| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Inoue, N Nagata, Y Koshihar. Participation of serotonin in capsaicin-induced mouse ear edema. Japanese journal of pharmacology. vol 69. issue 1. 1996-10-24. PMID:8847833. |
these results suggest that 5-ht released from mast cells is partly involved in the development of capsaicin-induced mouse ear edema via 5-ht2 receptors in the ear skin. |
1996-10-24 |
2023-08-12 |
mouse |
| G Sedvall, S Pauli, P Karlsson, L Farde, A L Nordström, S Nyberg, C Halldi. PET imaging of neuroreceptors in schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 5 Suppl. 1996-10-23. PMID:8775755. |
by using a combination of selective ligands labelled with positron emitting isotopes, d1 and d2 dopamine, serotonin 5ht2 and benzodiazepine receptors were examined in schizophrenic patients (dsm-iiir) and healthy control subjects. |
1996-10-23 |
2023-08-12 |
human |
| J Lincol. Innervation of cerebral arteries by nerves containing 5-hydroxytryptamine and noradrenaline. Pharmacology & therapeutics. vol 68. issue 3. 1996-10-23. PMID:8788567. |
in most species, na is a weak vasoconstrictor (alpha 1- or alpha 2-adrenoceptors), while 5-ht is a potent vasoconstrictor (5-ht2 or 5-ht1-like receptors) of large cerebral arteries. |
1996-10-23 |
2023-08-12 |
Not clear |
| V L Lucaites, D L Nelson, D B Wainscott, M Bae. Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily. Life sciences. vol 59. issue 13. 1996-10-18. PMID:8809227. |
the 5-hydroxytryptamine (5-ht)2c receptor (originally known as the 5-ht1c receptor) is a member of the 5-ht2 subfamily of g protein coupled receptors, which is known to couple to phospholipase c. within the 5-ht2 subfamily, only the 5-ht2c receptor also coupled to inhibition of forskolin-stimulated camp production when expressed at high density (12 pmol/mg membrane protein) in stably transformed av12 cells. |
1996-10-18 |
2023-08-12 |
Not clear |
| V L Ellingrod, P J Perr. Nefazodone: a new antidepressant. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 52. issue 24. 1996-10-10. PMID:8748566. |
nefazodone enhances serotonin (5-hydroxytryptamine [5-ht]) synaptic transmission by acting as an antagonist at 5-ht2 receptors and by inhibiting the reuptake of 5-ht. |
1996-10-10 |
2023-08-12 |
Not clear |
| Y Nagakura, T Kamato, A Nishida, H Ito, M Yamano, K Miyat. Characterization of 5-hydroxytryptamine (5-HT) receptor subtypes influencing colonic motility in conscious dogs. Naunyn-Schmiedeberg's archives of pharmacology. vol 353. issue 5. 1996-10-08. PMID:8740141. |
these results indicate that exogenous 5-ht stimulates motility along the entire length of the fasted canine colon and that 5-ht-induced responses in the proximal colon are mediated mainly by 5-ht1, whereas those in the middle and distal colon are mediated by both 5-ht1 and 5-ht2 receptors. |
1996-10-08 |
2023-08-12 |
Not clear |
| M J Doughty, W M Lyl. Medications used to prevent migraine headaches and their potential ocular adverse effects. Optometry and vision science : official publication of the American Academy of Optometry. vol 72. issue 12. 1996-10-03. PMID:8749335. |
those drugs that are administered for the purpose of reducing the frequency or severity of migraine attacks are classified according to whether they act on the cerebral vasculature primarily at serotonin (5-ht2) receptors (e.g., methysergide, cyproheptadine, and pizotyline), beta adrenergic (primarily beta-2) receptors (e.g., propranolol and timolol), via central nervous system (cns) adrenergic (alpha-2) receptors (e.g., clonidine), or calcium channels (e.g., flunarizine). |
1996-10-03 |
2023-08-12 |
Not clear |
| F Licata, G Li Volsi, G Maugeri, F Santangel. Neuronal responses to 5-hydroxytryptamine in the red nucleus of rats. Experimental brain research. vol 107. issue 2. 1996-10-03. PMID:8773241. |
these results support the hypothesis that 5-ht exerts control throughout the rn, mostly by acting on 5-ht2 receptors. |
1996-10-03 |
2023-08-12 |
rat |
| L Kostal, C J Savor. Behavioral responses of restricted-fed fowls to pharmacological manipulation of 5-HT and GABA receptor subtypes. Pharmacology, biochemistry, and behavior. vol 53. issue 4. 1996-09-30. PMID:8801608. |
the only significant (p < 0.05) effect of 5-ht antagonists [nan-190 (5-ht1a), ketanserin (5-ht2), mdl-72222 (5-ht3)] was an increase in pacing with ketanserin (0.8 mg/kg). |
1996-09-30 |
2023-08-12 |
Not clear |
| L Kostal, C J Savor. Behavioral responses of restricted-fed fowls to pharmacological manipulation of 5-HT and GABA receptor subtypes. Pharmacology, biochemistry, and behavior. vol 53. issue 4. 1996-09-30. PMID:8801608. |
