Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
H Giles, S J Lansdell, M L Bolofo, H L Wilson, G R Marti. Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882605. |
8-oh-dpat (1 microm) and renzapride (3 microm) were without effect on forskolin-stimulated cyclic amp production and ketanserin (0.3 microm) did not antagonize the inhibition produced by 5-ht, thus excluding the involvement of 5-ht1a, 5-ht4, and 5-ht2 receptors. |
1996-12-11 |
2023-08-12 |
Not clear |
P Soares-da-Silva, M A Vieira-Coelho, M Pestan. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-HT1A receptors and antinatriuresis during high sodium intake. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882615. |
the present study has examined the effect of (+)-way 100135, a selective antagonist of 5-ht1a receptors, and ketanserin, an antagonist of 5-ht2 receptors, on the urinary excretion of na+, k+, dopamine, 5-hydroxytryptamine (5-ht) and their metabolites in rats treated with the selective type a monoamine oxidase (mao-a) inhibitor, ro 41-1049 (15 mg kg-1 day-1) in conditions of normal sodium (ns) and high sodium (hs; 1.0% nacl in drinking water) intake. |
1996-12-11 |
2023-08-12 |
rat |
Y Nishimur. Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882632. |
spiperone (1 nm-1 microm, a 5-ht2 receptor antagonist), produced biphasic displacement of the 5-ht curves in wky and shrsp arteries. |
1996-12-11 |
2023-08-12 |
rat |
Y Nishimur. Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882632. |
ketanserin (1-100 nm, 5-ht2) also produced a biphasic shift of the 5-ht curves for both arteries. |
1996-12-11 |
2023-08-12 |
rat |
Y Nishimur. Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882632. |
these findings suggest that 5-ht elicits vasoconstriction in rat basilar arteries by stimulation of a mixed receptor population of 5-ht2 and 5-ht1-like receptors (similar to the 5-ht1b receptor subtype), and that the contraction mediated by 5-ht1-like receptors is enhanced in the basilar artery from shrsp. |
1996-12-11 |
2023-08-12 |
rat |
J L Szarek, J Z Zhang, C A Gruette. Mechanisms of 5-hydroxytryptamine-induced contraction of isolated rat intrapulmonary bronchi. Pulmonary pharmacology. vol 8. issue 6. 1996-12-06. PMID:8819182. |
previous studies in our laboratory and others suggested that activation of 5-ht2 receptors mediates 5-hydroxytryptamine (5-ht)-induced contraction of airway smooth muscle and that this response is dependent in part on endogenous acetylcholine (ach). |
1996-12-06 |
2023-08-12 |
rat |
J L Szarek, J Z Zhang, C A Gruette. Mechanisms of 5-hydroxytryptamine-induced contraction of isolated rat intrapulmonary bronchi. Pulmonary pharmacology. vol 8. issue 6. 1996-12-06. PMID:8819182. |
in this study, we examined the effects of 5-ht2 receptor antagonists (ketanserin and ly53857), acetylcholinesterase inhibitors (physostigmine and neostigmine), and a muscarinic receptor alkylating agent [propylbenzilylcholine mustard (pbcm)] on contractile responses evoked by 5-ht and the 5-ht2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-me-5-ht). |
1996-12-06 |
2023-08-12 |
rat |
J L Szarek, J Z Zhang, C A Gruette. Mechanisms of 5-hydroxytryptamine-induced contraction of isolated rat intrapulmonary bronchi. Pulmonary pharmacology. vol 8. issue 6. 1996-12-06. PMID:8819182. |
together, the results suggest that 5-ht contracts rat airways directly by activating 5-ht2 receptors located on airway smooth muscle and indirectly by activation of 5-ht2 receptors on parasympathetic nerve endings to cause release of ach. |
1996-12-06 |
2023-08-12 |
rat |
S Belcheva, V D Petkov, E Konstantinova, V V Petkov, E Boyanov. Effects on nociception of the Ca2+ and 5-HT antagonist dotarizine and other 5-HT receptor agonists and antagonists. Acta physiologica et pharmacologica Bulgarica. vol 21. issue 4. 1996-12-06. PMID:8830881. |
the effects of the ca2+ and 5-ht1 and 5-ht2 receptor antagonist dotarizine and of some other agonists and antagonists of different 5-ht receptor subtypes administered alone or in combination with the 5-ht uptake inhibitor fluoxetine (flu) on nociception were studied, using a foot-pressure method (analgesy-meter testing). |
1996-12-06 |
2023-08-12 |
Not clear |
J R Grider, J F Kuemmerle, J G Ji. 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons. The American journal of physiology. vol 270. issue 5 Pt 1. 1996-12-06. PMID:8967488. |
release of cgrp induced by exogenous 5-ht or mucosal stimulation was inhibited by selective 5-ht4 and 5-ht1p antagonists but was not affected by 5-ht1a, 5-ht2, and 5-ht3 antagonists. |
