All Relations between 5-ht receptor 2 and serotonin

Publication Sentence Publish Date Extraction Date Species
J F Liao, Y M Jan, S Y Huang, H H Wang, L L Yu, C F Che. Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs. Proceedings of the National Science Council, Republic of China. Part B, Life sciences. vol 19. issue 3. 1995-12-07. PMID:7480361. the results indicated that these water extracts contained the principles acting on the dopamine (d1 & d2), muscarinice acetylcholine (m1), or 5-ht (5-ht1a & 5-ht2) receptors, or the benzodiazepine and the gamma-amino-n-butyric acid (gaba) binding sites of gabaa receptors as determined by receptor binding assays. 1995-12-07 2023-08-12 Not clear
Y Chen, L Peng, X Zhang, J U Stolzenburg, L Hert. Further evidence that fluoxetine interacts with a 5-HT2C receptor in glial cells. Brain research bulletin. vol 38. issue 2. 1995-12-07. PMID:7583341. fluoxetine appears to act on a different subtype of receptor (the 5-ht2c receptor [in original terminology the 5-ht1c receptor]) than the one on which micromolar concentrations of serotonin are known to act in astrocytes (the 5-ht2a receptor [in original terminology the 5-ht2 receptor]). 1995-12-07 2023-08-12 Not clear
Z H Zhang, S W Yang, J Y Chen, Y F Xie, J T Qiao, N Dafn. Interaction of serotonin and norepinephrine in spinal antinociception. Brain research bulletin. vol 38. issue 2. 1995-12-07. PMID:7583343. the results indicate that (1) intrathecal (it) administration of low doses of 5-ht (60 nmol) or ne (1.5 nmol) suppresses the nociceptive fr by 40% for 20 min, respectively; (2) administration of higher doses of 5-ht (240 nmol, it) multiplies the suppression of the nociceptive fr by 80% for 40 min, and ne (15 nmol, it) produces similar suppression of the nociceptive fr for 80 min; (3) concomitant administration of low doses of 5-ht (60 nmol, it) and ne (1.5 nmol, it) produces a summation of the nociceptive fr suppression both in amplitude and duration; (4) concomitant administration of the higher doses of 5-ht (240 nmol it) with ne (15 nmol, it) produces similar effect obtained as 5-ht given separately, and no summation was obtained as observed following the lower dosages; (5) serotonin (240 nmol, it) given 40 min before ne (15 nmol, it) attenuates the duration of the suppression induced by ne; (6) pretreatment with a selective 5-ht2 receptor antagonist ketanserin (60 nmol, it) failed to abolish the 5-ht effects; (7) pretreatment with ketanserin prior to concomitant administration of the higher doses of 5-ht and ne prolongs the time duration of the nociceptive fr suppression. 1995-12-07 2023-08-12 rat
F J Miranda, G Torregrosa, J B Salom, J A Alabadí, T Jover, M D Barberá, E Alborc. Characterization of 5-hydroxytryptamine receptors in goat cerebral arteries. General pharmacology. vol 26. issue 6. 1995-12-07. PMID:7590117. pretreatment with the antagonist of 5-ht1a and 5-ht1b receptors cyanopindolol (10(-8), 10(-6) m), the antagonist of 5-ht1/5-ht2 receptors methysergide (10(-11), 10(-9) m) and the antagonist of 5-ht2 receptors ketanserin (10(-11), 10(-9) m) induced non-competitive inhibition of the concentration-response curve to 5-ht. 1995-12-07 2023-08-12 Not clear
F J Miranda, G Torregrosa, J B Salom, J A Alabadí, T Jover, M D Barberá, E Alborc. Characterization of 5-hydroxytryptamine receptors in goat cerebral arteries. General pharmacology. vol 26. issue 6. 1995-12-07. PMID:7590117. these results suggest that 5-ht contracts the goat middle cerebral artery by acting mainly on 5-ht2 receptors. 1995-12-07 2023-08-12 Not clear
