| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Briejer, L M Akkermans, A L Meulemans, R A Lefebvre, J A Schuurke. 5-HT-induced neurogenic relaxations of the guinea-pig proximal colon: investigation into the role of ATP and VIP in addition to nitric oxide. Naunyn-Schmiedeberg's archives of pharmacology. vol 351. issue 2. 1995-07-06. PMID:7770095. |
antagonists to block the contractile response to 5-ht via 5-ht2, 5-ht3 or 5-ht4 receptors were present throughout the experiments and methacholine was administered to precontract the strips. |
1995-07-06 |
2023-08-12 |
Not clear |
| b' L Smejkal-Jagar, M Borani\\xc4\\x8. Serotonin and serotoninergic agents affect proliferation of normal and transformed lymphoid cells. Immunopharmacology and immunotoxicology. vol 17. issue 1. 1995-06-29. PMID:7759768.' |
ketanserin (5-ht2 receptor ligand) and propranolol (5-ht1a and beta-adrenergic ligand) did not block the suppressive effect of serotonin if used along with it in equimolar concentrations (10(-9) m). |
1995-06-29 |
2023-08-12 |
mouse |
| H Kalan. Problems in the search for mechanisms of tolerance. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1995-06-22. PMID:7748283. |
however, explanation of the various time-frames of tolerance, and of the role of associative and instrumental learning in its development, requires consideration of probable interactions among nmda, arginine vasopressin, serotonin 5-ht2, gaba and acetylcholine receptors. |
1995-06-22 |
2023-08-12 |
Not clear |
| W J McBride, J M Murphy, G J Gatto, A D Levy, K Yoshimoto, L Lumeng, T K L. CNS mechanisms of alcohol self-administration. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1995-06-22. PMID:7748340. |
this is indicated by (a) lower contents of da and 5-ht; (b) fewer 5-ht immunostained fibers; (c) lower densities of 5-ht1b, 5-ht2 and d2 receptors; and (d) higher densities of 5-ht1a receptors in the cns of p rats compared to the alcohol-nonpreferring np line of rats. |
1995-06-22 |
2023-08-12 |
rat |
| Y L Du, B D Wilcox, J J Jeffre. Regulation of rat 5-hydroxytryptamine type 2 receptor gene activity: identification of cis elements that mediate basal and 5-hydroxytryptamine-dependent gene activation. Molecular pharmacology. vol 47. issue 5. 1995-06-12. PMID:7746279. |
the 5-hydroxytryptamine type 2 receptor gene is transcriptionally induced by 5-ht-mediated activation of the 5-ht2 receptor in rat myometrial smooth muscle cells. |
1995-06-12 |
2023-08-12 |
rat |
| C S Venugopalan, E P Holmes, K M Kleino. Evidence for serotonin involvement in the NANC excitatory neurotransmission in the catfish intestine. Journal of autonomic pharmacology. vol 15. issue 1. 1995-06-09. PMID:7538135. |
three types of serotonin receptor antagonists, namely methiothepin (predominantly a 5-ht1 antagonist), ketanserin (a selective 5-ht2 antagonist), methysergide and cyproheptadine (predominantly 5-ht2 blockers) and metoclopramide (a selective 5-ht3 blocker) were tested for their effectiveness against serotonin and efs-induced contractions. |
1995-06-09 |
2023-08-12 |
Not clear |
| J A Watson, A C Elliott, P D Brow. Serotonin elevates intracellular Ca2+ in rat choroid plexus epithelial cells by acting on 5-HT2C receptors. Cell calcium. vol 17. issue 2. 1995-06-08. PMID:7736561. |
spiperone and ketanserin (200 nm), less specific 5-ht2 receptor blockers, caused only a slight reduction in the response to 1 microm 5-ht. |
1995-06-08 |
2023-08-12 |
rat |
| P Roevens, D de Chaffoy de Courcelle. Desensitization and resensitization of human platelets to 5-hydroxytryptamine at the level of signal transduction. The Biochemical journal. vol 307 ( Pt 3). 1995-06-06. PMID:7741708. |
without occupation of the 5ht2 receptor, neither an increase in cytosolic [ca2+] (30 nm ionomycin), nor a separate or simultaneous activation of protein kinase c (by 10 microm 1-oleoyl-2-acetylglycerol), could induce desensitization to 5ht (1 microm). |
1995-06-06 |
2023-08-12 |
human |
| J F Marwoo. Influence of alpha 1-adrenoceptor antagonism of ketanserin on the nature of its 5-HT2 receptor antagonism. Clinical and experimental pharmacology & physiology. vol 21. issue 12. 1995-06-05. PMID:7736654. |
in order to investigate alpha 1-adrenoceptor interactions with 5-ht2 receptors, the effect of ketanserin (which antagonizes both types of the above receptors) on responses to 5-hydroxytryptamine (5-ht) and phenylephrine (pe) was measured in isolated perfused rat tail arteries. |
1995-06-05 |
2023-08-12 |
rat |
| A L Killam, S W Watts, M L Cohe. Role of alpha 1-adrenoceptors and 5-HT2 receptors in serotonin-induced contraction of rat prostate: autoradiographical and functional studies. European journal of pharmacology. vol 273. issue 1-2. 1995-06-05. PMID:7737320. |
the concentration-response curve to 5-ht in the presence of 1 microm prazosin was competitively inhibited by the 5-ht2 receptor antagonist ly53857 (6-methyl-1-(1-methylethyl)ergoline-8-carboxylic acid 2-hydroxyl-1-methylpropylester (z)-2-butenedioate (1:1)) (pkb = 9.02). |
