| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Vhora, S Chib. Functional 5-HT receptor subtypes in the isolated canine common carotid artery. Heart and vessels. vol 9. issue 5. 1995-02-03. PMID:7814300. |
the vascular responses to 5-hydroxytrypamine (5-ht), 5-carboxamidotryptamine (5-ct, a selective 5-ht1-like receptor agonist), alpha-methyl-5-ht (alpha-m-5-ht, a relatively selective 5-ht2 receptor agonist), noradrenaline (na), and kcl were examined in isolated, cannulated, and perfused canine common carotid arterial preparations. |
1995-02-03 |
2023-08-12 |
Not clear |
| A Moulignie. [Central serotonin receptors. Principal fundamental and functional aspects. Therapeutic applications]. Revue neurologique. vol 150. issue 1. 1995-01-26. PMID:7801037. |
most 5-ht receptors belong to the g-protein-coupled receptor family (5-ht1, 5-ht2 and 5-ht4 receptors), whereas one is a member of the ligand-gated ion-channel receptor family (5-ht3 receptor). |
1995-01-26 |
2023-08-12 |
Not clear |
| M el Mansari, F Radja, A Ferron, T A Reader, E Molina-Holgado, L Descarrie. Hypersensitivity to serotonin and its agonists in serotonin-hyperinnervated neostriatum after neonatal dopamine denervation. European journal of pharmacology. vol 261. issue 1-2. 1995-01-23. PMID:8001641. |
neonatal destruction of the nigrostriatal dopamine projection by intraventricular 6-hydroxydopamine leads to a serotonin (5-hydroxytryptamine, 5-ht) hyperinnervation of the adult neostriatum accompanied by increased radioligand binding to 5-ht1b, 5-ht1nonab and 5-ht2 receptors. |
1995-01-23 |
2023-08-12 |
rat |
| P Martin, F Lemonnie. [The role of type 2 serotonin receptors, 5-HT2A and 5-HT2C, in depressive disorders: effect of medifoxamine]. L'Encephale. vol 20. issue 4. 1995-01-12. PMID:7988407. |
concerning 5-ht2 family, it is possible that some 5-ht binding drugs properties initially attributed to 5-ht2a receptors, might well be mediated by 5-ht2c receptors. |
1995-01-12 |
2023-08-12 |
human |
| M R Pranzatelli, P T Tailor, R Pluchino, W Gonzales, S Simmen. p,p'-DDT myoclonic/epileptic model: serotonin receptor binding and behavioral studies in the rat. Neurotoxicology. vol 15. issue 2. 1995-01-12. PMID:7991214. |
to study the role of serotonin (5-ht) receptors in myoclonus induced by p,p'-ddt in the rat, we performed time-course and dose-response studies of the effects of p,p'-ddt on behavior and regional 5-ht1 and 5-ht2 binding sites. |
1995-01-12 |
2023-08-12 |
rat |
| M R Pranzatelli, P T Tailor, R Pluchino, W Gonzales, S Simmen. p,p'-DDT myoclonic/epileptic model: serotonin receptor binding and behavioral studies in the rat. Neurotoxicology. vol 15. issue 2. 1995-01-12. PMID:7991214. |
at a time when low dose (80 mg/kg) p,p'-ddt elicited stimulus-sensitive and spontaneous myoclonus, there were no significant changes in bmax or kd of 5-ht1a, 5-ht1b, 5-ht1c sites in cortex, striatum, brainstem or spinal cord, agonist- or antagonist-labelled 5-ht2 sites in cortex, or 5-ht uptake sites. |
1995-01-12 |
2023-08-12 |
rat |
| S Grant, A Fitto. Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia. Drugs. vol 48. issue 2. 1995-01-10. PMID:7527327. |
risperidone, a benzisoxazol derivative, is a novel antipsychotic agent which combines potent serotonin (5-hydroxytryptamine) 5-ht2 and dopamine d2 receptor antagonism. |
1995-01-10 |
2023-08-12 |
Not clear |
| S Grant, A Fitto. Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia. Drugs. vol 48. issue 2. 1995-01-10. PMID:7527327. |
development of the drug was stimulated by reports that the selective serotonin 5-ht2 antagonist ritanserin improved the negative symptoms of schizophrenia and decreased extrapyramidal symptoms when combined with haloperidol. |
1995-01-10 |
2023-08-12 |
Not clear |
| J Malyszko, T Urano, R Knofler, A Taminato, T Yoshimi, Y Takada, A Takad. Daily variations of platelet aggregation in relation to blood and plasma serotonin in diabetes. Thrombosis research. vol 75. issue 5. 1995-01-09. PMID:7992257. |
an enhanced response of diabetic platelets to 5-ht together with elevated plasma 5-ht levels may contribute, at least partly, to the pathogenesis of diabetic vasculopathy and 5ht2 receptor blockers may be of value in dm patients. |
1995-01-09 |
2023-08-12 |
human |