1996-12-06 |
2023-08-12 |
rat |
M A Geye. Serotonergic functions in arousal and motor activity. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788473. |
thus, studies of locomotor and investigatory responses can be used to demonstrate and differentiate the effects of direct agonists at 5-ht1a, 5-ht1b, and 5-ht2 receptors as well as indirect serotonin agonists. |
1996-12-04 |
2023-08-12 |
rat |
M Skingle, D T Beattie, D I Scopes, S J Starkey, H E Connor, W Feniuk, M B Tyer. GR127935: a potent and selective 5-HT1D receptor antagonist. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788495. |
in functional studies, gr127935 fails to affect 5-ht2 receptor-mediated 'wet dog shakes' in guinea-pigs and 5-ht1a receptor-mediated inhibition of 5-ht release in rat dorsal raphé nucleus. |
1996-12-04 |
2023-08-12 |
human |
D R Brow. Mucosal protection through active intestinal secretion: neural and paracrine modulation by 5-hydroxytryptamine. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788501. |
the intestinal secretory effects of 5-ht appear to be mediated in part by epithelial 5-ht2 like receptors that are linked to phosphatidylinositol turnover. |
1996-12-04 |
2023-08-12 |
Not clear |
D Hoyer, G R Marti. Classification and nomenclature of 5-HT receptors: a comment on current issues. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788515. |
at the time of the serotonin satellite meeting in chicago, the iuphar classification of receptors for 5-ht recognised four distinct receptor classes (5-ht1, 5-ht2, 5-ht3 and 5-ht4), comprising seven fully characterised functional receptor subtypes and four recombinant receptors (5-ht1d alpha, 5-ht1d beta, 5-ht1e and 5-ht1f). |
1996-12-04 |
2023-08-12 |
Not clear |
G Bagd. Role of the hypothalamic paraventricular nucleus in 5-HT1A, 5-HT2A and 5-HT2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788518. |
to test the hypothesis that the mechanisms of 5-ht1 and 5-ht2 receptor-mediated hormonal responses are different, we compared the effects of hypothalamic paraventricular nucleus (pvn) lesions on the acth/corticosterone, prolactin and oxytocin responses to the 5-ht1a agonist ipsapirone (1 and 2 mg/kg), the 5-ht2c agonist m-chlorophenylpiperazine (m-cpp, 0.6 mg/kg), which also binds to other 5-ht receptors with lower affinity, and the 5-ht2a/2c agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi, 1 mg/kg) in chronically cannulated, freely moving male rats. |
1996-12-04 |
2023-08-12 |
rat |
D A Cox, M L Cohe. 5-HT2B receptor signaling in the rat stomach fundus: dependence on calcium influx, calcium release and protein kinase C. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788521. |
5-ht2b receptor signaling in the rat stomach fundus: dependence on calcium influx, calcium release and protein kinase c. the rat stomach fundus is enriched with the 5-hydroxytryptamine (5-ht)2b receptor, a recently cloned subtype of the 5-ht2 receptor family. |
1996-12-04 |
2023-08-12 |
rat |
G Muñoz-Acedo, E Arill. Modulation by 5-hydroxytryptamine of the somatostatin receptor-effector system and somatostatin levels in rat brain. Brain research. Molecular brain research. vol 37. issue 1-2. 1996-12-03. PMID:8738159. |
to determine if the above-mentioned changes were related to the 5-ht activation of central 5-ht1 and 5-ht2 receptors, a non-selective 5-ht1 and 5-ht2 receptor antagonist, methysergide, was administered 60 min before the 5-ht injection. |
1996-12-03 |
2023-08-12 |
rat |
R C Ma, J H Szurszewsk. 5-Hydroxytryptamine depolarizes neurons of cat pancreatic ganglia. Journal of the autonomic nervous system. vol 57. issue 1-2. 1996-12-03. PMID:8867089. |
spiperone (a 5-ht1a receptor antagonist) and mianserin (a 5-ht2 receptor antagonist) had no effect on either depolarizing response to 5-ht. |
1996-12-03 |
2023-08-12 |
cat |
E J Yoder, H Tamir, M H Ellisma. 5-Hydroxytryptamine2A receptors on cultured rat Schwann cells. Glia. vol 17. issue 1. 1996-11-27. PMID:8723839. |
these results also suggested that 5-ht acted by stimulating a member of the 5-ht2 receptor family since this family employs inositol trisphosphate as a second messenger. |
1996-11-27 |
2023-08-12 |
rat |
K R Bonson, J W Buckholtz, D L Murph. Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 6. 1996-11-27. PMID:8726753. |
possible mechanisms of action for the effects from serotonergic antidepressants involve 5-ht2 and 5-ht1a receptors, changes in extracellular brain serotonin concentrations, and changes in brain catecholamine systems. |
1996-11-27 |
2023-08-12 |
human |