| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Kusumi, S Matsubara, Y Takahashi, T Ishikane, T Koyam. Characterization of [3H]clozapine binding sites in rat brain. Journal of neural transmission. General section. vol 101. issue 1-3. 1996-09-03. PMID:8695057. |
serotonin 5-ht2 and dopamine d4 receptor binding sites could also be detected by displacement experiments using ketanserin and nemonapride, respectively, in frontal cortex and limbic area, but not in hippocampus or striatum. |
1996-09-03 |
2023-08-12 |
rat |
| A Mar, P Drapea. Modulation of conduction block in leech mechanosensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 14. 1996-08-30. PMID:8699244. |
the effects of 5-ht on posterior fields were blocked by the nonspecific 5-ht antagonist methysergide and were partly suppressed by the 5-ht2 antagonist ketanserin. |
1996-08-30 |
2023-08-12 |
Not clear |
| R B Raffa, E E Cod. Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays). Life sciences. vol 59. issue 2. 1996-08-30. PMID:8699917. |
in the present study, we measured the affinity of acetaminophen at 5-ht3, as well as 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2, 5-ht2c, 5-ht4, 5-ht6, 5-ht7 and eleven other receptor sites and at serotonin and norepinephrine reuptake sites. |
1996-08-30 |
2023-08-12 |
Not clear |
| B D'Agostino, M G Matera, M Cazzola, M Mangrella, F Ross. Effects of in vitro 5-HT1 receptor activation in guinea pig trachea. Life sciences. vol 59. issue 2. 1996-08-30. PMID:8699922. |
in tissues pretreated with both ketanserin (10 microm), an antagonist of 5-ht2 receptors, and ondansetron (10 microm), an antagonist of 5-ht3 receptors, 5-ht (from 10 nm to 10 mm) relaxed guinea pig trachea precontracted with acetylcholine (ach, 100 microm). |
1996-08-30 |
2023-08-12 |
Not clear |
| M Ishizaw. Inhibitory action of 5-hydroxytryptamine on propulsive activity of the guinea-pig isolated colon. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. vol 114. issue 1. 1996-08-27. PMID:8689526. |
these results suggest that 5-ht may inhibit spontaneous propulsive activities of the colonic segment via release of endogenous pgs (e.g., e and i types) in the circular muscle cells mediated by an inhibitory neurotransmitter, which release was stimulated by 5-ht1-like 5-ht2 and 5-ht4 receptors on the myenteric neurones in the circular muscle layer. |
1996-08-27 |
2023-08-12 |
Not clear |
| A Miyamoto, T Obi, A Nishi. The vasomotor effects of 5-hydroxytryptamine on equine basilar arteries in vitro. Veterinary research communications. vol 20. issue 1. 1996-08-27. PMID:8693702. |
contractions were not competitively inhibited by the 5-ht2 receptor antagonist ketanserin at low concentrations of 5-ht. |
1996-08-27 |
2023-08-12 |
Not clear |
| A Miyamoto, T Obi, A Nishi. The vasomotor effects of 5-hydroxytryptamine on equine basilar arteries in vitro. Veterinary research communications. vol 20. issue 1. 1996-08-27. PMID:8693702. |
the 5-ht1 and 5-ht2 receptor antagonist methiothepin shifted the concentration-response curve of 5-ht downwards and to the right in a concentration-dependent manner. |
1996-08-27 |
2023-08-12 |
Not clear |
| S M Wallerstedt, K Törnebrandt, M Bodelsso. Characteristics of contractile 5-HT receptors in isolated human omental arteries: presence of 5-HT1 and 5-HT2 receptors. Pharmacology & toxicology. vol 78. issue 1. 1996-08-22. PMID:8685087. |
characteristics of contractile 5-ht receptors in isolated human omental arteries: presence of 5-ht1 and 5-ht2 receptors. |
1996-08-22 |
2023-08-12 |
human |
| S M Wallerstedt, K Törnebrandt, M Bodelsso. Characteristics of contractile 5-HT receptors in isolated human omental arteries: presence of 5-HT1 and 5-HT2 receptors. Pharmacology & toxicology. vol 78. issue 1. 1996-08-22. PMID:8685087. |
four 5-ht receptor agonists with different selectivity all induced concentration-dependent contraction (potency and order of potency indicated): 5-ht (non-selective; 6.12 +/- 0.14)=sumatriptan (5-ht1; 6.32 +/- 0.07) > alpha-methyl-5-ht (5-ht2; 5.41 +/- 0.05) > 2-methyl-5-ht (5-ht3; < or =4.46+/-0.05). |
1996-08-22 |
2023-08-12 |
human |
| S M Wallerstedt, K Törnebrandt, M Bodelsso. Characteristics of contractile 5-HT receptors in isolated human omental arteries: presence of 5-HT1 and 5-HT2 receptors. Pharmacology & toxicology. vol 78. issue 1. 1996-08-22. PMID:8685087. |
the 5-ht2 receptor antagonist ketanserin antagonised the contraction induced by 5-ht, alpha-methyl-5-ht and 2-methyl-5-ht. |