E Messori, C A Rizzi, S M Candura, A Lucchelli, B Balestra, M Tonin. 5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle. British journal of pharmacology. vol 115. issue 4. 1995-11-30. PMID:7582490. like 5-ht, the 5-ht3 receptor agonist, 2-methyl-5-hydroxytryptamine (2-methyl-5-ht: 0.3-100 microm), the 5-ht2 receptor agonist, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi: 30 nm-3 microm) and the 5-ht4 receptor agonist, 5-methoxytryptamine (5-meot: 0.1-30 microm) potentiated, though with lower potency, detrusor contractions. 1995-11-30 2023-08-12 Not clear
Y Fischer, J Thomas, J Kamp, E Jüngling, H Rose, Carpéné, H Kammermeie. 5-hydroxytryptamine stimulates glucose transport in cardiomyocytes via a monoamine oxidase-dependent reaction. The Biochemical journal. vol 311 ( Pt 2). 1995-11-28. PMID:7487898. in conclusion, the stimulation of glucose transport by 5-ht in cardiomyocytes is not mediated by a 5-ht1, 5-ht2, 5-ht3 or 5-ht4 receptor, nor by an adrenergic or dopaminergic receptor, but is likely to occur through the degradation of by a monoamine oxidase and concomitant formation of h2o2. 1995-11-28 2023-08-12 rat
R J Omeljaniu. Specific [3H]spiperone binding sites in the pituitary of rainbow trout (Oncorhynchus mykiss) and goldfish (Carassius auratus). Canadian journal of physiology and pharmacology. vol 73. issue 5. 1995-11-28. PMID:7585324. dopamine d2 receptor ligands differentially displaced [3h]spiperone from the trout pituitary, while d1 ligands, a d4 ligand, and a 5-hydroxytryptamine (5ht2) receptor antagonist had only small nonspecific effects. 1995-11-28 2023-08-12 Not clear
G J Wang, N D Volkow, J Logan, J S Fowler, D Schlyer, R R MacGregor, R J Hitzemann, R C Gur, A P Wol. Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects. Life sciences. vol 56. issue 14. 1995-11-27. PMID:7475891. evaluation of age-related changes in serotonin 5-ht2 and dopamine d2 receptor availability in healthy human subjects. 1995-11-27 2023-08-12 human
G J Wang, N D Volkow, J Logan, J S Fowler, D Schlyer, R R MacGregor, R J Hitzemann, R C Gur, A P Wol. Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects. Life sciences. vol 56. issue 14. 1995-11-27. PMID:7475891. we assessed the relation between serotonin 5-ht2 receptor availability and aging and compared it with that for dopamine d2 receptors on 19 healthy male volunteers (age range, 21-49 years) using positron emission tomography (pet) and f-18 n-methylspiperone (nms). 1995-11-27 2023-08-12 human
A Plech, R Brus, J H Kalbfleisch, R M Kostrzew. Enhanced oral activity responses to intrastriatal SKF 38393 and m-CPP are attenuated by intrastriatal mianserin in neonatal 6-OHDA-lesioned rats. Psychopharmacology. vol 119. issue 4. 1995-11-24. PMID:7480527. the 5-ht2 antagonist mianserin attenuates the effects of both m-cpp and skf 38393, suggesting that da agonist effects are mediated by 5-ht neurochemical systems. 1995-11-24 2023-08-12 rat
S Li, G Pelletie. Involvement of serotonin in the regulation of GnRH gene expression in the male rat brain. Neuropeptides. vol 29. issue 1. 1995-11-22. PMID:7566509. in order to evaluate the influence of 5-ht on gonadotropin-releasing hormone (gnrh) neurons, we have investigated the effects of repeated administration (during 2 days) of 5-ht, the 5-ht1+2 receptor antagonist methysergide, the 5-ht2 receptor antagonist ketanserin, and the 5-ht3 receptor antagonist ondansetron on gnrh mrna levels in the male rat medial preoptic area (mpoa), as measured by quantitative in situ hybridization. 1995-11-22 2023-08-12 rat
S Li, G Pelletie. Involvement of serotonin in the regulation of GnRH gene expression in the male rat brain. Neuropeptides. vol 29. issue 1. 1995-11-22. PMID:7566509. they also strongly suggest that the influence of 5-ht in the regulation of gnrh neuronal activity is mediated via activation of 5-ht2 receptor, although an involvement of 5-ht1 receptors cannot be totally excluded. 1995-11-22 2023-08-12 rat
