to healthy individuals. 2016-10-20 2023-08-13 Not clear
Jinping Qiao, Junhui Wang, Hongxing Wang, Yanbo Zhang, Shenghua Zhu, Abulimiti Adilijiang, Huining Guo, Ruiguo Zhang, Wei Guo, Gang Luo, Yiqing Qiu, Haiyun Xu, Jiming Kong, Qingjun Huang, Xin-Min L. Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS1 mouse model. Glia. vol 64. issue 2. 2016-10-06. PMID:26446044. these astrocytes produced high levels of soluble β-amyloid (aβ) which could be significantly inhibited by fluoxetine (flx) via activating serotonin 5-ht2 receptors. 2016-10-06 2023-08-13 mouse
Kota Naito, Chizuru Tanaka, Manami Mitsuhashi, Hajime Moteki, Mitsutoshi Kimura, Hideshi Natsume, Masahiko Ogihar. Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Biological & pharmaceutical bulletin. vol 39. issue 1. 2016-10-06. PMID:26567725. the involvement of serotonin (5-hydroxytryptamine; 5-ht) and the 5-ht2 receptor subtypes in the induction of dna synthesis and proliferation was investigated in primary cultures of adult rat hepatocytes to elucidate the intracellular signal transduction mechanisms. 2016-10-06 2023-08-13 rat
Alexandra Charron, Cynthia El Hage, Alice Servonnet, Anne-Noël Samah. 5-HT2 receptors modulate the expression of antipsychotic-induced dopamine supersensitivity. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26508706. serotonin 5-ht2 receptors modulate dopamine function and thereby influence dopamine-dependent responses. 2016-10-05 2023-08-13 rat
Beatriz Restrepo, Mónica García, Alicia Rodríguez-Barbero, Luis San Román, María Luisa Martin, Asunción Morá. Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. European journal of pharmacology. vol 659. issue 1. 2016-06-27. PMID:21414306. the selective 5-ht2 receptor agonist, α-methyl-5-ht, caused a local vasoconstrictor effect in the in situ autoperfused rat kidney similar to 5-ht. 2016-06-27 2023-08-12 rat
Beatriz Restrepo, Mónica García, Alicia Rodríguez-Barbero, Luis San Román, María Luisa Martin, Asunción Morá. Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. European journal of pharmacology. vol 659. issue 1. 2016-06-27. PMID:21414306. in long-term diabetic rats, vasoconstriction elicited by 5-ht and α-methyl-5-ht was significantly decreased by ritanserin (a 5-ht2 receptor antagonist), spiperone (a 5-ht2a receptor antagonist), and the cyclooxygenase (cox) inhibitors, indomethacin (non-selective cox inhibitor), fr 122047 or nimesulide (selective cox-1 and cox-2 inhibitors, respectively), but was not modified by pretreatment with sb 206553 (3,5-dihydro-5-methyl-n-3-pyridinylbenzo[1,2.b:4,5-b']dipyrrole(1h)-carboxamide hydrochloride), a non-selective 5-ht2c receptor antagonist, prazosin, propranolol, enalapril or losartan. 2016-06-27 2023-08-12 rat
Niklas Palmqvist, Max Siller, Cecilia Klint, Anders Sjödi. A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030. Journal of inflammation (London, England). vol 13. 2016-06-24. PMID:27340371. 5-hydroxytryptamine (5-ht) and the 5-ht2 receptor family may contribute to inflammation and pruritus in the skin. 2016-06-24 2023-08-13 human
Shigeru Hasebe, Yukio Ago, Saki Nishiyama, Satoshi Oka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsud. Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice. Behavioural pharmacology. vol 26. issue 7 Spec No. 2016-05-25. PMID:25932719. encounter-induced hyperactivity was reduced by acute administration of various antidepressants including the tricyclic antidepressant desipramine (10 mg/kg), the selective serotonin (5-ht) reuptake inhibitors fluvoxamine (10 mg/kg) and paroxetine (10 mg/kg), the 5-ht/noradrenaline reuptake inhibitors venlafaxine (10 mg/kg) and duloxetine (10 mg/kg), the antipsychotic drug risperidone (0.01 mg/kg), the 5-ht2 antagonist ritanserin (1 mg/kg), and the glucocorticoid receptor antagonist ru-43044 (30 mg/kg). 2016-05-25 2023-08-13 mouse
Derek A Mann, Fiona Oakle. Serotonin paracrine signaling in tissue fibrosis. Biochimica et biophysica acta. vol 1832. issue 7. 2016-04-23. PMID:23032152. this review highlights the diverse actions of serotonin signaling in the pathogenesis of fibrotic disease and explores how modulating the activity of specific 5-ht receptors, in particular the 5-ht2 subclass could have the potential to limit fibrosis and restore tissue regeneration. 2016-04-23 2023-08-12 human
David E Nichols, M Flori Sassano, Adam L Halberstadt, Landon M Klein, Simon D Brandt, Simon P Elliott, Wolfgang J Fiedle. N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25547199. n-benzyl-5-methoxytryptamines as potent serotonin 5-ht2 receptor family agonists and comparison with a series of phenethylamine analogues. 2016-04-19 2023-08-13 mouse
David E Nichols, M Flori Sassano, Adam L Halberstadt, Landon M Klein, Simon D Brandt, Simon P Elliott, Wolfgang J Fiedle. N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25547199. a broad affinity screen at serotonin receptors showed that most of the compounds had the highest affinity at the 5-ht2 family receptors. 2016-04-19 2023-08-13 mouse