| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R R Matsumoto, M J Hussong, D D Truon. Effects of selective serotonergic ligands on posthypoxic audiogenic myoclonus. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 5. 1996-02-20. PMID:8552114. |
the audiogenic posthypoxic myoclonus in these animals could be attenuated with the following drugs: 5-hydroxytryptophan (5-htp, serotonin [5-ht] precursor), n-(3-trifluoro-methylphenyl)piperazine hydrochloride (tfmpp, 5-ht1b/1c/2 agonist), (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrobromide (doi, 5-ht2 agonist), and 1-(m-chlorophenyl)-biguanide hydrochloride (m-cpbg, 5-ht3 agonist). |
1996-02-20 |
2023-08-12 |
rat |
| R R Matsumoto, M J Hussong, D D Truon. Effects of selective serotonergic ligands on posthypoxic audiogenic myoclonus. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 5. 1996-02-20. PMID:8552114. |
in contrast, the following drugs were ineffective: (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide (8-oh-dpat, 5-ht1a agonist), buspirone hydrochloride (5-ht1a agonist), 7-trifluoromethyl-4(4-methyl-l-piperazinyl)-pyrrolo[1,2- a]quinoxaline maleate (cgs 12066b, 5-ht1b agonist), ketanserin tartrate (5-ht2 antagonist), methysergide maleate (5-ht2 antagonist), fluoxetine (5-ht uptake blocker), and saline (vehicle). |
1996-02-20 |
2023-08-12 |
rat |
| I K Anderson, G R Martin, A G Ramag. Evidence that activation of 5-HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation. British journal of pharmacology. vol 116. issue 2. 1996-02-01. PMID:8528555. |
the aim of the present experiments was to determine whether the effects of lateral ventricular application of 5-ht on cardiovascular and respiratory variables in anaesthetized cats are mediated by forebrain 5-ht2 receptors. |
1996-02-01 |
2023-08-12 |
cat |
| I K Anderson, G R Martin, A G Ramag. Evidence that activation of 5-HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation. British journal of pharmacology. vol 116. issue 2. 1996-02-01. PMID:8528555. |
this was carried out by determining whether the effects of 5-ht are blocked by the 5-ht2 antagonist, cinanserin and if they are mimicked by the selective 5-ht2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi). |
1996-02-01 |
2023-08-12 |
cat |
| I K Anderson, G R Martin, A G Ramag. Evidence that activation of 5-HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation. British journal of pharmacology. vol 116. issue 2. 1996-02-01. PMID:8528555. |
the effects of 5-ht also differed from doi in that 5-ht evoked maximal pressor and near maximal sympathoexcitatory effects after the first dose, whereas the pressor and sympathoexcitatory effects of doi were graded over the complete dose-range.4 the 5-ht2 antagonist, cinanserin (265 nmol kg-1, i.c.v.) |
1996-02-01 |
2023-08-12 |
cat |
| I K Anderson, G R Martin, A G Ramag. Evidence that activation of 5-HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation. British journal of pharmacology. vol 116. issue 2. 1996-02-01. PMID:8528555. |
after pretreatment with cinanserin all cardiovascular and respiratory effects of 5-ht were significantly attenuated.5 it is concluded that in the cat, as doi and 5-ht have similar effects on the cardiovascular variables recorded and as the effects of 5-ht are blocked by cinanserin, 5-ht can act on 5-ht2 receptors located in the forebrain to cause differential sympathoexcitation and a rise in arterial blood pressure. |
1996-02-01 |
2023-08-12 |
cat |
| L L Howell, L D Byr. Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 275. issue 3. 1996-02-01. PMID:8531128. |
in drug interaction studies, the 5ht uptake inhibitors and quipazine produced an insurmountable attenuation of the behavioral-stimulant effects of cocaine, whereas the 5ht antagonists (ketanserin, mianserin and ritanserin) with high affinity for 5ht2 binding sites enhanced the behavioral-stimulant effects of low or intermediate doses of cocaine. |
1996-02-01 |
2023-08-12 |
monkey |
| J L Andersson, G G Nomikos, M Marcus, P Hertel, J M Mathé, T H Svensso. Ritanserin potentiates the stimulatory effects of raclopride on neuronal activity and dopamine release selectivity in the mesolimbic dopaminergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 4. 1996-02-01. PMID:8532065. |
the atypical profile of clozapine and some other new antipsychotic drugs has been attributed to a relatively selective effect on the mesolimbic dopaminergic system, as well as to their potent serotonin 5-ht2 receptor antagonism and high ratio of 5-ht2 to dopamine d2 receptor affinities. |
1996-02-01 |
2023-08-12 |
rat |
| D Rose, J Khater-Boidin, P Toussaint, B Duro. Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat. Respiration physiology. vol 101. issue 1. 1996-01-24. PMID:8525122. |
the responses to 8-oh-dpat and doi indicate that 5-ht modulates the respiratory frequency via activation of both 5-ht1a and 5-ht2 receptors. |
1996-01-24 |
2023-08-12 |
cat |
