| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M H Lade. Tolerability and safety: essentials in antidepressant pharmacotherapy. The Journal of clinical psychiatry. vol 57 Suppl 2. 1996-06-25. PMID:8626362. |
it is different from other antidepressants because of its two actions in the serotonin system, moderate serotonin selective reuptake blocking properties and direct 5-ht2 antagonism, which also can enhance 5-ht1 neurotransmission. |
1996-06-25 |
2023-08-12 |
human |
| S Delion, S Chalon, D Guilloteau, J C Besnard, G Duran. alpha-Linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627314. |
the deficiency also induced an 18-46% increase in serotonin 5-ht2 receptor density in the frontal cortex during aging, without variation in endogenous serotonin level, and a 10% reduction in density of dopaminergic d2 receptors. |
1996-06-25 |
2023-08-12 |
rat |
| J M Launay, G Birraux, D Bondoux, J Callebert, D S Choi, S Loric, L Maroteau. Ras involvement in signal transduction by the serotonin 5-HT2B receptor. The Journal of biological chemistry. vol 271. issue 6. 1996-06-19. PMID:8621713. |
the family of serotonin 5-ht2 receptors stimulates the phospholipase c second messenger pathway via the alpha subunit of the gq gtp-binding protein. |
1996-06-19 |
2023-08-12 |
mouse |
| H Z Mao, Z Li, M W Chaplea. Platelet activation in carotid sinuses triggers reflex sympathoinhibition and hypotension. Hypertension (Dallas, Tex. : 1979). vol 27. issue 3 Pt 2. 1996-06-05. PMID:8613208. |
the results indicate that (1) platelet activation in carotid sinuses triggers reflex inhibition of sympathetic nerve activity and hypotension; (2) the reflex is not caused by carotid vasoconstriction and is not mediated by prostanoids; and (3) the reflex is mediated by 5-ht acting primarily on 5-ht3 and to a lesser extent on 5-ht2 receptors. |
1996-06-05 |
2023-08-12 |
rabbit |
| G J Wang, N D Volkow, J Logan, J S Fowler, D Schlyer, R R MacGregor, R J Hitzemann, A Gjedde, A P Wol. Serotonin 5-HT2 receptor availability in chronic cocaine abusers. Life sciences. vol 56. issue 16. 1996-06-03. PMID:8614247. |
serotonin 5-ht2 receptor availability in chronic cocaine abusers. |
1996-06-03 |
2023-08-12 |
human |
| G J Wang, N D Volkow, J Logan, J S Fowler, D Schlyer, R R MacGregor, R J Hitzemann, A Gjedde, A P Wol. Serotonin 5-HT2 receptor availability in chronic cocaine abusers. Life sciences. vol 56. issue 16. 1996-06-03. PMID:8614247. |
serotonin 5-ht2 receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and f-18 n-methylspiperone and was compared to control subjects (n =19). |
1996-06-03 |
2023-08-12 |
human |
| C M Villalón, E Ramírez-San Juan, C Castillo, E Castillo, F J López-Muñoz, J A Terró. Pharmacological profile of the receptors that mediate external carotid vasoconstriction by 5-HT in vagosympathectomized dogs. British journal of pharmacology. vol 116. issue 6. 1996-04-04. PMID:8591004. |
these responses to 5-ht were resistant to blockade by antagonists at 5-ht2 (ritanserin) and 5-ht3/5-ht4 (tropisetron) receptors, but were partly blocked by the 5-ht1-like and 5-ht2 receptor antagonist, methiothepin (0.3 mg kg-1); higher doses of methiothepin (1 and 3 mg kg-1) caused little, if any, further blockade. |
1996-04-04 |
2023-08-12 |
Not clear |
| S Gidener, Z Kirkali, H Güve. Influence of serotonin on the human ureter: an in vitro pharmacological study. Urologia internationalis. vol 55. issue 4. 1996-03-27. PMID:8588266. |
the 5ht2 receptor antagonist ketanserin (kt; 10(-5)-10(-4) m) and mixed 5ht1/5ht2 receptor antagonist methysergide (ms; 5 x 10(-5) m) inhibited the effect of 5-ht. |
1996-03-27 |
2023-08-12 |
human |
| A N Singh, C Barlas, S Singh, P Franks, R K Mishr. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. Journal of psychiatry & neuroscience : JPN. vol 21. issue 1. 1996-03-21. PMID:8580115. |
a neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine d1, d2, d4 and serotonin 5-ht2 receptor subtypes. |
1996-03-21 |
2023-08-12 |
Not clear |
| A N Singh, C Barlas, S Singh, P Franks, R K Mishr. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. Journal of psychiatry & neuroscience : JPN. vol 21. issue 1. 1996-03-21. PMID:8580115. |
the findings indicate that loxapine displays an extremely strong binding affinity for dopamine d4 and serotonin 5-ht2 receptors, which suggests that both serotonergic and dopaminergic mechanisms contribute to the antipsychotic drug action and eps associated with loxapine in the treatment of schizophrenia. |
1996-03-21 |
2023-08-12 |
Not clear |