S Gidener, S Apaydin, A Küpelioğlu, H Güven, A Gelal, A Gür. Serotonin causes acute gastric mucosal injury in rats, probably via 5HT1D receptors. International journal of experimental pathology. vol 76. issue 4. 1995-11-14. PMID:7547436. 5ht2 antagonist ketanserine (2.5-15 mg/kg), 5ht3 antagonist ondansetron (1-5 mg/kg), 5ht4 antagonist dau 6285 (1-10 mg/kg) and atropine (1.5-30 mg/kg) exerted no effect whereas 5ht1/2 antagonist metitepine (0.05-0.5 mg/kg) caused a dose dependent inhibition of the effect of 5-ht. 1995-11-14 2023-08-12 rat
A Kugaya, A Kagaya, Y Uchitomi, N Motohashi, S Yamawak. Inhibition of serotonin-induced Ca2+ mobilization by interleukin-1 beta in rat C6BU-1 glioma cells. Brain research. vol 682. issue 1-2. 1995-11-09. PMID:7552306. to study the potential interaction between cytokine and serotonin (5-ht) signal transduction, we evaluated the effect of interleukin-1 beta (il-1 beta) on the 5-ht2 receptor-mediated mobilization of intracellular ca2+ in cultured rat c6bu-1 glioma cells. 1995-11-09 2023-08-12 rat
A Kugaya, A Kagaya, Y Uchitomi, N Motohashi, S Yamawak. Inhibition of serotonin-induced Ca2+ mobilization by interleukin-1 beta in rat C6BU-1 glioma cells. Brain research. vol 682. issue 1-2. 1995-11-09. PMID:7552306. the inhibitory effects of il-1 beta and lps were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by h7, a potent inhibitor of protein kinase c. these results indicate that il-1 beta and lps inhibit 5-ht2 receptor-mediated ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase c. the interaction between cytokines (il-1 beta) and monoamines (5-ht) may serve to modulate signal transduction in the central nervous system. 1995-11-09 2023-08-12 rat
C Yokoyama, H Okamura, Y Ibat. Dopamine D2-like receptors labeled by [3H]YM-09151-2 in the rat hippocampus: characterization and autoradiographic distribution. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552274. the hippocampal [3h]ym-09151-2 binding did not represent serotonergic receptors (5-ht1a and 5-ht2) and sigma receptor, since ki values of ketanserine, serotonin, 8-oh-dpat and dtg were much lower than d2-like receptor antagonists. 1995-11-06 2023-08-12 rat
F Wappler, N Roewer, A Köchling, J Scholz, M Steinfath, E Rumberger, W Löscher, J Schulte am Esc. [Effects of serotonin 2 receptor agonists on skeletal muscle preparations in patients with a disposition toward malignant hyperthermia]. Der Anaesthesist. vol 44. issue 8. 1995-10-27. PMID:7573901. in pigs genetically susceptible to malignant hyperthermia (mh), it has been shown that serotonin (5-ht2) receptor agonists can induce mh and "psychotic" behaviour. 1995-10-27 2023-08-12 human
D C Bolser, D J Blythin, R W Chapman, R W Egan, J A Hey, C Rizzo, S C Kuo, W Kreutne. The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562513. sch 50911 had no binding affinity for gaba-a, histamine h1, histamine h3, dopamine d1, dopamine d2, serotonin 5-ht2, or muscarinic m1, m2, or m4 receptors. 1995-10-25 2023-08-12 rat
M R Szewczak, R Corbett, D K Rush, C A Wilmot, P G Conway, J T Strupczewski, M Cornfeld. The pharmacological profile of iloperidone, a novel atypical antipsychotic agent. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562515. iloperidone displaced ligand binding at d2 dopamine receptors (ic50 = 0.11 microm) and displayed a high affinity for serotonin (5-ht2) receptors (ic50 = 0.011 microm) and alpha-1 receptors (ic50 = 0.00037 microm). 1995-10-25 2023-08-12 mouse