1995-06-05 |
2023-08-12 |
rat |
| A L Killam, S W Watts, M L Cohe. Role of alpha 1-adrenoceptors and 5-HT2 receptors in serotonin-induced contraction of rat prostate: autoradiographical and functional studies. European journal of pharmacology. vol 273. issue 1-2. 1995-06-05. PMID:7737320. |
autoradiographic studies with [125i]lsd (2-iodo-lysergic acid diethylamide) documented the presence of 5-ht2 receptors since significant displacement of the radioligand occurred with 5-ht and ly53857, but not with prazosin. |
1995-06-05 |
2023-08-12 |
rat |
| F H Mourad, L J O'Donnell, E Ogutu, J A Dias, M J Farthin. Role of 5-hydroxytryptamine in intestinal water and electrolyte movement during gut anaphylaxis. Gut. vol 36. issue 4. 1995-06-05. PMID:7737563. |
thus, the profound water secretion that occurs in the early stages of intestinal anaphylaxis is partly 5-ht dependent because it can be reversed by 5-ht2 and 5-ht3 receptor antagonists. |
1995-06-05 |
2023-08-12 |
rat |
| G Ciurzyńska, J Dzierzkowska, S Maślińsk. Gastric cytoprotective activity of endogenous 5-HT. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 45. issue 4. 1995-06-01. PMID:7537126. |
the present studies demonstrate that cytoprotective effect of endogenous serotonin depends on 5-ht1 and 5-ht2 receptors stimulation in the gastric mucosa and the protective effect of prostaglandins depends partly on the regulation of serotonin metabolism. |
1995-06-01 |
2023-08-12 |
rat |
| b' Z Tuce, V Soski\\xc4\\x87, J Joksimovi\\xc4\\x8. Synthesis and binding properties of several new dopaminergic ligands. Drug design and discovery. vol 11. issue 4. 1995-06-01. PMID:7727678.' |
none of these compounds expressed significant affinity for the d-1 receptors, while compounds 3, 4, 2 and 1 in this order of potency strongly competed with [3h]spiperone binding to d-2 receptors under conditions that prevented radioligand binding to serotonin 5ht2 receptors (50 nm ketanserin). |
1995-06-01 |
2023-08-12 |
cattle |
| L Farde, S Nyberg, G Oxenstierna, Y Nakashima, C Halldin, B Ericsso. Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients. Journal of clinical psychopharmacology. vol 15. issue 1 Suppl 1. 1995-05-31. PMID:7537284. |
the observation that low doses of clozapine (125 to 175 mg daily) induced more than 80% (5-hydroxytryptamine) 5-ht2 occupancy supports the view that 5-ht2 antagonism may be related to the atypical effects of clozapine. |
1995-05-31 |
2023-08-12 |
Not clear |
| T H Svensson, J M Mathé, J L Andersson, G G Nomikos, B E Hildebrand, M Marcu. Mode of action of atypical neuroleptics in relation to the phencyclidine model of schizophrenia: role of 5-HT2 receptor and alpha 1-adrenoceptor antagonism [corrected]. Journal of clinical psychopharmacology. vol 15. issue 1 Suppl 1. 1995-05-31. PMID:7730496. |
the administration of high doses of ritanserin or atypical neuroleptics with prominent serotonin (5-hydroxytrypyamine) 5-ht2 receptor antagonist action, such as clozapine or amperozide, produced preferential activation of the pfc da projection. |
1995-05-31 |
2023-08-12 |
rat |
| T A Sipes, M A Geye. 8-OH-DPAT disruption of prepulse inhibition in rats: reversal with (+)WAY 100,135 and localization of site of action. Psychopharmacology. vol 117. issue 1. 1995-05-25. PMID:7724701. |
both serotonin (5-ht) releasers and agonists at 5-ht1a, 5-ht1b, and 5-ht2 receptors reduce ppi in the rat. |
1995-05-25 |
2023-08-12 |
rat |
| S Kojima, Y Shim. An enhancing effect of 5-hydroxytryptamine on electrically evoked atropine-resistant contraction of guinea-pig proximal colon. British journal of pharmacology. vol 114. issue 1. 1995-05-17. PMID:7712032. |
dau 6285 (3 microm), a 5-ht4 receptor antagonist, abolished the enhancing action of 5-ht (30 nm), but metitepine (0.03 microm), a 5-ht1/5-ht2 receptor antagonist, ketanserin (0.01 microm), a 5-ht2 receptor antagonist, and ondansetron (1 microm), a 5-ht3 receptor antagonist, had no effect on the enhancement. |
1995-05-17 |
2023-08-12 |
Not clear |
| D Salgado, K A Alkadh. Inhibition of epileptiform activity by serotonin in rat CA1 neurons. Brain research. vol 669. issue 2. 1995-05-15. PMID:7712172. |
the presence of the 5-ht3 antagonist mdl 72222 (30 microm), and the 5-ht2 antagonist ketanserin (3 microm) did not influence the ability of serotonin to inhibit epileptiform bursts. |
1995-05-15 |
2023-08-12 |
rat |
| L Uphouse, S Maswood, M Caldarola-Pastuszk. Agonist activation of 5-HT1A receptors in the median raphe nucleus and female rat lordosis behavior. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704614. |
infusion of 2,000 ng of the 5-ht2 agonist, (+/-)-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hcl (doi), or 4,000 ng 5-ht (creatinine sulfate) failed to substantially reduce lordosis behavior. |
1995-05-10 |
2023-08-12 |
rat |