| K Ishizumi, A Kojima, F Antoku, I Saji, M Yoshig. Succinimide derivatives. II. Synthesis and antipsychotic activity of N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cis- cyclohexanedicarboximide (SM-9018) and related compounds. Chemical & pharmaceutical bulletin. vol 43. issue 12. 1996-03-21. PMID:8582016. |
the in vitro binding affinities of these compounds were examined for dopamine 2 (d2) and serotonin 2 (5-ht2) receptor sites. |
1996-03-21 |
2023-08-12 |
Not clear |
| T Fujiwara, S Chib. Augmented responses to 5-HT2-receptor-mediated vasoconstrictions in atherosclerotic rabbit common carotid arteries. Journal of cardiovascular pharmacology. vol 26. issue 3. 1996-03-21. PMID:8583795. |
vascular effects of 5-ht and its analogs (5-ct, a 5-ht1-like receptor agonist; alpha-methyl-5-ht, a 5-ht2 agonist; 8-oh-dpat and tfmpp, 5-ht1 agonists) were investigated in each group. |
1996-03-21 |
2023-08-12 |
rabbit |
| Y Ohno, T Ishibashi, K Okada, K Ishida, M Nakamur. Effects of subchronic treatments with SM-9018, a novel 5-HT2 and D2 antagonist, on dopamine and 5-HT receptors in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 6. 1996-03-19. PMID:8584685. |
effects of subchronic treatments with sm-9018, a novel 5-ht2 and d2 antagonist, on dopamine and 5-ht receptors in rats. |
1996-03-19 |
2023-08-12 |
rat |
| Y Ohno, T Ishibashi, K Okada, K Ishida, M Nakamur. Effects of subchronic treatments with SM-9018, a novel 5-HT2 and D2 antagonist, on dopamine and 5-HT receptors in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 6. 1996-03-19. PMID:8584685. |
receptor binding and behavioral studies were performed to compare the effects of subchronic treatments with sm-9018, a novel 5-ht2 and d2 antagonist, and with haloperidol (hal) on dopamine and 5-ht receptors in rats. |
1996-03-19 |
2023-08-12 |
rat |
| J Hardcastle, P T Hardcastl. Evidence that the secretory response of rat intestine to 5-hydroxytryptamine in-vivo involves more than one 5-hydroxytryptamine-receptor subtype. The Journal of pharmacy and pharmacology. vol 47. issue 9. 1996-03-15. PMID:8583387. |
the 5-ht2 antagonist ketanserin failed to influence the response to 5-ht in either the small intestine or the colon, but it did inhibit the action of 5-mt, having a much greater effect in the small intestine. |
1996-03-15 |
2023-08-12 |
rat |
| J Hardcastle, P T Hardcastl. Evidence that the secretory response of rat intestine to 5-hydroxytryptamine in-vivo involves more than one 5-hydroxytryptamine-receptor subtype. The Journal of pharmacy and pharmacology. vol 47. issue 9. 1996-03-15. PMID:8583387. |
these observations suggest that both 5-ht2 and 5-ht3 receptors contribute to the stimulation of electrogenic c1 secretion by 5-ht, with 5-ht2 receptors playing a more prominent role in the small intestine and 5-ht3 receptors being more important in the colon. |
1996-03-15 |
2023-08-12 |
rat |
| M H Norman, D J Minick, G C Rigdo. Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives. Journal of medicinal chemistry. vol 39. issue 1. 1996-03-01. PMID:8568802. |
the compounds were evaluated in vitro at dopamine d2 and serotonin 5-ht1a and 5-ht2 receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. |
1996-03-01 |
2023-08-12 |
mouse |
| C M Villalón, J A Terrón, E Ramírez-San Juan, P R Saxen. 5-hydroxytryptamine: considerations about discovery, receptor classification and relevance to medical research. Archives of medical research. vol 26. issue 4. 1996-02-27. PMID:8555727. |
later on, this classification was confronted with the new peroutka's 5-ht, and 5-ht2 classification derived from radioligand binding studies. |
1996-02-27 |
2023-08-12 |
human |
| C M Villalón, J A Terrón, E Ramírez-San Juan, P R Saxen. 5-hydroxytryptamine: considerations about discovery, receptor classification and relevance to medical research. Archives of medical research. vol 26. issue 4. 1996-02-27. PMID:8555727. |
since these 5-ht receptors were being referred to by many names, an international committee formulated some criteria for the characterization and a framework for the nomenclature of 5-ht receptors into 5-ht1, 5-ht2 and 5-ht3 categories. |
1996-02-27 |
2023-08-12 |
human |
| H Arita, K Ichikawa, M Sakamot. Serotonergic cells in nucleus raphe pallidus provide tonic drive to posterior cricoarytenoid motoneurons via 5-hydroxytryptamine2 receptors in cats. Neuroscience letters. vol 197. issue 2. 1996-02-22. PMID:8552273. |
microinjection of serotonin and 5-hydroxytryptamine2 (5-ht2) agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (dom) in nucleus ambiguus caused excitation of posterior cricoarytenoid (pca) muscles of the larynx in anesthetized, spontaneously breathing cats. |
1996-02-22 |
2023-08-12 |
Not clear |