1996-08-22 |
2023-08-12 |
human |
| J M Dickenson, S J Hil. Coupling of an endogenous 5-HT1B-like receptor to increases in intracellular calcium through a pertussis toxin-sensitive mechanism in CHO-K1 cells. British journal of pharmacology. vol 116. issue 7. 1996-08-16. PMID:8680721. |
5-ht (1 microm)-mediated increases in [ca2+]i were insensitive to the 5-ht receptor antagonist, ritanserin (5-ht2; 100 nm), ketanserin (5-ht2; 100 nm), ly-278,584 (5-ht3; 1 microm) and way 100635 (5-ht1a; 1 microm). |
1996-08-16 |
2023-08-12 |
human |
| M H Norman, G C Rigdon, W R Hall, F Nava. Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents. Journal of medicinal chemistry. vol 39. issue 5. 1996-08-15. PMID:8676355. |
the target compounds were readily prepared from their benzoyl chloride, benzoic acid, or isatoic anhydride precursors, and they were evaluated in vitro for their ability to bind to dopamine d2, serotonin 5-ht2, and serotonin 5-ht1a receptors. |
1996-08-15 |
2023-08-12 |
mouse |
| O Collin, J E Damber, A Berg. 5-Hydroxytryptamine--a local regulator of testicular blood flow and vasomotion in rats. Journal of reproduction and fertility. vol 106. issue 1. 1996-08-08. PMID:8667341. |
the effects of 5-hydroxytryptamine (5-ht), 5-ht2 receptor antagonists (ritanserin and ketanserin), histamine and substance 48/80 on testicular blood flow and microcirculation were studied in adult rats. |
1996-08-08 |
2023-08-12 |
rat |
| J Borawski, M Mazerska, A Rydzewski, K Pawlak, M Rowinski, M Mysliwie. Ketanserin: a new perspective in posttransplant erythrocytosis? Clinical transplantation. vol 10. issue 1 Pt 1. 1996-07-26. PMID:8652901. |
we have recently shown that ketanserin, an antagonist of peripheral serotonin 5-ht2 receptors lowers blood erythropoietin (epo) levels in some chronic hemodialysis patients. |
1996-07-26 |
2023-08-12 |
Not clear |
| M Sandrini, G Vitale, A V Vergoni, A Ottani, A Bertolin. Effect of acute and chronic treatment with triiodothyronine on serotonin levels and serotonergic receptor subtypes in the rat brain. Life sciences. vol 58. issue 18. 1996-07-25. PMID:8649184. |
this observation might indicate that thyroid hormones enhance 5-ht concentration in certain brain areas, thus causing a down-regulation of 5-ht2 receptors. |
1996-07-25 |
2023-08-12 |
rat |
| M K Mundey, A Fletcher, C A Marsde. Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646424. |
furthermore way100635 can increase 5-ht neuronal firing, suggesting that it blocks a 5-ht1a receptor-mediated inhibitory tone acting on guinea-pig 5-ht neurones resulting in increased 5-ht release and 5-ht2 receptor-mediated behaviours. |
1996-07-24 |
2023-08-12 |
Not clear |
| T de Boe. The pharmacologic profile of mirtazapine. The Journal of clinical psychiatry. vol 57 Suppl 4. 1996-07-09. PMID:8636062. |
blockade of 5-ht2 and 5-ht3 receptors possibly prevents side effects associated with nonselective 5-ht activation and may also contribute to the anxiolytic and sleep-improving properties of mirtazapine. |
1996-07-09 |
2023-08-12 |
rat |
| S W Watts, M Baez, R C Web. The 5-hydroxytryptamine2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertensive rats. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627522. |
agonist contractile potencies indicated that a 5-ht2 receptor mediates contraction to 5-ht in both sham and doca-salt arteries. |
1996-06-27 |
2023-08-12 |
rat |
| S W Watts, M Baez, R C Web. The 5-hydroxytryptamine2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertensive rats. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627522. |
in arteries from sham rats, ketanserin (5-ht2a/5-ht2c selective), ly53857 (5-ht2 selective) and spiperone (5-ht2a/5-ht2c selective) shifted contraction to 5-ht (pkb = 8.58, 8.35 and 9.52, respectively) indicating that a 5-ht2a receptor mediates contraction in arteries from normotensive rats. |
1996-06-27 |
2023-08-12 |
rat |
| C K Cohn, D S Robinson, D L Roberts, U E Schwiderski, K O'Brien, J R Ien. Responders to antidepressant drug treatment: a study comparing nefazodone, imipramine, and placebo in patients with major depression. The Journal of clinical psychiatry. vol 57 Suppl 2. 1996-06-25. PMID:8626358. |
nefazodone hydrochloride, an antidepressant that acts as a 5-ht2 antagonist and serotonin (5-ht) and norepinephrine uptake inhibitor, was evaluated in a double-blind, imipramine- and placebo-controlled study involving 128 patients with major depression. |
1996-06-25 |
2023-08-12 |
Not clear |