with 5-ht agonists, 8-oh-dpat (5-ht1a) suppressed the two oral stereotypies and increased standing (all 1.0 mg/kg) and preening (0.2 mg/kg), alpha-methylserotonin (5-ht2) suppressed the oral stereotypies and increased sitting (all 1.0 mg/kg), and m-cpbg (5-ht3) suppressed drinker-directed activity (1.0 mg/kg). |
1996-09-30 |
2023-08-12 |
Not clear |
| P D Feldma. Effects of serotonin-1 and serotonin-2 receptor agonists on neuronal activity in the nucleus tractus solitarius. Journal of the autonomic nervous system. vol 56. issue 1-2. 1996-09-26. PMID:8786274. |
these data provide electrophysiological evidence for the presence of 5-ht1 receptors in the nts, presumably of the 5-ht1b subclass, but cast further doubt on the contribution of 5-ht2 and 5-ht1a receptors to the actions of serotonin in the nucleus. |
1996-09-26 |
2023-08-12 |
Not clear |
| H Uchida, K Inagawa, C Tameda, T Miyauch. Pharmacological profile of (-)HT-90B, a novel 5-HT1A receptor agonist/5-HT2 receptor antagonist. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 7. 1996-09-26. PMID:8787043. |
5-ht2 receptor-mediated potentiation of rabbit platelet aggregation by serotonin (5-ht) was reduced by ht-90b (ic50 = 1.73 microm). |
1996-09-26 |
2023-08-12 |
mouse |
| D Simms, J P Gallaghe. Modification of serotonin responses in rat dorsolateral septal nucleus neurons by acute and chronic cocaine. The Journal of pharmacology and experimental therapeutics. vol 276. issue 3. 1996-09-20. PMID:8786562. |
additionally, 5-ht1a receptor up-regulation and/or 5-ht2 receptor down-regulation may contribute to the increased sensitivity of septal neurons to 5-ht. |
1996-09-20 |
2023-08-12 |
rat |
| R C Lov. Novel versus conventional antipsychotic drugs. Pharmacotherapy. vol 16. issue 1 Pt 2. 1996-09-17. PMID:8778684. |
most of the newer agents have an affinity for the serotonin 5ht2 receptor that is at least 10 times greater than that for the dopamine d2 receptor. |
1996-09-17 |
2023-08-12 |
Not clear |
| D S Choi, L Maroteau. Immunohistochemical localisation of the serotonin 5-HT2B receptor in mouse gut, cardiovascular system, and brain. FEBS letters. vol 391. issue 1-2. 1996-09-12. PMID:8706927. |
we recently reported the cloning of a new member of the serotonin 5-ht2 family, the 5-ht2b receptor. |
1996-09-12 |
2023-08-12 |
mouse |
| L S Lin, M T Li. Hypothalamic serotonin release and raised blood pressure after raphe nuclei stimulation in rats. Brain research bulletin. vol 39. issue 5. 1996-09-11. PMID:8705318. |
the dr stimulation-induced hypertension, tachycardia, or increased hypothalamic 5-ht release were attenuated by prior destruction of the ascending serotonergic system produced by icv injection of 5,7-dihydroxytryptamine and by prior blockade of postsynaptic serotonergic receptors produced by intrahypothalamic injection of 5-ht2 antagonists, cyproheptadine and ketanserin. |
1996-09-11 |
2023-08-12 |
rat |
| L S Lin, M T Li. Hypothalamic serotonin release and raised blood pressure after raphe nuclei stimulation in rats. Brain research bulletin. vol 39. issue 5. 1996-09-11. PMID:8705318. |
thus, it appears that dr stimulation activates the 5-ht release in the hypothalamus, then activates the hypothalamic 5-ht2 receptors and results in both hypertension and tachycardia in rats. |
1996-09-11 |
2023-08-12 |
rat |
| G B Varty, G A Higgin. Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology. vol 122. issue 1. 1996-09-11. PMID:8711060. |
there is also evidence to suggest a role of serotonergic (5-ht) and glutamatergic systems in schizophrenia, and accordingly ppi can be disrupted by the 5-ht2 agonist doi, and the non-competitive nmda antagonist, dizocilpine. |
1996-09-11 |
2023-08-12 |
rat |
| J E Audia, D A Evrard, G R Murdoch, J J Droste, J S Nissen, K W Schenck, P Fludzinski, V L Lucaites, D L Nelson, M L Cohe. Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus. Journal of medicinal chemistry. vol 39. issue 14. 1996-09-10. PMID:8709108. |
these high-affinity tetrahydro-beta-carboline antagonists are able to discriminate among the 5ht2 family of serotonin receptors, with members of the series showing selectivities of more than 100-fold versus both the 5ht2a and 5ht2c receptors based upon radioligand binding and functional assays. |
1996-09-10 |
2023-08-12 |
rat |
| A P Monte, D Marona-Lewicka, M A Parker, D B Wainscott, D L Nelson, D E Nichol. Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups. Journal of medicinal chemistry. vol 39. issue 15. 1996-09-06. PMID:8709129. |
in addition, the results provide information about the topography and relative orientation of residues involved in agonist binding in the serotonin 5-ht2 receptors. |
1996-09-06 |
2023-08-12 |
human |