| N R Newberry, S H Cheshire, M J Gilber. Evidence that the 5-HT3 receptors of the rat, mouse and guinea-pig superior cervical ganglion may be different. British journal of pharmacology. vol 102. issue 3. 1995-01-05. PMID:1364827. |
the 5-ht2 receptor antagonist ketanserin (1 microm) caused a clear rightward shift of the dose-response curve to 5-ht on the guinea-pig ganglion, but not on the mouse or rat ganglion. |
1995-01-05 |
2023-08-11 |
mouse |
| C J Done, T Shar. Biochemical evidence for the regulation of central noradrenergic activity by 5-HT1A and 5-HT2 receptors: microdialysis studies in the awake and anaesthetized rat. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984279. |
if this inhibitory tone is removed, either by decreasing 5-ht release through activation 5-ht1a autoreceptors or by blocking postsynaptic 5-ht2 receptors, noradrenaline release increases. |
1994-12-30 |
2023-08-12 |
rat |
| S Roychowdhury, H Haas, E G Anderso. 5-HT1A and 5-HT4 receptor colocalization on hippocampal pyramidal cells. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984294. |
the 5-ht3 agonist, 2-methyl 5-ht, had no effect, and the 5-ht2 antagonist, ketanserin, did not alter the excitatory responses to 5-ht. |
1994-12-30 |
2023-08-12 |
Not clear |
| J W Smythe, W B Rowe, M J Meane. Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7525113. |
neonatal handling alters serotonin (5-ht) turnover and 5-ht2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression. |
1994-12-20 |
2023-08-12 |
rat |
| J W Smythe, W B Rowe, M J Meane. Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7525113. |
the effect of postnatal handling on glucocorticoid receptor expression appears to be mediated by an increase in serotonin (5-ht) activity, acting via a 5-ht2 receptor with a high affinity for 5-ht (i.e. |
1994-12-20 |
2023-08-12 |
rat |
| J W Smythe, W B Rowe, M J Meane. Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7525113. |
hypothalamus and amygdala); (2) handling has no long-term effects on hippocampal or frontal cortex 5-ht turnover, and is actually associated with a decrease in 5-ht concentrations; and (3) handling does not alter 5-ht2 receptor density in the hippocampus or frontal cortex in neonates (although there are surprising effects on 5-ht2 receptor density in the frontal cortex of adult animals). |
1994-12-20 |
2023-08-12 |
rat |
| J W Smythe, W B Rowe, M J Meane. Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7525113. |
taken together these data provide further evidence for the importance of 5-ht in mediating the effects of handling on the development of glucocorticoid receptor expression, but suggest that the role of 5-ht is unique to early development; differences in glucocorticoid receptor expression in adult handled and non-handled animals are not associated with long-term differences in either 5-ht levels or 5-ht2 receptors. |
1994-12-20 |
2023-08-12 |
rat |
| Y Saruhashi, W Youn. Effect of mianserin on locomotory function after thoracic spinal cord hemisection in rats. Experimental neurology. vol 129. issue 2. 1994-12-20. PMID:7957735. |
to study the role of serotonin (5-ht) in spinal cord injury, we observed the effects of mianserin (a 5-ht1c and 5-ht2 receptor antagonist) on rat locomotory function after thoracic spinal cord hemisection. |
1994-12-20 |
2023-08-12 |
rat |
| J Bán. A comparative study of amitriptyline and fluvoxamine in migraine prophylaxis. Headache. vol 34. issue 8. 1994-12-16. PMID:7960733. |
prophylactic treatment of severe migraine may reduce attack frequency, and current therapy centers on beta-blockers, serotonin (5-ht) reuptake blockers and 5-ht2 receptor antagonists. |
1994-12-16 |
2023-08-12 |
human |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
electrophysiological studies have suggested that a subpopulation of interneurons near the border of layer ii and iii in rat piriform cortex are excited by serotonin (5-hydroxytryptamine; 5-ht) via 5-ht2a (formerly 5-ht2) rather than 5-ht2c (formerly 5-ht1c) receptors. |
1994-12-08 |
2023-08-12 |
rat |
| B Zhang, R M Harris-Warric. Multiple receptors mediate the modulatory effects of serotonergic neurons in a small neural network. The Journal of experimental biology. vol 190. 1994-12-08. PMID:7964396. |
the 5-ht agonists 5-ct (5-ht1) and alpha-me-5ht (5-ht2) also induced ab/pd bursting, which was blocked by cinanserin, but not by atropine. |
1994-12-08 |
2023-08-12 |
Not clear |