| D Rose, J Khater-Boidin, P Toussaint, B Duro. Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat. Respiration physiology. vol 101. issue 1. 1996-01-24. PMID:8525122. |
nevertheless, the effect of 5-ht on both the expiratory and hypoglossal-innervated muscles seems to depend on 5-ht2 receptors activation only. |
1996-01-24 |
2023-08-12 |
cat |
| P T Wong, H Feng, W L Te. Interaction of the dopaminergic and serotonergic systems in the rat striatum: effects of selective antagonists and uptake inhibitors. Neuroscience research. vol 23. issue 1. 1996-01-18. PMID:7501296. |
mianserin (5-ht2 antagonist, 2 mg/kg) and citalopram (5-ht uptake inhibitor, 11 mg/kg) also decreased both hva and 5-hiaa. |
1996-01-18 |
2023-08-12 |
rat |
| R J Goldber. Nefazodone and venlafaxine: two new agents for the treatment of depression. The Journal of family practice. vol 41. issue 6. 1996-01-17. PMID:7500069. |
in addition to inhibition of serotonin reuptake, nefazodone exhibits 5-ht2 antagonism. |
1996-01-17 |
2023-08-12 |
Not clear |
| S W Watts, L Gilbert, R C Web. 5-Hydroxytryptamine2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 26. issue 6 Pt 2. 1996-01-16. PMID:7498967. |
the receptor mediating contraction in isolated mesenteric arteries from sham and doca-salt hypertensive rats is a member of the 5-ht2 family based on rank order of agonist potency (5-ht = alpha-methyl-5-ht [5-ht2 receptor agonist]>tryptamine>5-hydroxykynuramine). |
1996-01-16 |
2023-08-12 |
rat |
| S W Watts, L Gilbert, R C Web. 5-Hydroxytryptamine2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 26. issue 6 Pt 2. 1996-01-16. PMID:7498967. |
however, in doca-salt hypertension, ketanserin-insensitive 5-ht2 receptors, possibly 5-ht2b receptors, mediate mesenteric arterial contraction to 5-ht. |
1996-01-16 |
2023-08-12 |
rat |
| b' D Dragovi\\xc4\\x87, V Soski\\xc4\\x87, J Joksimovi\\xc4\\x8. Synthesis and evaluation of N,N-di-n-propyl-5,6,7,8-tetrahydro-1 H-benz[f]benzimidazol-6-yl-amine and related congeners as dopaminergic ligands. Die Pharmazie. vol 50. issue 10. 1996-01-16. PMID:7501691.' |
none of the four compounds tested expressed significant affinity for d-1 receptors and all of them competed moderately with [3h]spiperone binding to d-2 receptors under conditions that prevented radioligand binding to serotonin 5ht2 receptors. |
1996-01-16 |
2023-08-12 |
cattle |
| N Tilakaratne, Z Yang, E Friedma. Chronic fluoxetine or desmethylimipramine treatment alters 5-HT2 receptor mediated c-fos gene expression. European journal of pharmacology. vol 290. issue 3. 1995-12-26. PMID:7589222. |
these studies examined the effects of a 21-day treatment regime with either the tricyclic antidepressant, desmethylimipramine (dmi), or the selective 5-ht uptake inhibitor, fluoxetine, on 5-ht2 receptors in rat brain, as assessed by selective agonist-mediated c-fos gene expression. |
1995-12-26 |
2023-08-12 |
rat |
| R L Smith, R J Barrett, E Sanders-Bus. Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor. The Journal of pharmacology and experimental therapeutics. vol 275. issue 2. 1995-12-19. PMID:7473132. |
the purposes of this study were to determine: first, if animals could be trained to discriminate a serotonin (5-ht)2 receptor agonist from a 5-ht2 receptor antagonist; second, which 5-ht2 receptor subtype was mediating the cues; and third, the usefulness of this model for studying adaptive changes in the 5-ht2 receptor system. |
1995-12-19 |
2023-08-12 |
rat |
| J M Maloteaux, M K Luabeya, M A Vanisberg, A P Jeanjean, P Baudhuin, D Scherman, P M Laduro. Subcellular distribution of receptor sites in human brain: differentiation between heavy and light structures of high and low density. Brain research. vol 687. issue 1-2. 1995-12-14. PMID:7583300. |
after fractionation by differential centrifugation of frontal cortex homogenates, benzodiazepine and serotonin 5-ht2 receptors were mainly found in the heavy mitochondrial (m) fraction, whereas mu-opiate and muscarinic cholinergic receptors were mainly concentrated in the microsomal (p) fraction. |
1995-12-14 |
2023-08-12 |
human |
| L G Cockerham, C D Forcin. Effect of antihistamines, disodium cromoglycate (DSCG) or methysergide on post-irradiation cerebral blood flow and mean systemic arterial blood pressure in primates after 25 Gy, whole-body, gamma irradiation. Journal of radiation research. vol 36. issue 2. 1995-12-13. PMID:7473348. |
results support the hypothesis that the irradiation-induced cerebral ischemia and, to some extent, the hypotension is mediated by serotonin through 5-ht2 receptor sites. |
1995-12-13 |
2023-08-12 |
monkey |
| P Drapeau, S Catarsi, D C Mer. Signalling synapse formation between identified neurons. Journal of physiology, Paris. vol 89. issue 3. 1995-12-12. PMID:7581300. |
cation channels in the postsynaptic neuron were modulated by protein kinase c (pkc) upon binding of 5-ht to a 5-ht2 receptor. |
1995-12-12 |
2023-08-12 |
Not clear |